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Protein

Transmembrane protein 120A

Gene

Tmem120a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for efficient adipogenesis (PubMed:26024229).1 Publication

GO - Biological processi

  • fat cell differentiation Source: UniProtKB
  • protein heterooligomerization Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Alternative name(s):
Transmembrane protein induced by tumor necrosis factor alpha
Gene namesi
Name:Tmem120a
Synonyms:Net291 Publication, Tmpit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2686991. Tmem120a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 135135ExtracellularSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Topological domaini157 – 1626CytoplasmicSequence analysis
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 1907ExtracellularSequence analysis
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 27362CytoplasmicSequence analysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Topological domaini295 – 30511ExtracellularSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Topological domaini327 – 34317CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Transmembrane protein 120APRO_0000309340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8C1E7.
MaxQBiQ8C1E7.
PaxDbiQ8C1E7.
PRIDEiQ8C1E7.

PTM databases

iPTMnetiQ8C1E7.
SwissPalmiQ8C1E7.

Expressioni

Tissue specificityi

Highly expressed in white adipose tissue (at protein level). Highly expressed in brown adipose tissue and expressed at low levels in liver.1 Publication

Inductioni

Up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiQ8C1E7.
CleanExiMM_TMEM120A.
ExpressionAtlasiQ8C1E7. baseline and differential.
GenevisibleiQ8C1E7. MM.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with TMEM120B.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045252.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ8C1E7.
OMAiGQFWQLY.
OrthoDBiEOG790G18.
PhylomeDBiQ8C1E7.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C1E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRLKLEEL TKLQANCTNS
60 70 80 90 100
ITRQKKRLQE LALVLKKCRP SLPSESMEAA QELENQMKER QGLFFDMEAY
110 120 130 140 150
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILIVISFT
160 170 180 190 200
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS
210 220 230 240 250
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA
260 270 280 290 300
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
310 320 330 340
ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQQHGN KKD
Length:343
Mass (Da):40,751
Last modified:March 1, 2003 - v1
Checksum:i7AC1BE2A31E0A6C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028119 mRNA. Translation: BAC25759.1.
AK050367 mRNA. Translation: BAC34212.1.
BC046757 mRNA. Translation: AAH46757.1.
CCDSiCCDS19744.1.
RefSeqiNP_766129.1. NM_172541.2.
UniGeneiMm.11688.

Genome annotation databases

EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886.
GeneIDi215210.
KEGGimmu:215210.
UCSCiuc008zyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028119 mRNA. Translation: BAC25759.1.
AK050367 mRNA. Translation: BAC34212.1.
BC046757 mRNA. Translation: AAH46757.1.
CCDSiCCDS19744.1.
RefSeqiNP_766129.1. NM_172541.2.
UniGeneiMm.11688.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045252.

PTM databases

iPTMnetiQ8C1E7.
SwissPalmiQ8C1E7.

Proteomic databases

EPDiQ8C1E7.
MaxQBiQ8C1E7.
PaxDbiQ8C1E7.
PRIDEiQ8C1E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886.
GeneIDi215210.
KEGGimmu:215210.
UCSCiuc008zyu.1. mouse.

Organism-specific databases

CTDi83862.
MGIiMGI:2686991. Tmem120a.

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ8C1E7.
OMAiGQFWQLY.
OrthoDBiEOG790G18.
PhylomeDBiQ8C1E7.
TreeFamiTF313552.

Miscellaneous databases

NextBioi374644.
PROiQ8C1E7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C1E7.
CleanExiMM_TMEM120A.
ExpressionAtlasiQ8C1E7. baseline and differential.
GenevisibleiQ8C1E7. MM.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope."
    Malik P., Korfali N., Srsen V., Lazou V., Batrakou D.G., Zuleger N., Kavanagh D.M., Wilkie G.S., Goldberg M.W., Schirmer E.C.
    Cell. Mol. Life Sci. 67:1353-1369(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "TMEM120A and B: nuclear envelope transmembrane proteins important for adipocyte differentiation."
    Batrakou D.G., de Las Heras J.I., Czapiewski R., Mouras R., Schirmer E.C.
    PLoS ONE 10:E0127712-E0127712(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiT120A_MOUSE
AccessioniPrimary (citable) accession number: Q8C1E7
Secondary accession number(s): Q8BWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.