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Q8C1R0 (TSSK5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-specific serine/threonine-protein kinase 5

Short name=TSK-5
Short name=TSSK-5
Short name=Testis-specific kinase 5
EC=2.7.11.1
Gene names
Name:Tssk5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in a signaling pathway during male germ cell development or mature sperm function By similarity. UniProtKB Q61241

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB Q9BXA7

Cofactor

Magnesium By similarity. UniProtKB Q9BXA7

Enzyme regulation

Activated by phosphorylation on Thr-207, potentially by autophosphorylation By similarity. UniProtKB Q9BXA7

Post-translational modification

Autophosphorylated By similarity. UniProtKB Q9BXA7

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAC25160.1 differs from that shown. Reason: Frameshift at position 213.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Testis-specific serine/threonine-protein kinase 5
PRO_0000281894

Regions

Domain27 – 302276Protein kinase
Nucleotide binding33 – 419ATP By similarity UniProtKB P28523

Sites

Active site1731Proton acceptor By similarity UniProtKB P28523
Binding site721ATP By similarity UniProtKB P28523

Sequences

Sequence LengthMass (Da)Tools
Q8C1R0 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 9F43A6148147DD06

FASTA37242,234
        10         20         30         40         50         60 
MRSSSWRKSD QRVFIEQVRE CMNNGYLLSS KKIGSGAFSK VYLAYATRER MKHNPRLSSD 

        70         80         90        100        110        120 
LRGKRHTMVA IKIVSMAEAP AEYSRKFLPR EILSLNATYK HMNIVQLYET YQNSQRSYLV 

       130        140        150        160        170        180 
LELAARGDLL EHINAVSDLR CCPGLEEEEA RRLFWQLVSA VAHCHNVGIV HRDLKCENIL 

       190        200        210        220        230        240 
LDDQGFIKLT DFGFANWVGL KNSLLSTFCG SVAYTAPEIL MSKKYNGEQA DLWSLGIILH 

       250        260        270        280        290        300 
AMVSGKLPFK EHQPHRMLNL IRRGPIFRPG LSPECRDLIR GLLQLHPCER LDLQQVAAHC 

       310        320        330        340        350        360 
WMLPAEHMLS SALGAPREQD HSWSTVAPDN TEPDRDTRHA RSKGSSSSSG RTSPRRPSLA 

       370 
QLCNTWKPAP EQ 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-255.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK007032 mRNA. Translation: BAC25160.1. Frameshift.
BC114543 mRNA. Translation: AAI14544.1.
CCDSCCDS37122.1.
RefSeqNP_898922.2. NM_183099.2.
UniGeneMm.159026.

3D structure databases

ProteinModelPortalQ8C1R0.
SMRQ8C1R0. Positions 31-362.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid216092. 2 interactions.
MINTMINT-1341605.

Proteomic databases

PRIDEQ8C1R0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000071119; ENSMUSP00000071120; ENSMUSG00000060794.
GeneID73542.
KEGGmmu:73542.
UCSCuc007wka.1. mouse.

Organism-specific databases

CTD73542.
MGIMGI:1920792. Tssk5.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000115122.
HOGENOMHOG000233016.
InParanoidQ8C1R0.
OMAGEQADLW.
OrthoDBEOG7TTQ7V.
PhylomeDBQ8C1R0.
TreeFamTF105333.

Gene expression databases

BgeeQ8C1R0.
CleanExMM_TSSK5.
GenevestigatorQ8C1R0.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio338498.
PROQ8C1R0.
SOURCESearch...

Entry information

Entry nameTSSK5_MOUSE
AccessionPrimary (citable) accession number: Q8C1R0
Secondary accession number(s): Q1WWK7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot