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Q8C0L8 (COG5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Conserved oligomeric Golgi complex subunit 5

Short name=COG complex subunit 5
Alternative name(s):
Component of oligomeric Golgi complex 5
Gene names
Name:Cog5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length829 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for normal Golgi function By similarity.

Subunit structure

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization By similarity.

Subcellular location

Cytoplasmcytosol By similarity. Golgi apparatus membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the COG5 family.

Sequence caution

The sequence BAC27065.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 829829Conserved oligomeric Golgi complex subunit 5
PRO_0000320146

Amino acid modifications

Modified residue1661Phosphoserine By similarity

Experimental info

Sequence conflict1901G → R in BAC27065. Ref.1
Sequence conflict4301F → Y in BAC27065. Ref.1
Sequence conflict6551L → M in BAC27065. Ref.1
Sequence conflict8261S → Y in BAC27065. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8C0L8 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: E4041125F09250DD

FASTA82991,391
        10         20         30         40         50         60 
MEGGDSTISV AGRGASGSAV VAATVQAILQ DDCYSEFLNE DFDVKTYTSQ SIHQAVIAEQ 

        70         80         90        100        110        120 
LAKLAQGISQ LDKELHLQVV ARHEDLLAQA TGIESLEGVL QMMQTRIGAL QGAVDRMKSK 

       130        140        150        160        170        180 
IVEPYNKIVA RTAQLARLQV ACDLLRRIIR ILYLSKRLQG QLQGGSREIT KAAQSLNELD 

       190        200        210        220        230        240 
YLSQGIDLSG IEVIENDLLF IARARLEVEN QAKRLLEQGV ETQNPTQVGT ALQVFHNLGT 

       250        260        270        280        290        300 
LKETVTSVVD GYCAALEDSI NNALDVKVLT QPSQSAVRGG PGRAAMPTPG STAGFRASLW 

       310        320        330        340        350        360 
TNMEKLMDHI CAACGQVQHL QKVLTKKRDP VSHICFIEEI IKDGQPEILY MFWNAVTLAL 

       370        380        390        400        410        420 
SSHFHSATNS SMFLKQAFEG EYPKLLRLYN DLWKRLQQSS QNTQGTFSPS GTPDLCVDLP 

       430        440        450        460        470        480 
HMEDDTQDMF RLKRPDYDPE KALKDSLQPY EAAYLSKSLS RLFDPINLVF PPGGRNPPSS 

       490        500        510        520        530        540 
DELDGITKTI TSELNVAAVD ANLTLAVSKN VAKTIQLYAV KSEQLLSTQG DASQVIGPLT 

       550        560        570        580        590        600 
EGQKRNVGVV NSLFKLHQSV TKVVASQSSF SATAEQTIMS ALKTIHDLMG NAIQPLLTSV 

       610        620        630        640        650        660 
ADAIEAIIIT MHQEDFSGAS SSSGKPDVPC SLYMKELQGF IARVMNDYFK HFECLDFVFD 

       670        680        690        700        710        720 
NTEAIAQRAI ELFIRNASLI RPLGEGGKLR LAADFAQMEL AVGPLCRRVS DLGKSYRMLR 

       730        740        750        760        770        780 
SFRPLLFQTS EHVADSPAVG DIIPFSIIIQ FLFTRAPAEL KSPFQRAEWS HARFSQWLDD 

       790        800        810        820 
HPSEKDRLLL LRGALEAYVQ SVRSRDGKEF APVYPIMVQL LQKAMSALQ 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030656 mRNA. Translation: BAC27065.1. Different initiation.
AC119950 Genomic DNA. No translation available.
AC125020 Genomic DNA. No translation available.
CT010463 Genomic DNA. No translation available.
CCDSCCDS49046.1.
RefSeqNP_001156598.1. NM_001163126.1.
UniGeneMm.173068.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000044797.

PTM databases

PhosphoSiteQ8C0L8.

Proteomic databases

MaxQBQ8C0L8.
PaxDbQ8C0L8.
PRIDEQ8C0L8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036862; ENSMUSP00000044797; ENSMUSG00000035933.
GeneID238123.
KEGGmmu:238123.
UCSCuc007nhs.1. mouse.

Organism-specific databases

CTD10466.
MGIMGI:2145130. Cog5.

Phylogenomic databases

eggNOGNOG298306.
GeneTreeENSGT00390000004586.
HOGENOMHOG000170357.
HOVERGENHBG051063.
InParanoidQ8C0L8.
OMAALQVFYN.
OrthoDBEOG7P5T08.
TreeFamTF313139.

Gene expression databases

BgeeQ8C0L8.
GenevestigatorQ8C0L8.

Family and domain databases

InterProIPR019465. Cog5.
[Graphical view]
PANTHERPTHR13228. PTHR13228. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCOG5. mouse.
NextBio383670.
PROQ8C0L8.
SOURCESearch...

Entry information

Entry nameCOG5_MOUSE
AccessionPrimary (citable) accession number: Q8C0L8
Secondary accession number(s): E9QM30
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot