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Q8C1E7

- T120A_MOUSE

UniProt

Q8C1E7 - T120A_MOUSE

Protein

Transmembrane protein 120A

Gene

Tmem120a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 120A
    Alternative name(s):
    Transmembrane protein induced by tumor necrosis factor alpha
    Gene namesi
    Name:Tmem120a
    Synonyms:Tmpit
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2686991. Tmem120a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Transmembrane protein 120APRO_0000309340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8C1E7.
    PaxDbiQ8C1E7.
    PRIDEiQ8C1E7.

    Expressioni

    Gene expression databases

    BgeeiQ8C1E7.
    CleanExiMM_TMEM120A.
    GenevestigatoriQ8C1E7.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 135135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini157 – 1626CytoplasmicSequence Analysis
    Topological domaini184 – 1907ExtracellularSequence Analysis
    Topological domaini212 – 27362CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini295 – 30511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini327 – 34317CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM120 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329433.
    GeneTreeiENSGT00390000007848.
    HOGENOMiHOG000267032.
    HOVERGENiHBG108532.
    InParanoidiQ8C1E7.
    OMAiFFEMEAY.
    OrthoDBiEOG790G18.
    PhylomeDBiQ8C1E7.
    TreeFamiTF313552.

    Family and domain databases

    InterProiIPR012926. TMPIT.
    [Graphical view]
    PANTHERiPTHR21433. PTHR21433. 1 hit.
    PfamiPF07851. TMPIT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C1E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRLKLEEL TKLQANCTNS    50
    ITRQKKRLQE LALVLKKCRP SLPSESMEAA QELENQMKER QGLFFDMEAY 100
    LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILIVISFT 150
    CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS 200
    TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA 250
    LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP 300
    ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQQHGN KKD 343
    Length:343
    Mass (Da):40,751
    Last modified:March 1, 2003 - v1
    Checksum:i7AC1BE2A31E0A6C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028119 mRNA. Translation: BAC25759.1.
    AK050367 mRNA. Translation: BAC34212.1.
    BC046757 mRNA. Translation: AAH46757.1.
    CCDSiCCDS19744.1.
    RefSeqiNP_766129.1. NM_172541.2.
    UniGeneiMm.11688.

    Genome annotation databases

    EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886.
    GeneIDi215210.
    KEGGimmu:215210.
    UCSCiuc008zyu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028119 mRNA. Translation: BAC25759.1 .
    AK050367 mRNA. Translation: BAC34212.1 .
    BC046757 mRNA. Translation: AAH46757.1 .
    CCDSi CCDS19744.1.
    RefSeqi NP_766129.1. NM_172541.2.
    UniGenei Mm.11688.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q8C1E7.
    PaxDbi Q8C1E7.
    PRIDEi Q8C1E7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043378 ; ENSMUSP00000045252 ; ENSMUSG00000039886 .
    GeneIDi 215210.
    KEGGi mmu:215210.
    UCSCi uc008zyu.1. mouse.

    Organism-specific databases

    CTDi 83862.
    MGIi MGI:2686991. Tmem120a.

    Phylogenomic databases

    eggNOGi NOG329433.
    GeneTreei ENSGT00390000007848.
    HOGENOMi HOG000267032.
    HOVERGENi HBG108532.
    InParanoidi Q8C1E7.
    OMAi FFEMEAY.
    OrthoDBi EOG790G18.
    PhylomeDBi Q8C1E7.
    TreeFami TF313552.

    Miscellaneous databases

    NextBioi 374644.
    PROi Q8C1E7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C1E7.
    CleanExi MM_TMEM120A.
    Genevestigatori Q8C1E7.

    Family and domain databases

    InterProi IPR012926. TMPIT.
    [Graphical view ]
    PANTHERi PTHR21433. PTHR21433. 1 hit.
    Pfami PF07851. TMPIT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiT120A_MOUSE
    AccessioniPrimary (citable) accession number: Q8C1E7
    Secondary accession number(s): Q8BWP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3