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Q8C145 (S39A6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP6
Alternative name(s):
Endoplasmic reticulum membrane-linked protein
Short name=Ermelin
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name=ZIP-6
Gene names
Name:Slc39a6
Synonyms:Zip6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length765 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a zinc-influx transporter By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Found in the endoplasmic reticulum when overexpressed. Ref.3

Tissue specificity

Highly expressed in the brain and testis. In the brain strongly expressed in the CA1 and CA3 regions, Purkinje cells in cerebellum and dentate gyrus in hippocampus. In testis found in spermatids or mature sperms in the central areas of seminiferous tubules. Ref.3

Induction

Induced during neuronal differentiation neuroblastoma cells line but down-regulated during myogenic differentiation of skeletal muscle cells line. Ref.3

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Sequence caution

The sequence AAH54780.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAB86300.1 differs from that shown. Reason: Frameshift at position 226.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 765745Zinc transporter ZIP6
PRO_0000041651

Regions

Topological domain21 – 335315Extracellular Potential
Transmembrane336 – 35621Helical; Name=1; Potential
Topological domain357 – 3659Cytoplasmic Potential
Transmembrane366 – 38621Helical; Name=2; Potential
Topological domain387 – 43347Extracellular Potential
Transmembrane434 – 45421Helical; Name=3; Potential
Topological domain455 – 667213Cytoplasmic Potential
Transmembrane668 – 68821Helical; Name=4; Potential
Topological domain689 – 6968Extracellular Potential
Transmembrane697 – 71721Helical; Name=5; Potential
Topological domain718 – 73417Cytoplasmic Potential
Transmembrane735 – 75521Helical; Name=6; Potential
Topological domain756 – 76510Extracellular Potential
Coiled coil475 – 49521 Potential
Compositional bias92 – 14150His-rich
Compositional bias458 – 4636Poly-Lys
Compositional bias523 – 5264Poly-Glu
Compositional bias551 – 58838His-rich

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Ref.5
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Ref.5
Glycosylation2921N-linked (GlcNAc...) Potential
Glycosylation6941N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict102 – 1076Missing in BAB86300. Ref.3
Sequence conflict2011A → V in AAH55012. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8C145 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C8938B9C3371377B

FASTA76586,380
        10         20         30         40         50         60 
MATDLSVIMI LTFALWVTSP LHELQSTAAF SQTTEKINSN WEPGVNVDLA VTMQRHHLQQ 

        70         80         90        100        110        120 
LFYRYGENDS LSVEGFRKLL QNIGIDKIKR VHIHHDHEHH ADHEHHSDHE HHSDHEHHSD 

       130        140        150        160        170        180 
HEHHSDHEHH SDHEHHSHRS HTVAGKNNRK AFCPDLDSDN SGKNPRTSLG KGSRPAEHMN 

       190        200        210        220        230        240 
GRRNIKESAS SSEVTSAVYN AVSEGTRFVE TIETPKPGRR TKDVNPSTPP SITEKSRVGR 

       250        260        270        280        290        300 
LSRLARKKSN ESVSEPRKSF MYSRNTNDNI QECFNTTKLL TSHGMSIQAL LNATEFNYLC 

       310        320        330        340        350        360 
PAIINQIDAR ACLIHTASEK KAEIPPKTYS LQIAWLGGFI AISIISFLSL LGVILVPLMN 

       370        380        390        400        410        420 
RVFFKFLLSF LVALAVGTLS GDALLHLLPH SHASHQHSHS HEEPAMEMKR GPLFSHLSAQ 

       430        440        450        460        470        480 
NIEESSYFDS TWKGLTALGG LYFMFLVEHV LTLIKQFKDK KKKNQKKPEN DEDVESKKQL 

       490        500        510        520        530        540 
SKYDSQLSSN EEKVDPGERP ESYLRADSQE PSPFDSQQPT MLEEEEVMIA HAHPQEVYNE 

       550        560        570        580        590        600 
YVPRGCKNKC HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA 

       610        620        630        640        650        660 
GIATLAWMVI MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA 

       670        680        690        700        710        720 
GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV ALVDMVPEML 

       730        740        750        760 
HNDASDHGCS RWGYFFLQNA GILLGFGIML LISIFEHKIV FRINF 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Olfactory epithelium.
[3]"Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes."
Suzuki A., Endo T.
Gene 284:31-40(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-765, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-275.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028976 mRNA. Translation: BAC26223.1.
BC054780 mRNA. Translation: AAH54780.2. Different initiation.
BC055012 mRNA. Translation: AAH55012.1.
AB071697 mRNA. Translation: BAB86300.1. Sequence problems.
RefSeqNP_631882.2. NM_139143.3.
UniGeneMm.21688.

3D structure databases

ProteinModelPortalQ8C145.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000064667.

PTM databases

PhosphoSiteQ8C145.

Proteomic databases

PaxDbQ8C145.
PRIDEQ8C145.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070726; ENSMUSP00000064667; ENSMUSG00000024270.
GeneID106957.
KEGGmmu:106957.
UCSCuc008egv.1. mouse.

Organism-specific databases

CTD25800.
MGIMGI:2147279. Slc39a6.

Phylogenomic databases

eggNOGCOG0428.
GeneTreeENSGT00750000117560.
HOGENOMHOG000013093.
HOVERGENHBG055748.
InParanoidQ8C145.
KOK14712.
OMAFNYLCPA.
OrthoDBEOG7H791W.
PhylomeDBQ8C145.
TreeFamTF318470.

Gene expression databases

ArrayExpressQ8C145.
BgeeQ8C145.
GenevestigatorQ8C145.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio358490.
PROQ8C145.
SOURCESearch...

Entry information

Entry nameS39A6_MOUSE
AccessionPrimary (citable) accession number: Q8C145
Secondary accession number(s): Q7TPP9, Q7TQE0, Q8R518
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot