SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8C156

- CND2_MOUSE

UniProt

Q8C156 - CND2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Condensin complex subunit 2

Gene
Ncaph, Brrn, Brrn1, Caph
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases By similarity.

GO - Biological processi

  1. mitotic chromosome condensation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog protein 1
Chromosome-associated protein H
Short name:
mCAP-H
Non-SMC condensin I complex subunit H
XCAP-H homolog
Gene namesi
Name:Ncaph
Synonyms:Brrn, Brrn1, Caph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2444777. Ncaph.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Chromosome By similarity
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase By similarity.

GO - Cellular componenti

  1. condensin complex Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
  3. microtubule cytoskeleton Source: Ensembl
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Condensin complex subunit 2PRO_0000095039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine By similarity
Modified residuei46 – 461Phosphothreonine By similarity
Modified residuei67 – 671Phosphoserine By similarity
Modified residuei75 – 751Phosphoserine By similarity
Modified residuei78 – 781Phosphoserine By similarity
Modified residuei83 – 831Phosphoserine By similarity
Modified residuei91 – 911Phosphoserine By similarity
Modified residuei195 – 1951Phosphoserine By similarity
Modified residuei425 – 4251Phosphoserine By similarity
Modified residuei587 – 5871Phosphothreonine By similarity
Modified residuei627 – 6271N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8C156.
PaxDbiQ8C156.
PRIDEiQ8C156.

PTM databases

PhosphoSiteiQ8C156.

Expressioni

Gene expression databases

BgeeiQ8C156.
CleanExiMM_NCAPH.
GenevestigatoriQ8C156.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG By similarity.

Protein-protein interaction databases

BioGridi229619. 1 interaction.
IntActiQ8C156. 2 interactions.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5229.
GeneTreeiENSGT00390000004149.
HOGENOMiHOG000231887.
HOVERGENiHBG036823.
InParanoidiQ8C156.
KOiK06676.
OMAiADSRDKR.
OrthoDBiEOG7JMGDB.
PhylomeDBiQ8C156.
TreeFamiTF105678.

Family and domain databases

InterProiIPR022816. Condensin_barren_su2.
[Graphical view]
PfamiPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFiPIRSF017126. Condensin_H. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C156-1 [UniParc]FASTAAdd to Basket

« Hide

MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE    50
DFPQNDDEKE RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT 100
QITEHYSTCI KLSSENKITT KNAFGLHLID FMSEILKQKD AEPTNFKVAA 150
GTLDASTKIY AVRVDAVHAD VYRVLGGLGK DTPPQGEESH SGDGSTLETE 200
RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ KTAASFDECS 250
TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL 300
QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA 350
EDDEEDVPDG PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI 400
SLEDRDIQVM CSFLSMKPGE YSYFSPRTMK MWAGPDHWRF RPRPKQDATS 450
CTEHKKKSAK KDFEINFDDD IDFDAYFQKT KAATILTKST LENQNWKATT 500
LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI EDYDYNNPND 550
TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG 600
VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR 650
KEADTEANHT ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL 700
AFACLLHLAN EKNLKLEGTE DLSDVLVMQG D 731
Length:731
Mass (Da):82,303
Last modified:March 1, 2003 - v1
Checksum:i23D2504024C2F0D5
GO

Sequence cautioni

The sequence AAH21499.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH25060.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC31339.1 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028919 mRNA. Translation: BAC26195.1.
AK042706 mRNA. Translation: BAC31339.1. Sequence problems.
BC021499 mRNA. Translation: AAH21499.1. Different initiation.
BC025060 mRNA. Translation: AAH25060.1. Different initiation.
CCDSiCCDS16693.2.
RefSeqiNP_659067.2. NM_144818.3.
UniGeneiMm.29786.

Genome annotation databases

EnsembliENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906.
GeneIDi215387.
KEGGimmu:215387.
UCSCiuc008met.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028919 mRNA. Translation: BAC26195.1 .
AK042706 mRNA. Translation: BAC31339.1 . Sequence problems.
BC021499 mRNA. Translation: AAH21499.1 . Different initiation.
BC025060 mRNA. Translation: AAH25060.1 . Different initiation.
CCDSi CCDS16693.2.
RefSeqi NP_659067.2. NM_144818.3.
UniGenei Mm.29786.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229619. 1 interaction.
IntActi Q8C156. 2 interactions.

PTM databases

PhosphoSitei Q8C156.

Proteomic databases

MaxQBi Q8C156.
PaxDbi Q8C156.
PRIDEi Q8C156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000110387 ; ENSMUSP00000106017 ; ENSMUSG00000034906 .
GeneIDi 215387.
KEGGi mmu:215387.
UCSCi uc008met.2. mouse.

Organism-specific databases

CTDi 23397.
MGIi MGI:2444777. Ncaph.

Phylogenomic databases

eggNOGi COG5229.
GeneTreei ENSGT00390000004149.
HOGENOMi HOG000231887.
HOVERGENi HBG036823.
InParanoidi Q8C156.
KOi K06676.
OMAi ADSRDKR.
OrthoDBi EOG7JMGDB.
PhylomeDBi Q8C156.
TreeFami TF105678.

Enzyme and pathway databases

Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

NextBioi 374690.
PROi Q8C156.
SOURCEi Search...

Gene expression databases

Bgeei Q8C156.
CleanExi MM_NCAPH.
Genevestigatori Q8C156.

Family and domain databases

InterProi IPR022816. Condensin_barren_su2.
[Graphical view ]
Pfami PF05786. Cnd2. 1 hit.
[Graphical view ]
PIRSFi PIRSF017126. Condensin_H. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCND2_MOUSE
AccessioniPrimary (citable) accession number: Q8C156
Secondary accession number(s): Q8BY01, Q8VDM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi