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Protein

TCDD-inducible poly [ADP-ribose] polymerase

Gene

Tiparp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri238 – 26528C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • enhancer binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: MGI

GO - Biological processi

  • androgen metabolic process Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • estrogen metabolic process Source: MGI
  • face morphogenesis Source: MGI
  • female gonad development Source: MGI
  • hemopoiesis Source: MGI
  • kidney development Source: MGI
  • multicellular organism metabolic process Source: MGI
  • negative regulation of gene expression Source: MGI
  • nitrogen compound metabolic process Source: MGI
  • palate development Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of protein catabolic process Source: MGI
  • post-embryonic development Source: MGI
  • protein ADP-ribosylation Source: MGI
  • skeletal system morphogenesis Source: MGI
  • smooth muscle tissue development Source: MGI
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
TCDD-inducible poly [ADP-ribose] polymerase (EC:2.4.2.30)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 14
Short name:
ARTD14
Gene namesi
Name:Tiparp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2159210. Tiparp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657TCDD-inducible poly [ADP-ribose] polymerasePRO_0000247836Add
BLAST

Proteomic databases

PaxDbiQ8C1B2.
PRIDEiQ8C1B2.

PTM databases

iPTMnetiQ8C1B2.
PhosphoSiteiQ8C1B2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a by-product of industrial processes and an important environmental contaminant. This induction is concentration and time-dependent and is mediated through an aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocation (Arnt) signal transduction. Superinduced by cycloheximide and by inhibitors of the 26S proteasome.2 Publications

Gene expression databases

BgeeiQ8C1B2.
CleanExiMM_TIPARP.
ExpressionAtlasiQ8C1B2. baseline and differential.
GenevisibleiQ8C1B2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048051.

Structurei

3D structure databases

ProteinModelPortaliQ8C1B2.
SMRiQ8C1B2. Positions 462-648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini333 – 41179WWEPROSITE-ProRule annotationAdd
BLAST
Domaini449 – 657209PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 1 WWE domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri238 – 26528C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIZH. Eukaryota.
ENOG410YI58. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000115453.
HOVERGENiHBG082109.
InParanoidiQ8C1B2.
KOiK15259.
OMAiLNQLQYH.
OrthoDBiEOG7P5T0J.
PhylomeDBiQ8C1B2.
TreeFamiTF328965.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C1B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVETTEPEP DCVVQPPSPS DDFSCQMRIS EKISPLKTCF KKKQEQKRLG
60 70 80 90 100
TGTLRSLRPI LNTLLESGSL DGVFRARDQN RDESSLHEHI VKKPLEINPS
110 120 130 140 150
CPPAENSMPV LIPDGTNVEG QLPEAHPSTD APEQGVPIQD HSFPPETISG
160 170 180 190 200
TVADSTTGHF QTDLLHPVSG DVPTSPDCVD KVMDYVPGAF QDNSFTIQYI
210 220 230 240 250
LDTSDKLSTE LFQDKSEEAS LELVFELVNQ LQYHTHQENG IEICMDFLQG
260 270 280 290 300
TCIYGRDCLK HHTVLPYHWQ IKRTTTQKWQ SVSNDSQEHL ERFYCNPEND
310 320 330 340 350
RMRMKYGGQD FWADLNAMTV FETTEFDQLR RLSTPPCSNS NSIYHTFWKF
360 370 380 390 400
FCRDHFGWRE YPESVVRLIE EANSRGLKEV RFMMWNNHYI LHNSFFRREI
410 420 430 440 450
KRRPLFRSCF ILIPYLQTLG GVPTQASLPL EATSSQIICP DGVTSANFYP
460 470 480 490 500
ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN
510 520 530 540 550
QFLWEKYKRK KEYMNRKMSG RDRIINERHL FHGTSQDVVD GICKHNFDPR
560 570 580 590 600
VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS
610 620 630 640 650
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE

VSNTVSI
Length:657
Mass (Da):75,901
Last modified:March 1, 2003 - v1
Checksum:i332CB9721C7EBC33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti521 – 5211R → H in BAC27876 (PubMed:16141072).Curated
Sequence conflicti620 – 6201D → N in BAC27876 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028529 mRNA. Translation: BAC25994.1.
AK032453 mRNA. Translation: BAC27876.1.
AK150248 mRNA. Translation: BAE29412.1.
AK162094 mRNA. Translation: BAE36720.1.
BC068173 mRNA. Translation: AAH68173.1.
CCDSiCCDS17388.1.
RefSeqiNP_849223.2. NM_178892.5.
UniGeneiMm.246398.

Genome annotation databases

EnsembliENSMUST00000047906; ENSMUSP00000048051; ENSMUSG00000034640.
GeneIDi99929.
KEGGimmu:99929.
UCSCiuc008pkr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028529 mRNA. Translation: BAC25994.1.
AK032453 mRNA. Translation: BAC27876.1.
AK150248 mRNA. Translation: BAE29412.1.
AK162094 mRNA. Translation: BAE36720.1.
BC068173 mRNA. Translation: AAH68173.1.
CCDSiCCDS17388.1.
RefSeqiNP_849223.2. NM_178892.5.
UniGeneiMm.246398.

3D structure databases

ProteinModelPortaliQ8C1B2.
SMRiQ8C1B2. Positions 462-648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048051.

PTM databases

iPTMnetiQ8C1B2.
PhosphoSiteiQ8C1B2.

Proteomic databases

PaxDbiQ8C1B2.
PRIDEiQ8C1B2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047906; ENSMUSP00000048051; ENSMUSG00000034640.
GeneIDi99929.
KEGGimmu:99929.
UCSCiuc008pkr.1. mouse.

Organism-specific databases

CTDi25976.
MGIiMGI:2159210. Tiparp.

Phylogenomic databases

eggNOGiENOG410IIZH. Eukaryota.
ENOG410YI58. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000115453.
HOVERGENiHBG082109.
InParanoidiQ8C1B2.
KOiK15259.
OMAiLNQLQYH.
OrthoDBiEOG7P5T0J.
PhylomeDBiQ8C1B2.
TreeFamiTF328965.

Miscellaneous databases

ChiTaRSiTiparp. mouse.
PROiQ8C1B2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C1B2.
CleanExiMM_TIPARP.
ExpressionAtlasiQ8C1B2. baseline and differential.
GenevisibleiQ8C1B2. MM.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Ma Q., Baldwin K.T., Renzelli A.J., McDaniel A., Dong L.
    Biochem. Biophys. Res. Commun. 289:499-506(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Olfactory bulb and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  4. "Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-rho-dioxin-inducible poly(ADP-ribose) polymerase: role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor."
    Ma Q.
    Arch. Biochem. Biophys. 404:309-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPARPT_MOUSE
AccessioniPrimary (citable) accession number: Q8C1B2
Secondary accession number(s): Q3UD50, Q8C032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.