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Q8C0Q2

- ZHX3_MOUSE

UniProt

Q8C0Q2 - ZHX3_MOUSE

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Protein

Zinc fingers and homeoboxes protein 3

Gene

Zhx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 10024C2H2-type 1Sequence AnalysisAdd
BLAST
Zinc fingeri109 – 13224C2H2-type 2Sequence AnalysisAdd
BLAST
DNA bindingi300 – 35960Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi489 – 54860Homeobox 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi607 – 66660Homeobox 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi759 – 81860Homeobox 4PROSITE-ProRule annotationAdd
BLAST
DNA bindingi830 – 88960Homeobox 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein heterodimerization activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  6. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. positive regulation of osteoblast differentiation Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 3
Alternative name(s):
Triple homeobox protein 1
Zinc finger and homeodomain protein 3
Gene namesi
Name:Zhx3
Synonyms:Kiaa0395, Tix1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2444772. Zhx3.

Subcellular locationi

Nucleus By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Zinc fingers and homeoboxes protein 3PRO_0000049396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031Phosphoserine1 Publication
Modified residuei941 – 9411PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0Q2.
PaxDbiQ8C0Q2.
PRIDEiQ8C0Q2.

PTM databases

PhosphoSiteiQ8C0Q2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ8C0Q2.
CleanExiMM_ZHX3.
ExpressionAtlasiQ8C0Q2. baseline and differential.
GenevestigatoriQ8C0Q2.

Interactioni

Subunit structurei

Homodimer (via homeobox domain). Also forms heterodimers with ZHX1 and ZHX2. Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.

Protein-protein interaction databases

IntActiQ8C0Q2. 1 interaction.
MINTiMINT-4140601.

Structurei

3D structure databases

ProteinModelPortaliQ8C0Q2.
SMRiQ8C0Q2. Positions 77-157, 491-552, 608-670, 765-829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 107107Required for nuclear localizationBy similarityAdd
BLAST
Regioni238 – 483246Required for homodimerization and interaction with NFYABy similarityAdd
BLAST
Regioni299 – 497199Required for repressor activityBy similarityAdd
BLAST
Regioni492 – 55059Required for nuclear localizationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the ZHX family.Sequence Analysis
Contains 2 C2H2-type zinc fingers.Sequence Analysis
Contains 5 homeobox DNA-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 10024C2H2-type 1Sequence AnalysisAdd
BLAST
Zinc fingeri109 – 13224C2H2-type 2Sequence AnalysisAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG39488.
GeneTreeiENSGT00530000063149.
HOGENOMiHOG000013231.
HOVERGENiHBG007920.
InParanoidiQ8C0Q2.
OMAiMKGKAEA.
OrthoDBiEOG76HQ0T.
PhylomeDBiQ8C0Q2.
TreeFamiTF333363.

Family and domain databases

Gene3Di1.10.10.60. 5 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 3 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 5 hits.
PROSITEiPS50071. HOMEOBOX_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKRKSTTP CMIPVKTVVL PGASTEPQPV ESLPEGPQQD LPSEAPDASS
60 70 80 90 100
EAAPNPSSTD GSALANGHRS TLDGYVYCCK ECEFRSQDVT HFIGHMNSEH
110 120 130 140 150
TDFNKDPTFV CTGCSFLAKN PEGLSLHNAK CHSGEASFLW NVTKPDNHVV
160 170 180 190 200
VEQSVPDSAS SSVLAGESTT EGTEIIITKT PIMKIMKGKA EAKKIHMLKE
210 220 230 240 250
NAPNQPGSEA LPKPLAGERE VKEGDHTFIN GAAPGSQASA KSTKPPPAAN
260 270 280 290 300
GPLIGTVPVL PAGIAQFLSL QQQPPVHAQH HTHQPLPTSK TLPKVMIPLS
310 320 330 340 350
SIPTYNAAMD SNSFLKNSFH KFPYPTKAEL CYLTVVTKYP EEQLKIWFTA
360 370 380 390 400
QRLKQGISWS PEEIEDARKK MFNTVIQSVP QPTITVLNTP LVASAGNVQH
410 420 430 440 450
LIQATLPGHA VGQPEGTAGG LLVTQPLMAN GLQASSSSLP LTTASVPKPT
460 470 480 490 500
VAPINTVCSN SASAVKVVNA AQSLLTACPS ITSQAFLDAN IYKNKKSHEQ
510 520 530 540 550
LSALKGSFCR NQFPGQSEVE HLTKVTGLST REVRKWFSDR RYHCRNLKGS
560 570 580 590 600
RAMMPGEHGS VLIDSVPEVP FPLASKVPEV TCIPTATSLV SHPATKRQSW
610 620 630 640 650
HQTPDFTPTK YKERAPEQLR VLENSFAQNP LPPEEELDRL RSETKMTRRE
660 670 680 690 700
IDGWFSERRK KVNTEETKKA DGHMPKEEEE GAEQEGRDEE LANELRVPGE
710 720 730 740 750
NGSPEMFLSH ALAERKVSPI KINLKNLRVT EASGKSEFPG MGVCEPEEDG
760 770 780 790 800
LNKLVEQPPS KVSYKKTAQQ RHLLRQLFVQ TQWPSNQDYD SIMAQTGLPR
810 820 830 840 850
PEVVRWFGDS RYALKNGQLK WYEDYKRGNF PPGLLVIAPG NRELLQDYYM
860 870 880 890 900
THKMLCEEDL QTLCDKTQMS AQQVKQWFAE KMGEETRAVA DISSEDQGPR
910 920 930 940 950
NGEPVAVHKV LGDAYSELSE NSESWEPSAP EASSEPFDTS SPQSGRQLEA

