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Q8C0L8

- COG5_MOUSE

UniProt

Q8C0L8 - COG5_MOUSE

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Protein

Conserved oligomeric Golgi complex subunit 5

Gene

Cog5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

  1. intra-Golgi vesicle-mediated transport Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 5
Short name:
COG complex subunit 5
Alternative name(s):
Component of oligomeric Golgi complex 5
Gene namesi
Name:Cog5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2145130. Cog5.

Subcellular locationi

Cytoplasmcytosol By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. Golgi transport complex Source: InterPro
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Conserved oligomeric Golgi complex subunit 5PRO_0000320146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0L8.
PaxDbiQ8C0L8.
PRIDEiQ8C0L8.

PTM databases

PhosphoSiteiQ8C0L8.

Expressioni

Gene expression databases

BgeeiQ8C0L8.
GenevestigatoriQ8C0L8.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044797.

Family & Domainsi

Sequence similaritiesi

Belongs to the COG5 family.Curated

Phylogenomic databases

eggNOGiNOG298306.
GeneTreeiENSGT00390000004586.
HOGENOMiHOG000170357.
HOVERGENiHBG051063.
InParanoidiQ8C0L8.
OMAiALQVFYN.
OrthoDBiEOG7P5T08.
TreeFamiTF313139.

Family and domain databases

InterProiIPR019465. Cog5.
[Graphical view]
PANTHERiPTHR13228. PTHR13228. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C0L8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGGDSTISV AGRGASGSAV VAATVQAILQ DDCYSEFLNE DFDVKTYTSQ
60 70 80 90 100
SIHQAVIAEQ LAKLAQGISQ LDKELHLQVV ARHEDLLAQA TGIESLEGVL
110 120 130 140 150
QMMQTRIGAL QGAVDRMKSK IVEPYNKIVA RTAQLARLQV ACDLLRRIIR
160 170 180 190 200
ILYLSKRLQG QLQGGSREIT KAAQSLNELD YLSQGIDLSG IEVIENDLLF
210 220 230 240 250
IARARLEVEN QAKRLLEQGV ETQNPTQVGT ALQVFHNLGT LKETVTSVVD
260 270 280 290 300
GYCAALEDSI NNALDVKVLT QPSQSAVRGG PGRAAMPTPG STAGFRASLW
310 320 330 340 350
TNMEKLMDHI CAACGQVQHL QKVLTKKRDP VSHICFIEEI IKDGQPEILY
360 370 380 390 400
MFWNAVTLAL SSHFHSATNS SMFLKQAFEG EYPKLLRLYN DLWKRLQQSS
410 420 430 440 450
QNTQGTFSPS GTPDLCVDLP HMEDDTQDMF RLKRPDYDPE KALKDSLQPY
460 470 480 490 500
EAAYLSKSLS RLFDPINLVF PPGGRNPPSS DELDGITKTI TSELNVAAVD
510 520 530 540 550
ANLTLAVSKN VAKTIQLYAV KSEQLLSTQG DASQVIGPLT EGQKRNVGVV
560 570 580 590 600
NSLFKLHQSV TKVVASQSSF SATAEQTIMS ALKTIHDLMG NAIQPLLTSV
610 620 630 640 650
ADAIEAIIIT MHQEDFSGAS SSSGKPDVPC SLYMKELQGF IARVMNDYFK
660 670 680 690 700
HFECLDFVFD NTEAIAQRAI ELFIRNASLI RPLGEGGKLR LAADFAQMEL
710 720 730 740 750
AVGPLCRRVS DLGKSYRMLR SFRPLLFQTS EHVADSPAVG DIIPFSIIIQ
760 770 780 790 800
FLFTRAPAEL KSPFQRAEWS HARFSQWLDD HPSEKDRLLL LRGALEAYVQ
810 820
SVRSRDGKEF APVYPIMVQL LQKAMSALQ
Length:829
Mass (Da):91,391
Last modified:July 27, 2011 - v3
Checksum:iE4041125F09250DD
GO

Sequence cautioni

The sequence BAC27065.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901G → R in BAC27065. (PubMed:16141072)Curated
Sequence conflicti430 – 4301F → Y in BAC27065. (PubMed:16141072)Curated
Sequence conflicti655 – 6551L → M in BAC27065. (PubMed:16141072)Curated
Sequence conflicti826 – 8261S → Y in BAC27065. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030656 mRNA. Translation: BAC27065.1. Different initiation.
AC119950 Genomic DNA. No translation available.
AC125020 Genomic DNA. No translation available.
CT010463 Genomic DNA. No translation available.
CCDSiCCDS49046.1.
RefSeqiNP_001156598.1. NM_001163126.1.
UniGeneiMm.173068.

Genome annotation databases

EnsembliENSMUST00000036862; ENSMUSP00000044797; ENSMUSG00000035933.
GeneIDi238123.
KEGGimmu:238123.
UCSCiuc007nhs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030656 mRNA. Translation: BAC27065.1 . Different initiation.
AC119950 Genomic DNA. No translation available.
AC125020 Genomic DNA. No translation available.
CT010463 Genomic DNA. No translation available.
CCDSi CCDS49046.1.
RefSeqi NP_001156598.1. NM_001163126.1.
UniGenei Mm.173068.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044797.

PTM databases

PhosphoSitei Q8C0L8.

Proteomic databases

MaxQBi Q8C0L8.
PaxDbi Q8C0L8.
PRIDEi Q8C0L8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036862 ; ENSMUSP00000044797 ; ENSMUSG00000035933 .
GeneIDi 238123.
KEGGi mmu:238123.
UCSCi uc007nhs.1. mouse.

Organism-specific databases

CTDi 10466.
MGIi MGI:2145130. Cog5.

Phylogenomic databases

eggNOGi NOG298306.
GeneTreei ENSGT00390000004586.
HOGENOMi HOG000170357.
HOVERGENi HBG051063.
InParanoidi Q8C0L8.
OMAi ALQVFYN.
OrthoDBi EOG7P5T08.
TreeFami TF313139.

Miscellaneous databases

ChiTaRSi COG5. mouse.
NextBioi 383670.
PROi Q8C0L8.
SOURCEi Search...

Gene expression databases

Bgeei Q8C0L8.
Genevestigatori Q8C0L8.

Family and domain databases

InterProi IPR019465. Cog5.
[Graphical view ]
PANTHERi PTHR13228. PTHR13228. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCOG5_MOUSE
AccessioniPrimary (citable) accession number: Q8C0L8
Secondary accession number(s): E9QM30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3