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Q8C1R0

- TSSK5_MOUSE

UniProt

Q8C1R0 - TSSK5_MOUSE

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Protein

Testis-specific serine/threonine-protein kinase 5

Gene

Tssk5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in a signaling pathway during male germ cell development or mature sperm function.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium.By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-207, potentially by autophosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPBy similarityPROSITE-ProRule annotation
Active sitei173 – 1731Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 419ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein phosphorylation Source: UniProtKB
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 5 (EC:2.7.11.1)
Short name:
TSK-5
Short name:
TSSK-5
Short name:
Testis-specific kinase 5
Gene namesi
Name:Tssk5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1920792. Tssk5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Testis-specific serine/threonine-protein kinase 5PRO_0000281894Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8C1R0.

Expressioni

Gene expression databases

BgeeiQ8C1R0.
CleanExiMM_TSSK5.
GenevestigatoriQ8C1R0.

Interactioni

Protein-protein interaction databases

BioGridi216092. 2 interactions.
MINTiMINT-1341605.

Structurei

3D structure databases

ProteinModelPortaliQ8C1R0.
SMRiQ8C1R0. Positions 31-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 302276Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119240.
HOGENOMiHOG000233016.
InParanoidiQ8C1R0.
OMAiGEQADLW.
OrthoDBiEOG7TTQ7V.
PhylomeDBiQ8C1R0.
TreeFamiTF105333.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C1R0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSSSWRKSD QRVFIEQVRE CMNNGYLLSS KKIGSGAFSK VYLAYATRER
60 70 80 90 100
MKHNPRLSSD LRGKRHTMVA IKIVSMAEAP AEYSRKFLPR EILSLNATYK
110 120 130 140 150
HMNIVQLYET YQNSQRSYLV LELAARGDLL EHINAVSDLR CCPGLEEEEA
160 170 180 190 200
RRLFWQLVSA VAHCHNVGIV HRDLKCENIL LDDQGFIKLT DFGFANWVGL
210 220 230 240 250
KNSLLSTFCG SVAYTAPEIL MSKKYNGEQA DLWSLGIILH AMVSGKLPFK
260 270 280 290 300
EHQPHRMLNL IRRGPIFRPG LSPECRDLIR GLLQLHPCER LDLQQVAAHC
310 320 330 340 350
WMLPAEHMLS SALGAPREQD HSWSTVAPDN TEPDRDTRHA RSKGSSSSSG
360 370
RTSPRRPSLA QLCNTWKPAP EQ
Length:372
Mass (Da):42,234
Last modified:April 3, 2007 - v2
Checksum:i9F43A6148147DD06
GO

Sequence cautioni

The sequence BAC25160.1 differs from that shown. Reason: Frameshift at position 213.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007032 mRNA. Translation: BAC25160.1. Frameshift.
BC114543 mRNA. Translation: AAI14544.1.
CCDSiCCDS37122.1.
RefSeqiNP_898922.2. NM_183099.2.
UniGeneiMm.159026.

Genome annotation databases

EnsembliENSMUST00000071119; ENSMUSP00000071120; ENSMUSG00000060794.
GeneIDi73542.
KEGGimmu:73542.
UCSCiuc007wka.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007032 mRNA. Translation: BAC25160.1 . Frameshift.
BC114543 mRNA. Translation: AAI14544.1 .
CCDSi CCDS37122.1.
RefSeqi NP_898922.2. NM_183099.2.
UniGenei Mm.159026.

3D structure databases

ProteinModelPortali Q8C1R0.
SMRi Q8C1R0. Positions 31-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 216092. 2 interactions.
MINTi MINT-1341605.

Proteomic databases

PRIDEi Q8C1R0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071119 ; ENSMUSP00000071120 ; ENSMUSG00000060794 .
GeneIDi 73542.
KEGGi mmu:73542.
UCSCi uc007wka.1. mouse.

Organism-specific databases

CTDi 73542.
MGIi MGI:1920792. Tssk5.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119240.
HOGENOMi HOG000233016.
InParanoidi Q8C1R0.
OMAi GEQADLW.
OrthoDBi EOG7TTQ7V.
PhylomeDBi Q8C1R0.
TreeFami TF105333.

Miscellaneous databases

NextBioi 338498.
PROi Q8C1R0.
SOURCEi Search...

Gene expression databases

Bgeei Q8C1R0.
CleanExi MM_TSSK5.
Genevestigatori Q8C1R0.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-255.

Entry informationi

Entry nameiTSSK5_MOUSE
AccessioniPrimary (citable) accession number: Q8C1R0
Secondary accession number(s): Q1WWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3