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Protein

Condensin complex subunit 2

Gene

Ncaph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic chromosome condensation Source: MGI
  • meiotic chromosome segregation Source: MGI
  • mitotic chromosome condensation Source: MGI

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog protein 1
Chromosome-associated protein H
Short name:
mCAP-H
Non-SMC condensin I complex subunit H
XCAP-H homolog
Gene namesi
Name:Ncaph
Synonyms:Brrn, Brrn1, Caph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2444777. Ncaph.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950391 – 731Condensin complex subunit 2Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei43PhosphothreonineCombined sources1
Modified residuei46PhosphothreonineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei91PhosphoserineBy similarity1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei227PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei489PhosphoserineBy similarity1
Modified residuei587PhosphothreonineBy similarity1
Modified residuei627N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8C156.
MaxQBiQ8C156.
PaxDbiQ8C156.
PeptideAtlasiQ8C156.
PRIDEiQ8C156.

PTM databases

iPTMnetiQ8C156.
PhosphoSitePlusiQ8C156.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034906.
CleanExiMM_NCAPH.
ExpressionAtlasiQ8C156. baseline and differential.
GenevisibleiQ8C156. MM.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229619. 19 interactors.
IntActiQ8C156. 20 interactors.
STRINGi10090.ENSMUSP00000106017.

Family & Domainsi

Sequence similaritiesi

Belongs to the CND2 (condensin subunit 2) family.Curated

Phylogenomic databases

eggNOGiKOG2328. Eukaryota.
COG5229. LUCA.
GeneTreeiENSGT00390000004149.
HOGENOMiHOG000231887.
HOVERGENiHBG036823.
InParanoidiQ8C156.
KOiK06676.
OMAiQALQKNW.
OrthoDBiEOG091G01HE.
PhylomeDBiQ8C156.
TreeFamiTF105678.

Family and domain databases

InterProiView protein in InterPro
IPR022816. Condensin_barren_su2.
PANTHERiPTHR13108. PTHR13108. 1 hit.
PfamiView protein in Pfam
PF05786. Cnd2. 1 hit.
PIRSFiPIRSF017126. Condensin_H. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE
60 70 80 90 100
DFPQNDDEKE RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT
110 120 130 140 150
QITEHYSTCI KLSSENKITT KNAFGLHLID FMSEILKQKD AEPTNFKVAA
160 170 180 190 200
GTLDASTKIY AVRVDAVHAD VYRVLGGLGK DTPPQGEESH SGDGSTLETE
210 220 230 240 250
RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ KTAASFDECS
260 270 280 290 300
TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL
310 320 330 340 350
QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA
360 370 380 390 400
EDDEEDVPDG PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI
410 420 430 440 450
SLEDRDIQVM CSFLSMKPGE YSYFSPRTMK MWAGPDHWRF RPRPKQDATS
460 470 480 490 500
CTEHKKKSAK KDFEINFDDD IDFDAYFQKT KAATILTKST LENQNWKATT
510 520 530 540 550
LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI EDYDYNNPND
560 570 580 590 600
TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG
610 620 630 640 650
VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR
660 670 680 690 700
KEADTEANHT ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL
710 720 730
AFACLLHLAN EKNLKLEGTE DLSDVLVMQG D
Length:731
Mass (Da):82,303
Last modified:March 1, 2003 - v1
Checksum:i23D2504024C2F0D5
GO

Sequence cautioni

The sequence AAH21499 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH25060 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC31339 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028919 mRNA. Translation: BAC26195.1.
AK042706 mRNA. Translation: BAC31339.1. Sequence problems.
BC021499 mRNA. Translation: AAH21499.1. Different initiation.
BC025060 mRNA. Translation: AAH25060.1. Different initiation.
CCDSiCCDS16693.2.
RefSeqiNP_659067.2. NM_144818.3.
UniGeneiMm.29786.

Genome annotation databases

EnsembliENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906.
GeneIDi215387.
KEGGimmu:215387.
UCSCiuc008met.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCND2_MOUSE
AccessioniPrimary (citable) accession number: Q8C156
Secondary accession number(s): Q8BY01, Q8VDM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families