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Q8C0S1

- DI3L1_MOUSE

UniProt

Q8C0S1 - DI3L1_MOUSE

Protein

DIS3-like exonuclease 1

Gene

Dis3l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: UniProtKB
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
    2. rRNA catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Magnesium, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DIS3-like exonuclease 1 (EC:3.1.13.-)
    Gene namesi
    Name:Dis3l
    Synonyms:Kiaa1955
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2143272. Dis3l.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasmic exosome (RNase complex) Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Exosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10531053DIS3-like exonuclease 1PRO_0000314811Add
    BLAST

    Proteomic databases

    MaxQBiQ8C0S1.
    PaxDbiQ8C0S1.
    PRIDEiQ8C0S1.

    PTM databases

    PhosphoSiteiQ8C0S1.

    Expressioni

    Gene expression databases

    BgeeiQ8C0S1.
    CleanExiMM_DIS3L.
    GenevestigatoriQ8C0S1.

    Interactioni

    Subunit structurei

    Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C0S1.
    SMRiQ8C0S1. Positions 9-905.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNR ribonuclease family.Curated

    Phylogenomic databases

    eggNOGiCOG0557.
    GeneTreeiENSGT00530000063106.
    HOGENOMiHOG000191945.
    HOVERGENiHBG059397.
    InParanoidiQ8C0S1.
    KOiK12585.
    OMAiIPRFGIK.
    OrthoDBiEOG77T13R.
    PhylomeDBiQ8C0S1.
    TreeFamiTF105755.

    Family and domain databases

    InterProiIPR012340. NA-bd_OB-fold.
    IPR022966. RNase_II/R_CS.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 4 hits.
    PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C0S1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQKREKVLL LRTFQGRTLR IVREHYLRPS VPCNSPLCPQ PAACRNDGKL     50
    LAAEVTHYVI PDWKVVQDYL EVLEFPELKG VIFMQTACQA VQHQRGRRQY 100
    NKLRNLLKDA RHDCVLFANE FQQHCYLPRE KGEAMEKWQT RSIYNSAVWY 150
    YHHCEDRMPI VMVTEDEEAI QKYGSETEGV FVISFKNYLD NFWPDLKAAH 200
    DLCDSILQSR RERETESQET HGKEYPEHLP LEVLEAGIKS GRYIQGILNV 250
    NKHRAQIEAF VRLHGASSKD SGLVSDILIH GSKARNRSIH GDVVVVEMLP 300
    KSEWKGRTAA LGENDSDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP 350
    SKEEVQSQGK NAQKILVTPW DYRIPKIRIS TQQAEALQDF RVVVRIDSWE 400
    ATSVYPNGHF VRVLGRIGDL EGEIATILVE NSISVVPFSE AQMCEMPVNT 450
    PENPWKVSPK EEQERKDLRT THLVFSIDPK GCEDVDDTLS VRTLNNGNLE 500
    LGVHIADVTH FVAPNSYIDV EARTRATTYY LADRRYDMLP SILSADLCSL 550
    LGGVDRYAVS VMWELDKTSY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN 600
    FSIVDDIPEL KALDKQSQQA KLEELVWAIG KLTDIARHIR AKRDRCGALE 650
    LEGVEVRVQL DDKKNIRDLI PKQPLEVHET VAECMILANH WVAKKIWESF 700
    PHQALLRQHP PPHQEFFSEL RECAKAKGFF IDTRSNKTLA DSLDSANDPK 750
    DPLVNKLLRS MATQAMSNAL YFSTGSCAEE EFHHYGLALD KYTHFTSPIR 800
    RYSDIVVHRL LMAAISKDKK MEIKENLFSN KNLEELCRHI NNRNRAAQRS 850
    QKQSTELFQC MYFKDRDAET EERCIADGVI YSIRTNGVLV FIPRFGIKGA 900
    AYLKNKDSLV ISCGPEGSSE WKPGSLQRSQ NKIISTTAGG QSVTFHLFDH 950
    VTVRISVQAS RCHSDTIRLE IVSNKPYMIP NTELCHQSSL LKSELVKEVT 1000
    RSVEEAQLAQ EVKGKVIQEE HQEYCQTKGR SLYTLLEEIR DLALLDVSDS 1050
    CAM 1053
    Length:1,053
    Mass (Da):120,284
    Last modified:January 15, 2008 - v2
    Checksum:iA60616AB9A904722
    GO
    Isoform 2 (identifier: Q8C0S1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: Missing.

    Show »
    Length:970
    Mass (Da):110,655
    Checksum:i8C72AC2ABE9EBC10
    GO

    Sequence cautioni

    The sequence AAH56939.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAD32588.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8383Missing in isoform 2. 1 PublicationVSP_030370Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK173310 mRNA. Translation: BAD32588.1. Different initiation.
    AK029974 mRNA. Translation: BAC26710.1.
    BC056939 mRNA. Translation: AAH56939.1. Different initiation.
    CCDSiCCDS23280.1. [Q8C0S1-2]
    CCDS52832.1. [Q8C0S1-1]
    RefSeqiNP_001001295.2. NM_001001295.2. [Q8C0S1-1]
    NP_001171255.1. NM_001177784.1. [Q8C0S1-2]
    NP_766107.1. NM_172519.3. [Q8C0S1-2]
    XP_006511045.1. XM_006510982.1. [Q8C0S1-2]
    UniGeneiMm.268341.

    Genome annotation databases

    EnsembliENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396. [Q8C0S1-2]
    ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396. [Q8C0S1-2]
    ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396. [Q8C0S1-2]
    ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396. [Q8C0S1-1]
    GeneIDi213550.
    KEGGimmu:213550.
    UCSCiuc009qbu.2. mouse. [Q8C0S1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK173310 mRNA. Translation: BAD32588.1 . Different initiation.
    AK029974 mRNA. Translation: BAC26710.1 .
    BC056939 mRNA. Translation: AAH56939.1 . Different initiation.
    CCDSi CCDS23280.1. [Q8C0S1-2 ]
    CCDS52832.1. [Q8C0S1-1 ]
    RefSeqi NP_001001295.2. NM_001001295.2. [Q8C0S1-1 ]
    NP_001171255.1. NM_001177784.1. [Q8C0S1-2 ]
    NP_766107.1. NM_172519.3. [Q8C0S1-2 ]
    XP_006511045.1. XM_006510982.1. [Q8C0S1-2 ]
    UniGenei Mm.268341.

    3D structure databases

    ProteinModelPortali Q8C0S1.
    SMRi Q8C0S1. Positions 9-905.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8C0S1.

    Proteomic databases

    MaxQBi Q8C0S1.
    PaxDbi Q8C0S1.
    PRIDEi Q8C0S1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068367 ; ENSMUSP00000063830 ; ENSMUSG00000032396 . [Q8C0S1-2 ]
    ENSMUST00000113890 ; ENSMUSP00000109522 ; ENSMUSG00000032396 . [Q8C0S1-2 ]
    ENSMUST00000120760 ; ENSMUSP00000113503 ; ENSMUSG00000032396 . [Q8C0S1-2 ]
    ENSMUST00000168844 ; ENSMUSP00000129772 ; ENSMUSG00000032396 . [Q8C0S1-1 ]
    GeneIDi 213550.
    KEGGi mmu:213550.
    UCSCi uc009qbu.2. mouse. [Q8C0S1-1 ]

    Organism-specific databases

    CTDi 115752.
    MGIi MGI:2143272. Dis3l.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0557.
    GeneTreei ENSGT00530000063106.
    HOGENOMi HOG000191945.
    HOVERGENi HBG059397.
    InParanoidi Q8C0S1.
    KOi K12585.
    OMAi IPRFGIK.
    OrthoDBi EOG77T13R.
    PhylomeDBi Q8C0S1.
    TreeFami TF105755.

    Miscellaneous databases

    NextBioi 374039.
    PROi Q8C0S1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C0S1.
    CleanExi MM_DIS3L.
    Genevestigatori Q8C0S1.

    Family and domain databases

    InterProi IPR012340. NA-bd_OB-fold.
    IPR022966. RNase_II/R_CS.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 4 hits.
    PROSITEi PS01175. RIBONUCLEASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thymus.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiDI3L1_MOUSE
    AccessioniPrimary (citable) accession number: Q8C0S1
    Secondary accession number(s): Q69Z56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3