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Protein

Calmodulin-regulated spectrin-associated protein 2

Gene

Camsap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule minus-end binding protein that may regulate the organization of non-centrosomal microtubules. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • microtubule cytoskeleton organization Source: MGI
  • neuron projection development Source: InterPro
  • regulation of organelle organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 2
Alternative name(s):
Calmodulin-regulated spectrin-associated protein 1-like protein 1
Gene namesi
Name:Camsap2
Synonyms:Camsap1l1, Kiaa1078
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1922434. Camsap2.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Associated with the minus-end of microtubules and also detected at the centrosomes.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule minus-end Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14611461Calmodulin-regulated spectrin-associated protein 2PRO_0000316833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei391 – 3911PhosphoserineCombined sources
Modified residuei393 – 3931PhosphoserineCombined sources
Modified residuei401 – 4011PhosphothreonineCombined sources
Modified residuei439 – 4391PhosphoserineCombined sources
Modified residuei572 – 5721PhosphoserineBy similarity
Modified residuei573 – 5731PhosphoserineCombined sources
Modified residuei585 – 5851PhosphoserineCombined sources
Modified residuei647 – 6471PhosphoserineBy similarity
Modified residuei652 – 6521PhosphothreonineCombined sources
Modified residuei654 – 6541PhosphoserineCombined sources
Modified residuei836 – 8361PhosphoserineCombined sources
Modified residuei905 – 9051PhosphoserineBy similarity
Modified residuei910 – 9101PhosphoserineBy similarity
Modified residuei970 – 9701PhosphothreonineBy similarity
Modified residuei975 – 9751PhosphothreonineBy similarity
Modified residuei977 – 9771PhosphothreonineBy similarity
Modified residuei981 – 9811PhosphoserineBy similarity
Modified residuei992 – 9921PhosphoserineBy similarity
Modified residuei1120 – 11201PhosphoserineCombined sources
Modified residuei1285 – 12851PhosphoserineCombined sources
Modified residuei1291 – 12911PhosphoserineCombined sources
Modified residuei1293 – 12931PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C1B1.
MaxQBiQ8C1B1.
PaxDbiQ8C1B1.
PeptideAtlasiQ8C1B1.
PRIDEiQ8C1B1.

PTM databases

iPTMnetiQ8C1B1.

Expressioni

Gene expression databases

BgeeiQ8C1B1.
ExpressionAtlasiQ8C1B1. baseline and differential.
GenevisibleiQ8C1B1. MM.

Interactioni

Subunit structurei

Interacts with CAMSAP3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Camsap3Q80VC92EBI-8839434,EBI-2125556

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212510. 1 interaction.
DIPiDIP-60092N.
IntActiQ8C1B1. 2 interactions.
STRINGi10090.ENSMUSP00000041920.

Structurei

3D structure databases

ProteinModelPortaliQ8C1B1.
SMRiQ8C1B1. Positions 1320-1449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 321147CHAdd
BLAST
Domaini1321 – 1455135CKKPROSITE-ProRule annotationAdd
BLAST

Domaini

The CKK domain binds microtubules.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation
Contains 1 CKK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IU7J. Eukaryota.
ENOG411033G. LUCA.
GeneTreeiENSGT00390000010026.
HOVERGENiHBG107572.
InParanoidiQ8C1B1.
PhylomeDBiQ8C1B1.

