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Q8C1E7 (T120A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 120A
Alternative name(s):
Transmembrane protein induced by tumor necrosis factor alpha
Gene names
Name:Tmem120a
Synonyms:Tmpit
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM120 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Transmembrane protein 120A
PRO_0000309340

Regions

Topological domain1 – 135135Extracellular Potential
Transmembrane136 – 15621Helical; Potential
Topological domain157 – 1626Cytoplasmic Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 1907Extracellular Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 27362Cytoplasmic Potential
Transmembrane274 – 29421Helical; Potential
Topological domain295 – 30511Extracellular Potential
Transmembrane306 – 32621Helical; Potential
Topological domain327 – 34317Cytoplasmic Potential

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8C1E7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7AC1BE2A31E0A6C1

FASTA34340,751
        10         20         30         40         50         60 
MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRLKLEEL TKLQANCTNS ITRQKKRLQE 

        70         80         90        100        110        120 
LALVLKKCRP SLPSESMEAA QELENQMKER QGLFFDMEAY LPKKNGLYLS LVLGNVNVTL 

       130        140        150        160        170        180 
LSKQAKFAYK DEYEKFKLYL TIILIVISFT CRFLLNSRVT DAAFNFLLVW YYCTLTIRES 

       190        200        210        220        230        240 
ILINNGSRIK GWWVFHHYVS TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY 

       250        260        270        280        290        300 
QSGCLYRLRA LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP 

       310        320        330        340 
ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQQHGN KKD 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver and Small intestine.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028119 mRNA. Translation: BAC25759.1.
AK050367 mRNA. Translation: BAC34212.1.
BC046757 mRNA. Translation: AAH46757.1.
RefSeqNP_766129.1. NM_172541.2.
UniGeneMm.11688.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ8C1E7.
PRIDEQ8C1E7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886.
GeneID215210.
KEGGmmu:215210.
UCSCuc008zyu.1. mouse.

Organism-specific databases

CTD83862.
MGIMGI:2686991. Tmem120a.

Phylogenomic databases

eggNOGNOG329433.
GeneTreeENSGT00390000007848.
HOGENOMHOG000267032.
HOVERGENHBG108532.
InParanoidQ8C1E7.
OMALPECKEW.
OrthoDBEOG790G18.
PhylomeDBQ8C1E7.
TreeFamTF313552.

Gene expression databases

BgeeQ8C1E7.
CleanExMM_TMEM120A.
GenevestigatorQ8C1E7.

Family and domain databases

InterProIPR012926. TMPIT.
[Graphical view]
PANTHERPTHR21433. PTHR21433. 1 hit.
PfamPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374644.
PROQ8C1E7.
SOURCESearch...

Entry information

Entry nameT120A_MOUSE
AccessionPrimary (citable) accession number: Q8C1E7
Secondary accession number(s): Q8BWP7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot