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Protein

Testis-specific serine/threonine-protein kinase 5

Gene

Tssk5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in a signaling pathway during male germ cell development or mature sperm function.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-207, potentially by autophosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72ATPPROSITE-ProRule annotationBy similarity1
Active sitei173Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 41ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 5 (EC:2.7.11.1)
Short name:
TSK-5
Short name:
TSSK-5
Short name:
Testis-specific kinase 5
Gene namesi
Name:Tssk5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920792 Tssk5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818941 – 372Testis-specific serine/threonine-protein kinase 5Add BLAST372

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C1R0
PRIDEiQ8C1R0

PTM databases

SwissPalmiQ8C1R0

Expressioni

Gene expression databases

BgeeiENSMUSG00000060794
CleanExiMM_TSSK5
GenevisibleiQ8C1R0 MM

Interactioni

Protein-protein interaction databases

BioGridi216092, 2 interactors
MINTiQ8C1R0
STRINGi10090.ENSMUSP00000071120

Structurei

3D structure databases

ProteinModelPortaliQ8C1R0
SMRiQ8C1R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 302Protein kinasePROSITE-ProRule annotationAdd BLAST276

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00770000120521
HOGENOMiHOG000233016
InParanoidiQ8C1R0
OMAiGEQADLW
OrthoDBiEOG091G0D5X
PhylomeDBiQ8C1R0
TreeFamiTF105333

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C1R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSSWRKSD QRVFIEQVRE CMNNGYLLSS KKIGSGAFSK VYLAYATRER
60 70 80 90 100
MKHNPRLSSD LRGKRHTMVA IKIVSMAEAP AEYSRKFLPR EILSLNATYK
110 120 130 140 150
HMNIVQLYET YQNSQRSYLV LELAARGDLL EHINAVSDLR CCPGLEEEEA
160 170 180 190 200
RRLFWQLVSA VAHCHNVGIV HRDLKCENIL LDDQGFIKLT DFGFANWVGL
210 220 230 240 250
KNSLLSTFCG SVAYTAPEIL MSKKYNGEQA DLWSLGIILH AMVSGKLPFK
260 270 280 290 300
EHQPHRMLNL IRRGPIFRPG LSPECRDLIR GLLQLHPCER LDLQQVAAHC
310 320 330 340 350
WMLPAEHMLS SALGAPREQD HSWSTVAPDN TEPDRDTRHA RSKGSSSSSG
360 370
RTSPRRPSLA QLCNTWKPAP EQ
Length:372
Mass (Da):42,234
Last modified:April 3, 2007 - v2
Checksum:i9F43A6148147DD06
GO

Sequence cautioni

The sequence BAC25160 differs from that shown. Reason: Frameshift at position 213.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007032 mRNA Translation: BAC25160.1 Frameshift.
BC114543 mRNA Translation: AAI14544.1
CCDSiCCDS37122.1
RefSeqiNP_898922.2, NM_183099.2
UniGeneiMm.159026

Genome annotation databases

EnsembliENSMUST00000071119; ENSMUSP00000071120; ENSMUSG00000060794
GeneIDi73542
KEGGimmu:73542
UCSCiuc007wka.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTSSK5_MOUSE
AccessioniPrimary (citable) accession number: Q8C1R0
Secondary accession number(s): Q1WWK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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