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Protein

Graves disease carrier protein homolog

Gene

Slc25a16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-196783. Coenzyme A biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Graves disease carrier protein homolog
Short name:
GDC
Alternative name(s):
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene namesi
Name:Slc25a16
Synonyms:Gda
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1920382. Slc25a16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906171 – 332Graves disease carrier protein homologAdd BLAST332

Proteomic databases

PaxDbiQ8C0K5.
PeptideAtlasiQ8C0K5.
PRIDEiQ8C0K5.

PTM databases

PhosphoSitePlusiQ8C0K5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071253.
CleanExiMM_GDA.
ExpressionAtlasiQ8C0K5. baseline and differential.
GenevisibleiQ8C0K5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8C0K5. 1 interactor.
STRINGi10090.ENSMUSP00000043370.

Structurei

3D structure databases

ProteinModelPortaliQ8C0K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 120Solcar 1Add BLAST87
Repeati128 – 216Solcar 2Add BLAST89
Repeati238 – 328Solcar 3Add BLAST91

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ8C0K5.
KOiK15084.
OMAiHHYKHLE.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ8C0K5.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C0K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALVAAAAL AAAEPAPAVP QAAGSGGPTS RRDFYWLRSF LAGGIAGCCA
60 70 80 90 100
KTTVAPLDRV KVLLQAHNRH YKHLGVLSTL RAVPQKEGYL GLYKGNGAMM
110 120 130 140 150
IRIFPYGAIQ FMAFEHYKTF ITTKLGVSGH VHRLMAGSMA GMTAVICTYP
160 170 180 190 200
LDVVRVRLAF QVKGEHTYSG IIHAFKTIYA KEGGFLGFYR GLMPTILGMA
210 220 230 240 250
PYAGVSFFTF GTLKSVGLSY APALLGRPSS DNPNVLVLKT HINLLCGGVA
260 270 280 290 300
GAIAQTISYP FDVTRRRMQL GAVLPEFEKC LTMRETMKYV YGQHGIRRGL
310 320 330
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
Length:332
Mass (Da):36,220
Last modified:March 1, 2003 - v1
Checksum:iFEA5E7C41DF2C757
GO
Isoform 2 (identifier: Q8C0K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-81: VLSTLR → EFYMQS
     82-332: Missing.

Note: No experimental confirmation available.
Show »
Length:81
Mass (Da):8,498
Checksum:i7F87C2616BDAF5A8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01654976 – 81VLSTLR → EFYMQS in isoform 2. 1 Publication6
Alternative sequenceiVSP_01655082 – 332Missing in isoform 2. 1 PublicationAdd BLAST251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030865 mRNA. Translation: BAC27163.1.
BC062168 mRNA. Translation: AAH62168.1.
BC138983 mRNA. Translation: AAI38984.1.
BC138984 mRNA. Translation: AAI38985.1.
CCDSiCCDS23893.1. [Q8C0K5-1]
RefSeqiNP_780403.1. NM_175194.2. [Q8C0K5-1]
UniGeneiMm.37457.

Genome annotation databases

EnsembliENSMUST00000044977; ENSMUSP00000043370; ENSMUSG00000071253. [Q8C0K5-1]
GeneIDi73132.
KEGGimmu:73132.
UCSCiuc007fjh.1. mouse. [Q8C0K5-1]
uc029qye.1. mouse. [Q8C0K5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030865 mRNA. Translation: BAC27163.1.
BC062168 mRNA. Translation: AAH62168.1.
BC138983 mRNA. Translation: AAI38984.1.
BC138984 mRNA. Translation: AAI38985.1.
CCDSiCCDS23893.1. [Q8C0K5-1]
RefSeqiNP_780403.1. NM_175194.2. [Q8C0K5-1]
UniGeneiMm.37457.

3D structure databases

ProteinModelPortaliQ8C0K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C0K5. 1 interactor.
STRINGi10090.ENSMUSP00000043370.

PTM databases

PhosphoSitePlusiQ8C0K5.

Proteomic databases

PaxDbiQ8C0K5.
PeptideAtlasiQ8C0K5.
PRIDEiQ8C0K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044977; ENSMUSP00000043370; ENSMUSG00000071253. [Q8C0K5-1]
GeneIDi73132.
KEGGimmu:73132.
UCSCiuc007fjh.1. mouse. [Q8C0K5-1]
uc029qye.1. mouse. [Q8C0K5-2]

Organism-specific databases

CTDi8034.
MGIiMGI:1920382. Slc25a16.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ8C0K5.
KOiK15084.
OMAiHHYKHLE.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ8C0K5.
TreeFamiTF314806.

Enzyme and pathway databases

ReactomeiR-MMU-196783. Coenzyme A biosynthesis.

Miscellaneous databases

PROiQ8C0K5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071253.
CleanExiMM_GDA.
ExpressionAtlasiQ8C0K5. baseline and differential.
GenevisibleiQ8C0K5. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDC_MOUSE
AccessioniPrimary (citable) accession number: Q8C0K5
Secondary accession number(s): B2RSS4, Q6P6K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.