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Protein

Zinc transporter ZIP6

Gene

Slc39a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP6
Alternative name(s):
Endoplasmic reticulum membrane-linked protein
Short name:
Ermelin
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name:
ZIP-6
Gene namesi
Name:Slc39a6
Synonyms:Zip6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147279. Slc39a6.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Found in the endoplasmic reticulum when overexpressed.1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 335ExtracellularSequence analysisAdd BLAST315
Transmembranei336 – 356Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini357 – 365CytoplasmicSequence analysis9
Transmembranei366 – 386Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini387 – 433ExtracellularSequence analysisAdd BLAST47
Transmembranei434 – 454Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini455 – 667CytoplasmicSequence analysisAdd BLAST213
Transmembranei668 – 688Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini689 – 696ExtracellularSequence analysis8
Transmembranei697 – 717Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini718 – 734CytoplasmicSequence analysisAdd BLAST17
Transmembranei735 – 755Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini756 – 765ExtracellularSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004165121 – 765Zinc transporter ZIP6Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)1 Publication1
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)1 Publication1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Modified residuei481PhosphoserineBy similarity1
Modified residuei488PhosphoserineBy similarity1
Glycosylationi694N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8C145.
MaxQBiQ8C145.
PaxDbiQ8C145.
PeptideAtlasiQ8C145.
PRIDEiQ8C145.

PTM databases

iPTMnetiQ8C145.
PhosphoSitePlusiQ8C145.

Expressioni

Tissue specificityi

Highly expressed in the brain and testis. In the brain strongly expressed in the CA1 and CA3 regions, Purkinje cells in cerebellum and dentate gyrus in hippocampus. In testis found in spermatids or mature sperms in the central areas of seminiferous tubules.1 Publication

Inductioni

Induced during neuronal differentiation neuroblastoma cells line but down-regulated during myogenic differentiation of skeletal muscle cells line.1 Publication

Gene expression databases

BgeeiENSMUSG00000024270.
ExpressionAtlasiQ8C145. baseline and differential.
GenevisibleiQ8C145. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064667.

Structurei

3D structure databases

ProteinModelPortaliQ8C145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili475 – 495Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 141His-richAdd BLAST50
Compositional biasi458 – 463Poly-Lys6
Compositional biasi523 – 526Poly-Glu4
Compositional biasi551 – 588His-richAdd BLAST38

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ8C145.
KOiK14712.
OMAiSQGKGSH.
OrthoDBiEOG091G02WM.
PhylomeDBiQ8C145.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDLSVIMI LTFALWVTSP LHELQSTAAF SQTTEKINSN WEPGVNVDLA
60 70 80 90 100
VTMQRHHLQQ LFYRYGENDS LSVEGFRKLL QNIGIDKIKR VHIHHDHEHH
110 120 130 140 150
ADHEHHSDHE HHSDHEHHSD HEHHSDHEHH SDHEHHSHRS HTVAGKNNRK
160 170 180 190 200
AFCPDLDSDN SGKNPRTSLG KGSRPAEHMN GRRNIKESAS SSEVTSAVYN
210 220 230 240 250
AVSEGTRFVE TIETPKPGRR TKDVNPSTPP SITEKSRVGR LSRLARKKSN
260 270 280 290 300
ESVSEPRKSF MYSRNTNDNI QECFNTTKLL TSHGMSIQAL LNATEFNYLC
310 320 330 340 350
PAIINQIDAR ACLIHTASEK KAEIPPKTYS LQIAWLGGFI AISIISFLSL
360 370 380 390 400
LGVILVPLMN RVFFKFLLSF LVALAVGTLS GDALLHLLPH SHASHQHSHS
410 420 430 440 450
HEEPAMEMKR GPLFSHLSAQ NIEESSYFDS TWKGLTALGG LYFMFLVEHV
460 470 480 490 500
LTLIKQFKDK KKKNQKKPEN DEDVESKKQL SKYDSQLSSN EEKVDPGERP
510 520 530 540 550
ESYLRADSQE PSPFDSQQPT MLEEEEVMIA HAHPQEVYNE YVPRGCKNKC
560 570 580 590 600
HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA
610 620 630 640 650
GIATLAWMVI MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE
660 670 680 690 700
LGDFAVLLKA GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF
710 720 730 740 750
ALTAGLFMYV ALVDMVPEML HNDASDHGCS RWGYFFLQNA GILLGFGIML
760
LISIFEHKIV FRINF
Length:765
Mass (Da):86,380
Last modified:March 1, 2003 - v1
Checksum:iC8938B9C3371377B
GO

Sequence cautioni

The sequence AAH54780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB86300 differs from that shown. Reason: Frameshift at position 226.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102 – 107Missing in BAB86300 (PubMed:11891044).Curated6
Sequence conflicti201A → V in AAH55012 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028976 mRNA. Translation: BAC26223.1.
BC054780 mRNA. Translation: AAH54780.2. Different initiation.
BC055012 mRNA. Translation: AAH55012.1.
AB071697 mRNA. Translation: BAB86300.1. Sequence problems.
CCDSiCCDS50239.1.
RefSeqiNP_631882.2. NM_139143.3.
UniGeneiMm.21688.

Genome annotation databases

EnsembliENSMUST00000070726; ENSMUSP00000064667; ENSMUSG00000024270.
GeneIDi106957.
KEGGimmu:106957.
UCSCiuc008egv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028976 mRNA. Translation: BAC26223.1.
BC054780 mRNA. Translation: AAH54780.2. Different initiation.
BC055012 mRNA. Translation: AAH55012.1.
AB071697 mRNA. Translation: BAB86300.1. Sequence problems.
CCDSiCCDS50239.1.
RefSeqiNP_631882.2. NM_139143.3.
UniGeneiMm.21688.

3D structure databases

ProteinModelPortaliQ8C145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064667.

PTM databases

iPTMnetiQ8C145.
PhosphoSitePlusiQ8C145.

Proteomic databases

EPDiQ8C145.
MaxQBiQ8C145.
PaxDbiQ8C145.
PeptideAtlasiQ8C145.
PRIDEiQ8C145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070726; ENSMUSP00000064667; ENSMUSG00000024270.
GeneIDi106957.
KEGGimmu:106957.
UCSCiuc008egv.1. mouse.

Organism-specific databases

CTDi25800.
MGIiMGI:2147279. Slc39a6.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ8C145.
KOiK14712.
OMAiSQGKGSH.
OrthoDBiEOG091G02WM.
PhylomeDBiQ8C145.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ8C145.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024270.
ExpressionAtlasiQ8C145. baseline and differential.
GenevisibleiQ8C145. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A6_MOUSE
AccessioniPrimary (citable) accession number: Q8C145
Secondary accession number(s): Q7TPP9, Q7TQE0, Q8R518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.