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Protein

Dynein intermediate chain 1, axonemal

Gene

Dnai1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the dynein complex of respiratory cilia.By similarity

GO - Molecular functioni

GO - Biological processi

  • cilium movement Source: MGI
  • determination of left/right symmetry Source: MGI
  • epithelial cilium movement Source: MGI
  • heart development Source: MGI
  • outer dynein arm assembly Source: MGI
  • sperm motility Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein intermediate chain 1, axonemal
Alternative name(s):
Axonemal dynein intermediate chain 1
Gene namesi
Name:Dnai1
Synonyms:Dnaic1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916172. Dnaic1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 701701Dynein intermediate chain 1, axonemalPRO_0000254655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei127 – 1271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0M8.
PaxDbiQ8C0M8.
PRIDEiQ8C0M8.

PTM databases

iPTMnetiQ8C0M8.
PhosphoSiteiQ8C0M8.

Expressioni

Gene expression databases

BgeeiQ8C0M8.
CleanExiMM_DNAIC1.
ExpressionAtlasiQ8C0M8. baseline and differential.
GenevisibleiQ8C0M8. MM.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100028.

Structurei

3D structure databases

ProteinModelPortaliQ8C0M8.
SMRiQ8C0M8. Positions 341-647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati382 – 42241WD 1Add
BLAST
Repeati431 – 47444WD 2Add
BLAST
Repeati539 – 57941WD 3Add
BLAST
Repeati581 – 62141WD 4Add
BLAST
Repeati629 – 66840WD 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi134 – 17744Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IU35. Eukaryota.
ENOG410YQQE. LUCA.
GeneTreeiENSGT00730000110228.
HOGENOMiHOG000231705.
HOVERGENiHBG005545.
InParanoidiQ8C0M8.
KOiK10409.
OMAiVSWNPYH.
OrthoDBiEOG751NDV.
TreeFamiTF300553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKQIRKQS ISVTRGARRR DEDSGTDVGE GTDEWSQSKA TVRPPDQLEL
60 70 80 90 100
TDAELKEEFT RILTANNPHA PQNIVRYSFK EGTYKLIGFV NQMAVHFSQV
110 120 130 140 150
GNLIPKDSDE GRRQHYRDEM VAGSQESIKV VTSEAENLEE EEEPKEGEGE
160 170 180 190 200
AEAEAEAGSQ TDIPAAAETT EKVIEEELMA PVQPKERKLT NQFNFSERAS
210 220 230 240 250
QTFNNPLRDR ECQMEPPPRT NFSATANQWE IYDAYVDELE KQEKTKEKEK
260 270 280 290 300
AKTPVAKKTE KMAMRKLTSM ESQSDDITKV TQAAKIVERM VNQNTYDDVA
310 320 330 340 350
QDFKYYEDTA DEYRDQEGTL LPLWKFQNDK AKRLAVTALC WNPKYKDLFA
360 370 380 390 400
VGHGSYDFMK QSRGMLLLYS MKNPSFPEYM FSSESGIMCL DVHVDHPYLV
410 420 430 440 450
VVGYYDGNVA IYNLKKPHSQ PCFRSTSKSG KHTDPVWQVK WQKDDMDHNL
460 470 480 490 500
NFFSVSSDGR IVSWTLVKSE LVHIDIIKLK TEGSTTEIPE GLQLHTVGCG
510 520 530 540 550
TAFDFHKEID YMFLVGTEEG KIYKCSKSYS SQFLDTYDAH NMAVDAVLWN
560 570 580 590 600
PYHTKVFMSC SSDWTVKIWD HTIKTPMFIY DLNSAVGDVA WAPYSSTVFA
610 620 630 640 650
AVTTDGKAHV FDLAVNKYEA ICNQPVVAKK KNKITHVQFN PIHPIIIVGD
660 670 680 690 700
DRGHIICLKL SPNLRKMPKE KKGQEVQKGP AVEIAKLDKL LNLVREVKTK

T
Length:701
Mass (Da):79,758
Last modified:March 1, 2003 - v1
Checksum:i4FC542B80B37931E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti636 – 6361H → R in BAC33160 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030213 mRNA. Translation: BAC26847.1.
AK047808 mRNA. Translation: BAC33160.1.
CCDSiCCDS18066.1.
RefSeqiNP_780347.2. NM_175138.4.
UniGeneiMm.79127.

Genome annotation databases

EnsembliENSMUST00000102963; ENSMUSP00000100028; ENSMUSG00000061322.
GeneIDi68922.
KEGGimmu:68922.
UCSCiuc008sjc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030213 mRNA. Translation: BAC26847.1.
AK047808 mRNA. Translation: BAC33160.1.
CCDSiCCDS18066.1.
RefSeqiNP_780347.2. NM_175138.4.
UniGeneiMm.79127.

3D structure databases

ProteinModelPortaliQ8C0M8.
SMRiQ8C0M8. Positions 341-647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100028.

PTM databases

iPTMnetiQ8C0M8.
PhosphoSiteiQ8C0M8.

Proteomic databases

MaxQBiQ8C0M8.
PaxDbiQ8C0M8.
PRIDEiQ8C0M8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102963; ENSMUSP00000100028; ENSMUSG00000061322.
GeneIDi68922.
KEGGimmu:68922.
UCSCiuc008sjc.2. mouse.

Organism-specific databases

CTDi68922.
MGIiMGI:1916172. Dnaic1.

Phylogenomic databases

eggNOGiENOG410IU35. Eukaryota.
ENOG410YQQE. LUCA.
GeneTreeiENSGT00730000110228.
HOGENOMiHOG000231705.
HOVERGENiHBG005545.
InParanoidiQ8C0M8.
KOiK10409.
OMAiVSWNPYH.
OrthoDBiEOG751NDV.
TreeFamiTF300553.

Miscellaneous databases

NextBioi328193.
PROiQ8C0M8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C0M8.
CleanExiMM_DNAIC1.
ExpressionAtlasiQ8C0M8. baseline and differential.
GenevisibleiQ8C0M8. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpus striatum and Testis.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiDNAI1_MOUSE
AccessioniPrimary (citable) accession number: Q8C0M8
Secondary accession number(s): Q8BKY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.