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Q8C1R0

- TSSK5_MOUSE

UniProt

Q8C1R0 - TSSK5_MOUSE

Protein

Testis-specific serine/threonine-protein kinase 5

Gene

Tssk5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    May be involved in a signaling pathway during male germ cell development or mature sperm function.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by phosphorylation on Thr-207, potentially by autophosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPBy similarityPROSITE-ProRule annotation
    Active sitei173 – 1731Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 419ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein phosphorylation Source: UniProtKB
    4. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific serine/threonine-protein kinase 5 (EC:2.7.11.1)
    Short name:
    TSK-5
    Short name:
    TSSK-5
    Short name:
    Testis-specific kinase 5
    Gene namesi
    Name:Tssk5Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1920792. Tssk5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Testis-specific serine/threonine-protein kinase 5PRO_0000281894Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8C1R0.

    Expressioni

    Gene expression databases

    BgeeiQ8C1R0.
    CleanExiMM_TSSK5.
    GenevestigatoriQ8C1R0.

    Interactioni

    Protein-protein interaction databases

    BioGridi216092. 2 interactions.
    MINTiMINT-1341605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C1R0.
    SMRiQ8C1R0. Positions 31-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 302276Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000115122.
    HOGENOMiHOG000233016.
    InParanoidiQ8C1R0.
    OMAiGEQADLW.
    OrthoDBiEOG7TTQ7V.
    PhylomeDBiQ8C1R0.
    TreeFamiTF105333.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C1R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSSSWRKSD QRVFIEQVRE CMNNGYLLSS KKIGSGAFSK VYLAYATRER    50
    MKHNPRLSSD LRGKRHTMVA IKIVSMAEAP AEYSRKFLPR EILSLNATYK 100
    HMNIVQLYET YQNSQRSYLV LELAARGDLL EHINAVSDLR CCPGLEEEEA 150
    RRLFWQLVSA VAHCHNVGIV HRDLKCENIL LDDQGFIKLT DFGFANWVGL 200
    KNSLLSTFCG SVAYTAPEIL MSKKYNGEQA DLWSLGIILH AMVSGKLPFK 250
    EHQPHRMLNL IRRGPIFRPG LSPECRDLIR GLLQLHPCER LDLQQVAAHC 300
    WMLPAEHMLS SALGAPREQD HSWSTVAPDN TEPDRDTRHA RSKGSSSSSG 350
    RTSPRRPSLA QLCNTWKPAP EQ 372
    Length:372
    Mass (Da):42,234
    Last modified:April 3, 2007 - v2
    Checksum:i9F43A6148147DD06
    GO

    Sequence cautioni

    The sequence BAC25160.1 differs from that shown. Reason: Frameshift at position 213.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007032 mRNA. Translation: BAC25160.1. Frameshift.
    BC114543 mRNA. Translation: AAI14544.1.
    CCDSiCCDS37122.1.
    RefSeqiNP_898922.2. NM_183099.2.
    UniGeneiMm.159026.

    Genome annotation databases

    EnsembliENSMUST00000071119; ENSMUSP00000071120; ENSMUSG00000060794.
    GeneIDi73542.
    KEGGimmu:73542.
    UCSCiuc007wka.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007032 mRNA. Translation: BAC25160.1 . Frameshift.
    BC114543 mRNA. Translation: AAI14544.1 .
    CCDSi CCDS37122.1.
    RefSeqi NP_898922.2. NM_183099.2.
    UniGenei Mm.159026.

    3D structure databases

    ProteinModelPortali Q8C1R0.
    SMRi Q8C1R0. Positions 31-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 216092. 2 interactions.
    MINTi MINT-1341605.

    Proteomic databases

    PRIDEi Q8C1R0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071119 ; ENSMUSP00000071120 ; ENSMUSG00000060794 .
    GeneIDi 73542.
    KEGGi mmu:73542.
    UCSCi uc007wka.1. mouse.

    Organism-specific databases

    CTDi 73542.
    MGIi MGI:1920792. Tssk5.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000115122.
    HOGENOMi HOG000233016.
    InParanoidi Q8C1R0.
    OMAi GEQADLW.
    OrthoDBi EOG7TTQ7V.
    PhylomeDBi Q8C1R0.
    TreeFami TF105333.

    Miscellaneous databases

    NextBioi 338498.
    PROi Q8C1R0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C1R0.
    CleanExi MM_TSSK5.
    Genevestigatori Q8C1R0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-255.

    Entry informationi

    Entry nameiTSSK5_MOUSE
    AccessioniPrimary (citable) accession number: Q8C1R0
    Secondary accession number(s): Q1WWK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3