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Q8C0P7

- ZN451_MOUSE

UniProt

Q8C0P7 - ZN451_MOUSE

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Protein

Zinc finger protein 451

Gene
Znf451, Zfp451
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19527C2H2-type 1Add
BLAST
Zinc fingeri212 – 23423C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri253 – 27725C2H2-type 3Add
BLAST
Zinc fingeri315 – 33824C2H2-type 4; atypicalAdd
BLAST
Zinc fingeri362 – 38524C2H2-type 5Add
BLAST
Zinc fingeri494 – 51724C2H2-type 6Add
BLAST
Zinc fingeri527 – 55024C2H2-type 7Add
BLAST
Zinc fingeri604 – 62926C2H2-type 8; atypicalAdd
BLAST
Zinc fingeri634 – 65724C2H2-type 9Add
BLAST
Zinc fingeri665 – 68824C2H2-type 10Add
BLAST
Zinc fingeri751 – 77424C2H2-type 11Add
BLAST
Zinc fingeri787 – 81024C2H2-type 12Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 451
Gene namesi
Name:Znf451
Synonyms:Zfp451
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2137896. Zfp451.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10561056Zinc finger protein 451PRO_0000047599Add
BLAST

Proteomic databases

PRIDEiQ8C0P7.

PTM databases

PhosphoSiteiQ8C0P7.

Expressioni

Gene expression databases

ArrayExpressiQ8C0P7.
BgeeiQ8C0P7.
CleanExiMM_ZFP451.
GenevestigatoriQ8C0P7.

Structurei

3D structure databases

ProteinModelPortaliQ8C0P7.
SMRiQ8C0P7. Positions 152-273, 313-339, 491-553, 622-696, 741-781.

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19527C2H2-type 1Add
BLAST
Zinc fingeri212 – 23423C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri253 – 27725C2H2-type 3Add
BLAST
Zinc fingeri315 – 33824C2H2-type 4; atypicalAdd
BLAST
Zinc fingeri362 – 38524C2H2-type 5Add
BLAST
Zinc fingeri494 – 51724C2H2-type 6Add
BLAST
Zinc fingeri527 – 55024C2H2-type 7Add
BLAST
Zinc fingeri604 – 62926C2H2-type 8; atypicalAdd
BLAST
Zinc fingeri634 – 65724C2H2-type 9Add
BLAST
Zinc fingeri665 – 68824C2H2-type 10Add
BLAST
Zinc fingeri751 – 77424C2H2-type 11Add
BLAST
Zinc fingeri787 – 81024C2H2-type 12Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG316281.
GeneTreeiENSGT00390000011354.
HOGENOMiHOG000155796.
HOVERGENiHBG057364.
InParanoidiQ8C0P7.
OMAiGHRYFYE.
PhylomeDBiQ8C0P7.
TreeFamiTF331947.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0P7-1 [UniParc]FASTAAdd to Basket

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MGDPGPEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS     50
SDDEEPSTSH SDENFKCKDY IDHQKDKVAL TLARLARHVE VEKQQKEEKN 100
RAFREKIDFQ HAHGLQELEF IQGHSETEAA RQCVDQWLKM PGLRTNAANS 150
GTKRSFQRGG RMWRSEKPIL CPIMHCNKEF DNGHLLLGHL KRFDHSPCDP 200
TITLHGPLAN SFACAVCYEH FVTQQQYKDH LLSRTAAADG HSNSLLPQII 250
QCYACPQCFL LFSTKDECLK HMSTKNHFHQ SFKLSDNKGT ARPISFPSFA 300
KKRLVSLCKD VPFQVKCVAC HQTLRSHMEL TAHFRVRCQN AGPVAIAEKS 350
ITQVAKEFIV RGYCSDCNQV FMDVASTQSH KNSGHKITLA NSVEESVLLY 400
CHISEGSRPP CDLHLFSQPK ISSLKRILSV KESSAEDCIV PTKKVNLGVE 450
SLGGATRVQR QSPAVTAWFC ECRRQFPSEE AVEKHVFSAN TMCYKCVVCG 500
KVCEDSGVMR LHMSRFHGGA HLNNFLFWCR TCKKELVKKD AIMAHITEFH 550
SGHRYFYEMD EVEEEEEEAM PSSSVESHLN TDKPPSPIAV VDHCPANSPP 600
RGRWQCRICE DMFESQECVK QHCMSLTSHR FHRYSCAHCR KTFHKVETLY 650
RHCQDEHDSE IMMKYFCGLC DLIFNKEEEF LSHYKEHHSI DYVFVSEKTK 700
TSIKTEGDFK IVETSSLLSC GCHESYMCKI NRKEDYDRCL PVLLEKGRLW 750
FRCSSCSATA QNVTDINTHV CQVHRKEKSE EEQQYVIKCG ICTKAFQNTE 800
SAQQHFHRKH AALQKPTATP GGANRSSTCQ LAASASHAEK NLKQPSSQKH 850
SDVEKGAEHD VRCQNIEEEV ELPDVDYLRT MTHIVFVDFD NWSNFFGHLP 900
GHLNQGTFIW GFQGGNTNWK PPLSCKVYNY LSRIGCFFLH PRCSKRKDAA 950
DFAICMHAGR LDEQLPKQIP FTILSGDQGF LELENQFKKT QRPAHILNPH 1000
HLEGDMMCAL LNSISDTTKE CDSDDSSGMK GSPAEELRAT EDVELEEAIR 1050
RSLEEM 1056
Length:1,056
Mass (Da):120,070
Last modified:March 1, 2003 - v1
Checksum:i7D8FBC0B50ECA622
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030088 mRNA. Translation: BAC26778.1.
CCDSiCCDS14865.1.
RefSeqiNP_001277628.1. NM_001290699.1.
NP_598578.1. NM_133817.3.
UniGeneiMm.289103.
Mm.440137.

Genome annotation databases

EnsembliENSMUST00000019861; ENSMUSP00000019861; ENSMUSG00000042197.
GeneIDi98403.
KEGGimmu:98403.
UCSCiuc007anz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030088 mRNA. Translation: BAC26778.1 .
CCDSi CCDS14865.1.
RefSeqi NP_001277628.1. NM_001290699.1.
NP_598578.1. NM_133817.3.
UniGenei Mm.289103.
Mm.440137.

3D structure databases

ProteinModelPortali Q8C0P7.
SMRi Q8C0P7. Positions 152-273, 313-339, 491-553, 622-696, 741-781.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8C0P7.

Proteomic databases

PRIDEi Q8C0P7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019861 ; ENSMUSP00000019861 ; ENSMUSG00000042197 .
GeneIDi 98403.
KEGGi mmu:98403.
UCSCi uc007anz.1. mouse.

Organism-specific databases

CTDi 98403.
MGIi MGI:2137896. Zfp451.

Phylogenomic databases

eggNOGi NOG316281.
GeneTreei ENSGT00390000011354.
HOGENOMi HOG000155796.
HOVERGENi HBG057364.
InParanoidi Q8C0P7.
OMAi GHRYFYE.
PhylomeDBi Q8C0P7.
TreeFami TF331947.

Miscellaneous databases

NextBioi 353460.
PROi Q8C0P7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8C0P7.
Bgeei Q8C0P7.
CleanExi MM_ZFP451.
Genevestigatori Q8C0P7.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiZN451_MOUSE
AccessioniPrimary (citable) accession number: Q8C0P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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