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Q8C145

- S39A6_MOUSE

UniProt

Q8C145 - S39A6_MOUSE

Protein

Zinc transporter ZIP6

Gene

Slc39a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May act as a zinc-influx transporter.By similarity

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular zinc ion homeostasis Source: Ensembl
    2. zinc ion transmembrane import Source: Ensembl
    3. zinc ion transmembrane transport Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP6
    Alternative name(s):
    Endoplasmic reticulum membrane-linked protein
    Short name:
    Ermelin
    Solute carrier family 39 member 6
    Zrt- and Irt-like protein 6
    Short name:
    ZIP-6
    Gene namesi
    Name:Slc39a6
    Synonyms:Zip6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2147279. Slc39a6.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Found in the endoplasmic reticulum when overexpressed.1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. integral component of plasma membrane Source: Ensembl
    3. lamellipodium membrane Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 765745Zinc transporter ZIP6PRO_0000041651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi68 – 681N-linked (GlcNAc...)1 Publication
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)1 Publication
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8C145.
    PaxDbiQ8C145.
    PRIDEiQ8C145.

    PTM databases

    PhosphoSiteiQ8C145.

    Expressioni

    Tissue specificityi

    Highly expressed in the brain and testis. In the brain strongly expressed in the CA1 and CA3 regions, Purkinje cells in cerebellum and dentate gyrus in hippocampus. In testis found in spermatids or mature sperms in the central areas of seminiferous tubules.1 Publication

    Inductioni

    Induced during neuronal differentiation neuroblastoma cells line but down-regulated during myogenic differentiation of skeletal muscle cells line.1 Publication

    Gene expression databases

    ArrayExpressiQ8C145.
    BgeeiQ8C145.
    GenevestigatoriQ8C145.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000064667.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C145.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 335315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 3659CytoplasmicSequence Analysis
    Topological domaini387 – 43347ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini455 – 667213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini689 – 6968ExtracellularSequence Analysis
    Topological domaini718 – 73417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini756 – 76510ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei336 – 35621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei668 – 68821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei697 – 71721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei735 – 75521Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili475 – 49521Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 14150His-richAdd
    BLAST
    Compositional biasi458 – 4636Poly-Lys
    Compositional biasi523 – 5264Poly-Glu
    Compositional biasi551 – 58838His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    GeneTreeiENSGT00750000117560.
    HOGENOMiHOG000013093.
    HOVERGENiHBG055748.
    InParanoidiQ8C145.
    KOiK14712.
    OMAiFNYLCPA.
    OrthoDBiEOG7H791W.
    PhylomeDBiQ8C145.
    TreeFamiTF318470.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8C145-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATDLSVIMI LTFALWVTSP LHELQSTAAF SQTTEKINSN WEPGVNVDLA    50
    VTMQRHHLQQ LFYRYGENDS LSVEGFRKLL QNIGIDKIKR VHIHHDHEHH 100
    ADHEHHSDHE HHSDHEHHSD HEHHSDHEHH SDHEHHSHRS HTVAGKNNRK 150
    AFCPDLDSDN SGKNPRTSLG KGSRPAEHMN GRRNIKESAS SSEVTSAVYN 200
    AVSEGTRFVE TIETPKPGRR TKDVNPSTPP SITEKSRVGR LSRLARKKSN 250
    ESVSEPRKSF MYSRNTNDNI QECFNTTKLL TSHGMSIQAL LNATEFNYLC 300
    PAIINQIDAR ACLIHTASEK KAEIPPKTYS LQIAWLGGFI AISIISFLSL 350
    LGVILVPLMN RVFFKFLLSF LVALAVGTLS GDALLHLLPH SHASHQHSHS 400
    HEEPAMEMKR GPLFSHLSAQ NIEESSYFDS TWKGLTALGG LYFMFLVEHV 450
    LTLIKQFKDK KKKNQKKPEN DEDVESKKQL SKYDSQLSSN EEKVDPGERP 500
    ESYLRADSQE PSPFDSQQPT MLEEEEVMIA HAHPQEVYNE YVPRGCKNKC 550
    HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA 600
    GIATLAWMVI MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE 650
    LGDFAVLLKA GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF 700
    ALTAGLFMYV ALVDMVPEML HNDASDHGCS RWGYFFLQNA GILLGFGIML 750
    LISIFEHKIV FRINF 765
    Length:765
    Mass (Da):86,380
    Last modified:March 1, 2003 - v1
    Checksum:iC8938B9C3371377B
    GO

    Sequence cautioni

    The sequence BAB86300.1 differs from that shown. Reason: Frameshift at position 226.
    The sequence AAH54780.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1076Missing in BAB86300. (PubMed:11891044)Curated
    Sequence conflicti201 – 2011A → V in AAH55012. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028976 mRNA. Translation: BAC26223.1.
    BC054780 mRNA. Translation: AAH54780.2. Different initiation.
    BC055012 mRNA. Translation: AAH55012.1.
    AB071697 mRNA. Translation: BAB86300.1. Sequence problems.
    CCDSiCCDS50239.1.
    RefSeqiNP_631882.2. NM_139143.3.
    UniGeneiMm.21688.

    Genome annotation databases

    EnsembliENSMUST00000070726; ENSMUSP00000064667; ENSMUSG00000024270.
    GeneIDi106957.
    KEGGimmu:106957.
    UCSCiuc008egv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028976 mRNA. Translation: BAC26223.1 .
    BC054780 mRNA. Translation: AAH54780.2 . Different initiation.
    BC055012 mRNA. Translation: AAH55012.1 .
    AB071697 mRNA. Translation: BAB86300.1 . Sequence problems.
    CCDSi CCDS50239.1.
    RefSeqi NP_631882.2. NM_139143.3.
    UniGenei Mm.21688.

    3D structure databases

    ProteinModelPortali Q8C145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000064667.

    PTM databases

    PhosphoSitei Q8C145.

    Proteomic databases

    MaxQBi Q8C145.
    PaxDbi Q8C145.
    PRIDEi Q8C145.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070726 ; ENSMUSP00000064667 ; ENSMUSG00000024270 .
    GeneIDi 106957.
    KEGGi mmu:106957.
    UCSCi uc008egv.1. mouse.

    Organism-specific databases

    CTDi 25800.
    MGIi MGI:2147279. Slc39a6.

    Phylogenomic databases

    eggNOGi COG0428.
    GeneTreei ENSGT00750000117560.
    HOGENOMi HOG000013093.
    HOVERGENi HBG055748.
    InParanoidi Q8C145.
    KOi K14712.
    OMAi FNYLCPA.
    OrthoDBi EOG7H791W.
    PhylomeDBi Q8C145.
    TreeFami TF318470.

    Enzyme and pathway databases

    Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    NextBioi 358490.
    PROi Q8C145.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C145.
    Bgeei Q8C145.
    Genevestigatori Q8C145.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Olfactory epithelium.
    3. "Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes."
      Suzuki A., Endo T.
      Gene 284:31-40(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-765, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-275.

    Entry informationi

    Entry nameiS39A6_MOUSE
    AccessioniPrimary (citable) accession number: Q8C145
    Secondary accession number(s): Q7TPP9, Q7TQE0, Q8R518
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3