D
Length:951
Mass (Da):104,343
Last modified:February 16, 2004 - v2
Checksum:iC6625D6FB139E3DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti763 – 7631S → N in BAC26763. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099527 mRNA. Translation: BAC87711.2.
AB099703 Genomic DNA. Translation: BAC87741.2.
AK030057 mRNA. Translation: BAC26763.1.
BC058111 mRNA. Translation: AAH58111.1.
AK122271 mRNA. Translation: BAC65553.1.
CCDSiCCDS16997.1.
RefSeqiNP_796237.2. NM_177263.3.
UniGeneiMm.436734.
Mm.489808.

Genome annotation databases

EnsembliENSMUST00000103111; ENSMUSP00000099400; ENSMUSG00000035877.
ENSMUST00000103112; ENSMUSP00000099401; ENSMUSG00000035877.
ENSMUST00000109460; ENSMUSP00000105086; ENSMUSG00000035877.
GeneIDi320799.
KEGGimmu:320799.
UCSCiuc008nre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099527 mRNA. Translation: BAC87711.2 .
AB099703 Genomic DNA. Translation: BAC87741.2 .
AK030057 mRNA. Translation: BAC26763.1 .
BC058111 mRNA. Translation: AAH58111.1 .
AK122271 mRNA. Translation: BAC65553.1 .
CCDSi CCDS16997.1.
RefSeqi NP_796237.2. NM_177263.3.
UniGenei Mm.436734.
Mm.489808.

3D structure databases

ProteinModelPortali Q8C0Q2.
SMRi Q8C0Q2. Positions 77-157, 491-552, 608-670, 765-829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8C0Q2. 1 interaction.
MINTi MINT-4140601.

PTM databases

PhosphoSitei Q8C0Q2.

Proteomic databases

MaxQBi Q8C0Q2.
PaxDbi Q8C0Q2.
PRIDEi Q8C0Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103111 ; ENSMUSP00000099400 ; ENSMUSG00000035877 .
ENSMUST00000103112 ; ENSMUSP00000099401 ; ENSMUSG00000035877 .
ENSMUST00000109460 ; ENSMUSP00000105086 ; ENSMUSG00000035877 .
GeneIDi 320799.
KEGGi mmu:320799.
UCSCi uc008nre.1. mouse.

Organism-specific databases

CTDi 23051.
MGIi MGI:2444772. Zhx3.
Rougei Search...

Phylogenomic databases

eggNOGi NOG39488.
GeneTreei ENSGT00530000063149.
HOGENOMi HOG000013231.
HOVERGENi HBG007920.
InParanoidi Q8C0Q2.
OMAi MKGKAEA.
OrthoDBi EOG76HQ0T.
PhylomeDBi Q8C0Q2.
TreeFami TF333363.

Miscellaneous databases

NextBioi 397455.
PROi Q8C0Q2.
SOURCEi Search...

Gene expression databases

Bgeei Q8C0Q2.
CleanExi MM_ZHX3.
ExpressionAtlasi Q8C0Q2. baseline and differential.
Genevestigatori Q8C0Q2.

Family and domain databases

Gene3Di 1.10.10.60. 5 hits.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00046. Homeobox. 3 hits.
[Graphical view ]
SMARTi SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 5 hits.
PROSITEi PS50071. HOMEOBOX_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse zinc-fingers and homeoboxes (ZHX) family: ZHX2 forms a heterodimer with ZHX3."
    Kawata H., Yamada K., Shou Z., Mizutani T., Miyamoto K.
    Gene 323:133-140(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], HETERODIMERIZATION WITH ZHX2, TISSUE SPECIFICITY.
    Strain: 1291 Publication.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-951.
    Tissue: BrainImported.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZHX3_MOUSE
AccessioniPrimary (citable) accession number: Q8C0Q2
Secondary accession number(s): Q80U14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: February 16, 2004
Last modified: November 26, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3