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Q8C1B7

- SEP11_MOUSE

UniProt

Q8C1B7 - SEP11_MOUSE

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Protein

Septin-11

Gene

Sept11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis Potential. May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity By similarity.By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031GTP; via amide nitrogenBy similarity
Binding sitei238 – 2381GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei253 – 2531GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 558GTPBy similarity
Nucleotide bindingi184 – 1929GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein heterooligomerization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-11
Gene namesi
Name:Sept11
Synonyms:D5Ertd606e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1277214. Sept11.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication. Cell junctionsynapse 1 Publication. Cell projectiondendritic spine 1 Publication. Cell projectionaxon By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: Ensembl
  4. septin complex Source: InterPro
  5. stress fiber Source: Ensembl
  6. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 431430Septin-11PRO_0000173543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8C1B7.
PaxDbiQ8C1B7.
PRIDEiQ8C1B7.

PTM databases

PhosphoSiteiQ8C1B7.

Expressioni

Gene expression databases

BgeeiQ8C1B7.
CleanExiMM_SEPT11.
GenevestigatoriQ8C1B7.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers By similarity.By similarity

Protein-protein interaction databases

BioGridi206563. 1 interaction.
IntActiQ8C1B7. 4 interactions.
MINTiMINT-1870095.

Structurei

3D structure databases

ProteinModelPortaliQ8C1B7.
SMRiQ8C1B7. Positions 18-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 304267Septin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili320 – 41394Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5019.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ8C1B7.
KOiK16939.
OMAiEVSNFQK.
OrthoDBiEOG7J9VQK.
PhylomeDBiQ8C1B7.
TreeFamiTF101080.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C1B7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET
60 70 80 90 100
GIGKSTLMDT LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD
110 120 130 140 150
TVGFGDQINK DDSYKPIVEY IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC
160 170 180 190 200
LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP IIAKADTIAK NELHKFKSKI
210 220 230 240 250
MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST EEVKIGNKMA
260 270 280 290 300
KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC
310 320 330 340 350
KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK
360 370 380 390 400
EKEAELKEAE KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVSNFQKKKA
410 420 430
AAQLLQSQAQ QSGAQQTKKD KDKKNPWLCT E

Note: No experimental confirmation available.

Length:431
Mass (Da):49,695
Last modified:January 23, 2007 - v4
Checksum:iCC838B791729B511
GO
Isoform 2 (identifier: Q8C1B7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: PWLCTE → ASFA

Show »
Length:429
Mass (Da):49,341
Checksum:iC817F1F30511DED8
GO
Isoform 3 (identifier: Q8C1B7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: Missing.

Show »
Length:425
Mass (Da):48,965
Checksum:iA511DED8DD2E0767
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711K → N in BAC25969. (PubMed:16141072)Curated
Sequence conflicti418 – 4181K → T in BAE42414. (PubMed:16141072)Curated
Sequence conflicti425 – 4251N → K in BAE42414. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei426 – 4316PWLCTE → ASFA in isoform 2. 2 PublicationsVSP_011041
Alternative sequencei426 – 4316Missing in isoform 3. 2 PublicationsVSP_011042

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028475 mRNA. Translation: BAC25969.1.
AK166517 mRNA. Translation: BAE38822.1.
AK170945 mRNA. Translation: BAE42133.1.
AK171368 mRNA. Translation: BAE42414.1.
BC031456 mRNA. Translation: AAH31456.1.
BC062206 mRNA. Translation: AAH62206.1.
BC064466 mRNA. Translation: AAH64466.1.
CCDSiCCDS51549.1. [Q8C1B7-2]
RefSeqiNP_001009818.1. NM_001009818.1. [Q8C1B7-2]
XP_006535168.1. XM_006535105.1. [Q8C1B7-1]
XP_006535170.1. XM_006535107.1. [Q8C1B7-3]
UniGeneiMm.394184.
Mm.428571.

Genome annotation databases

EnsembliENSMUST00000074733; ENSMUSP00000074293; ENSMUSG00000058013. [Q8C1B7-2]
GeneIDi52398.
KEGGimmu:52398.
UCSCiuc008ydx.1. mouse. [Q8C1B7-1]
uc008ydy.1. mouse. [Q8C1B7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028475 mRNA. Translation: BAC25969.1 .
AK166517 mRNA. Translation: BAE38822.1 .
AK170945 mRNA. Translation: BAE42133.1 .
AK171368 mRNA. Translation: BAE42414.1 .
BC031456 mRNA. Translation: AAH31456.1 .
BC062206 mRNA. Translation: AAH62206.1 .
BC064466 mRNA. Translation: AAH64466.1 .
CCDSi CCDS51549.1. [Q8C1B7-2 ]
RefSeqi NP_001009818.1. NM_001009818.1. [Q8C1B7-2 ]
XP_006535168.1. XM_006535105.1. [Q8C1B7-1 ]
XP_006535170.1. XM_006535107.1. [Q8C1B7-3 ]
UniGenei Mm.394184.
Mm.428571.

3D structure databases

ProteinModelPortali Q8C1B7.
SMRi Q8C1B7. Positions 18-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206563. 1 interaction.
IntActi Q8C1B7. 4 interactions.
MINTi MINT-1870095.

PTM databases

PhosphoSitei Q8C1B7.

Proteomic databases

MaxQBi Q8C1B7.
PaxDbi Q8C1B7.
PRIDEi Q8C1B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074733 ; ENSMUSP00000074293 ; ENSMUSG00000058013 . [Q8C1B7-2 ]
GeneIDi 52398.
KEGGi mmu:52398.
UCSCi uc008ydx.1. mouse. [Q8C1B7-1 ]
uc008ydy.1. mouse. [Q8C1B7-2 ]

Organism-specific databases

CTDi 55752.
MGIi MGI:1277214. Sept11.

Phylogenomic databases

eggNOGi COG5019.
GeneTreei ENSGT00760000118899.
HOGENOMi HOG000233586.
HOVERGENi HBG065093.
InParanoidi Q8C1B7.
KOi K16939.
OMAi EVSNFQK.
OrthoDBi EOG7J9VQK.
PhylomeDBi Q8C1B7.
TreeFami TF101080.

Miscellaneous databases

ChiTaRSi SEPT11. mouse.
NextBioi 308900.
PROi Q8C1B7.
SOURCEi Search...

Gene expression databases

Bgeei Q8C1B7.
CleanExi MM_SEPT11.
Genevestigatori Q8C1B7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J and NOD.
    Tissue: Mammary gland and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.
  3. Lubec G., Kang S.U., Klug S., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 15-79; 84-93; 96-110; 138-146; 163-170; 176-184; 280-286; 293-298; 309-336; 387-397 AND 399-418, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  4. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."
    Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.
    Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSEP11_MOUSE
AccessioniPrimary (citable) accession number: Q8C1B7
Secondary accession number(s): Q3TBA0
, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3