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Q8C0P7

- ZN451_MOUSE

UniProt

Q8C0P7 - ZN451_MOUSE

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Protein

Zinc finger protein 451

Gene

Znf451

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19527C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27725C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33824C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51724C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 55024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62926C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65724C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68824C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri751 – 77424C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri787 – 81024C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 451
Gene namesi
Name:Znf451
Synonyms:Zfp451
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2137896. Zfp451.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10561056Zinc finger protein 451PRO_0000047599Add
BLAST

Proteomic databases

MaxQBiQ8C0P7.
PRIDEiQ8C0P7.

PTM databases

PhosphoSiteiQ8C0P7.

Expressioni

Gene expression databases

BgeeiQ8C0P7.
CleanExiMM_ZFP451.
ExpressionAtlasiQ8C0P7. baseline and differential.
GenevestigatoriQ8C0P7.

Structurei

3D structure databases

ProteinModelPortaliQ8C0P7.
SMRiQ8C0P7. Positions 158-200, 212-237, 491-557, 622-696, 741-781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19527C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27725C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33824C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51724C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 55024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62926C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65724C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68824C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri751 – 77424C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri787 – 81024C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG316281.
GeneTreeiENSGT00390000011354.
HOGENOMiHOG000155796.
HOVERGENiHBG057364.
InParanoidiQ8C0P7.
OMAiGHRYFYE.
PhylomeDBiQ8C0P7.
TreeFamiTF331947.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0P7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDPGPEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS
60 70 80 90 100
SDDEEPSTSH SDENFKCKDY IDHQKDKVAL TLARLARHVE VEKQQKEEKN
110 120 130 140 150
RAFREKIDFQ HAHGLQELEF IQGHSETEAA RQCVDQWLKM PGLRTNAANS
160 170 180 190 200
GTKRSFQRGG RMWRSEKPIL CPIMHCNKEF DNGHLLLGHL KRFDHSPCDP
210 220 230 240 250
TITLHGPLAN SFACAVCYEH FVTQQQYKDH LLSRTAAADG HSNSLLPQII
260 270 280 290 300
QCYACPQCFL LFSTKDECLK HMSTKNHFHQ SFKLSDNKGT ARPISFPSFA
310 320 330 340 350
KKRLVSLCKD VPFQVKCVAC HQTLRSHMEL TAHFRVRCQN AGPVAIAEKS
360 370 380 390 400
ITQVAKEFIV RGYCSDCNQV FMDVASTQSH KNSGHKITLA NSVEESVLLY
410 420 430 440 450
CHISEGSRPP CDLHLFSQPK ISSLKRILSV KESSAEDCIV PTKKVNLGVE
460 470 480 490 500
SLGGATRVQR QSPAVTAWFC ECRRQFPSEE AVEKHVFSAN TMCYKCVVCG
510 520 530 540 550
KVCEDSGVMR LHMSRFHGGA HLNNFLFWCR TCKKELVKKD AIMAHITEFH
560 570 580 590 600
SGHRYFYEMD EVEEEEEEAM PSSSVESHLN TDKPPSPIAV VDHCPANSPP
610 620 630 640 650
RGRWQCRICE DMFESQECVK QHCMSLTSHR FHRYSCAHCR KTFHKVETLY
660 670 680 690 700
RHCQDEHDSE IMMKYFCGLC DLIFNKEEEF LSHYKEHHSI DYVFVSEKTK
710 720 730 740 750
TSIKTEGDFK IVETSSLLSC GCHESYMCKI NRKEDYDRCL PVLLEKGRLW
760 770 780 790 800
FRCSSCSATA QNVTDINTHV CQVHRKEKSE EEQQYVIKCG ICTKAFQNTE
810 820 830 840 850
SAQQHFHRKH AALQKPTATP GGANRSSTCQ LAASASHAEK NLKQPSSQKH
860 870 880 890 900
SDVEKGAEHD VRCQNIEEEV ELPDVDYLRT MTHIVFVDFD NWSNFFGHLP
910 920 930 940 950
GHLNQGTFIW GFQGGNTNWK PPLSCKVYNY LSRIGCFFLH PRCSKRKDAA
960 970 980 990 1000
DFAICMHAGR LDEQLPKQIP FTILSGDQGF LELENQFKKT QRPAHILNPH
1010 1020 1030 1040 1050
HLEGDMMCAL LNSISDTTKE CDSDDSSGMK GSPAEELRAT EDVELEEAIR

RSLEEM
Length:1,056
Mass (Da):120,070
Last modified:March 1, 2003 - v1
Checksum:i7D8FBC0B50ECA622
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030088 mRNA. Translation: BAC26778.1.
CCDSiCCDS14865.1.
RefSeqiNP_001277628.1. NM_001290699.1.
NP_598578.1. NM_133817.3.
UniGeneiMm.289103.
Mm.440137.

Genome annotation databases

EnsembliENSMUST00000019861; ENSMUSP00000019861; ENSMUSG00000042197.
GeneIDi98403.
KEGGimmu:98403.
UCSCiuc007anz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030088 mRNA. Translation: BAC26778.1 .
CCDSi CCDS14865.1.
RefSeqi NP_001277628.1. NM_001290699.1.
NP_598578.1. NM_133817.3.
UniGenei Mm.289103.
Mm.440137.

3D structure databases

ProteinModelPortali Q8C0P7.
SMRi Q8C0P7. Positions 158-200, 212-237, 491-557, 622-696, 741-781.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8C0P7.

Proteomic databases

MaxQBi Q8C0P7.
PRIDEi Q8C0P7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019861 ; ENSMUSP00000019861 ; ENSMUSG00000042197 .
GeneIDi 98403.
KEGGi mmu:98403.
UCSCi uc007anz.1. mouse.

Organism-specific databases

CTDi 98403.
MGIi MGI:2137896. Zfp451.

Phylogenomic databases

eggNOGi NOG316281.
GeneTreei ENSGT00390000011354.
HOGENOMi HOG000155796.
HOVERGENi HBG057364.
InParanoidi Q8C0P7.
OMAi GHRYFYE.
PhylomeDBi Q8C0P7.
TreeFami TF331947.

Miscellaneous databases

NextBioi 353460.
PROi Q8C0P7.
SOURCEi Search...

Gene expression databases

Bgeei Q8C0P7.
CleanExi MM_ZFP451.
ExpressionAtlasi Q8C0P7. baseline and differential.
Genevestigatori Q8C0P7.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiZN451_MOUSE
AccessioniPrimary (citable) accession number: Q8C0P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3