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Protein

Ankyrin repeat domain-containing protein SOWAHC

Gene

Sowahc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein SOWAHC
Alternative name(s):
Ankyrin repeat domain-containing protein 57
Protein sosondowah homolog C
Gene namesi
Name:Sowahc
Synonyms:Ankrd57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3606051. Sowahc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Ankyrin repeat domain-containing protein SOWAHCPRO_0000274341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821PhosphoserineCombined sources
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C0J6.
MaxQBiQ8C0J6.
PRIDEiQ8C0J6.

PTM databases

iPTMnetiQ8C0J6.
PhosphoSiteiQ8C0J6.

Expressioni

Gene expression databases

CleanExiMM_ANKRD57.
GenevisibleiQ8C0J6. MM.

Interactioni

Protein-protein interaction databases

BioGridi234481. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8C0J6.
SMRiQ8C0J6. Positions 223-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati288 – 31730ANK 1Add
BLAST
Repeati327 – 35731ANK 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi481 – 49212Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the SOWAH family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063547.
HOGENOMiHOG000116317.
HOVERGENiHBG079715.
InParanoidiQ8C0J6.
OMAiQLKRSVC.
PhylomeDBiQ8C0J6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSLELSSE AILRFLAERG GRAGHSELVQ HFRDVLGGQR EQRTRARERF
60 70 80 90 100
KELVNAVATV RTDPADGTKY VHLKKRFCTG DSPPLEAKLP REPPRIEVTE
110 120 130 140 150
EPQVPDLAAE PCEGSQLQEA NPQLSLGLGG EVSDQEPPAP AQGGAQGKDS
160 170 180 190 200
PPQEVEAVSW ASGPGSSENL KLPPQGEAEG GSSPSGPNTP RSARQNFRDL
210 220 230 240 250
VLGSSPQLKR SVGPGDGNAG GRSRGGGDSD TASLASSSAE EESSVGASVT
260 270 280 290 300
LDPLDHAWML SASEGKWDSL EGLLTCEPGL LSKRDFITGF TCLHWAAKHG
310 320 330 340 350
RQELLAMLVN FATKHQLPVN INAKSSGGYT ALHLAAMHGH VEVVKLLVGA
360 370 380 390 400
YDADVDIRDY SGRKASQYLS ESIAEEIKNL VGALDEDDGD SPAARGGGRW
410 420 430 440 450
RLSKVLPSHI THKLSPVVED GAELHHHVPE GWTGGSKAKD SGRKASGSSS
460 470 480 490 500
GRMKPRLNKI RFRTQIIHTT PSFRDAKPTL EEGEEEEEEE EERSLRGYSS
510
SFKLRPKSNV FG
Length:512
Mass (Da):54,938
Last modified:February 6, 2007 - v2
Checksum:iAA4B1D706B1607F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 606NAVATV → MPWPPL in BAC34291 (PubMed:16141072).Curated
Sequence conflicti119 – 1191E → Q in BAC34291 (PubMed:16141072).Curated
Sequence conflicti123 – 1231Q → K in BAC34291 (PubMed:16141072).Curated
Sequence conflicti167 – 1671S → T in BAC34291 (PubMed:16141072).Curated
Sequence conflicti330 – 3301T → S in BAC27191 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030944 mRNA. Translation: BAC27191.1.
AK050497 mRNA. Translation: BAC34291.1.
CCDSiCCDS59544.1.
RefSeqiNP_766527.3. NM_172939.3.
UniGeneiMm.3036.

Genome annotation databases

EnsembliENSMUST00000182161; ENSMUSP00000138351; ENSMUSG00000098188.
GeneIDi268301.
KEGGimmu:268301.
UCSCiuc011xed.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030944 mRNA. Translation: BAC27191.1.
AK050497 mRNA. Translation: BAC34291.1.
CCDSiCCDS59544.1.
RefSeqiNP_766527.3. NM_172939.3.
UniGeneiMm.3036.

3D structure databases

ProteinModelPortaliQ8C0J6.
SMRiQ8C0J6. Positions 223-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234481. 1 interaction.

PTM databases

iPTMnetiQ8C0J6.
PhosphoSiteiQ8C0J6.

Proteomic databases

EPDiQ8C0J6.
MaxQBiQ8C0J6.
PRIDEiQ8C0J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000182161; ENSMUSP00000138351; ENSMUSG00000098188.
GeneIDi268301.
KEGGimmu:268301.
UCSCiuc011xed.1. mouse.

Organism-specific databases

CTDi65124.
MGIiMGI:3606051. Sowahc.

Phylogenomic databases

GeneTreeiENSGT00530000063547.
HOGENOMiHOG000116317.
HOVERGENiHBG079715.
InParanoidiQ8C0J6.
OMAiQLKRSVC.
PhylomeDBiQ8C0J6.

Miscellaneous databases

PROiQ8C0J6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ANKRD57.
GenevisibleiQ8C0J6. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Thymus.
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSWAHC_MOUSE
AccessioniPrimary (citable) accession number: Q8C0J6
Secondary accession number(s): Q8BWN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.