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Protein

Ceramide synthase 6

Gene

Cers6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sphingolipid synthesis or its regulation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi66 – 12762HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • sphingosine N-acyltransferase activity Source: MGI

GO - Biological processi

  • ceramide biosynthetic process Source: MGI
  • sphingolipid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Chemistry

SwissLipidsiSLP:000000119.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 6
Short name:
CerS6
Alternative name(s):
LAG1 longevity assurance homolog 6
Gene namesi
Name:Cers6
Synonyms:Lass6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442564. Cers6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 173118CytoplasmicSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Topological domaini195 – 20410LumenalSequence analysis
Transmembranei205 – 22521HelicalSequence analysisAdd
BLAST
Topological domaini226 – 26237CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Topological domaini284 – 30219LumenalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Topological domaini324 – 38461CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Ceramide synthase 6PRO_0000185517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylation on Asn-18 is not necessary for function.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei285 – 2851Not glycosylated

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8C172.
MaxQBiQ8C172.
PaxDbiQ8C172.
PRIDEiQ8C172.

PTM databases

iPTMnetiQ8C172.
PhosphoSiteiQ8C172.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in kidney and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000027035.
CleanExiMM_LASS6.
ExpressionAtlasiQ8C172. baseline and differential.
GenevisibleiQ8C172. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028426.

Structurei

Secondary structure

1
384
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi79 – 8810Combined sources
Helixi96 – 10611Combined sources
Helixi110 – 12314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X2MNMR-A76-126[»]
ProteinModelPortaliQ8C172.
SMRiQ8C172. Positions 76-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8C172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 331202TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ8C172.
KOiK04710.
PhylomeDBiQ8C172.
TreeFamiTF314319.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGILAWFWN ERFWLPHNVT WADLKNTEEA TFPQAEDLYL AFPLAFCIFM
60 70 80 90 100
VRLIFERFIA KPCAIALNIQ ANGPQTAQPN AILEKVFTAI TKHPDEKRLE
110 120 130 140 150
GLSKQLDWDV RSIQRWFRQR RNQEKPSTLT RFCESMWRFS FYLYVFSYGV
160 170 180 190 200
RFLKQTPWLW NTRHCWYNYP YQPLTADLHY YYILELSFYW SLMVSQFTDI
210 220 230 240 250
KRKDFGIMFL HHLATIFLIT FSYVNNMARV GTLVLCLHDS ADALLEAAKM
260 270 280 290 300
ANYAKFQKMC DLLFVMFAVV FITTRLGIFP LWVLNTTLFE SWEIVGPYPS
310 320 330 340 350
WWVFNLLLLL LQGLNCFWSY LIVKIACKTV SKGKVSKDDR SDIESSSDDE
360 370 380
DSEPPGKKPH SSTTTNGTSG TNGYLLTGPC SVDD
Length:384
Mass (Da):44,813
Last modified:March 1, 2003 - v1
Checksum:i9D43AF6CA06A335A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028849 mRNA. Translation: BAC26153.1.
AK081354 mRNA. Translation: BAC38204.1. Sequence problems.
AK151848 mRNA. Translation: BAE30739.1.
AK152417 mRNA. Translation: BAE31202.1.
BC057629 mRNA. Translation: AAH57629.1.
CCDSiCCDS16086.1.
RefSeqiNP_766444.1. NM_172856.3.
UniGeneiMm.222222.
Mm.393211.

Genome annotation databases

EnsembliENSMUST00000028426; ENSMUSP00000028426; ENSMUSG00000027035.
GeneIDi241447.
KEGGimmu:241447.
UCSCiuc008jxs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028849 mRNA. Translation: BAC26153.1.
AK081354 mRNA. Translation: BAC38204.1. Sequence problems.
AK151848 mRNA. Translation: BAE30739.1.
AK152417 mRNA. Translation: BAE31202.1.
BC057629 mRNA. Translation: AAH57629.1.
CCDSiCCDS16086.1.
RefSeqiNP_766444.1. NM_172856.3.
UniGeneiMm.222222.
Mm.393211.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X2MNMR-A76-126[»]
ProteinModelPortaliQ8C172.
SMRiQ8C172. Positions 76-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028426.

Chemistry

SwissLipidsiSLP:000000119.

PTM databases

iPTMnetiQ8C172.
PhosphoSiteiQ8C172.

Proteomic databases

EPDiQ8C172.
MaxQBiQ8C172.
PaxDbiQ8C172.
PRIDEiQ8C172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028426; ENSMUSP00000028426; ENSMUSG00000027035.
GeneIDi241447.
KEGGimmu:241447.
UCSCiuc008jxs.1. mouse.

Organism-specific databases

CTDi253782.
MGIiMGI:2442564. Cers6.

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ8C172.
KOiK04710.
PhylomeDBiQ8C172.
TreeFamiTF314319.

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

EvolutionaryTraceiQ8C172.
PROiQ8C172.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027035.
CleanExiMM_LASS6.
ExpressionAtlasiQ8C172. baseline and differential.
GenevisibleiQ8C172. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCERS6_MOUSE
AccessioniPrimary (citable) accession number: Q8C172
Secondary accession number(s): Q3U817, Q8BV12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.