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Q8C0R0

- UBP37_MOUSE

UniProt

Q8C0R0 - UBP37_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene
Usp37, Kiaa1594
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei350 – 3501Nucleophile By similarity
Active sitei906 – 9061Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein K11-linked deubiquitination Source: UniProtKB
  4. protein K48-linked deubiquitination Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.053.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:Usp37
Synonyms:Kiaa1594
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2442483. Usp37.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Ubiquitin carboxyl-terminal hydrolase 37PRO_0000259610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei628 – 6281Phosphoserine; by CDK2 By similarity
Modified residuei650 – 6501Phosphoserine By similarity
Modified residuei652 – 6521Phosphoserine By similarity

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination By similarity.
Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8C0R0.
PRIDEiQ8C0R0.

PTM databases

PhosphoSiteiQ8C0R0.

Expressioni

Gene expression databases

BgeeiQ8C0R0.
CleanExiMM_USP37.
GenevestigatoriQ8C0R0.

Interactioni

Subunit structurei

Interacts with FZR1/CDH1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8C0R0.
SMRiQ8C0R0. Positions 4-106, 331-601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 951611USPAdd
BLAST
Repeati704 – 72320UIM 1Add
BLAST
Repeati806 – 82520UIM 2Add
BLAST
Repeati828 – 84720UIM 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 343KEN box 1 By similarity
Motifi71 – 799D-box 1 By similarity
Motifi96 – 10510D-box 2 By similarity
Motifi160 – 1689D-box 3 By similarity
Motifi222 – 2243KEN box 2 By similarity
Motifi782 – 7843KEN box 3 By similarity

Domaini

The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination By similarity.

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG279142.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiB2RT12.
KOiK11850.
OrthoDBiEOG7HMS09.
PhylomeDBiQ8C0R0.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8C0R0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPLKIYGPI RIRSMQTGIT KWKEGSFEIV EKDNRVSLLV HYNTGGIPRV    50
FQLSHNIKNV VLRPSGIKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD 100
AVHQNRLHAA MKASQGSGSF GTILGSRTSQ KETNRQLSYS DNQASSKRGS 150
LETKDEIPFR KVLGSPGRGP IKTVTGGGMA VTRTIPSLTL TSTPLRSGLL 200
ENRTEKRKRM LSGSELTEDY PKENDSSSNN KAMTDPSRKY LTSCREKQLS 250
LKQAEENRTS GLLPLQSSSF YGSRAGSKDY SSGVTNLDRC NVSSQTPSAK 300
RSLGFLPQPT PLSVKKLRCN QDYAGWNRPR VPLSSHQQQL QGFSNLGNTC 350
YMNAILQSLF SLQSFANDLL KQSIPWKKIP FNALIRRFAN LLIKKDICNS 400
ETKKELLKKV KNAISATAER FSGYVQNDAH EFLSQCLDQL KEDMEKLNKT 450
WKTEPVLGEE NLPDTSATKV FTCPVITNLE FEVQHSIICK ACGETIPKRE 500
QFNDLSIDLP RRKKPLPPRS IQDSLDLFFR AEELEYSCEK CGGKCALVRH 550
KFNRLPRVLI LHLKRYSFNV ALSLNNKLGQ QVIIPRFLTL ASHCTESTKP 600
PVTLGWSAPV AISRPLRACQ MMNSCITSPS APSKKFTFKS KSSVTSCLDS 650
DSEDELKRSV VLSQRLCDLP GNEQYQEDVE KDLKLCRLEP GKAELENSGF 700
DRMSEEEVLA AVLEISRREA SPVLSPEDDD KPTSSPDTGF AEDDIPEMPE 750
NPDAMEIEKS KTITEPGPAS FTEITKDCDE NKENKTPEGS QGEVDWLQQY 800
DVDREREEQE LQQALAQSLQ EQEAWEQKED DDLKRATELS LQEFNNSFLD 850
SLGSDEDSGN EDVFDMEYTE AEAEELKRNA ETGALPHSYR LISVVSHIGS 900
TSSSGHYISD VYDIKKQAWF TYNDLEVSKI QEAAVQSDRD RSGYIFFYMH 950
KEIFDELLET EKTSQALSME VGRAARQAS 979
Length:979
Mass (Da):110,063
Last modified:March 1, 2003 - v1
Checksum:iFF11DB673C1CA902
GO
Isoform 22 Publications (identifier: Q8C0R0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-634: ISRPLRACQMMNSCITSPSAPSK → M

