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Q8C156 (CND2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog protein 1
Chromosome-associated protein H
Short name=mCAP-H
Non-SMC condensin I complex subunit H
XCAP-H homolog
Gene names
Name:Ncaph
Synonyms:Brrn, Brrn1, Caph
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length731 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases By similarity.

Subunit structure

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Chromosome By similarity. Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase By similarity.

Post-translational modification

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation By similarity.

Sequence similarities

Belongs to the CND2 (condensin subunit 2) family.

Sequence caution

The sequence AAH21499.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH25060.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC31339.1 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 731731Condensin complex subunit 2
PRO_0000095039

Amino acid modifications

Modified residue121Phosphoserine By similarity
Modified residue461Phosphothreonine By similarity
Modified residue671Phosphoserine By similarity
Modified residue751Phosphoserine By similarity
Modified residue781Phosphoserine By similarity
Modified residue831Phosphoserine By similarity
Modified residue911Phosphoserine By similarity
Modified residue1951Phosphoserine By similarity
Modified residue4251Phosphoserine By similarity
Modified residue5871Phosphothreonine By similarity
Modified residue6271N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8C156 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 23D2504024C2F0D5

FASTA73182,303
        10         20         30         40         50         60 
MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE DFPQNDDEKE 

        70         80         90        100        110        120 
RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT QITEHYSTCI KLSSENKITT 

       130        140        150        160        170        180 
KNAFGLHLID FMSEILKQKD AEPTNFKVAA GTLDASTKIY AVRVDAVHAD VYRVLGGLGK 

       190        200        210        220        230        240 
DTPPQGEESH SGDGSTLETE RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ 

       250        260        270        280        290        300 
KTAASFDECS TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL 

       310        320        330        340        350        360 
QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA EDDEEDVPDG 

       370        380        390        400        410        420 
PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI SLEDRDIQVM CSFLSMKPGE 

       430        440        450        460        470        480 
YSYFSPRTMK MWAGPDHWRF RPRPKQDATS CTEHKKKSAK KDFEINFDDD IDFDAYFQKT 

       490        500        510        520        530        540 
KAATILTKST LENQNWKATT LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI 

       550        560        570        580        590        600 
EDYDYNNPND TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG 

       610        620        630        640        650        660 
VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR KEADTEANHT 

       670        680        690        700        710        720 
ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL AFACLLHLAN EKNLKLEGTE 

       730 
DLSDVLVMQG D 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028919 mRNA. Translation: BAC26195.1.
AK042706 mRNA. Translation: BAC31339.1. Sequence problems.
BC021499 mRNA. Translation: AAH21499.1. Different initiation.
BC025060 mRNA. Translation: AAH25060.1. Different initiation.
CCDSCCDS16693.2.
RefSeqNP_659067.2. NM_144818.3.
UniGeneMm.29786.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid229619. 1 interaction.
IntActQ8C156. 2 interactions.

PTM databases

PhosphoSiteQ8C156.

Proteomic databases

MaxQBQ8C156.
PaxDbQ8C156.
PRIDEQ8C156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906.
GeneID215387.
KEGGmmu:215387.
UCSCuc008met.2. mouse.

Organism-specific databases

CTD23397.
MGIMGI:2444777. Ncaph.

Phylogenomic databases

eggNOGCOG5229.
GeneTreeENSGT00390000004149.
HOGENOMHOG000231887.
HOVERGENHBG036823.
InParanoidQ8C156.
KOK06676.
OMAADSRDKR.
OrthoDBEOG7JMGDB.
PhylomeDBQ8C156.
TreeFamTF105678.

Gene expression databases

BgeeQ8C156.
CleanExMM_NCAPH.
GenevestigatorQ8C156.

Family and domain databases

InterProIPR022816. Condensin_barren_su2.
[Graphical view]
PfamPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFPIRSF017126. Condensin_H. 1 hit.
ProtoNetSearch...

Other

NextBio374690.
PROQ8C156.
SOURCESearch...

Entry information

Entry nameCND2_MOUSE
AccessionPrimary (citable) accession number: Q8C156
Secondary accession number(s): Q8BY01, Q8VDM9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot