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Protein

Copine-1

Gene

Cpne1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-1483206 Glycerophospholipid biosynthesis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-1Curated
Alternative name(s):
Copine IBy similarityImported
Gene namesi
Name:Cpne1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2386621 Cpne1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448351 – 536Copine-1Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8C166
MaxQBiQ8C166
PaxDbiQ8C166
PeptideAtlasiQ8C166
PRIDEiQ8C166

2D gel databases

REPRODUCTION-2DPAGEQ8C166

PTM databases

iPTMnetiQ8C166
PhosphoSitePlusiQ8C166
SwissPalmiQ8C166

Expressioni

Gene expression databases

BgeeiENSMUSG00000074643
ExpressionAtlasiQ8C166 baseline and differential
GenevisibleiQ8C166 MM

Interactioni

Subunit structurei

Homodimer; homodimerizes via its C2 domains. Interacts with p65/RELA (via N-terminus); this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity. Interacts (via VWFA domain) with ACTB, CCDC22, MYCBP2, PPP5C, RDX and UBE2O.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234468, 2 interactors
IntActiQ8C166, 1 interactor
MINTiQ8C166
STRINGi10090.ENSMUSP00000105236

Structurei

3D structure databases

ProteinModelPortaliQ8C166
SMRiQ8C166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 97C2 1PROSITE-ProRule annotationAdd BLAST97
Domaini143 – 227C2 2PROSITE-ProRule annotationAdd BLAST85
Domaini284 – 504VWFAPROSITE-ProRule annotationAdd BLAST221

Domaini

C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner.By similarity

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ8C166
OMAiPYCQGIQ
OrthoDBiEOG091G05IT
PhylomeDBiQ8C166
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHCVTLVQL SVSCEHLIDK DIGSKSDPLC VLLQDVGGAW AELCRTERVR
60 70 80 90 100
NCSSPEFSKT LQIEYHFETV QKLRFGIYDI DNKTPELGDD DFLGGAECSL
110 120 130 140 150
GQIVSSQTLT LPLMLKPGKP AGRGTITVSA QELKDSRVVT MEVEARNLDK
160 170 180 190 200
KDFLGKSDPF LEFFRQGDGK WQLAYRTEVV KNNLNPTWKR FSVSLQHFCG
210 220 230 240 250
GDLSTPIQVR CSDYDSDGSH DLIGTFHTTL AQLQAVPAEF ECVHPEKQQR
260 270 280 290 300
KKNYRNSGTV RVKTCRVETE YSFLDYVMGG CQINFTVGVD FTGSNGDPSS
310 320 330 340 350
PDSLHYLSPT GVNEYLTALW SVGSVVQDYD SDKLFPAFGF GAQVPPDWQV
360 370 380 390 400
SHEFALNFNP SNPYCAGIQG IVDAYRQALP QVRLYGPTNF APIINHVARF
410 420 430 440 450
AAQAAQQRSA SQYFVLLLLT DGAVTDVEAT CKAVVDASKL PMSVIIVGVG
460 470 480 490 500
GADFEVMEQL DADGGPLRTR SGEAAARDIV QFVPYRRFQN APRETLAQTV
510 520 530
LAEVPTQMVS YFRAQGWAPL KAPPTPGKGP AQAPQA
Length:536
Mass (Da):58,887
Last modified:March 1, 2003 - v1
Checksum:iDF603A71A1A74F7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43L → P in AAH57554 (PubMed:15489334).Curated1
Sequence conflicti452 – 454ADF → GHS in AAK56087 (PubMed:11471062).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028882 mRNA Translation: BAC26170.1
BC057554 mRNA Translation: AAH57554.1
AF332057 mRNA Translation: AAK56086.1
AF332058 mRNA Translation: AAK56087.1
CCDSiCCDS16960.1
RefSeqiNP_733467.1, NM_170588.3
NP_733469.1, NM_170590.3
UniGeneiMm.27660

Genome annotation databases

EnsembliENSMUST00000109607; ENSMUSP00000105236; ENSMUSG00000074643
ENSMUST00000109608; ENSMUSP00000105237; ENSMUSG00000074643
GeneIDi266692
KEGGimmu:266692
UCSCiuc008nmf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCPNE1_MOUSE
AccessioniPrimary (citable) accession number: Q8C166
Secondary accession number(s): Q925K4, Q925K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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