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Q8C156

- CND2_MOUSE

UniProt

Q8C156 - CND2_MOUSE

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Protein

Condensin complex subunit 2

Gene

Ncaph

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).By similarity

GO - Biological processi

  1. mitotic chromosome condensation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog protein 1
Chromosome-associated protein H
Short name:
mCAP-H
Non-SMC condensin I complex subunit H
XCAP-H homolog
Gene namesi
Name:Ncaph
Synonyms:Brrn, Brrn1, Caph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2444777. Ncaph.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Chromosome By similarity
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity).By similarity

GO - Cellular componenti

  1. condensin complex Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. microtubule cytoskeleton Source: Ensembl
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Condensin complex subunit 2PRO_0000095039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei46 – 461PhosphothreonineBy similarity
Modified residuei67 – 671PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei91 – 911PhosphoserineBy similarity
Modified residuei195 – 1951PhosphoserineBy similarity
Modified residuei425 – 4251PhosphoserineBy similarity
Modified residuei587 – 5871PhosphothreonineBy similarity
Modified residuei627 – 6271N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8C156.
PaxDbiQ8C156.
PRIDEiQ8C156.

PTM databases

PhosphoSiteiQ8C156.

Expressioni

Gene expression databases

BgeeiQ8C156.
CleanExiMM_NCAPH.
GenevestigatoriQ8C156.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.By similarity

Protein-protein interaction databases

BioGridi229619. 1 interaction.
IntActiQ8C156. 2 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the CND2 (condensin subunit 2) family.Curated

Phylogenomic databases

eggNOGiCOG5229.
GeneTreeiENSGT00390000004149.
HOGENOMiHOG000231887.
HOVERGENiHBG036823.
InParanoidiQ8C156.
KOiK06676.
OMAiADSRDKR.
OrthoDBiEOG7JMGDB.
PhylomeDBiQ8C156.
TreeFamiTF105678.

Family and domain databases

InterProiIPR022816. Condensin_barren_su2.
[Graphical view]
PfamiPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFiPIRSF017126. Condensin_H. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C156-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE
60 70 80 90 100
DFPQNDDEKE RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT
110 120 130 140 150
QITEHYSTCI KLSSENKITT KNAFGLHLID FMSEILKQKD AEPTNFKVAA
160 170 180 190 200
GTLDASTKIY AVRVDAVHAD VYRVLGGLGK DTPPQGEESH SGDGSTLETE
210 220 230 240 250
RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ KTAASFDECS
260 270 280 290 300
TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL
310 320 330 340 350
QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA
360 370 380 390 400
EDDEEDVPDG PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI
410 420 430 440 450
SLEDRDIQVM CSFLSMKPGE YSYFSPRTMK MWAGPDHWRF RPRPKQDATS
460 470 480 490 500
CTEHKKKSAK KDFEINFDDD IDFDAYFQKT KAATILTKST LENQNWKATT
510 520 530 540 550
LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI EDYDYNNPND
560 570 580 590 600
TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG
610 620 630 640 650
VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR
660 670 680 690 700
KEADTEANHT ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL
710 720 730
AFACLLHLAN EKNLKLEGTE DLSDVLVMQG D
Length:731
Mass (Da):82,303
Last modified:March 1, 2003 - v1
Checksum:i23D2504024C2F0D5
GO

Sequence cautioni

The sequence AAH21499.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH25060.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC31339.1 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028919 mRNA. Translation: BAC26195.1.
AK042706 mRNA. Translation: BAC31339.1. Sequence problems.
BC021499 mRNA. Translation: AAH21499.1. Different initiation.
BC025060 mRNA. Translation: AAH25060.1. Different initiation.
CCDSiCCDS16693.2.
RefSeqiNP_659067.2. NM_144818.3.
UniGeneiMm.29786.

Genome annotation databases

EnsembliENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906.
GeneIDi215387.
KEGGimmu:215387.
UCSCiuc008met.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028919 mRNA. Translation: BAC26195.1 .
AK042706 mRNA. Translation: BAC31339.1 . Sequence problems.
BC021499 mRNA. Translation: AAH21499.1 . Different initiation.
BC025060 mRNA. Translation: AAH25060.1 . Different initiation.
CCDSi CCDS16693.2.
RefSeqi NP_659067.2. NM_144818.3.
UniGenei Mm.29786.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229619. 1 interaction.
IntActi Q8C156. 2 interactions.

PTM databases

PhosphoSitei Q8C156.

Proteomic databases

MaxQBi Q8C156.
PaxDbi Q8C156.
PRIDEi Q8C156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000110387 ; ENSMUSP00000106017 ; ENSMUSG00000034906 .
GeneIDi 215387.
KEGGi mmu:215387.
UCSCi uc008met.2. mouse.

Organism-specific databases

CTDi 23397.
MGIi MGI:2444777. Ncaph.

Phylogenomic databases

eggNOGi COG5229.
GeneTreei ENSGT00390000004149.
HOGENOMi HOG000231887.
HOVERGENi HBG036823.
InParanoidi Q8C156.
KOi K06676.
OMAi ADSRDKR.
OrthoDBi EOG7JMGDB.
PhylomeDBi Q8C156.
TreeFami TF105678.

Enzyme and pathway databases

Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

NextBioi 374690.
PROi Q8C156.
SOURCEi Search...

Gene expression databases

Bgeei Q8C156.
CleanExi MM_NCAPH.
Genevestigatori Q8C156.

Family and domain databases

InterProi IPR022816. Condensin_barren_su2.
[Graphical view ]
Pfami PF05786. Cnd2. 1 hit.
[Graphical view ]
PIRSFi PIRSF017126. Condensin_H. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCND2_MOUSE
AccessioniPrimary (citable) accession number: Q8C156
Secondary accession number(s): Q8BY01, Q8VDM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3