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Protein

DIS3-like exonuclease 1

Gene

Dis3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DIS3-like exonuclease 1 (EC:3.1.13.-)
Gene namesi
Name:Dis3l
Synonyms:Kiaa1955
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143272. Dis3l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10531053DIS3-like exonuclease 1PRO_0000314811Add
BLAST

Proteomic databases

MaxQBiQ8C0S1.
PaxDbiQ8C0S1.
PRIDEiQ8C0S1.

PTM databases

PhosphoSiteiQ8C0S1.

Expressioni

Gene expression databases

BgeeiQ8C0S1.
CleanExiMM_DIS3L.
ExpressionAtlasiQ8C0S1. baseline and differential.
GenevisibleiQ8C0S1. MM.

Interactioni

Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129772.

Structurei

3D structure databases

ProteinModelPortaliQ8C0S1.
SMRiQ8C0S1. Positions 9-905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

eggNOGiCOG0557.
GeneTreeiENSGT00530000063106.
HOGENOMiHOG000191945.
HOVERGENiHBG059397.
InParanoidiQ8C0S1.
KOiK18681.
OMAiIPRFGIK.
OrthoDBiEOG77T13R.
PhylomeDBiQ8C0S1.
TreeFamiTF105755.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQKREKVLL LRTFQGRTLR IVREHYLRPS VPCNSPLCPQ PAACRNDGKL
60 70 80 90 100
LAAEVTHYVI PDWKVVQDYL EVLEFPELKG VIFMQTACQA VQHQRGRRQY
110 120 130 140 150
NKLRNLLKDA RHDCVLFANE FQQHCYLPRE KGEAMEKWQT RSIYNSAVWY
160 170 180 190 200
YHHCEDRMPI VMVTEDEEAI QKYGSETEGV FVISFKNYLD NFWPDLKAAH
210 220 230 240 250
DLCDSILQSR RERETESQET HGKEYPEHLP LEVLEAGIKS GRYIQGILNV
260 270 280 290 300
NKHRAQIEAF VRLHGASSKD SGLVSDILIH GSKARNRSIH GDVVVVEMLP
310 320 330 340 350
KSEWKGRTAA LGENDSDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP
360 370 380 390 400
SKEEVQSQGK NAQKILVTPW DYRIPKIRIS TQQAEALQDF RVVVRIDSWE
410 420 430 440 450
ATSVYPNGHF VRVLGRIGDL EGEIATILVE NSISVVPFSE AQMCEMPVNT
460 470 480 490 500
PENPWKVSPK EEQERKDLRT THLVFSIDPK GCEDVDDTLS VRTLNNGNLE
510 520 530 540 550
LGVHIADVTH FVAPNSYIDV EARTRATTYY LADRRYDMLP SILSADLCSL
560 570 580 590 600
LGGVDRYAVS VMWELDKTSY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
610 620 630 640 650
FSIVDDIPEL KALDKQSQQA KLEELVWAIG KLTDIARHIR AKRDRCGALE
660 670 680 690 700
LEGVEVRVQL DDKKNIRDLI PKQPLEVHET VAECMILANH WVAKKIWESF
710 720 730 740 750
PHQALLRQHP PPHQEFFSEL RECAKAKGFF IDTRSNKTLA DSLDSANDPK
760 770 780 790 800
DPLVNKLLRS MATQAMSNAL YFSTGSCAEE EFHHYGLALD KYTHFTSPIR
810 820 830 840 850
RYSDIVVHRL LMAAISKDKK MEIKENLFSN KNLEELCRHI NNRNRAAQRS
860 870 880 890 900
QKQSTELFQC MYFKDRDAET EERCIADGVI YSIRTNGVLV FIPRFGIKGA
910 920 930 940 950
AYLKNKDSLV ISCGPEGSSE WKPGSLQRSQ NKIISTTAGG QSVTFHLFDH
960 970 980 990 1000
VTVRISVQAS RCHSDTIRLE IVSNKPYMIP NTELCHQSSL LKSELVKEVT
1010 1020 1030 1040 1050
RSVEEAQLAQ EVKGKVIQEE HQEYCQTKGR SLYTLLEEIR DLALLDVSDS

CAM
Length:1,053
Mass (Da):120,284
Last modified:January 15, 2008 - v2
Checksum:iA60616AB9A904722
GO
Isoform 2 (identifier: Q8C0S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:970
Mass (Da):110,655
Checksum:i8C72AC2ABE9EBC10
GO

Sequence cautioni

The sequence AAH56939.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD32588.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 2. 1 PublicationVSP_030370Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173310 mRNA. Translation: BAD32588.1. Different initiation.
AK029974 mRNA. Translation: BAC26710.1.
BC056939 mRNA. Translation: AAH56939.1. Different initiation.
CCDSiCCDS23280.1. [Q8C0S1-2]
CCDS52832.1. [Q8C0S1-1]
RefSeqiNP_001001295.2. NM_001001295.2. [Q8C0S1-1]
NP_001171255.1. NM_001177784.1. [Q8C0S1-2]
NP_766107.1. NM_172519.3. [Q8C0S1-2]
XP_006511045.1. XM_006510982.2. [Q8C0S1-2]
UniGeneiMm.268341.

Genome annotation databases

EnsembliENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396. [Q8C0S1-1]
GeneIDi213550.
KEGGimmu:213550.
UCSCiuc009qbu.2. mouse. [Q8C0S1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173310 mRNA. Translation: BAD32588.1. Different initiation.
AK029974 mRNA. Translation: BAC26710.1.
BC056939 mRNA. Translation: AAH56939.1. Different initiation.
CCDSiCCDS23280.1. [Q8C0S1-2]
CCDS52832.1. [Q8C0S1-1]
RefSeqiNP_001001295.2. NM_001001295.2. [Q8C0S1-1]
NP_001171255.1. NM_001177784.1. [Q8C0S1-2]
NP_766107.1. NM_172519.3. [Q8C0S1-2]
XP_006511045.1. XM_006510982.2. [Q8C0S1-2]
UniGeneiMm.268341.

3D structure databases

ProteinModelPortaliQ8C0S1.
SMRiQ8C0S1. Positions 9-905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129772.

PTM databases

PhosphoSiteiQ8C0S1.

Proteomic databases

MaxQBiQ8C0S1.
PaxDbiQ8C0S1.
PRIDEiQ8C0S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396. [Q8C0S1-1]
GeneIDi213550.
KEGGimmu:213550.
UCSCiuc009qbu.2. mouse. [Q8C0S1-1]

Organism-specific databases

CTDi115752.
MGIiMGI:2143272. Dis3l.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG0557.
GeneTreeiENSGT00530000063106.
HOGENOMiHOG000191945.
HOVERGENiHBG059397.
InParanoidiQ8C0S1.
KOiK18681.
OMAiIPRFGIK.
OrthoDBiEOG77T13R.
PhylomeDBiQ8C0S1.
TreeFamiTF105755.

Miscellaneous databases

NextBioi374039.
PROiQ8C0S1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C0S1.
CleanExiMM_DIS3L.
ExpressionAtlasiQ8C0S1. baseline and differential.
GenevisibleiQ8C0S1. MM.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiDI3L1_MOUSE
AccessioniPrimary (citable) accession number: Q8C0S1
Secondary accession number(s): Q69Z56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 24, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.