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Q8C0S1 (DI3L1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DIS3-like exonuclease 1

EC=3.1.13.-
Gene names
Name:Dis3l
Synonyms:Kiaa1955
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1053 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the RNR ribonuclease family.

Sequence caution

The sequence AAH56939.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAD32588.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C0S1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C0S1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10531053DIS3-like exonuclease 1
PRO_0000314811

Natural variations

Alternative sequence1 – 8383Missing in isoform 2.
VSP_030370

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: A60616AB9A904722

FASTA1,053120,284
        10         20         30         40         50         60 
MLQKREKVLL LRTFQGRTLR IVREHYLRPS VPCNSPLCPQ PAACRNDGKL LAAEVTHYVI 

        70         80         90        100        110        120 
PDWKVVQDYL EVLEFPELKG VIFMQTACQA VQHQRGRRQY NKLRNLLKDA RHDCVLFANE 

       130        140        150        160        170        180 
FQQHCYLPRE KGEAMEKWQT RSIYNSAVWY YHHCEDRMPI VMVTEDEEAI QKYGSETEGV 

       190        200        210        220        230        240 
FVISFKNYLD NFWPDLKAAH DLCDSILQSR RERETESQET HGKEYPEHLP LEVLEAGIKS 

       250        260        270        280        290        300 
GRYIQGILNV NKHRAQIEAF VRLHGASSKD SGLVSDILIH GSKARNRSIH GDVVVVEMLP 

       310        320        330        340        350        360 
KSEWKGRTAA LGENDSDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP SKEEVQSQGK 

       370        380        390        400        410        420 
NAQKILVTPW DYRIPKIRIS TQQAEALQDF RVVVRIDSWE ATSVYPNGHF VRVLGRIGDL 

       430        440        450        460        470        480 
EGEIATILVE NSISVVPFSE AQMCEMPVNT PENPWKVSPK EEQERKDLRT THLVFSIDPK 

       490        500        510        520        530        540 
GCEDVDDTLS VRTLNNGNLE LGVHIADVTH FVAPNSYIDV EARTRATTYY LADRRYDMLP 

       550        560        570        580        590        600 
SILSADLCSL LGGVDRYAVS VMWELDKTSY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN 

       610        620        630        640        650        660 
FSIVDDIPEL KALDKQSQQA KLEELVWAIG KLTDIARHIR AKRDRCGALE LEGVEVRVQL 

       670        680        690        700        710        720 
DDKKNIRDLI PKQPLEVHET VAECMILANH WVAKKIWESF PHQALLRQHP PPHQEFFSEL 

       730        740        750        760        770        780 
RECAKAKGFF IDTRSNKTLA DSLDSANDPK DPLVNKLLRS MATQAMSNAL YFSTGSCAEE 

       790        800        810        820        830        840 
EFHHYGLALD KYTHFTSPIR RYSDIVVHRL LMAAISKDKK MEIKENLFSN KNLEELCRHI 

       850        860        870        880        890        900 
NNRNRAAQRS QKQSTELFQC MYFKDRDAET EERCIADGVI YSIRTNGVLV FIPRFGIKGA 

       910        920        930        940        950        960 
AYLKNKDSLV ISCGPEGSSE WKPGSLQRSQ NKIISTTAGG QSVTFHLFDH VTVRISVQAS 

       970        980        990       1000       1010       1020 
RCHSDTIRLE IVSNKPYMIP NTELCHQSSL LKSELVKEVT RSVEEAQLAQ EVKGKVIQEE 

      1030       1040       1050 
HQEYCQTKGR SLYTLLEEIR DLALLDVSDS CAM 

« Hide

Isoform 2 [UniParc].

Checksum: 8C72AC2ABE9EBC10
Show »

FASTA970110,655

References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thymus.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK173310 mRNA. Translation: BAD32588.1. Different initiation.
AK029974 mRNA. Translation: BAC26710.1.
BC056939 mRNA. Translation: AAH56939.1. Different initiation.
CCDSCCDS23280.1. [Q8C0S1-2]
CCDS52832.1. [Q8C0S1-1]
RefSeqNP_001001295.2. NM_001001295.2. [Q8C0S1-1]
NP_001171255.1. NM_001177784.1. [Q8C0S1-2]
NP_766107.1. NM_172519.3. [Q8C0S1-2]
XP_006511045.1. XM_006510982.1. [Q8C0S1-2]
UniGeneMm.268341.

3D structure databases

ProteinModelPortalQ8C0S1.
SMRQ8C0S1. Positions 9-905.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8C0S1.

Proteomic databases

MaxQBQ8C0S1.
PaxDbQ8C0S1.
PRIDEQ8C0S1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396. [Q8C0S1-2]
ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396. [Q8C0S1-1]
GeneID213550.
KEGGmmu:213550.
UCSCuc009qbu.2. mouse. [Q8C0S1-1]

Organism-specific databases

CTD115752.
MGIMGI:2143272. Dis3l.
RougeSearch...

Phylogenomic databases

eggNOGCOG0557.
GeneTreeENSGT00530000063106.
HOGENOMHOG000191945.
HOVERGENHBG059397.
InParanoidQ8C0S1.
KOK12585.
OMAIPRFGIK.
OrthoDBEOG77T13R.
PhylomeDBQ8C0S1.
TreeFamTF105755.

Gene expression databases

BgeeQ8C0S1.
CleanExMM_DIS3L.
GenevestigatorQ8C0S1.

Family and domain databases

InterProIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
[Graphical view]
SUPFAMSSF50249. SSF50249. 4 hits.
PROSITEPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374039.
PROQ8C0S1.
SOURCESearch...

Entry information

Entry nameDI3L1_MOUSE
AccessionPrimary (citable) accession number: Q8C0S1
Secondary accession number(s): Q69Z56
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot