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Q8C1E7

- T120A_MOUSE

UniProt

Q8C1E7 - T120A_MOUSE

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Protein
Transmembrane protein 120A
Gene
Tmem120a, Tmpit
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Alternative name(s):
Transmembrane protein induced by tumor necrosis factor alpha
Gene namesi
Name:Tmem120a
Synonyms:Tmpit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2686991. Tmem120a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 135135Extracellular Reviewed prediction
Add
BLAST
Transmembranei136 – 15621Helical; Reviewed prediction
Add
BLAST
Topological domaini157 – 1626Cytoplasmic Reviewed prediction
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 1907Extracellular Reviewed prediction
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Topological domaini212 – 27362Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Topological domaini295 – 30511Extracellular Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Reviewed prediction
Add
BLAST
Topological domaini327 – 34317Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Transmembrane protein 120A
PRO_0000309340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8C1E7.
PaxDbiQ8C1E7.
PRIDEiQ8C1E7.

Expressioni

Gene expression databases

BgeeiQ8C1E7.
CleanExiMM_TMEM120A.
GenevestigatoriQ8C1E7.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329433.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ8C1E7.
OMAiFFEMEAY.
OrthoDBiEOG790G18.
PhylomeDBiQ8C1E7.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C1E7-1 [UniParc]FASTAAdd to Basket

« Hide

MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRLKLEEL TKLQANCTNS    50
ITRQKKRLQE LALVLKKCRP SLPSESMEAA QELENQMKER QGLFFDMEAY 100
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILIVISFT 150
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS 200
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA 250
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP 300
ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQQHGN KKD 343
Length:343
Mass (Da):40,751
Last modified:March 1, 2003 - v1
Checksum:i7AC1BE2A31E0A6C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028119 mRNA. Translation: BAC25759.1.
AK050367 mRNA. Translation: BAC34212.1.
BC046757 mRNA. Translation: AAH46757.1.
CCDSiCCDS19744.1.
RefSeqiNP_766129.1. NM_172541.2.
UniGeneiMm.11688.

Genome annotation databases

EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886.
GeneIDi215210.
KEGGimmu:215210.
UCSCiuc008zyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028119 mRNA. Translation: BAC25759.1 .
AK050367 mRNA. Translation: BAC34212.1 .
BC046757 mRNA. Translation: AAH46757.1 .
CCDSi CCDS19744.1.
RefSeqi NP_766129.1. NM_172541.2.
UniGenei Mm.11688.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q8C1E7.
PaxDbi Q8C1E7.
PRIDEi Q8C1E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043378 ; ENSMUSP00000045252 ; ENSMUSG00000039886 .
GeneIDi 215210.
KEGGi mmu:215210.
UCSCi uc008zyu.1. mouse.

Organism-specific databases

CTDi 83862.
MGIi MGI:2686991. Tmem120a.

Phylogenomic databases

eggNOGi NOG329433.
GeneTreei ENSGT00390000007848.
HOGENOMi HOG000267032.
HOVERGENi HBG108532.
InParanoidi Q8C1E7.
OMAi FFEMEAY.
OrthoDBi EOG790G18.
PhylomeDBi Q8C1E7.
TreeFami TF313552.

Miscellaneous databases

NextBioi 374644.
PROi Q8C1E7.
SOURCEi Search...

Gene expression databases

Bgeei Q8C1E7.
CleanExi MM_TMEM120A.
Genevestigatori Q8C1E7.

Family and domain databases

InterProi IPR012926. TMPIT.
[Graphical view ]
PANTHERi PTHR21433. PTHR21433. 1 hit.
Pfami PF07851. TMPIT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiT120A_MOUSE
AccessioniPrimary (citable) accession number: Q8C1E7
Secondary accession number(s): Q8BWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi