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Protein

Signal-induced proliferation-associated 1-like protein 1

Gene

Sipa1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).By similarity

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • activation of GTPase activity Source: UniProtKB
  • ephrin receptor signaling pathway Source: UniProtKB
  • regulation of axonogenesis Source: UniProtKB
  • regulation of dendritic spine morphogenesis Source: UniProtKB
  • regulation of GTPase activity Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: InterPro
  • regulation of synaptic plasticity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 1
Short name:
SIPA1-like protein 1
Gene namesi
Name:Sipa1l1
Synonyms:Kiaa0440
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2443679. Sipa1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567471 – 1782Signal-induced proliferation-associated 1-like protein 1Add BLAST1782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei255PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei1078PhosphoserineBy similarity1
Modified residuei1087PhosphoserineBy similarity1
Modified residuei1116PhosphoserineBy similarity1
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1149PhosphoserineBy similarity1
Modified residuei1170PhosphoserineBy similarity1
Modified residuei1181PhosphoserineBy similarity1
Modified residuei1234PhosphoserineBy similarity1
Modified residuei1249PhosphoserineBy similarity1
Modified residuei1305Phosphoserine; by PLK2By similarity1
Modified residuei1309Phosphothreonine; by PLK2By similarity1
Modified residuei1328Phosphoserine; by CDK5By similarity1
Modified residuei1345PhosphoserineBy similarity1
Modified residuei1369PhosphoserineBy similarity1
Modified residuei1370PhosphoserineBy similarity1
Modified residuei1391PhosphoserineBy similarity1
Modified residuei1410PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1
Modified residuei1507PhosphoserineBy similarity1
Modified residuei1528PhosphoserineCombined sources1
Modified residuei1530PhosphothreonineBy similarity1
Modified residuei1533PhosphoserineBy similarity1
Modified residuei1544PhosphoserineBy similarity1
Modified residuei1547PhosphoserineCombined sources1
Modified residuei1564PhosphoserineCombined sources1
Modified residuei1567PhosphoserineBy similarity1
Modified residuei1580Asymmetric dimethylarginineCombined sources1
Modified residuei1582PhosphoserineCombined sources1
Modified residuei1624PhosphoserineCombined sources1
Modified residuei1626PhosphoserineCombined sources1
Modified residuei1629PhosphoserineCombined sources1
Modified residuei1687PhosphoserineCombined sources1
Modified residuei1690PhosphoserineCombined sources1
Modified residuei1707PhosphoserineCombined sources1
Modified residuei1708PhosphoserineCombined sources1
Modified residuei1712PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.By similarity
Phosphorylated at Ser-1328 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8C0T5.
PaxDbiQ8C0T5.
PeptideAtlasiQ8C0T5.
PRIDEiQ8C0T5.

PTM databases

iPTMnetiQ8C0T5.
PhosphoSitePlusiQ8C0T5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042700.
CleanExiMM_SIPA1L1.
GenevisibleiQ8C0T5. MM.

Interactioni

Subunit structurei

Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.By similarity1 Publication

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi229945. 2 interactors.
IntActiQ8C0T5. 1 interactor.
MINTiMINT-4134650.
STRINGi10090.ENSMUSP00000061014.

Structurei

3D structure databases

ProteinModelPortaliQ8C0T5.
SMRiQ8C0T5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini599 – 816Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini953 – 1031PDZPROSITE-ProRule annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1713 – 1773Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi93 – 129Ser-richAdd BLAST37
Compositional biasi1114 – 1447Ser-richAdd BLAST334
Compositional biasi1438 – 1447Poly-Ser10

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiQ8C0T5.
KOiK17701.
OMAiPTCHLPA.
OrthoDBiEOG091G016P.
PhylomeDBiQ8C0T5.
TreeFamiTF318626.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR030770. SIPA1L1.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF10. PTHR15711:SF10. 4 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0T5-1) [UniParc]FASTAAdd to basket
Also known as: E6TP1 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLKRSQTE RPVTADRASV VSTDGAPKVH TDDFYMRRFR SQNGSLGSSV
60 70 80 90 100
MAAVGPPRSE GPHHITSTPG VPKMGVRARI ADWPPRKENV KESSRSSQEI
110 120 130 140 150
ETSSCLESLS SKGSPVSQGS SVSLNSNDSA MLKSIQNTLK NKTGPAESMD
160 170 180 190 200
SRFLMPEAYP SSPRKALRRI RQRSNSDITI SELDVDSFDE CISPTYKSGP
210 220 230 240 250
SLHREYGSTS SIDKQGTSGD SFFDLLKGYK DDRSDRGPTP TKLSDFLITG
260 270 280 290 300
GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR
360 370 380 390 400
HNVIKRRNTT TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLGM
410 420 430 440 450
DQGDDKSNEL VMSCPYFRNE IGGEGERKIS LSKSNSGSFS GCESTSFESA
460 470 480 490 500
LSSHCTNAGV AVLEVPKESL MLHLDRVKRY TVEHVDLGAY YYRKFFYQKE
510 520 530 540 550
HWNYFGADEN LGPVAVSIRR EKPEDMKENG SPYNYRIIFR TSELMTLRGS
560 570 580 590 600
VLEDAIPSTA KHSTARGLPL KEVLEHVIPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR
660 670 680 690 700
LKGFEKYRAQ LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL
710 720 730 740 750
LRKRHIGNDI VTIVFQEPGA QPFSPKNIRS HFQHVFVIVR AHNPCTESVC
760 770 780 790 800
YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF RDFLLAKVIN AENAAHKSEK
810 820 830 840 850
FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK KKEKSKPYPG
860 870 880 890 900
AELSSMGAIV WAVRAKDYNK AMEFDCLLGI SSEFIVLIEQ ETKSVAFNCS
910 920 930 940 950
CRDVIGWTSS DTSLKIFYER GECVSVESFI SGEDIKEIVR RLQFVSKGCE
960 970 980 990 1000
SVEMTLRRNG LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV
1010 1020 1030 1040 1050
AVATLSHEQM IDLLRTSVTV KVVIIPPHDD CTPRRSCSET YRMPVMEYQM
1060 1070 1080 1090 1100
NEGISYEFKF PFRNNNKWQR NASKGAHSPQ VPSQLQSPMT SRLNAGKGDG
1110 1120 1130 1140 1150
KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA LARSQCRNSP
1160 1170 1180 1190 1200
SNLSSSSETG SGGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDISGSGKS
1210 1220 1230 1240 1250
TPSWQRSEDS LADQMEPTCH LPAVSKVLPA FRESPSGRLM RQDPVVHLSP
1260 1270 1280 1290 1300
NKQGHSDSHY SSHSSSNTLS SNASSAHSDE KWYDGDRTES DLNSYNYLQG
1310 1320 1330 1340 1350
TSADSGIDTA SYGPSHGSTA SLGASTSSPR SGPGKEKVAP LWHSSSEVLS
1360 1370 1380 1390 1400
LADRTLETEG HGMDRKAESS LSLDIHSKSQ GGSSPLSREN STFSINDAAS
1410 1420 1430 1440 1450
HTSTMSSRHS ASPVVFSSAR SSPKEELHPT ASSQLAPSFS SSSSSSSGPR
1460 1470 1480 1490 1500
TFYPRQGATS KYLIGWKKPE GTINSVGFMD TRKRHQSDGN EIAHTRLRAS
1510 1520 1530 1540 1550
TRDLQASPKP TSKSTIEEDL KKLIDLESPT PESQKNFKFH ALSSPQSPFP
1560 1570 1580 1590 1600
TTPTSRRALH RTLSDESIYS SQREHFFTSR ASLLDQALPN DVLFSSTYPS
1610 1620 1630 1640 1650
LPKSLPLRRP SYTLGMKSLH GEFSASDSSL TDIQETRRQP IPDPGLMPLP
1660 1670 1680 1690 1700
DAASDLDWSN LVDAAKAYEV QRASFFAASD ENHRPLSAAS NSDQLEEQAL
1710 1720 1730 1740 1750
VQMKSYSSKD PSPTLASKVD QLEGMLKMLR EDLKKEKEDK AQLQAEVEHL
1760 1770 1780
REDNLRLQEE SQNASDKLKK FTEWVFNTID MS
Length:1,782
Mass (Da):197,031
Last modified:July 19, 2004 - v2
Checksum:iA5BBD8CD69A481FC
GO
Isoform 2 (identifier: Q8C0T5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1736-1751: EKEDKAQLQAEVEHLR → VNALRKRRQGPAAGGS
     1752-1782: Missing.

Show »
Length:1,751
Mass (Da):193,047
Checksum:iFFFFD7A29B909C4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti855S → N in BAC26660 (PubMed:16141072).Curated1
Sequence conflicti1204W → C in BAC65566 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109181736 – 1751EKEDK…VEHLR → VNALRKRRQGPAAGGS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0109191752 – 1782Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029889 mRNA. Translation: BAC26660.1.
AK032493 mRNA. Translation: BAC27896.1.
BC058681 mRNA. Translation: AAH58681.1.
AK122284 mRNA. Translation: BAC65566.1.
CCDSiCCDS26026.1. [Q8C0T5-1]
CCDS49105.1. [Q8C0T5-2]
RefSeqiNP_001161455.1. NM_001167983.1. [Q8C0T5-2]
NP_766167.2. NM_172579.3. [Q8C0T5-1]
XP_011242371.1. XM_011244069.2. [Q8C0T5-1]
XP_017170514.1. XM_017315025.1. [Q8C0T5-1]
UniGeneiMm.261333.

Genome annotation databases

EnsembliENSMUST00000053969; ENSMUSP00000061014; ENSMUSG00000042700. [Q8C0T5-1]
ENSMUST00000166429; ENSMUSP00000131030; ENSMUSG00000042700. [Q8C0T5-2]
GeneIDi217692.
KEGGimmu:217692.
UCSCiuc007ocu.2. mouse. [Q8C0T5-1]
uc007ocw.2. mouse. [Q8C0T5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029889 mRNA. Translation: BAC26660.1.
AK032493 mRNA. Translation: BAC27896.1.
BC058681 mRNA. Translation: AAH58681.1.
AK122284 mRNA. Translation: BAC65566.1.
CCDSiCCDS26026.1. [Q8C0T5-1]
CCDS49105.1. [Q8C0T5-2]
RefSeqiNP_001161455.1. NM_001167983.1. [Q8C0T5-2]
NP_766167.2. NM_172579.3. [Q8C0T5-1]
XP_011242371.1. XM_011244069.2. [Q8C0T5-1]
XP_017170514.1. XM_017315025.1. [Q8C0T5-1]
UniGeneiMm.261333.

3D structure databases

ProteinModelPortaliQ8C0T5.
SMRiQ8C0T5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229945. 2 interactors.
IntActiQ8C0T5. 1 interactor.
MINTiMINT-4134650.
STRINGi10090.ENSMUSP00000061014.

PTM databases

iPTMnetiQ8C0T5.
PhosphoSitePlusiQ8C0T5.

Proteomic databases

EPDiQ8C0T5.
PaxDbiQ8C0T5.
PeptideAtlasiQ8C0T5.
PRIDEiQ8C0T5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053969; ENSMUSP00000061014; ENSMUSG00000042700. [Q8C0T5-1]
ENSMUST00000166429; ENSMUSP00000131030; ENSMUSG00000042700. [Q8C0T5-2]
GeneIDi217692.
KEGGimmu:217692.
UCSCiuc007ocu.2. mouse. [Q8C0T5-1]
uc007ocw.2. mouse. [Q8C0T5-2]

Organism-specific databases

CTDi26037.
MGIiMGI:2443679. Sipa1l1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiQ8C0T5.
KOiK17701.
OMAiPTCHLPA.
OrthoDBiEOG091G016P.
PhylomeDBiQ8C0T5.
TreeFamiTF318626.

Miscellaneous databases

ChiTaRSiSipa1l1. mouse.
PROiQ8C0T5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042700.
CleanExiMM_SIPA1L1.
GenevisibleiQ8C0T5. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR030770. SIPA1L1.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF10. PTHR15711:SF10. 4 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSI1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8C0T5
Secondary accession number(s): Q6PDI8, Q80U02, Q8C026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.