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Protein

FERM domain-containing protein 6

Gene

Frmd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • apical constriction Source: MGI
  • cellular protein localization Source: MGI
  • regulation of actin filament-based process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 6
Gene namesi
Name:Frmd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442579. Frmd6.

Subcellular locationi

GO - Cellular componenti

  • apical junction complex Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: InterPro
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622FERM domain-containing protein 6PRO_0000219449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei522 – 5221PhosphoserineCombined sources
Modified residuei523 – 5231PhosphothreonineCombined sources
Modified residuei525 – 5251PhosphoserineCombined sources
Modified residuei542 – 5421PhosphoserineBy similarity
Modified residuei544 – 5441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0V9.
PaxDbiQ8C0V9.
PeptideAtlasiQ8C0V9.
PRIDEiQ8C0V9.

PTM databases

iPTMnetiQ8C0V9.
PhosphoSiteiQ8C0V9.

Expressioni

Gene expression databases

BgeeiQ8C0V9.
CleanExiMM_FRMD6.
GenevisibleiQ8C0V9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052202.

Structurei

3D structure databases

ProteinModelPortaliQ8C0V9.
SMRiQ8C0V9. Positions 25-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 328313FERMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1334Poly-Tyr
Compositional biasi506 – 5127Poly-Ser

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4371. Eukaryota.
ENOG410XSKD. LUCA.
GeneTreeiENSGT00840000129875.
HOGENOMiHOG000294082.
HOVERGENiHBG081539.
InParanoidiQ8C0V9.
KOiK16822.
OMAiAQQCVNI.
OrthoDBiEOG7PGDQ8.
PhylomeDBiQ8C0V9.
TreeFamiTF319780.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0V9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKLTFHNNK AMQDRRRVCI FLPNDKSVSI IINVKILCHQ LLVQVCDLLR
60 70 80 90 100
LKDSHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI
110 120 130 140 150
DQFGPPMIIH FRVQYYVENG KLISDRIARY YYYWHLRKQV LHSQCVLREE
160 170 180 190 200
AYFLLAAFAL QADLGNFKRK LHHGDYFEPE AYFPAWVVSK RGKDYILKHI
210 220 230 240 250
PNMHKDQFAL TASEAYLKYI KEAVRLDDVA IHYYRLYKDK REAEGSLTLG
260 270 280 290 300
LTMRGIQIFQ NLEEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
310 320 330 340 350
VYYTGCPTRS RHLLQLLSNS HRLYMNLQPV LRHLRKQEEN EEKKQYRESY
360 370 380 390 400
ISDNLDLDMD PLEKRSRASG SSAGSVKHKR LSRHSTASHS SSHTSGIEAD
410 420 430 440 450
TKPRDPGPED SCSGSAMHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDS
460 470 480 490 500
QDEEIEMLVD DPRDLEPMPE ESLEVSPEMC IYITEDMLLS RKLNGHSGLI
510 520 530 540 550
VKEIGSSTSS SSETVVRLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL
560 570 580 590 600
YQKDFLRIAG LCQDTAQSYT FGCGHELDES GLYCNSCLAQ QCVNIQDAFP
610 620
VKRASKYFSL DLTHDEVPEF VV
Note: No experimental confirmation available.
Length:622
Mass (Da):71,652
Last modified:August 15, 2003 - v2
Checksum:iEDDC8490CD84305C
GO
Isoform 2 (identifier: Q8C0V9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     23-33: PNDKSVSIIIN → MCRIPRHCCLR
     91-98: Missing.

Note: No experimental confirmation available.
Show »
Length:592
Mass (Da):68,059
Checksum:i6F61019C80FC3416
GO
Isoform 3 (identifier: Q8C0V9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.
     499-571: LIVKEIGSST...CQDTAQSYTF → ELLGQAVACR...FSEASSVGLI
     572-622: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):64,224
Checksum:i1EE158B4D08B7FCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti321 – 3211H → Q in BAC26574 (PubMed:16141072).Curated
Sequence conflicti431 – 4311G → S in BAC35785 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform 2. 1 PublicationVSP_008024Add
BLAST
Alternative sequencei23 – 3311PNDKSVSIIIN → MCRIPRHCCLR in isoform 2. 1 PublicationVSP_008025Add
BLAST
Alternative sequencei91 – 988Missing in isoform 2 and isoform 3. 1 PublicationVSP_008026
Alternative sequencei499 – 57173LIVKE…QSYTF → ELLGQAVACRSPQAGTSKNR TVVGTLNPPGRRATAGGLIP GQVPSVEEMGEGTRVVSMFC SARFSEASSVGLI in isoform 3. 1 PublicationVSP_008027Add
BLAST
Alternative sequencei572 – 62251Missing in isoform 3. 1 PublicationVSP_008028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029709 mRNA. Translation: BAC26574.1.
AK054457 mRNA. Translation: BAC35785.1.
BC053929 mRNA. Translation: AAH53929.1.
CCDSiCCDS25959.1. [Q8C0V9-1]
RefSeqiNP_082403.2. NM_028127.3. [Q8C0V9-1]
XP_006516040.1. XM_006515977.2. [Q8C0V9-1]
UniGeneiMm.2962.

Genome annotation databases

EnsembliENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285. [Q8C0V9-1]
GeneIDi319710.
KEGGimmu:319710.
UCSCiuc007ntv.1. mouse. [Q8C0V9-1]
uc007ntw.1. mouse. [Q8C0V9-3]
uc007ntx.1. mouse. [Q8C0V9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029709 mRNA. Translation: BAC26574.1.
AK054457 mRNA. Translation: BAC35785.1.
BC053929 mRNA. Translation: AAH53929.1.
CCDSiCCDS25959.1. [Q8C0V9-1]
RefSeqiNP_082403.2. NM_028127.3. [Q8C0V9-1]
XP_006516040.1. XM_006515977.2. [Q8C0V9-1]
UniGeneiMm.2962.

3D structure databases

ProteinModelPortaliQ8C0V9.
SMRiQ8C0V9. Positions 25-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052202.

PTM databases

iPTMnetiQ8C0V9.
PhosphoSiteiQ8C0V9.

Proteomic databases

MaxQBiQ8C0V9.
PaxDbiQ8C0V9.
PeptideAtlasiQ8C0V9.
PRIDEiQ8C0V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285. [Q8C0V9-1]
GeneIDi319710.
KEGGimmu:319710.
UCSCiuc007ntv.1. mouse. [Q8C0V9-1]
uc007ntw.1. mouse. [Q8C0V9-3]
uc007ntx.1. mouse. [Q8C0V9-2]

Organism-specific databases

CTDi122786.
MGIiMGI:2442579. Frmd6.

Phylogenomic databases

eggNOGiKOG4371. Eukaryota.
ENOG410XSKD. LUCA.
GeneTreeiENSGT00840000129875.
HOGENOMiHOG000294082.
HOVERGENiHBG081539.
InParanoidiQ8C0V9.
KOiK16822.
OMAiAQQCVNI.
OrthoDBiEOG7PGDQ8.
PhylomeDBiQ8C0V9.
TreeFamiTF319780.

Miscellaneous databases

PROiQ8C0V9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C0V9.
CleanExiMM_FRMD6.
GenevisibleiQ8C0V9. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Ovary and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 AND SER-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522; THR-523; SER-525 AND SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiFRMD6_MOUSE
AccessioniPrimary (citable) accession number: Q8C0V9
Secondary accession number(s): Q8BW34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.