Family and domain databases

InterProiIPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like.
[Graphical view]
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiPF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
[Graphical view]
SMARTiSM01051. CAMSAP_CKK. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiPS51508. CKK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C1B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDAADPREM RRTFIVPAIK PFDHYDFSRA KIACNLAWLV AKAFGTENVP
60 70 80 90 100
EELGDPFYTD QYDQEHIKPP VVNLLLSAEL YCRAGSLILK SDAAKPLLGH
110 120 130 140 150
DAVIQALAQK GLYVTDQEKL VTERDLHKKP IQMSAHLAMI DTLMMAYTVE
160 170 180 190 200
MISIEKVIAC AQQYSAFFQA TDLPYDIEDA VMYWMNKVNE HLKDIMEQEQ
210 220 230 240 250
KSKEHHPAEA PGGQKARYRK EQTLLKQLPC IPLVENLLKD GTDGCALAAL
260 270 280 290 300
IHFYCPAVVR LEDICLKETM SLADSLYNLQ LIQEFCQEYL NHCCHFSLED
310 320 330 340 350
MLYAASSIKS NYLVFMAELF WWFEVVKPSF VQPRVVRPQG AEPAKDVPSV
360 370 380 390 400
PVLNAAKRNI RDSSSSSDFS SRYTRPQTHS SASGGIRRSS SMSYVDGFIG
410 420 430 440 450
TWPKEKRTSV HGVSFDISFD KEDSAQSSTP NRGIIRSVSN EGLTLNNSRA
460 470 480 490 500
SKHIRKNLSF KPVNGEEEES IEEELHVDPH GDLQSPMPLN TNELNSNEST
510 520 530 540 550
HYKLPNGALQ NRVLLDEFGN QIETPSIEEA LQIIHDTERP PHTPRPDQIA
560 570 580 590 600
NGFFLHGQDL SILNSNIKLN QSSPDNLTDT KGALSPITDT TEVDTGIHVP
610 620 630 640 650
SEDIPETMDE DSSLRDYTVS LDSDMDDASK LLQDYDLRAS NPREALSPCP
660 670 680 690 700
STISTKSQPG SSASSSSGVK MTSFAEQKFR KLNHTDGKSS GSSSQKTTPE
710 720 730 740 750
GSELNIPHVV SWAQIPEEAG VAPGRDTTQL LASEMVHLRM RLEEKRRAIE
760 770 780 790 800
AQKKKMEAAF TKQRQKMGRT AFLTVVKKKG EGISPLREEA AGAEDEKVYT
810 820 830 840 850
DRAKERESQK MDGQRSKSLA DIKESMETPP GRWLKSPTTP VDPERQWNLT
860 870 880 890 900
SPSEETLNEG EILEYTKSIE KLNSSLHFLQ QEMQRLSLQQ EMLMQMREQQ
910 920 930 940 950
AWVISPPQPS PQKQIRDFKP RQAGLSSAAA PFSSDSPRPT HPSPQSSTRK
960 970 980 990 1000
SASFSVKNQR TPRPNELKIT PLNRTLTPPR SVDSLPRLRR FSPSQVPIQT
1010 1020 1030 1040 1050
RSFVCFGDDG EPQKEPKQKE EIKKEPSECK GTLGPCDHNP GEKEIKPVES
1060 1070 1080 1090 1100
TVSEVLSQPI TETVCVTPNE DQLSQPTEPP PKPVFPPTAP KNVNLIEVSL
1110 1120 1130 1140 1150
SDLKPPEKAD VSVEKLDGES DKEQFDDDQK VCCGFFFKDD QKAENDMAMK
1160 1170 1180 1190 1200
RAALLEKRLR REKETQLRKQ QLEAEMEHKK EETRRKTEEE RQKKEDERAR
1210 1220 1230 1240 1250
REFIRQEYMR RKQLKLMEDM DTVIKPRPQA AKQKKQRPKS IHRDHIESPK
1260 1270 1280 1290 1300
TPIKGPPVSS LSLASLNTGD SESVHSGKRT PRSESVEGFL SPSRCGSRNG
1310 1320 1330 1340 1350
EKDWENASTT SSVASGTEYT GPKLYKEPSA KSNKHIIQNA LAHCCLAGKV
1360 1370 1380 1390 1400
NEGQKKKILE EMEKSDANNF LILFRDSGCQ FRSLYTYCPE TEEINKLTGI
1410 1420 1430 1440 1450
GPKSITKKMI EGLYKYNSDR KQFSHIPAKT LSASVDAITI HSHLWQTKRP
1460
VTPKKLLPTK A
Length:1,461
Mass (Da):164,333
Last modified:February 5, 2008 - v3
Checksum:i24308DADC498788A
GO
Isoform 2 (identifier: Q8C1B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1257-1257: P → PGSRISRVFS

