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Protein

Testis-specific serine/threonine-protein kinase 5

Gene

Tssk5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in a signaling pathway during male germ cell development or mature sperm function.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-207, potentially by autophosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPPROSITE-ProRule annotationBy similarity
Active sitei173 – 1731Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 419ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 5 (EC:2.7.11.1)
Short name:
TSK-5
Short name:
TSSK-5
Short name:
Testis-specific kinase 5
Gene namesi
Name:Tssk5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920792. Tssk5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Testis-specific serine/threonine-protein kinase 5PRO_0000281894Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8C1R0.

Expressioni

Gene expression databases

BgeeiQ8C1R0.
CleanExiMM_TSSK5.
GenevisibleiQ8C1R0. MM.

Interactioni

Protein-protein interaction databases

BioGridi216092. 2 interactions.
MINTiMINT-1341605.
STRINGi10090.ENSMUSP00000071120.

Structurei

3D structure databases

ProteinModelPortaliQ8C1R0.
SMRiQ8C1R0. Positions 31-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 302276Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
InParanoidiQ8C1R0.
OMAiGEQADLW.
OrthoDBiEOG7TTQ7V.
PhylomeDBiQ8C1R0.
TreeFamiTF105333.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C1R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSSWRKSD QRVFIEQVRE CMNNGYLLSS KKIGSGAFSK VYLAYATRER
60 70 80 90 100
MKHNPRLSSD LRGKRHTMVA IKIVSMAEAP AEYSRKFLPR EILSLNATYK
110 120 130 140 150
HMNIVQLYET YQNSQRSYLV LELAARGDLL EHINAVSDLR CCPGLEEEEA
160 170 180 190 200
RRLFWQLVSA VAHCHNVGIV HRDLKCENIL LDDQGFIKLT DFGFANWVGL
210 220 230 240 250
KNSLLSTFCG SVAYTAPEIL MSKKYNGEQA DLWSLGIILH AMVSGKLPFK
260 270 280 290 300
EHQPHRMLNL IRRGPIFRPG LSPECRDLIR GLLQLHPCER LDLQQVAAHC
310 320 330 340 350
WMLPAEHMLS SALGAPREQD HSWSTVAPDN TEPDRDTRHA RSKGSSSSSG
360 370
RTSPRRPSLA QLCNTWKPAP EQ
Length:372
Mass (Da):42,234
Last modified:April 3, 2007 - v2
Checksum:i9F43A6148147DD06
GO

Sequence cautioni

The sequence BAC25160.1 differs from that shown. Reason: Frameshift at position 213. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007032 mRNA. Translation: BAC25160.1. Frameshift.
BC114543 mRNA. Translation: AAI14544.1.
CCDSiCCDS37122.1.
RefSeqiNP_898922.2. NM_183099.2.
UniGeneiMm.159026.

Genome annotation databases

EnsembliENSMUST00000071119; ENSMUSP00000071120; ENSMUSG00000060794.
GeneIDi73542.
KEGGimmu:73542.
UCSCiuc007wka.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007032 mRNA. Translation: BAC25160.1. Frameshift.
BC114543 mRNA. Translation: AAI14544.1.
CCDSiCCDS37122.1.
RefSeqiNP_898922.2. NM_183099.2.
UniGeneiMm.159026.

3D structure databases

ProteinModelPortaliQ8C1R0.
SMRiQ8C1R0. Positions 31-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216092. 2 interactions.
MINTiMINT-1341605.
STRINGi10090.ENSMUSP00000071120.

Proteomic databases

PRIDEiQ8C1R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071119; ENSMUSP00000071120; ENSMUSG00000060794.
GeneIDi73542.
KEGGimmu:73542.
UCSCiuc007wka.1. mouse.

Organism-specific databases

CTDi73542.
MGIiMGI:1920792. Tssk5.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
InParanoidiQ8C1R0.
OMAiGEQADLW.
OrthoDBiEOG7TTQ7V.
PhylomeDBiQ8C1R0.
TreeFamiTF105333.

Miscellaneous databases

NextBioi338498.
PROiQ8C1R0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C1R0.
CleanExiMM_TSSK5.
GenevisibleiQ8C1R0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-255.

Entry informationi

Entry nameiTSSK5_MOUSE
AccessioniPrimary (citable) accession number: Q8C1R0
Secondary accession number(s): Q1WWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 24, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.