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Q8C0P7

- ZN451_MOUSE

UniProt

Q8C0P7 - ZN451_MOUSE

Protein

Zinc finger protein 451

Gene

Znf451

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri169 – 19527C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27725C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri315 – 33824C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38524C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51724C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri527 – 55024C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri604 – 62926C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri634 – 65724C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri665 – 68824C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri751 – 77424C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri787 – 81024C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 451
    Gene namesi
    Name:Znf451
    Synonyms:Zfp451
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2137896. Zfp451.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10561056Zinc finger protein 451PRO_0000047599Add
    BLAST

    Proteomic databases

    PRIDEiQ8C0P7.

    PTM databases

    PhosphoSiteiQ8C0P7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8C0P7.
    BgeeiQ8C0P7.
    CleanExiMM_ZFP451.
    GenevestigatoriQ8C0P7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C0P7.
    SMRiQ8C0P7. Positions 152-273, 313-339, 491-553, 622-696, 741-781.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri169 – 19527C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27725C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri315 – 33824C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38524C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51724C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri527 – 55024C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri604 – 62926C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri634 – 65724C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri665 – 68824C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri751 – 77424C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri787 – 81024C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG316281.
    GeneTreeiENSGT00390000011354.
    HOGENOMiHOG000155796.
    HOVERGENiHBG057364.
    InParanoidiQ8C0P7.
    OMAiGHRYFYE.
    PhylomeDBiQ8C0P7.
    TreeFamiTF331947.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C0P7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDPGPEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS     50
    SDDEEPSTSH SDENFKCKDY IDHQKDKVAL TLARLARHVE VEKQQKEEKN 100
    RAFREKIDFQ HAHGLQELEF IQGHSETEAA RQCVDQWLKM PGLRTNAANS 150
    GTKRSFQRGG RMWRSEKPIL CPIMHCNKEF DNGHLLLGHL KRFDHSPCDP 200
    TITLHGPLAN SFACAVCYEH FVTQQQYKDH LLSRTAAADG HSNSLLPQII 250
    QCYACPQCFL LFSTKDECLK HMSTKNHFHQ SFKLSDNKGT ARPISFPSFA 300
    KKRLVSLCKD VPFQVKCVAC HQTLRSHMEL TAHFRVRCQN AGPVAIAEKS 350
    ITQVAKEFIV RGYCSDCNQV FMDVASTQSH KNSGHKITLA NSVEESVLLY 400
    CHISEGSRPP CDLHLFSQPK ISSLKRILSV KESSAEDCIV PTKKVNLGVE 450
    SLGGATRVQR QSPAVTAWFC ECRRQFPSEE AVEKHVFSAN TMCYKCVVCG 500
    KVCEDSGVMR LHMSRFHGGA HLNNFLFWCR TCKKELVKKD AIMAHITEFH 550
    SGHRYFYEMD EVEEEEEEAM PSSSVESHLN TDKPPSPIAV VDHCPANSPP 600
    RGRWQCRICE DMFESQECVK QHCMSLTSHR FHRYSCAHCR KTFHKVETLY 650
    RHCQDEHDSE IMMKYFCGLC DLIFNKEEEF LSHYKEHHSI DYVFVSEKTK 700
    TSIKTEGDFK IVETSSLLSC GCHESYMCKI NRKEDYDRCL PVLLEKGRLW 750
    FRCSSCSATA QNVTDINTHV CQVHRKEKSE EEQQYVIKCG ICTKAFQNTE 800
    SAQQHFHRKH AALQKPTATP GGANRSSTCQ LAASASHAEK NLKQPSSQKH 850
    SDVEKGAEHD VRCQNIEEEV ELPDVDYLRT MTHIVFVDFD NWSNFFGHLP 900
    GHLNQGTFIW GFQGGNTNWK PPLSCKVYNY LSRIGCFFLH PRCSKRKDAA 950
    DFAICMHAGR LDEQLPKQIP FTILSGDQGF LELENQFKKT QRPAHILNPH 1000
    HLEGDMMCAL LNSISDTTKE CDSDDSSGMK GSPAEELRAT EDVELEEAIR 1050
    RSLEEM 1056
    Length:1,056
    Mass (Da):120,070
    Last modified:March 1, 2003 - v1
    Checksum:i7D8FBC0B50ECA622
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030088 mRNA. Translation: BAC26778.1.
    CCDSiCCDS14865.1.
    RefSeqiNP_001277628.1. NM_001290699.1.
    NP_598578.1. NM_133817.3.
    UniGeneiMm.289103.
    Mm.440137.

    Genome annotation databases

    EnsembliENSMUST00000019861; ENSMUSP00000019861; ENSMUSG00000042197.
    GeneIDi98403.
    KEGGimmu:98403.
    UCSCiuc007anz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030088 mRNA. Translation: BAC26778.1 .
    CCDSi CCDS14865.1.
    RefSeqi NP_001277628.1. NM_001290699.1.
    NP_598578.1. NM_133817.3.
    UniGenei Mm.289103.
    Mm.440137.

    3D structure databases

    ProteinModelPortali Q8C0P7.
    SMRi Q8C0P7. Positions 152-273, 313-339, 491-553, 622-696, 741-781.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8C0P7.

    Proteomic databases

    PRIDEi Q8C0P7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019861 ; ENSMUSP00000019861 ; ENSMUSG00000042197 .
    GeneIDi 98403.
    KEGGi mmu:98403.
    UCSCi uc007anz.1. mouse.

    Organism-specific databases

    CTDi 98403.
    MGIi MGI:2137896. Zfp451.

    Phylogenomic databases

    eggNOGi NOG316281.
    GeneTreei ENSGT00390000011354.
    HOGENOMi HOG000155796.
    HOVERGENi HBG057364.
    InParanoidi Q8C0P7.
    OMAi GHRYFYE.
    PhylomeDBi Q8C0P7.
    TreeFami TF331947.

    Miscellaneous databases

    NextBioi 353460.
    PROi Q8C0P7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C0P7.
    Bgeei Q8C0P7.
    CleanExi MM_ZFP451.
    Genevestigatori Q8C0P7.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiZN451_MOUSE
    AccessioniPrimary (citable) accession number: Q8C0P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3