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Protein

Serine/threonine-protein kinase Nek11

Gene

Nek11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

Enzyme regulationi

Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2. Activated in response to DNA damage. Inhibited by zinc (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62ATPPROSITE-ProRule annotationBy similarity1
Active sitei159Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek11 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 11
Short name:
NimA-related protein kinase 11
Gene namesi
Name:Nek11Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442276. Nek11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864401 – 628Serine/threonine-protein kinase Nek11Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274Phosphoserine; by CHEK1By similarity1

Post-translational modificationi

Phosphorylated by NEK2. Phosphorylation at Ser-274 is important for its activation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C0Q4.
PRIDEiQ8C0Q4.

PTM databases

iPTMnetiQ8C0Q4.
PhosphoSitePlusiQ8C0Q4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035032.
ExpressionAtlasiQ8C0Q4. baseline and differential.

Interactioni

Subunit structurei

Interacts with NEK2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038611.

Structurei

3D structure databases

ProteinModelPortaliQ8C0Q4.
SMRiQ8C0Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili347 – 385Sequence analysisAdd BLAST39

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000293260.
HOVERGENiHBG082016.
InParanoidiQ8C0Q4.
KOiK20880.
OMAiLYELCCM.
OrthoDBiEOG091G0FBH.
TreeFamiTF106472.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C0Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFQETAKC VGRRPTVIPM YPTALIARRY VLQQKLGSGS FGTVYLVSDK
60 70 80 90 100
KAKPGEELKV LKEISVGELN PNETVQANVE AQLLSRLHHP AIVRFHASFM
110 120 130 140 150
EQETFCIITE YCEGRDLDYR IQEYKEAGKV FAENQIVEWF IQLLLGVDYM
160 170 180 190 200
HERRILHRDL KSKNIFLKNN LLKIGDFGVS RLLMGSCELA TTLTGTPHYM
210 220 230 240 250
SPEALKHQGY DAKSDIWSLA CILYEMCCLD HAFAGSSFLS VVLNIVEGKT
260 270 280 290 300
PSLPDRYPRE LNTIMERMLN KSPSLRPSAA DILKAPYMEE QLQLLMCKYP
310 320 330 340 350
EMTLEDKNSV CQKEAAHTIN AVQKKLHLQT LQALSDTQKT TPRERMWLRK
360 370 380 390 400
LQAADERARR LKKIAEENYK ENDKRMQALR SRNVGSVHAH VLHELDERTL
410 420 430 440 450
ESLPEPQSLP CLDLDELEPS LEDTIVDLGH YEIPEDPLVA EQYYSDVFDS
460 470 480 490 500
CSEDSEEQEE EMIFSEAGGD TKEEESPSVY RTNQQDSDTA ALVGCLEHVL
510 520 530 540 550
GYTSLDTKTI TNAVTDMSPG PMVFNSAVAR TKMKRMKESA VQKLGMETFE
560 570 580 590 600
EVYDYLKRAR HQNAREAEIW EHLETVVPRA SDCFEVDQLL YFEELLLTME
610 620
GKEPSLQNLP CEAAQKKPVK GTHFCDNP
Length:628
Mass (Da):71,648
Last modified:July 27, 2011 - v2
Checksum:i2D8672AA753CEB84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196T → A in BAC31576 (PubMed:16141072).Curated1
Sequence conflicti433 – 438IPEDPL → KRKKER in BAC31576 (PubMed:16141072).Curated6
Sequence conflicti561H → R in BAC26756 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030042 mRNA. Translation: BAC26756.1.
AK043543 mRNA. Translation: BAC31576.1.
AK054237 mRNA. Translation: BAC35699.1.
AC113016 Genomic DNA. No translation available.
AC161250 Genomic DNA. No translation available.
CCDSiCCDS23464.1.
RefSeqiNP_766049.2. NM_172461.3.
XP_006511742.1. XM_006511679.3.
UniGeneiMm.347509.

Genome annotation databases

EnsembliENSMUST00000038648; ENSMUSP00000038611; ENSMUSG00000035032.
GeneIDi208583.
KEGGimmu:208583.
UCSCiuc009rhy.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiNEK11_MOUSE
AccessioniPrimary (citable) accession number: Q8C0Q4
Secondary accession number(s): E9QNC3, Q8BLS6, Q8BW62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families