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Q8C145

- S39A6_MOUSE

UniProt

Q8C145 - S39A6_MOUSE

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Protein
Zinc transporter ZIP6
Gene
Slc39a6, Zip6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter By similarity.

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cellular zinc ion homeostasis Source: Ensembl
  2. zinc ion transmembrane import Source: Ensembl
  3. zinc ion transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP6
Alternative name(s):
Endoplasmic reticulum membrane-linked protein
Short name:
Ermelin
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name:
ZIP-6
Gene namesi
Name:Slc39a6
Synonyms:Zip6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2147279. Slc39a6.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Found in the endoplasmic reticulum when overexpressed.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 335315Extracellular Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini357 – 3659Cytoplasmic Reviewed prediction
Transmembranei366 – 38621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini387 – 43347Extracellular Reviewed prediction
Add
BLAST
Transmembranei434 – 45421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini455 – 667213Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei668 – 68821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini689 – 6968Extracellular Reviewed prediction
Transmembranei697 – 71721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini718 – 73417Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei735 – 75521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini756 – 76510Extracellular Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. integral component of plasma membrane Source: Ensembl
  3. lamellipodium membrane Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 765745Zinc transporter ZIP6
PRO_0000041651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)1 Publication
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi275 – 2751N-linked (GlcNAc...)1 Publication
Glycosylationi292 – 2921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi694 – 6941N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8C145.
PaxDbiQ8C145.
PRIDEiQ8C145.

PTM databases

PhosphoSiteiQ8C145.

Expressioni

Tissue specificityi

Highly expressed in the brain and testis. In the brain strongly expressed in the CA1 and CA3 regions, Purkinje cells in cerebellum and dentate gyrus in hippocampus. In testis found in spermatids or mature sperms in the central areas of seminiferous tubules.1 Publication

Inductioni

Induced during neuronal differentiation neuroblastoma cells line but down-regulated during myogenic differentiation of skeletal muscle cells line.1 Publication

Gene expression databases

ArrayExpressiQ8C145.
BgeeiQ8C145.
GenevestigatoriQ8C145.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064667.

Structurei

3D structure databases

ProteinModelPortaliQ8C145.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili475 – 49521 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 14150His-rich
Add
BLAST
Compositional biasi458 – 4636Poly-Lys
Compositional biasi523 – 5264Poly-Glu
Compositional biasi551 – 58838His-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00750000117560.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ8C145.
KOiK14712.
OMAiFNYLCPA.
OrthoDBiEOG7H791W.
PhylomeDBiQ8C145.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C145-1 [UniParc]FASTAAdd to Basket

« Hide

MATDLSVIMI LTFALWVTSP LHELQSTAAF SQTTEKINSN WEPGVNVDLA    50
VTMQRHHLQQ LFYRYGENDS LSVEGFRKLL QNIGIDKIKR VHIHHDHEHH 100
ADHEHHSDHE HHSDHEHHSD HEHHSDHEHH SDHEHHSHRS HTVAGKNNRK 150
AFCPDLDSDN SGKNPRTSLG KGSRPAEHMN GRRNIKESAS SSEVTSAVYN 200
AVSEGTRFVE TIETPKPGRR TKDVNPSTPP SITEKSRVGR LSRLARKKSN 250
ESVSEPRKSF MYSRNTNDNI QECFNTTKLL TSHGMSIQAL LNATEFNYLC 300
PAIINQIDAR ACLIHTASEK KAEIPPKTYS LQIAWLGGFI AISIISFLSL 350
LGVILVPLMN RVFFKFLLSF LVALAVGTLS GDALLHLLPH SHASHQHSHS 400
HEEPAMEMKR GPLFSHLSAQ NIEESSYFDS TWKGLTALGG LYFMFLVEHV 450
LTLIKQFKDK KKKNQKKPEN DEDVESKKQL SKYDSQLSSN EEKVDPGERP 500
ESYLRADSQE PSPFDSQQPT MLEEEEVMIA HAHPQEVYNE YVPRGCKNKC 550
HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA 600
GIATLAWMVI MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE 650
LGDFAVLLKA GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF 700
ALTAGLFMYV ALVDMVPEML HNDASDHGCS RWGYFFLQNA GILLGFGIML 750
LISIFEHKIV FRINF 765
Length:765
Mass (Da):86,380
Last modified:March 1, 2003 - v1
Checksum:iC8938B9C3371377B
GO

Sequence cautioni

The sequence BAB86300.1 differs from that shown. Reason: Frameshift at position 226.
The sequence AAH54780.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1076Missing in BAB86300. 1 Publication
Sequence conflicti201 – 2011A → V in AAH55012. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028976 mRNA. Translation: BAC26223.1.
BC054780 mRNA. Translation: AAH54780.2. Different initiation.
BC055012 mRNA. Translation: AAH55012.1.
AB071697 mRNA. Translation: BAB86300.1. Sequence problems.
CCDSiCCDS50239.1.
RefSeqiNP_631882.2. NM_139143.3.
UniGeneiMm.21688.

Genome annotation databases

EnsembliENSMUST00000070726; ENSMUSP00000064667; ENSMUSG00000024270.
GeneIDi106957.
KEGGimmu:106957.
UCSCiuc008egv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028976 mRNA. Translation: BAC26223.1 .
BC054780 mRNA. Translation: AAH54780.2 . Different initiation.
BC055012 mRNA. Translation: AAH55012.1 .
AB071697 mRNA. Translation: BAB86300.1 . Sequence problems.
CCDSi CCDS50239.1.
RefSeqi NP_631882.2. NM_139143.3.
UniGenei Mm.21688.

3D structure databases

ProteinModelPortali Q8C145.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000064667.

PTM databases

PhosphoSitei Q8C145.

Proteomic databases

MaxQBi Q8C145.
PaxDbi Q8C145.
PRIDEi Q8C145.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070726 ; ENSMUSP00000064667 ; ENSMUSG00000024270 .
GeneIDi 106957.
KEGGi mmu:106957.
UCSCi uc008egv.1. mouse.

Organism-specific databases

CTDi 25800.
MGIi MGI:2147279. Slc39a6.

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00750000117560.
HOGENOMi HOG000013093.
HOVERGENi HBG055748.
InParanoidi Q8C145.
KOi K14712.
OMAi FNYLCPA.
OrthoDBi EOG7H791W.
PhylomeDBi Q8C145.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

NextBioi 358490.
PROi Q8C145.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8C145.
Bgeei Q8C145.
Genevestigatori Q8C145.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Olfactory epithelium.
  3. "Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes."
    Suzuki A., Endo T.
    Gene 284:31-40(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-765, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-275.

Entry informationi

Entry nameiS39A6_MOUSE
AccessioniPrimary (citable) accession number: Q8C145
Secondary accession number(s): Q7TPP9, Q7TQE0, Q8R518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi