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Q8C156

- CND2_MOUSE

UniProt

Q8C156 - CND2_MOUSE

Protein

Condensin complex subunit 2

Gene

Ncaph

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases By similarity.By similarity

    GO - Biological processi

    1. mitotic chromosome condensation Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division, DNA condensation, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Condensin complex subunit 2
    Alternative name(s):
    Barren homolog protein 1
    Chromosome-associated protein H
    Short name:
    mCAP-H
    Non-SMC condensin I complex subunit H
    XCAP-H homolog
    Gene namesi
    Name:Ncaph
    Synonyms:Brrn, Brrn1, Caph
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2444777. Ncaph.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Chromosome By similarity
    Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase By similarity.By similarity

    GO - Cellular componenti

    1. condensin complex Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell
    3. microtubule cytoskeleton Source: Ensembl
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 731731Condensin complex subunit 2PRO_0000095039Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Modified residuei46 – 461PhosphothreonineBy similarity
    Modified residuei67 – 671PhosphoserineBy similarity
    Modified residuei75 – 751PhosphoserineBy similarity
    Modified residuei78 – 781PhosphoserineBy similarity
    Modified residuei83 – 831PhosphoserineBy similarity
    Modified residuei91 – 911PhosphoserineBy similarity
    Modified residuei195 – 1951PhosphoserineBy similarity
    Modified residuei425 – 4251PhosphoserineBy similarity
    Modified residuei587 – 5871PhosphothreonineBy similarity
    Modified residuei627 – 6271N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8C156.
    PaxDbiQ8C156.
    PRIDEiQ8C156.

    PTM databases

    PhosphoSiteiQ8C156.

    Expressioni

    Gene expression databases

    BgeeiQ8C156.
    CleanExiMM_NCAPH.
    GenevestigatoriQ8C156.

    Interactioni

    Subunit structurei

    Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.By similarity

    Protein-protein interaction databases

    BioGridi229619. 1 interaction.
    IntActiQ8C156. 2 interactions.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CND2 (condensin subunit 2) family.Curated

    Phylogenomic databases

    eggNOGiCOG5229.
    GeneTreeiENSGT00390000004149.
    HOGENOMiHOG000231887.
    HOVERGENiHBG036823.
    InParanoidiQ8C156.
    KOiK06676.
    OMAiADSRDKR.
    OrthoDBiEOG7JMGDB.
    PhylomeDBiQ8C156.
    TreeFamiTF105678.

    Family and domain databases

    InterProiIPR022816. Condensin_barren_su2.
    [Graphical view]
    PfamiPF05786. Cnd2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017126. Condensin_H. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8C156-1 [UniParc]FASTAAdd to Basket

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    MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE    50
    DFPQNDDEKE RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT 100
    QITEHYSTCI KLSSENKITT KNAFGLHLID FMSEILKQKD AEPTNFKVAA 150
    GTLDASTKIY AVRVDAVHAD VYRVLGGLGK DTPPQGEESH SGDGSTLETE 200
    RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ KTAASFDECS 250
    TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL 300
    QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA 350
    EDDEEDVPDG PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI 400
    SLEDRDIQVM CSFLSMKPGE YSYFSPRTMK MWAGPDHWRF RPRPKQDATS 450
    CTEHKKKSAK KDFEINFDDD IDFDAYFQKT KAATILTKST LENQNWKATT 500
    LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI EDYDYNNPND 550
    TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG 600
    VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR 650
    KEADTEANHT ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL 700
    AFACLLHLAN EKNLKLEGTE DLSDVLVMQG D 731
    Length:731
    Mass (Da):82,303
    Last modified:March 1, 2003 - v1
    Checksum:i23D2504024C2F0D5
    GO

    Sequence cautioni

    The sequence AAH21499.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH25060.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC31339.1 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028919 mRNA. Translation: BAC26195.1.
    AK042706 mRNA. Translation: BAC31339.1. Sequence problems.
    BC021499 mRNA. Translation: AAH21499.1. Different initiation.
    BC025060 mRNA. Translation: AAH25060.1. Different initiation.
    CCDSiCCDS16693.2.
    RefSeqiNP_659067.2. NM_144818.3.
    UniGeneiMm.29786.

    Genome annotation databases

    EnsembliENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906.
    GeneIDi215387.
    KEGGimmu:215387.
    UCSCiuc008met.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028919 mRNA. Translation: BAC26195.1 .
    AK042706 mRNA. Translation: BAC31339.1 . Sequence problems.
    BC021499 mRNA. Translation: AAH21499.1 . Different initiation.
    BC025060 mRNA. Translation: AAH25060.1 . Different initiation.
    CCDSi CCDS16693.2.
    RefSeqi NP_659067.2. NM_144818.3.
    UniGenei Mm.29786.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229619. 1 interaction.
    IntActi Q8C156. 2 interactions.

    PTM databases

    PhosphoSitei Q8C156.

    Proteomic databases

    MaxQBi Q8C156.
    PaxDbi Q8C156.
    PRIDEi Q8C156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000110387 ; ENSMUSP00000106017 ; ENSMUSG00000034906 .
    GeneIDi 215387.
    KEGGi mmu:215387.
    UCSCi uc008met.2. mouse.

    Organism-specific databases

    CTDi 23397.
    MGIi MGI:2444777. Ncaph.

    Phylogenomic databases

    eggNOGi COG5229.
    GeneTreei ENSGT00390000004149.
    HOGENOMi HOG000231887.
    HOVERGENi HBG036823.
    InParanoidi Q8C156.
    KOi K06676.
    OMAi ADSRDKR.
    OrthoDBi EOG7JMGDB.
    PhylomeDBi Q8C156.
    TreeFami TF105678.

    Enzyme and pathway databases

    Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.

    Miscellaneous databases

    NextBioi 374690.
    PROi Q8C156.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C156.
    CleanExi MM_NCAPH.
    Genevestigatori Q8C156.

    Family and domain databases

    InterProi IPR022816. Condensin_barren_su2.
    [Graphical view ]
    Pfami PF05786. Cnd2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017126. Condensin_H. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCND2_MOUSE
    AccessioniPrimary (citable) accession number: Q8C156
    Secondary accession number(s): Q8BY01, Q8VDM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3