Note: No experimental confirmation available.
Show »
Length:1,470
Mass (Da):165,323
Checksum:iF056D5FAB0D69AFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301A → T in AAI45259 (PubMed:15489334).Curated
Sequence conflicti802 – 8021R → Q in AAI45259 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1257 – 12571P → PGSRISRVFS in isoform 2. 1 PublicationVSP_030807

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145258 mRNA. Translation: AAI45259.1.
AK028542 mRNA. Translation: BAC25999.2.
AK081975 mRNA. Translation: BAC38384.1.
AK122436 mRNA. Translation: BAC65718.1.
RefSeqiXP_006529897.1. XM_006529834.1. [Q8C1B1-2]
XP_006529898.1. XM_006529835.1. [Q8C1B1-1]
UniGeneiMm.144143.

Genome annotation databases

EnsembliENSMUST00000192001; ENSMUSP00000142166; ENSMUSG00000041570. [Q8C1B1-1]
GeneIDi67886.
UCSCiuc007cur.2. mouse. [Q8C1B1-1]
uc011wsz.1. mouse. [Q8C1B1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145258 mRNA. Translation: AAI45259.1.
AK028542 mRNA. Translation: BAC25999.2.
AK081975 mRNA. Translation: BAC38384.1.
AK122436 mRNA. Translation: BAC65718.1.
RefSeqiXP_006529897.1. XM_006529834.1. [Q8C1B1-2]
XP_006529898.1. XM_006529835.1. [Q8C1B1-1]
UniGeneiMm.144143.

3D structure databases

ProteinModelPortaliQ8C1B1.
SMRiQ8C1B1. Positions 1320-1449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212510. 1 interaction.
DIPiDIP-60092N.
IntActiQ8C1B1. 2 interactions.
STRINGi10090.ENSMUSP00000041920.

PTM databases

iPTMnetiQ8C1B1.

Proteomic databases

EPDiQ8C1B1.
MaxQBiQ8C1B1.
PaxDbiQ8C1B1.
PeptideAtlasiQ8C1B1.
PRIDEiQ8C1B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192001; ENSMUSP00000142166; ENSMUSG00000041570. [Q8C1B1-1]
GeneIDi67886.
UCSCiuc007cur.2. mouse. [Q8C1B1-1]
uc011wsz.1. mouse. [Q8C1B1-2]

Organism-specific databases

CTDi23271.
MGIiMGI:1922434. Camsap2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IU7J. Eukaryota.
ENOG411033G. LUCA.
GeneTreeiENSGT00390000010026.
HOVERGENiHBG107572.
InParanoidiQ8C1B1.
PhylomeDBiQ8C1B1.

Miscellaneous databases

PROiQ8C1B1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C1B1.
ExpressionAtlasiQ8C1B1. baseline and differential.
GenevisibleiQ8C1B1. MM.

Family and domain databases

InterProiIPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like.
[Graphical view]
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiPF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
[Graphical view]
SMARTiSM01051. CAMSAP_CKK. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiPS51508. CKK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1185 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1223-1461 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head and Skin.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 658-1461 (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391; SER-393; THR-401; SER-439; SER-573; SER-585; THR-652; SER-654; SER-836; SER-1120; SER-1285; SER-1291 AND SER-1293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Spleen and Testis.
  7. "Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules."
    Tanaka N., Meng W., Nagae S., Takeichi M.
    Proc. Natl. Acad. Sci. U.S.A. 109:20029-20034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CAMSAP3.

Entry informationi

Entry nameiCAMP2_MOUSE
AccessioniPrimary (citable) accession number: Q8C1B1
Secondary accession number(s): B7ZNI4, Q80TK8, Q8C4J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.