Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8C0R0

- UBP37_MOUSE

UniProt

Q8C0R0 - UBP37_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

Usp37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei350 – 3501NucleophilePROSITE-ProRule annotation
Active sitei906 – 9061Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein K11-linked deubiquitination Source: UniProtKB
  4. protein K48-linked deubiquitination Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:Usp37Imported
Synonyms:Kiaa1594Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2442483. Usp37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Ubiquitin carboxyl-terminal hydrolase 37PRO_0000259610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei628 – 6281Phosphoserine; by CDK2By similarity
Modified residuei650 – 6501PhosphoserineBy similarity
Modified residuei652 – 6521PhosphoserineBy similarity

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination (By similarity).By similarity
Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8C0R0.
PaxDbiQ8C0R0.
PRIDEiQ8C0R0.

PTM databases

PhosphoSiteiQ8C0R0.

Expressioni

Gene expression databases

BgeeiQ8C0R0.
CleanExiMM_USP37.
GenevestigatoriQ8C0R0.

Interactioni

Subunit structurei

Interacts with FZR1/CDH1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8C0R0.
SMRiQ8C0R0. Positions 4-106, 331-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 951611USPAdd
BLAST
Repeati704 – 72320UIM 1Sequence AnalysisAdd
BLAST
Repeati806 – 82520UIM 2Sequence AnalysisAdd
BLAST
Repeati828 – 84720UIM 3Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 343KEN box 1By similarity
Motifi71 – 799D-box 1By similarity
Motifi96 – 10510D-box 2By similarity
Motifi160 – 1689D-box 3By similarity
Motifi222 – 2243KEN box 2By similarity
Motifi782 – 7843KEN box 3By similarity

Domaini

The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Sequence Analysis
Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG279142.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ8C0R0.
KOiK11850.
OrthoDBiEOG7HMS09.
PhylomeDBiQ8C0R0.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8C0R0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLKIYGPI RIRSMQTGIT KWKEGSFEIV EKDNRVSLLV HYNTGGIPRV
60 70 80 90 100
FQLSHNIKNV VLRPSGIKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD
110 120 130 140 150
AVHQNRLHAA MKASQGSGSF GTILGSRTSQ KETNRQLSYS DNQASSKRGS
160 170 180 190 200
LETKDEIPFR KVLGSPGRGP IKTVTGGGMA VTRTIPSLTL TSTPLRSGLL
210 220 230 240 250
ENRTEKRKRM LSGSELTEDY PKENDSSSNN KAMTDPSRKY LTSCREKQLS
260 270 280 290 300
LKQAEENRTS GLLPLQSSSF YGSRAGSKDY SSGVTNLDRC NVSSQTPSAK
310 320 330 340 350
RSLGFLPQPT PLSVKKLRCN QDYAGWNRPR VPLSSHQQQL QGFSNLGNTC
360 370 380 390 400
YMNAILQSLF SLQSFANDLL KQSIPWKKIP FNALIRRFAN LLIKKDICNS
410 420 430 440 450
ETKKELLKKV KNAISATAER FSGYVQNDAH EFLSQCLDQL KEDMEKLNKT
460 470 480 490 500
WKTEPVLGEE NLPDTSATKV FTCPVITNLE FEVQHSIICK ACGETIPKRE
510 520 530 540 550
QFNDLSIDLP RRKKPLPPRS IQDSLDLFFR AEELEYSCEK CGGKCALVRH
560 570 580 590 600
KFNRLPRVLI LHLKRYSFNV ALSLNNKLGQ QVIIPRFLTL ASHCTESTKP
610 620 630 640 650
PVTLGWSAPV AISRPLRACQ MMNSCITSPS APSKKFTFKS KSSVTSCLDS
660 670 680 690 700
DSEDELKRSV VLSQRLCDLP GNEQYQEDVE KDLKLCRLEP GKAELENSGF
710 720 730 740 750
DRMSEEEVLA AVLEISRREA SPVLSPEDDD KPTSSPDTGF AEDDIPEMPE
760 770 780 790 800
NPDAMEIEKS KTITEPGPAS FTEITKDCDE NKENKTPEGS QGEVDWLQQY
810 820 830 840 850
DVDREREEQE LQQALAQSLQ EQEAWEQKED DDLKRATELS LQEFNNSFLD
860 870 880 890 900
SLGSDEDSGN EDVFDMEYTE AEAEELKRNA ETGALPHSYR LISVVSHIGS
910 920 930 940 950
TSSSGHYISD VYDIKKQAWF TYNDLEVSKI QEAAVQSDRD RSGYIFFYMH
960 970
KEIFDELLET EKTSQALSME VGRAARQAS
Length:979
Mass (Da):110,063
Last modified:March 1, 2003 - v1
Checksum:iFF11DB673C1CA902
GO
Isoform 22 Publications (identifier: Q8C0R0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-634: ISRPLRACQMMNSCITSPSAPSK → M

Show »
Length:957
Mass (Da):107,733
Checksum:i1ACD5A844FBCB4D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti622 – 6221M → V in AAI39092. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei612 – 63423ISRPL…SAPSK → M in isoform 2. 2 PublicationsVSP_052196Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030013 mRNA. Translation: BAC26734.1.
AK035640 mRNA. Translation: BAC29135.1.
AK173210 mRNA. Translation: BAD32488.1.
BC139091 mRNA. Translation: AAI39092.1.
CCDSiCCDS15050.1. [Q8C0R0-1]
RefSeqiNP_795946.2. NM_176972.4.
XP_006496117.1. XM_006496054.1.
XP_006496118.1. XM_006496055.1.
XP_006496119.1. XM_006496056.1.
XP_006496121.1. XM_006496058.1. [Q8C0R0-2]
UniGeneiMm.471601.
Mm.66568.

Genome annotation databases

EnsembliENSMUST00000044260; ENSMUSP00000035445; ENSMUSG00000033364. [Q8C0R0-2]
ENSMUST00000189257; ENSMUSP00000140670; ENSMUSG00000033364.
GeneIDi319651.
KEGGimmu:319651.
UCSCiuc007bmc.2. mouse. [Q8C0R0-2]
uc007bmd.2. mouse. [Q8C0R0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030013 mRNA. Translation: BAC26734.1 .
AK035640 mRNA. Translation: BAC29135.1 .
AK173210 mRNA. Translation: BAD32488.1 .
BC139091 mRNA. Translation: AAI39092.1 .
CCDSi CCDS15050.1. [Q8C0R0-1 ]
RefSeqi NP_795946.2. NM_176972.4.
XP_006496117.1. XM_006496054.1.
XP_006496118.1. XM_006496055.1.
XP_006496119.1. XM_006496056.1.
XP_006496121.1. XM_006496058.1. [Q8C0R0-2 ]
UniGenei Mm.471601.
Mm.66568.

3D structure databases

ProteinModelPortali Q8C0R0.
SMRi Q8C0R0. Positions 4-106, 331-601.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8C0R0.

Proteomic databases

MaxQBi Q8C0R0.
PaxDbi Q8C0R0.
PRIDEi Q8C0R0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044260 ; ENSMUSP00000035445 ; ENSMUSG00000033364 . [Q8C0R0-2 ]
ENSMUST00000189257 ; ENSMUSP00000140670 ; ENSMUSG00000033364 .
GeneIDi 319651.
KEGGi mmu:319651.
UCSCi uc007bmc.2. mouse. [Q8C0R0-2 ]
uc007bmd.2. mouse. [Q8C0R0-1 ]

Organism-specific databases

CTDi 57695.
MGIi MGI:2442483. Usp37.
Rougei Search...

Phylogenomic databases

eggNOGi NOG279142.
GeneTreei ENSGT00440000033542.
HOGENOMi HOG000060197.
HOVERGENi HBG055893.
InParanoidi Q8C0R0.
KOi K11850.
OrthoDBi EOG7HMS09.
PhylomeDBi Q8C0R0.
TreeFami TF323032.

Miscellaneous databases

ChiTaRSi USP37. mouse.
NextBioi 395152.
PROi Q8C0R0.
SOURCEi Search...

Gene expression databases

Bgeei Q8C0R0.
CleanExi MM_USP37.
Genevestigatori Q8C0R0.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view ]
SMARTi SM00726. UIM. 3 hits.
[Graphical view ]
PROSITEi PS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-779 (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: TestisImported and Urinary bladderImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-979 (ISOFORM 2).
    Tissue: Pancreatic isletImported.

Entry informationi

Entry nameiUBP37_MOUSE
AccessioniPrimary (citable) accession number: Q8C0R0
Secondary accession number(s): B2RT12, Q69ZF6, Q8BZE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3