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Protein

DIS3-like exonuclease 1

Gene

Dis3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
DIS3-like exonuclease 1 (EC:3.1.13.-)
Gene namesi
Name:Dis3l
Synonyms:Kiaa1955
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143272 Dis3l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148111 – 1053DIS3-like exonuclease 1Add BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei989PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C0S1
PaxDbiQ8C0S1
PeptideAtlasiQ8C0S1
PRIDEiQ8C0S1

PTM databases

PhosphoSitePlusiQ8C0S1

Expressioni

Gene expression databases

BgeeiENSMUSG00000032396
CleanExiMM_DIS3L
ExpressionAtlasiQ8C0S1 baseline and differential
GenevisibleiQ8C0S1 MM

Interactioni

Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129772

Structurei

3D structure databases

ProteinModelPortaliQ8C0S1
SMRiQ8C0S1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

eggNOGiKOG2102 Eukaryota
COG0557 LUCA
GeneTreeiENSGT00530000063106
HOGENOMiHOG000191945
HOVERGENiHBG059397
InParanoidiQ8C0S1
KOiK18681
OMAiIPRFGIK
OrthoDBiEOG091G06EJ
PhylomeDBiQ8C0S1
TreeFamiTF105755

Family and domain databases

InterProiView protein in InterPro
IPR031192 DIS3L
IPR012340 NA-bd_OB-fold
IPR022966 RNase_II/R_CS
IPR033771 Rrp44_CSD1
IPR033770 RRP44_S1
PANTHERiPTHR23355:SF30 PTHR23355:SF30, 1 hit
PfamiView protein in Pfam
PF17216 Rrp44_CSD1, 1 hit
PF17215 Rrp44_S1, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQKREKVLL LRTFQGRTLR IVREHYLRPS VPCNSPLCPQ PAACRNDGKL
60 70 80 90 100
LAAEVTHYVI PDWKVVQDYL EVLEFPELKG VIFMQTACQA VQHQRGRRQY
110 120 130 140 150
NKLRNLLKDA RHDCVLFANE FQQHCYLPRE KGEAMEKWQT RSIYNSAVWY
160 170 180 190 200
YHHCEDRMPI VMVTEDEEAI QKYGSETEGV FVISFKNYLD NFWPDLKAAH
210 220 230 240 250
DLCDSILQSR RERETESQET HGKEYPEHLP LEVLEAGIKS GRYIQGILNV
260 270 280 290 300
NKHRAQIEAF VRLHGASSKD SGLVSDILIH GSKARNRSIH GDVVVVEMLP
310 320 330 340 350
KSEWKGRTAA LGENDSDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP
360 370 380 390 400
SKEEVQSQGK NAQKILVTPW DYRIPKIRIS TQQAEALQDF RVVVRIDSWE
410 420 430 440 450
ATSVYPNGHF VRVLGRIGDL EGEIATILVE NSISVVPFSE AQMCEMPVNT
460 470 480 490 500
PENPWKVSPK EEQERKDLRT THLVFSIDPK GCEDVDDTLS VRTLNNGNLE
510 520 530 540 550
LGVHIADVTH FVAPNSYIDV EARTRATTYY LADRRYDMLP SILSADLCSL
560 570 580 590 600
LGGVDRYAVS VMWELDKTSY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
610 620 630 640 650
FSIVDDIPEL KALDKQSQQA KLEELVWAIG KLTDIARHIR AKRDRCGALE
660 670 680 690 700
LEGVEVRVQL DDKKNIRDLI PKQPLEVHET VAECMILANH WVAKKIWESF
710 720 730 740 750
PHQALLRQHP PPHQEFFSEL RECAKAKGFF IDTRSNKTLA DSLDSANDPK
760 770 780 790 800
DPLVNKLLRS MATQAMSNAL YFSTGSCAEE EFHHYGLALD KYTHFTSPIR
810 820 830 840 850
RYSDIVVHRL LMAAISKDKK MEIKENLFSN KNLEELCRHI NNRNRAAQRS
860 870 880 890 900
QKQSTELFQC MYFKDRDAET EERCIADGVI YSIRTNGVLV FIPRFGIKGA
910 920 930 940 950
AYLKNKDSLV ISCGPEGSSE WKPGSLQRSQ NKIISTTAGG QSVTFHLFDH
960 970 980 990 1000
VTVRISVQAS RCHSDTIRLE IVSNKPYMIP NTELCHQSSL LKSELVKEVT
1010 1020 1030 1040 1050
RSVEEAQLAQ EVKGKVIQEE HQEYCQTKGR SLYTLLEEIR DLALLDVSDS

CAM
Length:1,053
Mass (Da):120,284
Last modified:January 15, 2008 - v2
Checksum:iA60616AB9A904722
GO
Isoform 2 (identifier: Q8C0S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:970
Mass (Da):110,655
Checksum:i8C72AC2ABE9EBC10
GO

Sequence cautioni

The sequence AAH56939 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD32588 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0303701 – 83Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173310 mRNA Translation: BAD32588.1 Different initiation.
AK029974 mRNA Translation: BAC26710.1
BC056939 mRNA Translation: AAH56939.1 Different initiation.
CCDSiCCDS23280.1 [Q8C0S1-2]
CCDS52832.1 [Q8C0S1-1]
RefSeqiNP_001001295.2, NM_001001295.2 [Q8C0S1-1]
NP_001171255.1, NM_001177784.1 [Q8C0S1-2]
NP_766107.1, NM_172519.3 [Q8C0S1-2]
XP_006511045.1, XM_006510982.3 [Q8C0S1-2]
UniGeneiMm.268341

Genome annotation databases

EnsembliENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396 [Q8C0S1-1]
GeneIDi213550
KEGGimmu:213550
UCSCiuc009qbu.2 mouse [Q8C0S1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDI3L1_MOUSE
AccessioniPrimary (citable) accession number: Q8C0S1
Secondary accession number(s): Q69Z56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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