Show »
Length:957
Mass (Da):107,733
Checksum:i1ACD5A844FBCB4D3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei612 – 63423ISRPL…SAPSK → M in isoform 2. 2 PublicationsVSP_052196Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti622 – 6221M → V in AAI39092. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030013 mRNA. Translation: BAC26734.1.
AK035640 mRNA. Translation: BAC29135.1.
AK173210 mRNA. Translation: BAD32488.1.
BC139091 mRNA. Translation: AAI39092.1.
CCDSiCCDS15050.1. [Q8C0R0-1]
RefSeqiNP_795946.2. NM_176972.4.
XP_006496117.1. XM_006496054.1.
XP_006496118.1. XM_006496055.1.
XP_006496119.1. XM_006496056.1.
XP_006496121.1. XM_006496058.1. [Q8C0R0-2]
UniGeneiMm.471601.
Mm.66568.

Genome annotation databases

EnsembliENSMUST00000044260; ENSMUSP00000035445; ENSMUSG00000033364.
GeneIDi319651.
KEGGimmu:319651.
UCSCiuc007bmc.2. mouse. [Q8C0R0-2]
uc007bmd.2. mouse. [Q8C0R0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030013 mRNA. Translation: BAC26734.1 .
AK035640 mRNA. Translation: BAC29135.1 .
AK173210 mRNA. Translation: BAD32488.1 .
BC139091 mRNA. Translation: AAI39092.1 .
CCDSi CCDS15050.1. [Q8C0R0-1 ]
RefSeqi NP_795946.2. NM_176972.4.
XP_006496117.1. XM_006496054.1.
XP_006496118.1. XM_006496055.1.
XP_006496119.1. XM_006496056.1.
XP_006496121.1. XM_006496058.1. [Q8C0R0-2 ]
UniGenei Mm.471601.
Mm.66568.

3D structure databases

ProteinModelPortali Q8C0R0.
SMRi Q8C0R0. Positions 4-106, 331-601.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.053.

PTM databases

PhosphoSitei Q8C0R0.

Proteomic databases

PaxDbi Q8C0R0.
PRIDEi Q8C0R0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044260 ; ENSMUSP00000035445 ; ENSMUSG00000033364 .
GeneIDi 319651.
KEGGi mmu:319651.
UCSCi uc007bmc.2. mouse. [Q8C0R0-2 ]
uc007bmd.2. mouse. [Q8C0R0-1 ]

Organism-specific databases

CTDi 57695.
MGIi MGI:2442483. Usp37.
Rougei Search...

Phylogenomic databases

eggNOGi NOG279142.
GeneTreei ENSGT00440000033542.
HOGENOMi HOG000060197.
HOVERGENi HBG055893.
InParanoidi B2RT12.
KOi K11850.
OrthoDBi EOG7HMS09.
PhylomeDBi Q8C0R0.
TreeFami TF323032.

Miscellaneous databases

ChiTaRSi USP37. mouse.
NextBioi 395152.
PROi Q8C0R0.
SOURCEi Search...

Gene expression databases

Bgeei Q8C0R0.
CleanExi MM_USP37.
Genevestigatori Q8C0R0.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view ]
SMARTi SM00726. UIM. 3 hits.
[Graphical view ]
PROSITEi PS50330. UIM. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-779 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis and Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-979 (ISOFORM 2).
    Tissue: Pancreatic islet.

Entry informationi

Entry nameiUBP37_MOUSE
AccessioniPrimary (citable) accession number: Q8C0R0
Secondary accession number(s): B2RT12, Q69ZF6, Q8BZE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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