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Q8C190 (VP9D1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
VPS9 domain-containing protein 1
Alternative name(s):
5-day ovary-specific transcript 1 protein
Gene names
Name:Vps9d1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length649 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 VPS9 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C190-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C190-2)

The sequence of this isoform differs from the canonical sequence as follows:
     552-555: VRTL → GAGI
     556-649: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 649649VPS9 domain-containing protein 1
PRO_0000079280

Regions

Domain487 – 648162VPS9

Natural variations

Alternative sequence552 – 5554VRTL → GAGI in isoform 2.
VSP_014703
Alternative sequence556 – 64994Missing in isoform 2.
VSP_014704

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 34385AD36C050552

FASTA64971,284
        10         20         30         40         50         60 
MAAAAGDGGA KPLQSAMKLA NKAIELDTGN RPREAYVEYL RSIHYISQVL LEDVENTTEA 

        70         80         90        100        110        120 
GETVPPETSK MLKLAEQCLE RAQSTATKLG RICLKPAVPA APPTPLPTSR HRRVCSDEGG 

       130        140        150        160        170        180 
KLSPFLPPEI FQKLQVAESQ NSKKELTPLE KASLQNQKLR ATYEARMARL DPSQAMQKTS 

       190        200        210        220        230        240 
LTLSLQRQMM ENLVIAKARE ETLQRKMEER RLRLQEAANR RFCSQVALTP EEREQRALYA 

       250        260        270        280        290        300 
AILEYEQDHD WPKHWRAKLK RSPGDLSLVT SLLSHLLSLP DHPISQLLKK LQCAVYSALY 

       310        320        330        340        350        360 
PIVSRAATSA APAPGSCSLP PEANGLLAPG SRRLRSSQSL YCMLSPSEPS AAPRVLDGPP 

       370        380        390        400        410        420 
PTPSVPTLHS GPLDREADGS PAGPSSPLVD ALSHLPDKDS SFEDLEQFLA MSEPQTPGAK 

       430        440        450        460        470        480 
REPLLECLKS TVKDIHNAID RLLSLTLLAF ESLNTATSKD RCLACIEEPF FSPLWPLLLA 

       490        500        510        520        530        540 
LYRSVHRTRE AAVSRSMELY RNAPPTALGI PTKLLPRVPE AQASTYPYCT AAQELGLLVL 

       550        560        570        580        590        600 
ESCPQKKLEC IVRTLRVICI CAEDYCRAQE ARPEGESQPP AAAIGADDLL PILSFVVLRS 

       610        620        630        640 
GLPQLVSECA ALEEFTHEGY LIGEEGYCLT SLQSALSYVE LLSRGRLDK 

« Hide

Isoform 2 [UniParc].

Checksum: 3D78A45279606553
Show »

FASTA55560,914

References

« Hide 'large scale' references
[1]"Identification of differentially expressed transcripts between 1 day ovary and 5 day ovary."
Park C.E., Hwang K.C., Kim N.H., Lee K.A.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: ICR.
Tissue: Ovary.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Skin.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY751521 mRNA. Translation: AAV30827.1.
AK028751 mRNA. Translation: BAC26098.1.
BC057621 mRNA. Translation: AAH57621.1.
RefSeqNP_082476.1. NM_028200.1.
UniGeneMm.276193.

3D structure databases

ProteinModelPortalQ8C190.
SMRQ8C190. Positions 455-648.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid215310. 1 interaction.
STRING10090.ENSMUSP00000113748.

PTM databases

PhosphoSiteQ8C190.

Proteomic databases

PaxDbQ8C190.
PRIDEQ8C190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000122363; ENSMUSP00000113575; ENSMUSG00000001062. [Q8C190-1]
GeneID72325.
KEGGmmu:72325.
UCSCuc009nuv.2. mouse. [Q8C190-1]

Organism-specific databases

CTD9605.
MGIMGI:1914143. Vps9d1.

Phylogenomic databases

eggNOGNOG70432.
GeneTreeENSGT00390000015057.
HOGENOMHOG000293285.
HOVERGENHBG062847.
OrthoDBEOG7P2XV3.
PhylomeDBQ8C190.
TreeFamTF332037.

Gene expression databases

ArrayExpressQ8C190.
BgeeQ8C190.
CleanExMM_1300018I17RIK.
GenevestigatorQ8C190.

Family and domain databases

Gene3D1.20.58.280. 1 hit.
InterProIPR007330. MIT.
IPR003123. VPS9.
[Graphical view]
PfamPF02204. VPS9. 1 hit.
[Graphical view]
SUPFAMSSF116846. SSF116846. 1 hit.
PROSITEPS51205. VPS9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio336024.
SOURCESearch...

Entry information

Entry nameVP9D1_MOUSE
AccessionPrimary (citable) accession number: Q8C190
Secondary accession number(s): Q6PFD1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot