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Protein

Sodium/hydrogen exchanger 9B1

Gene

Slc9b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 9B1
Alternative name(s):
Na(+)/H(+) exchanger-like domain-containing protein 1
Short name:
NHE domain-containing protein 1
Sodium/hydrogen exchanger-like domain-containing protein 1
Solute carrier family 9 subfamily B member 1
Gene namesi
Name:Slc9b1
Synonyms:Nhedc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921696. Slc9b1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei206 – 223HelicalSequence analysisAdd BLAST18
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140091 – 565Sodium/hydrogen exchanger 9B1Add BLAST565

Proteomic databases

PaxDbiQ8C0X2.
PRIDEiQ8C0X2.

PTM databases

iPTMnetiQ8C0X2.
PhosphoSitePlusiQ8C0X2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050150.
CleanExiMM_NHEDC1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077644.

Structurei

3D structure databases

ProteinModelPortaliQ8C0X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 98Glu-richAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3826. Eukaryota.
COG0025. LUCA.
HOGENOMiHOG000060325.
HOVERGENiHBG108184.
InParanoidiQ8C0X2.
PhylomeDBiQ8C0X2.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0X2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEHDVESNK KDDGFQSSVT VEMSKDPDSF HEETVEPKPE LKEPEPKEPE
60 70 80 90 100
PKEPERKEPE RKEPERKEPE RKEPERKVPG RRETQTKETQ TTEIERKETK
110 120 130 140 150
KKRGTNSYCP PQGTINKTIT DGAALIALWT LLWALIGQEV LPGGNLFGLV
160 170 180 190 200
VIFYSAFLGG KILEFIKIPV VPPLPPLIGM LLAGFTIRNV PIIYEFVHIP
210 220 230 240 250
TTWSSALRNT ALTIILVRAG LGLDPQALKH LKGVCLRLSF GPCFLEACSA
260 270 280 290 300
ALFSHFIMNF PWQWGFLLGF VLGAVSPAVV VPNMLMLQEN GYGVEKGIPT
310 320 330 340 350
LLVAASSMDD IVAITGFNTF LSIVFSSGSV ISNILSSLRD VLIGVLVGIV
360 370 380 390 400
MGVFVQYFPS GDQERLTQRR AFLVLSMCIS AVLGCQHIGL HGSGGLVTLV
410 420 430 440 450
LSFMAAKRWA EEKVGIQKIV ANTWNVFQPL LFGLVGTEVS VESLESKTIG
460 470 480 490 500
MCLATLGLAL SVRILSTFVL MSFANFRFKE KVFIALSWIP KATVQAVLGP
510 520 530 540 550
LALETARVMA PHLEGYAKAV MTVAFLAILI TAPNGALLIG ILGPKILEQS
560
EVTFPLKVEL SNFHH
Length:565
Mass (Da):61,958
Last modified:March 1, 2003 - v1
Checksum:i7ECBC2E03DC90655
GO
Isoform 2 (identifier: Q8C0X2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-378: ERLTQRRAFLVLSMC → AASTLAYMDLEDWSH
     379-565: Missing.

Show »
Length:378
Mass (Da):41,780
Checksum:iD07602DC1F1AAF6A
GO
Isoform 3 (identifier: Q8C0X2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-565: Missing.

Show »
Length:269
Mass (Da):30,312
Checksum:iACC7AC536D5B8764
GO
Isoform 4 (identifier: Q8C0X2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-145: AALIALWTLLWALIGQEVLPGGN → MSNKKCTWGENEKYKMQMIRLTV
     146-565: Missing.

Show »
Length:145
Mass (Da):17,045
Checksum:iFDCCBA61E2B6ACE2
GO
Isoform 5 (identifier: Q8C0X2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-114: KVPGRRETQT...TNSYCPPQGT → SCTHCTMDST...SYFLQCFPWG
     115-565: Missing.

Show »
Length:114
Mass (Da):13,561
Checksum:i7DDDDD73DD7FC0E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167K → R in BAB30495 (PubMed:16141072).Curated1
Sequence conflicti167K → R in AAH25002 (PubMed:15489334).Curated1
Sequence conflicti263Q → G in BAC25498 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03018177 – 114KVPGR…PPQGT → SCTHCTMDSTLGPYRSRSSP WWKFVWTCSYFLQCFPWG in isoform 5. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_030182115 – 565Missing in isoform 5. 1 PublicationAdd BLAST451
Alternative sequenceiVSP_030183123 – 145AALIA…LPGGN → MSNKKCTWGENEKYKMQMIR LTV in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_030184146 – 565Missing in isoform 4. 1 PublicationAdd BLAST420
Alternative sequenceiVSP_030185270 – 565Missing in isoform 3. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_030186364 – 378ERLTQ…VLSMC → AASTLAYMDLEDWSH in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_030187379 – 565Missing in isoform 2. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007064 mRNA. Translation: BAB24849.1.
AK015318 mRNA. Translation: BAB29794.1.
AK016883 mRNA. Translation: BAC25498.1.
AK016917 mRNA. Translation: BAB30495.1.
AK029525 mRNA. Translation: BAC26494.1.
BC025002 mRNA. Translation: AAH25002.1.
CCDSiCCDS17855.2. [Q8C0X2-1]
RefSeqiNP_083222.2. NM_028946.3.
XP_006502267.1. XM_006502204.1.
UniGeneiMm.85000.

Genome annotation databases

GeneIDi74446.
KEGGimmu:74446.
UCSCiuc008rlf.1. mouse. [Q8C0X2-4]
uc008rlj.3. mouse. [Q8C0X2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007064 mRNA. Translation: BAB24849.1.
AK015318 mRNA. Translation: BAB29794.1.
AK016883 mRNA. Translation: BAC25498.1.
AK016917 mRNA. Translation: BAB30495.1.
AK029525 mRNA. Translation: BAC26494.1.
BC025002 mRNA. Translation: AAH25002.1.
CCDSiCCDS17855.2. [Q8C0X2-1]
RefSeqiNP_083222.2. NM_028946.3.
XP_006502267.1. XM_006502204.1.
UniGeneiMm.85000.

3D structure databases

ProteinModelPortaliQ8C0X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077644.

PTM databases

iPTMnetiQ8C0X2.
PhosphoSitePlusiQ8C0X2.

Proteomic databases

PaxDbiQ8C0X2.
PRIDEiQ8C0X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi74446.
KEGGimmu:74446.
UCSCiuc008rlf.1. mouse. [Q8C0X2-4]
uc008rlj.3. mouse. [Q8C0X2-3]

Organism-specific databases

CTDi150159.
MGIiMGI:1921696. Slc9b1.

Phylogenomic databases

eggNOGiKOG3826. Eukaryota.
COG0025. LUCA.
HOGENOMiHOG000060325.
HOVERGENiHBG108184.
InParanoidiQ8C0X2.
PhylomeDBiQ8C0X2.

Miscellaneous databases

PROiQ8C0X2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050150.
CleanExiMM_NHEDC1.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSL9B1_MOUSE
AccessioniPrimary (citable) accession number: Q8C0X2
Secondary accession number(s): Q8C1I8
, Q8R3N0, Q9CPR9, Q9D400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.