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Protein

Kinesin-like protein KIF2B

Gene

Kif2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi303 – 3108ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-68877. Mitotic Prometaphase.
R-MMU-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2B
Gene namesi
Name:Kif2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920720. Kif2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Kinesin-like protein KIF2BPRO_0000253717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei125 – 1251Phosphothreonine; by PLK1By similarity
Modified residuei204 – 2041Phosphoserine; by PLK1By similarity

Post-translational modificationi

Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C0N1.
MaxQBiQ8C0N1.
PaxDbiQ8C0N1.
PRIDEiQ8C0N1.

PTM databases

iPTMnetiQ8C0N1.
PhosphoSiteiQ8C0N1.

Expressioni

Gene expression databases

BgeeiQ8C0N1.
CleanExiMM_KIF2B.
ExpressionAtlasiQ8C0N1. baseline.
GenevisibleiQ8C0N1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058084.

Structurei

3D structure databases

ProteinModelPortaliQ8C0N1.
SMRiQ8C0N1. Positions 154-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini213 – 543331Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili149 – 17729Sequence analysisAdd
BLAST
Coiled coili646 – 66722Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0246. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00830000128292.
HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ8C0N1.
KOiK10393.
OMAiQTFCFDH.
OrthoDBiEOG7K9K2C.
PhylomeDBiQ8C0N1.
TreeFamiTF105222.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQFCLPLA PRLSPLKPLK SHFTDFQVGI CVAIQRSDKR IHLAVVTEIN
60 70 80 90 100
RENSWVTVEW VEKGVKKGKK IELETVLLLN PALASLEHQR SRRPLRPVSV
110 120 130 140 150
VPSTAIGDQR TATKWIAMIP HRNETPSGDS QTLMIPSNPC LMKRKKSPCL
160 170 180 190 200
REIEKLQKQR EKRRRLQLEI RARRALDINT GNPNFETMRM IEEYRRRLDS
210 220 230 240 250
SKMSSLEPPE DHRICVCVRK RPLNQRETTM KDLDIITIPS HNVVMVHESK
260 270 280 290 300
QKVDLTRYLE NQTFCFDHAF DDKASNELVY QFTARPLVES IFRKGMATCF
310 320 330 340 350
AYGQTGSGKT HTMGGAFLGK AQDCSKGIYA LVAQDVFLLL KTPAYEKLEL
360 370 380 390 400
KVYGTFFEIY GGKVYDLLNW KKKLQVLEDG NQQVQVVGLQ EQEVSCVEEV
410 420 430 440 450
LNLVELGNSC RTSGQTSVNA HSSRSHAVFQ LILKAGGKLH GKFSLVDLAG
460 470 480 490 500
NERGADTAKA TRKRQLEGAE INKSLLALKE CIRALGKNKS HTPFRASKLT
510 520 530 540 550
QVLRDSFIGQ NSYTCMIATI SPGMTSCENT LNTLRYANRV KELALEARPY
560 570 580 590 600
HHCVSPPGHE VPLMIENDNT NSGKSLQRDE VIQIPTVEKE EEKESDELTS
610 620 630 640 650
KKEPAASWSR SNQWWEAIQE TAEGVNGDVD FCIAQSLSVL EQKIGVLTDI
660
QKKLQSLRED LQKKSQVE
Length:668
Mass (Da):75,469
Last modified:March 1, 2003 - v1
Checksum:i30743B57668E94D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030188 mRNA. Translation: BAC26831.1.
AL662779 Genomic DNA. Translation: CAI24277.1.
BC100484 mRNA. Translation: AAI00485.1.
CCDSiCCDS36281.1.
RefSeqiNP_082823.1. NM_028547.2.
UniGeneiMm.67677.

Genome annotation databases

EnsembliENSMUST00000061019; ENSMUSP00000058084; ENSMUSG00000046755.
GeneIDi73470.
KEGGimmu:73470.
UCSCiuc007kxf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030188 mRNA. Translation: BAC26831.1.
AL662779 Genomic DNA. Translation: CAI24277.1.
BC100484 mRNA. Translation: AAI00485.1.
CCDSiCCDS36281.1.
RefSeqiNP_082823.1. NM_028547.2.
UniGeneiMm.67677.

3D structure databases

ProteinModelPortaliQ8C0N1.
SMRiQ8C0N1. Positions 154-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058084.

PTM databases

iPTMnetiQ8C0N1.
PhosphoSiteiQ8C0N1.

Proteomic databases

EPDiQ8C0N1.
MaxQBiQ8C0N1.
PaxDbiQ8C0N1.
PRIDEiQ8C0N1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061019; ENSMUSP00000058084; ENSMUSG00000046755.
GeneIDi73470.
KEGGimmu:73470.
UCSCiuc007kxf.1. mouse.

Organism-specific databases

CTDi84643.
MGIiMGI:1920720. Kif2b.

Phylogenomic databases

eggNOGiKOG0246. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00830000128292.
HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ8C0N1.
KOiK10393.
OMAiQTFCFDH.
OrthoDBiEOG7K9K2C.
PhylomeDBiQ8C0N1.
TreeFamiTF105222.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-68877. Mitotic Prometaphase.
R-MMU-983189. Kinesins.

Miscellaneous databases

PROiQ8C0N1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C0N1.
CleanExiMM_KIF2B.
ExpressionAtlasiQ8C0N1. baseline.
GenevisibleiQ8C0N1. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-39, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiKIF2B_MOUSE
AccessioniPrimary (citable) accession number: Q8C0N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.