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Q8C1B7

- SEP11_MOUSE

UniProt

Q8C1B7 - SEP11_MOUSE

Protein

Septin-11

Gene

Sept11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Filament-forming cytoskeletal GTPase. May play a role in cytokinesis Potential. May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity By similarity.By similarityCurated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031GTP; via amide nitrogenBy similarity
    Binding sitei238 – 2381GTP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei253 – 2531GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi48 – 558GTPBy similarity
    Nucleotide bindingi184 – 1929GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein heterooligomerization Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Septin-11
    Gene namesi
    Name:Sept11
    Synonyms:D5Ertd606e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1277214. Sept11.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication. Cell junctionsynapse 1 Publication. Cell projectiondendritic spine 1 Publication. Cell projectionaxon By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. cell junction Source: UniProtKB-KW
    3. dendritic spine Source: UniProtKB-SubCell
    4. septin complex Source: InterPro
    5. stress fiber Source: Ensembl
    6. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 431430Septin-11PRO_0000173543Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8C1B7.
    PaxDbiQ8C1B7.
    PRIDEiQ8C1B7.

    PTM databases

    PhosphoSiteiQ8C1B7.

    Expressioni

    Gene expression databases

    BgeeiQ8C1B7.
    CleanExiMM_SEPT11.
    GenevestigatoriQ8C1B7.

    Interactioni

    Subunit structurei

    Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers By similarity.By similarity

    Protein-protein interaction databases

    BioGridi206563. 1 interaction.
    IntActiQ8C1B7. 4 interactions.
    MINTiMINT-1870095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C1B7.
    SMRiQ8C1B7. Positions 18-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 304267Septin-type GAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili320 – 41394Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5019.
    GeneTreeiENSGT00640000091237.
    HOGENOMiHOG000233586.
    HOVERGENiHBG065093.
    InParanoidiQ8C1B7.
    KOiK16939.
    OMAiEVSNFQK.
    OrthoDBiEOG7J9VQK.
    PhylomeDBiQ8C1B7.
    TreeFamiTF101080.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view]
    PANTHERiPTHR18884. PTHR18884. 1 hit.
    PfamiPF00735. Septin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006698. Septin. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51719. G_SEPTIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C1B7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET    50
    GIGKSTLMDT LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD 100
    TVGFGDQINK DDSYKPIVEY IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC 150
    LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP IIAKADTIAK NELHKFKSKI 200
    MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST EEVKIGNKMA 250
    KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC 300
    KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK 350
    EKEAELKEAE KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVSNFQKKKA 400
    AAQLLQSQAQ QSGAQQTKKD KDKKNPWLCT E 431

    Note: No experimental confirmation available.

    Length:431
    Mass (Da):49,695
    Last modified:January 23, 2007 - v4
    Checksum:iCC838B791729B511
    GO
    Isoform 2 (identifier: Q8C1B7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         426-431: PWLCTE → ASFA

    Show »
    Length:429
    Mass (Da):49,341
    Checksum:iC817F1F30511DED8
    GO
    Isoform 3 (identifier: Q8C1B7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         426-431: Missing.

    Show »
    Length:425
    Mass (Da):48,965
    Checksum:iA511DED8DD2E0767
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711K → N in BAC25969. (PubMed:16141072)Curated
    Sequence conflicti418 – 4181K → T in BAE42414. (PubMed:16141072)Curated
    Sequence conflicti425 – 4251N → K in BAE42414. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei426 – 4316PWLCTE → ASFA in isoform 2. 2 PublicationsVSP_011041
    Alternative sequencei426 – 4316Missing in isoform 3. 2 PublicationsVSP_011042

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028475 mRNA. Translation: BAC25969.1.
    AK166517 mRNA. Translation: BAE38822.1.
    AK170945 mRNA. Translation: BAE42133.1.
    AK171368 mRNA. Translation: BAE42414.1.
    BC031456 mRNA. Translation: AAH31456.1.
    BC062206 mRNA. Translation: AAH62206.1.
    BC064466 mRNA. Translation: AAH64466.1.
    CCDSiCCDS51549.1. [Q8C1B7-2]
    RefSeqiNP_001009818.1. NM_001009818.1. [Q8C1B7-2]
    XP_006535168.1. XM_006535105.1. [Q8C1B7-1]
    XP_006535170.1. XM_006535107.1. [Q8C1B7-3]
    UniGeneiMm.394184.
    Mm.428571.

    Genome annotation databases

    EnsembliENSMUST00000074733; ENSMUSP00000074293; ENSMUSG00000058013. [Q8C1B7-2]
    GeneIDi52398.
    KEGGimmu:52398.
    UCSCiuc008ydx.1. mouse. [Q8C1B7-1]
    uc008ydy.1. mouse. [Q8C1B7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028475 mRNA. Translation: BAC25969.1 .
    AK166517 mRNA. Translation: BAE38822.1 .
    AK170945 mRNA. Translation: BAE42133.1 .
    AK171368 mRNA. Translation: BAE42414.1 .
    BC031456 mRNA. Translation: AAH31456.1 .
    BC062206 mRNA. Translation: AAH62206.1 .
    BC064466 mRNA. Translation: AAH64466.1 .
    CCDSi CCDS51549.1. [Q8C1B7-2 ]
    RefSeqi NP_001009818.1. NM_001009818.1. [Q8C1B7-2 ]
    XP_006535168.1. XM_006535105.1. [Q8C1B7-1 ]
    XP_006535170.1. XM_006535107.1. [Q8C1B7-3 ]
    UniGenei Mm.394184.
    Mm.428571.

    3D structure databases

    ProteinModelPortali Q8C1B7.
    SMRi Q8C1B7. Positions 18-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206563. 1 interaction.
    IntActi Q8C1B7. 4 interactions.
    MINTi MINT-1870095.

    PTM databases

    PhosphoSitei Q8C1B7.

    Proteomic databases

    MaxQBi Q8C1B7.
    PaxDbi Q8C1B7.
    PRIDEi Q8C1B7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074733 ; ENSMUSP00000074293 ; ENSMUSG00000058013 . [Q8C1B7-2 ]
    GeneIDi 52398.
    KEGGi mmu:52398.
    UCSCi uc008ydx.1. mouse. [Q8C1B7-1 ]
    uc008ydy.1. mouse. [Q8C1B7-2 ]

    Organism-specific databases

    CTDi 55752.
    MGIi MGI:1277214. Sept11.

    Phylogenomic databases

    eggNOGi COG5019.
    GeneTreei ENSGT00640000091237.
    HOGENOMi HOG000233586.
    HOVERGENi HBG065093.
    InParanoidi Q8C1B7.
    KOi K16939.
    OMAi EVSNFQK.
    OrthoDBi EOG7J9VQK.
    PhylomeDBi Q8C1B7.
    TreeFami TF101080.

    Miscellaneous databases

    ChiTaRSi SEPT11. mouse.
    NextBioi 308900.
    PROi Q8C1B7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C1B7.
    CleanExi MM_SEPT11.
    Genevestigatori Q8C1B7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view ]
    PANTHERi PTHR18884. PTHR18884. 1 hit.
    Pfami PF00735. Septin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006698. Septin. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51719. G_SEPTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J and NOD.
      Tissue: Mammary gland and Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary tumor.
    3. Lubec G., Kang S.U., Klug S., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 15-79; 84-93; 96-110; 138-146; 163-170; 176-184; 280-286; 293-298; 309-336; 387-397 AND 399-418, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    4. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."
      Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.
      Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSEP11_MOUSE
    AccessioniPrimary (citable) accession number: Q8C1B7
    Secondary accession number(s): Q3TBA0
    , Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3