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Protein

FERM domain-containing protein 6

Gene

Frmd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actomyosin structure organization Source: GO_Central
  • apical constriction Source: MGI
  • cellular protein localization Source: MGI
  • regulation of actin filament-based process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 6
Gene namesi
Name:Frmd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442579. Frmd6.

Subcellular locationi

GO - Cellular componenti

  • apical junction complex Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: GO_Central
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194491 – 622FERM domain-containing protein 6Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei522PhosphoserineCombined sources1
Modified residuei523PhosphothreonineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei542PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C0V9.
PeptideAtlasiQ8C0V9.
PRIDEiQ8C0V9.

PTM databases

iPTMnetiQ8C0V9.
PhosphoSitePlusiQ8C0V9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048285.
CleanExiMM_FRMD6.
GenevisibleiQ8C0V9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052202.

Structurei

3D structure databases

ProteinModelPortaliQ8C0V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 328FERMPROSITE-ProRule annotationAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 133Poly-Tyr4
Compositional biasi506 – 512Poly-Ser7

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4371. Eukaryota.
ENOG410XSKD. LUCA.
GeneTreeiENSGT00830000128259.
HOGENOMiHOG000294082.
HOVERGENiHBG081539.
InParanoidiQ8C0V9.
KOiK16822.
OMAiAQQCVNI.
OrthoDBiEOG091G0443.
PhylomeDBiQ8C0V9.
TreeFamiTF319780.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0V9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKLTFHNNK AMQDRRRVCI FLPNDKSVSI IINVKILCHQ LLVQVCDLLR
60 70 80 90 100
LKDSHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI
110 120 130 140 150
DQFGPPMIIH FRVQYYVENG KLISDRIARY YYYWHLRKQV LHSQCVLREE
160 170 180 190 200
AYFLLAAFAL QADLGNFKRK LHHGDYFEPE AYFPAWVVSK RGKDYILKHI
210 220 230 240 250
PNMHKDQFAL TASEAYLKYI KEAVRLDDVA IHYYRLYKDK REAEGSLTLG
260 270 280 290 300
LTMRGIQIFQ NLEEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
310 320 330 340 350
VYYTGCPTRS RHLLQLLSNS HRLYMNLQPV LRHLRKQEEN EEKKQYRESY
360 370 380 390 400
ISDNLDLDMD PLEKRSRASG SSAGSVKHKR LSRHSTASHS SSHTSGIEAD
410 420 430 440 450
TKPRDPGPED SCSGSAMHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDS
460 470 480 490 500
QDEEIEMLVD DPRDLEPMPE ESLEVSPEMC IYITEDMLLS RKLNGHSGLI
510 520 530 540 550
VKEIGSSTSS SSETVVRLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL
560 570 580 590 600
YQKDFLRIAG LCQDTAQSYT FGCGHELDES GLYCNSCLAQ QCVNIQDAFP
610 620
VKRASKYFSL DLTHDEVPEF VV
Note: No experimental confirmation available.
Length:622
Mass (Da):71,652
Last modified:August 15, 2003 - v2
Checksum:iEDDC8490CD84305C
GO
Isoform 2 (identifier: Q8C0V9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     23-33: PNDKSVSIIIN → MCRIPRHCCLR
     91-98: Missing.

Note: No experimental confirmation available.
Show »
Length:592
Mass (Da):68,059
Checksum:i6F61019C80FC3416
GO
Isoform 3 (identifier: Q8C0V9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.
     499-571: LIVKEIGSST...CQDTAQSYTF → ELLGQAVACR...FSEASSVGLI
     572-622: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):64,224
Checksum:i1EE158B4D08B7FCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321H → Q in BAC26574 (PubMed:16141072).Curated1
Sequence conflicti431G → S in BAC35785 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0080241 – 22Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00802523 – 33PNDKSVSIIIN → MCRIPRHCCLR in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_00802691 – 98Missing in isoform 2 and isoform 3. 1 Publication8
Alternative sequenceiVSP_008027499 – 571LIVKE…QSYTF → ELLGQAVACRSPQAGTSKNR TVVGTLNPPGRRATAGGLIP GQVPSVEEMGEGTRVVSMFC SARFSEASSVGLI in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_008028572 – 622Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029709 mRNA. Translation: BAC26574.1.
AK054457 mRNA. Translation: BAC35785.1.
BC053929 mRNA. Translation: AAH53929.1.
CCDSiCCDS25959.1. [Q8C0V9-1]
RefSeqiNP_082403.2. NM_028127.3. [Q8C0V9-1]
XP_006516040.1. XM_006515977.3. [Q8C0V9-1]
UniGeneiMm.2962.

Genome annotation databases

EnsembliENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285. [Q8C0V9-1]
GeneIDi319710.
KEGGimmu:319710.
UCSCiuc007ntv.1. mouse. [Q8C0V9-1]
uc007ntw.1. mouse. [Q8C0V9-3]
uc007ntx.1. mouse. [Q8C0V9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029709 mRNA. Translation: BAC26574.1.
AK054457 mRNA. Translation: BAC35785.1.
BC053929 mRNA. Translation: AAH53929.1.
CCDSiCCDS25959.1. [Q8C0V9-1]
RefSeqiNP_082403.2. NM_028127.3. [Q8C0V9-1]
XP_006516040.1. XM_006515977.3. [Q8C0V9-1]
UniGeneiMm.2962.

3D structure databases

ProteinModelPortaliQ8C0V9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052202.

PTM databases

iPTMnetiQ8C0V9.
PhosphoSitePlusiQ8C0V9.

Proteomic databases

PaxDbiQ8C0V9.
PeptideAtlasiQ8C0V9.
PRIDEiQ8C0V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285. [Q8C0V9-1]
GeneIDi319710.
KEGGimmu:319710.
UCSCiuc007ntv.1. mouse. [Q8C0V9-1]
uc007ntw.1. mouse. [Q8C0V9-3]
uc007ntx.1. mouse. [Q8C0V9-2]

Organism-specific databases

CTDi122786.
MGIiMGI:2442579. Frmd6.

Phylogenomic databases

eggNOGiKOG4371. Eukaryota.
ENOG410XSKD. LUCA.
GeneTreeiENSGT00830000128259.
HOGENOMiHOG000294082.
HOVERGENiHBG081539.
InParanoidiQ8C0V9.
KOiK16822.
OMAiAQQCVNI.
OrthoDBiEOG091G0443.
PhylomeDBiQ8C0V9.
TreeFamiTF319780.

Miscellaneous databases

PROiQ8C0V9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048285.
CleanExiMM_FRMD6.
GenevisibleiQ8C0V9. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRMD6_MOUSE
AccessioniPrimary (citable) accession number: Q8C0V9
Secondary accession number(s): Q8BW34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.