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Q8C1B7 (SEP11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Septin-11
Gene names
Name:Sept11
Synonyms:D5Ertd606e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis Potential. May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity By similarity.

Subunit structure

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers By similarity.

Subcellular location

Cytoplasm. Cytoplasmcytoskeleton. Cell junctionsynapse. Cell projectiondendritic spine. Cell projectionaxon By similarity Ref.4.

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Contains 1 septin-type G (guanine nucleotide-binding) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C1B7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q8C1B7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: PWLCTE → ASFA
Isoform 3 (identifier: Q8C1B7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 431430Septin-11
PRO_0000173543

Regions

Domain38 – 304267Septin-type G
Nucleotide binding48 – 558GTP By similarity
Nucleotide binding184 – 1929GTP By similarity
Coiled coil320 – 41394 Potential

Sites

Binding site1031GTP; via amide nitrogen By similarity
Binding site2381GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2531GTP By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Alternative sequence426 – 4316PWLCTE → ASFA in isoform 2.
VSP_011041
Alternative sequence426 – 4316Missing in isoform 3.
VSP_011042

Experimental info

Sequence conflict1711K → N in BAC25969. Ref.1
Sequence conflict4181K → T in BAE42414. Ref.1
Sequence conflict4251N → K in BAE42414. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: CC838B791729B511

FASTA43149,695
        10         20         30         40         50         60 
MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET GIGKSTLMDT 

        70         80         90        100        110        120 
LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD TVGFGDQINK DDSYKPIVEY 

       130        140        150        160        170        180 
IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP 

       190        200        210        220        230        240 
IIAKADTIAK NELHKFKSKI MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST 

       250        260        270        280        290        300 
EEVKIGNKMA KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC 

       310        320        330        340        350        360 
KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK EKEAELKEAE 

       370        380        390        400        410        420 
KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVSNFQKKKA AAQLLQSQAQ QSGAQQTKKD 

       430 
KDKKNPWLCT E 

« Hide

Isoform 2 [UniParc].

Checksum: C817F1F30511DED8
Show »

FASTA42949,341
Isoform 3 [UniParc].

Checksum: A511DED8DD2E0767
Show »

FASTA42548,965

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Strain: C57BL/6J and NOD.
Tissue: Mammary gland and Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Mammary tumor.
[3]Lubec G., Kang S.U., Klug S., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 15-79; 84-93; 96-110; 138-146; 163-170; 176-184; 280-286; 293-298; 309-336; 387-397 AND 399-418, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6 and OF1.
Tissue: Brain and Hippocampus.
[4]"SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."
Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.
Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028475 mRNA. Translation: BAC25969.1.
AK166517 mRNA. Translation: BAE38822.1.
AK170945 mRNA. Translation: BAE42133.1.
AK171368 mRNA. Translation: BAE42414.1.
BC031456 mRNA. Translation: AAH31456.1.
BC062206 mRNA. Translation: AAH62206.1.
BC064466 mRNA. Translation: AAH64466.1.
CCDSCCDS51549.1. [Q8C1B7-2]
RefSeqNP_001009818.1. NM_001009818.1. [Q8C1B7-2]
XP_006535168.1. XM_006535105.1. [Q8C1B7-1]
XP_006535170.1. XM_006535107.1. [Q8C1B7-3]
UniGeneMm.394184.
Mm.428571.

3D structure databases

ProteinModelPortalQ8C1B7.
SMRQ8C1B7. Positions 18-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206563. 1 interaction.
IntActQ8C1B7. 4 interactions.
MINTMINT-1870095.

PTM databases

PhosphoSiteQ8C1B7.

Proteomic databases

MaxQBQ8C1B7.
PaxDbQ8C1B7.
PRIDEQ8C1B7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000074733; ENSMUSP00000074293; ENSMUSG00000058013. [Q8C1B7-2]
GeneID52398.
KEGGmmu:52398.
UCSCuc008ydx.1. mouse. [Q8C1B7-1]
uc008ydy.1. mouse. [Q8C1B7-2]

Organism-specific databases

CTD55752.
MGIMGI:1277214. Sept11.

Phylogenomic databases

eggNOGCOG5019.
GeneTreeENSGT00640000091237.
HOGENOMHOG000233586.
HOVERGENHBG065093.
InParanoidQ8C1B7.
KOK16939.
OMAEVSNFQK.
OrthoDBEOG7J9VQK.
PhylomeDBQ8C1B7.
TreeFamTF101080.

Gene expression databases

BgeeQ8C1B7.
CleanExMM_SEPT11.
GenevestigatorQ8C1B7.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERPTHR18884. PTHR18884. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSEPT11. mouse.
NextBio308900.
PROQ8C1B7.
SOURCESearch...

Entry information

Entry nameSEP11_MOUSE
AccessionPrimary (citable) accession number: Q8C1B7
Secondary accession number(s): Q3TBA0 expand/collapse secondary AC list , Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot