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Q8C0R0 (UBP37_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 37

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene names
Name:Usp37
Synonyms:Kiaa1594
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length979 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with FZR1/CDH1 By similarity.

Domain

The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination By similarity.

Post-translational modification

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination By similarity.

Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 3 UIM (ubiquitin-interacting motif) repeats.

Contains 1 USP domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q8C0R0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 Ref.3 (identifier: Q8C0R0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     612-634: ISRPLRACQMMNSCITSPSAPSK → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 979979Ubiquitin carboxyl-terminal hydrolase 37
PRO_0000259610

Regions

Domain341 – 951611USP
Repeat704 – 72320UIM 1
Repeat806 – 82520UIM 2
Repeat828 – 84720UIM 3
Motif32 – 343KEN box 1 By similarity
Motif71 – 799D-box 1 By similarity
Motif96 – 10510D-box 2 By similarity
Motif160 – 1689D-box 3 By similarity
Motif222 – 2243KEN box 2 By similarity
Motif782 – 7843KEN box 3 By similarity

Sites

Active site3501Nucleophile By similarity
Active site9061Proton acceptor By similarity

Amino acid modifications

Modified residue6281Phosphoserine; by CDK2 By similarity
Modified residue6501Phosphoserine By similarity
Modified residue6521Phosphoserine By similarity

Natural variations

Alternative sequence612 – 63423ISRPL…SAPSK → M in isoform 2. Ref.1 Ref.3
VSP_052196

Experimental info

Sequence conflict6221M → V in AAI39092. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: FF11DB673C1CA902

FASTA979110,063
        10         20         30         40         50         60 
MSPLKIYGPI RIRSMQTGIT KWKEGSFEIV EKDNRVSLLV HYNTGGIPRV FQLSHNIKNV 

        70         80         90        100        110        120 
VLRPSGIKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA MKASQGSGSF 

       130        140        150        160        170        180 
GTILGSRTSQ KETNRQLSYS DNQASSKRGS LETKDEIPFR KVLGSPGRGP IKTVTGGGMA 

       190        200        210        220        230        240 
VTRTIPSLTL TSTPLRSGLL ENRTEKRKRM LSGSELTEDY PKENDSSSNN KAMTDPSRKY 

       250        260        270        280        290        300 
LTSCREKQLS LKQAEENRTS GLLPLQSSSF YGSRAGSKDY SSGVTNLDRC NVSSQTPSAK 

       310        320        330        340        350        360 
RSLGFLPQPT PLSVKKLRCN QDYAGWNRPR VPLSSHQQQL QGFSNLGNTC YMNAILQSLF 

       370        380        390        400        410        420 
SLQSFANDLL KQSIPWKKIP FNALIRRFAN LLIKKDICNS ETKKELLKKV KNAISATAER 

       430        440        450        460        470        480 
FSGYVQNDAH EFLSQCLDQL KEDMEKLNKT WKTEPVLGEE NLPDTSATKV FTCPVITNLE 

       490        500        510        520        530        540 
FEVQHSIICK ACGETIPKRE QFNDLSIDLP RRKKPLPPRS IQDSLDLFFR AEELEYSCEK 

       550        560        570        580        590        600 
CGGKCALVRH KFNRLPRVLI LHLKRYSFNV ALSLNNKLGQ QVIIPRFLTL ASHCTESTKP 

       610        620        630        640        650        660 
PVTLGWSAPV AISRPLRACQ MMNSCITSPS APSKKFTFKS KSSVTSCLDS DSEDELKRSV 

       670        680        690        700        710        720 
VLSQRLCDLP GNEQYQEDVE KDLKLCRLEP GKAELENSGF DRMSEEEVLA AVLEISRREA 

       730        740        750        760        770        780 
SPVLSPEDDD KPTSSPDTGF AEDDIPEMPE NPDAMEIEKS KTITEPGPAS FTEITKDCDE 

       790        800        810        820        830        840 
NKENKTPEGS QGEVDWLQQY DVDREREEQE LQQALAQSLQ EQEAWEQKED DDLKRATELS 

       850        860        870        880        890        900 
LQEFNNSFLD SLGSDEDSGN EDVFDMEYTE AEAEELKRNA ETGALPHSYR LISVVSHIGS 

       910        920        930        940        950        960 
TSSSGHYISD VYDIKKQAWF TYNDLEVSKI QEAAVQSDRD RSGYIFFYMH KEIFDELLET 

       970 
EKTSQALSME VGRAARQAS 

« Hide

Isoform 2 [UniParc].

Checksum: 1ACD5A844FBCB4D3
Show »

FASTA957107,733

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-779 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis and Urinary bladder.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-979 (ISOFORM 2).
Tissue: Pancreatic islet.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030013 mRNA. Translation: BAC26734.1.
AK035640 mRNA. Translation: BAC29135.1.
AK173210 mRNA. Translation: BAD32488.1.
BC139091 mRNA. Translation: AAI39092.1.
RefSeqNP_795946.2. NM_176972.4.
XP_006496117.1. XM_006496054.1.
XP_006496118.1. XM_006496055.1.
XP_006496119.1. XM_006496056.1.
XP_006496121.1. XM_006496058.1.
UniGeneMm.471601.
Mm.66568.

3D structure databases

ProteinModelPortalQ8C0R0.
SMRQ8C0R0. Positions 4-106, 331-601.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.053.

PTM databases

PhosphoSiteQ8C0R0.

Proteomic databases

PaxDbQ8C0R0.
PRIDEQ8C0R0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044260; ENSMUSP00000035445; ENSMUSG00000033364.
GeneID319651.
KEGGmmu:319651.
UCSCuc007bmc.2. mouse. [Q8C0R0-2]
uc007bmd.2. mouse. [Q8C0R0-1]

Organism-specific databases

CTD57695.
MGIMGI:2442483. Usp37.
RougeSearch...

Phylogenomic databases

eggNOGNOG279142.
GeneTreeENSGT00440000033542.
HOGENOMHOG000060197.
HOVERGENHBG055893.
InParanoidB2RT12.
KOK11850.
OrthoDBEOG7HMS09.
PhylomeDBQ8C0R0.
TreeFamTF323032.

Gene expression databases

BgeeQ8C0R0.
CleanExMM_USP37.
GenevestigatorQ8C0R0.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTSM00726. UIM. 3 hits.
[Graphical view]
PROSITEPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUSP37. mouse.
NextBio395152.
PROQ8C0R0.
SOURCESearch...

Entry information

Entry nameUBP37_MOUSE
AccessionPrimary (citable) accession number: Q8C0R0
Secondary accession number(s): B2RT12, Q69ZF6, Q8BZE6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot