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Protein

Coronin-2A

Gene

Coro2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2A
Gene namesi
Name:Coro2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1345966. Coro2a.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: GO_Central
  • brush border Source: UniProtKB
  • transcriptional repressor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509291 – 524Coronin-2AAdd BLAST524

Proteomic databases

EPDiQ8C0P5.
MaxQBiQ8C0P5.
PaxDbiQ8C0P5.
PRIDEiQ8C0P5.

PTM databases

iPTMnetiQ8C0P5.
PhosphoSitePlusiQ8C0P5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028337.
CleanExiMM_CORO2A.
ExpressionAtlasiQ8C0P5. baseline and differential.
GenevisibleiQ8C0P5. MM.

Interactioni

Subunit structurei

Binds actin. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223484. 1 interactor.
DIPiDIP-59203N.
STRINGi10090.ENSMUSP00000030021.

Structurei

3D structure databases

ProteinModelPortaliQ8C0P5.
SMRiQ8C0P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 120WD 1Add BLAST41
Repeati130 – 170WD 2Add BLAST41
Repeati178 – 217WD 3Add BLAST40
Repeati220 – 263WD 4Add BLAST44
Repeati269 – 308WD 5Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili484 – 523Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ8C0P5.
KOiK13887.
PhylomeDBiQ8C0P5.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027335. CORO2A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF2. PTHR10856:SF2. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWHPQYRSS KFRHVYGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV
60 70 80 90 100
VTECAGGGAF LVIPLHQTGK LDPHYPKVCG HRGNVLDIKW NPFNDFEIAS
110 120 130 140 150
CSEDATIKIW NIPKQLLTRN LTTYRKELIG HARRVGLVEW HPTTANILFS
160 170 180 190 200
AGYDYKVMVW NLDTKDSVIA GPVKTINCHQ DVILSMSFNT NGSLLATTCK
210 220 230 240 250
DRKIRIVDPR LGIVLQEASY KGHRANKVLF LGSLKKLLST GTSRWNNRQM
260 270 280 290 300
ALWDQENLSV PLTEEDLDGS SGVLFPFFDS DTSMLYIVGK GDGNIRYYEV
310 320 330 340 350
SMEKPHLTYL TEYRSYNPQK GIGIMPKRGL DVSSCEIFRF YKLITTKSLI
360 370 380 390 400
EPVSMIVPRR SESYQEDIYP PTAAAQPSLT AHEWLSGMNR GPIMMSLRPG
410 420 430 440 450
SELLDSQTLP PERPLSNSMV QVSPQPLEPM KQPAEDGDQA PFSLLEEKLA
460 470 480 490 500
KWTAEHHLGE KSCLTNGFDV FECSPPKTEN ELLQMFYRQQ EEIRRLRELL
510 520
IQREVQTKQL ELEIKNLRMA LGQL
Length:524
Mass (Da):59,573
Last modified:March 1, 2003 - v1
Checksum:i21F73CFB3B27A5E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → R in BAC35761 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030097 mRNA. Translation: BAC26782.1.
AK054394 mRNA. Translation: BAC35761.2.
AK152490 mRNA. Translation: BAE31261.1.
AK153134 mRNA. Translation: BAE31746.1.
CCDSiCCDS18154.1.
RefSeqiNP_001158276.1. NM_001164804.1.
NP_849224.2. NM_178893.4.
UniGeneiMm.416311.
Mm.485361.

Genome annotation databases

EnsembliENSMUST00000030021; ENSMUSP00000030021; ENSMUSG00000028337.
ENSMUST00000107756; ENSMUSP00000103385; ENSMUSG00000028337.
GeneIDi107684.
KEGGimmu:107684.
UCSCiuc008sua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030097 mRNA. Translation: BAC26782.1.
AK054394 mRNA. Translation: BAC35761.2.
AK152490 mRNA. Translation: BAE31261.1.
AK153134 mRNA. Translation: BAE31746.1.
CCDSiCCDS18154.1.
RefSeqiNP_001158276.1. NM_001164804.1.
NP_849224.2. NM_178893.4.
UniGeneiMm.416311.
Mm.485361.

3D structure databases

ProteinModelPortaliQ8C0P5.
SMRiQ8C0P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223484. 1 interactor.
DIPiDIP-59203N.
STRINGi10090.ENSMUSP00000030021.

PTM databases

iPTMnetiQ8C0P5.
PhosphoSitePlusiQ8C0P5.

Proteomic databases

EPDiQ8C0P5.
MaxQBiQ8C0P5.
PaxDbiQ8C0P5.
PRIDEiQ8C0P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030021; ENSMUSP00000030021; ENSMUSG00000028337.
ENSMUST00000107756; ENSMUSP00000103385; ENSMUSG00000028337.
GeneIDi107684.
KEGGimmu:107684.
UCSCiuc008sua.2. mouse.

Organism-specific databases

CTDi7464.
MGIiMGI:1345966. Coro2a.

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ8C0P5.
KOiK13887.
PhylomeDBiQ8C0P5.
TreeFamiTF314280.

Miscellaneous databases

ChiTaRSiCoro2a. mouse.
PROiQ8C0P5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028337.
CleanExiMM_CORO2A.
ExpressionAtlasiQ8C0P5. baseline and differential.
GenevisibleiQ8C0P5. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027335. CORO2A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF2. PTHR10856:SF2. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOR2A_MOUSE
AccessioniPrimary (citable) accession number: Q8C0P5
Secondary accession number(s): Q3U6H8, Q8BW42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.