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Q8C0L8

- COG5_MOUSE

UniProt

Q8C0L8 - COG5_MOUSE

Protein

Conserved oligomeric Golgi complex subunit 5

Gene

Cog5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Required for normal Golgi function.By similarity

    GO - Biological processi

    1. intra-Golgi vesicle-mediated transport Source: InterPro
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Conserved oligomeric Golgi complex subunit 5
    Short name:
    COG complex subunit 5
    Alternative name(s):
    Component of oligomeric Golgi complex 5
    Gene namesi
    Name:Cog5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2145130. Cog5.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. Golgi transport complex Source: InterPro
    4. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 829829Conserved oligomeric Golgi complex subunit 5PRO_0000320146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei166 – 1661PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8C0L8.
    PaxDbiQ8C0L8.
    PRIDEiQ8C0L8.

    PTM databases

    PhosphoSiteiQ8C0L8.

    Expressioni

    Gene expression databases

    BgeeiQ8C0L8.
    GenevestigatoriQ8C0L8.

    Interactioni

    Subunit structurei

    Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000044797.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COG5 family.Curated

    Phylogenomic databases

    eggNOGiNOG298306.
    GeneTreeiENSGT00390000004586.
    HOGENOMiHOG000170357.
    HOVERGENiHBG051063.
    InParanoidiQ8C0L8.
    OMAiALQVFYN.
    OrthoDBiEOG7P5T08.
    TreeFamiTF313139.

    Family and domain databases

    InterProiIPR019465. Cog5.
    [Graphical view]
    PANTHERiPTHR13228. PTHR13228. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8C0L8-1 [UniParc]FASTAAdd to Basket

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    MEGGDSTISV AGRGASGSAV VAATVQAILQ DDCYSEFLNE DFDVKTYTSQ    50
    SIHQAVIAEQ LAKLAQGISQ LDKELHLQVV ARHEDLLAQA TGIESLEGVL 100
    QMMQTRIGAL QGAVDRMKSK IVEPYNKIVA RTAQLARLQV ACDLLRRIIR 150
    ILYLSKRLQG QLQGGSREIT KAAQSLNELD YLSQGIDLSG IEVIENDLLF 200
    IARARLEVEN QAKRLLEQGV ETQNPTQVGT ALQVFHNLGT LKETVTSVVD 250
    GYCAALEDSI NNALDVKVLT QPSQSAVRGG PGRAAMPTPG STAGFRASLW 300
    TNMEKLMDHI CAACGQVQHL QKVLTKKRDP VSHICFIEEI IKDGQPEILY 350
    MFWNAVTLAL SSHFHSATNS SMFLKQAFEG EYPKLLRLYN DLWKRLQQSS 400
    QNTQGTFSPS GTPDLCVDLP HMEDDTQDMF RLKRPDYDPE KALKDSLQPY 450
    EAAYLSKSLS RLFDPINLVF PPGGRNPPSS DELDGITKTI TSELNVAAVD 500
    ANLTLAVSKN VAKTIQLYAV KSEQLLSTQG DASQVIGPLT EGQKRNVGVV 550
    NSLFKLHQSV TKVVASQSSF SATAEQTIMS ALKTIHDLMG NAIQPLLTSV 600
    ADAIEAIIIT MHQEDFSGAS SSSGKPDVPC SLYMKELQGF IARVMNDYFK 650
    HFECLDFVFD NTEAIAQRAI ELFIRNASLI RPLGEGGKLR LAADFAQMEL 700
    AVGPLCRRVS DLGKSYRMLR SFRPLLFQTS EHVADSPAVG DIIPFSIIIQ 750
    FLFTRAPAEL KSPFQRAEWS HARFSQWLDD HPSEKDRLLL LRGALEAYVQ 800
    SVRSRDGKEF APVYPIMVQL LQKAMSALQ 829
    Length:829
    Mass (Da):91,391
    Last modified:July 27, 2011 - v3
    Checksum:iE4041125F09250DD
    GO

    Sequence cautioni

    The sequence BAC27065.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti190 – 1901G → R in BAC27065. (PubMed:16141072)Curated
    Sequence conflicti430 – 4301F → Y in BAC27065. (PubMed:16141072)Curated
    Sequence conflicti655 – 6551L → M in BAC27065. (PubMed:16141072)Curated
    Sequence conflicti826 – 8261S → Y in BAC27065. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030656 mRNA. Translation: BAC27065.1. Different initiation.
    AC119950 Genomic DNA. No translation available.
    AC125020 Genomic DNA. No translation available.
    CT010463 Genomic DNA. No translation available.
    CCDSiCCDS49046.1.
    RefSeqiNP_001156598.1. NM_001163126.1.
    UniGeneiMm.173068.

    Genome annotation databases

    EnsembliENSMUST00000036862; ENSMUSP00000044797; ENSMUSG00000035933.
    GeneIDi238123.
    KEGGimmu:238123.
    UCSCiuc007nhs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030656 mRNA. Translation: BAC27065.1 . Different initiation.
    AC119950 Genomic DNA. No translation available.
    AC125020 Genomic DNA. No translation available.
    CT010463 Genomic DNA. No translation available.
    CCDSi CCDS49046.1.
    RefSeqi NP_001156598.1. NM_001163126.1.
    UniGenei Mm.173068.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000044797.

    PTM databases

    PhosphoSitei Q8C0L8.

    Proteomic databases

    MaxQBi Q8C0L8.
    PaxDbi Q8C0L8.
    PRIDEi Q8C0L8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036862 ; ENSMUSP00000044797 ; ENSMUSG00000035933 .
    GeneIDi 238123.
    KEGGi mmu:238123.
    UCSCi uc007nhs.1. mouse.

    Organism-specific databases

    CTDi 10466.
    MGIi MGI:2145130. Cog5.

    Phylogenomic databases

    eggNOGi NOG298306.
    GeneTreei ENSGT00390000004586.
    HOGENOMi HOG000170357.
    HOVERGENi HBG051063.
    InParanoidi Q8C0L8.
    OMAi ALQVFYN.
    OrthoDBi EOG7P5T08.
    TreeFami TF313139.

    Miscellaneous databases

    ChiTaRSi COG5. mouse.
    NextBioi 383670.
    PROi Q8C0L8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C0L8.
    Genevestigatori Q8C0L8.

    Family and domain databases

    InterProi IPR019465. Cog5.
    [Graphical view ]
    PANTHERi PTHR13228. PTHR13228. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCOG5_MOUSE
    AccessioniPrimary (citable) accession number: Q8C0L8
    Secondary accession number(s): E9QM30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 70 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3