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Q8C0J2

- A16L1_MOUSE

UniProt

Q8C0J2 - A16L1_MOUSE

Protein

Autophagy-related protein 16-1

Gene

Atg16l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagic vacuole assembly Source: MGI
    2. negative stranded viral RNA replication Source: MGI
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 16-1
    Alternative name(s):
    APG16-like 1
    Gene namesi
    Name:Atg16l1
    Synonyms:Apg16l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1924290. Atg16l1.

    Subcellular locationi

    Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein
    Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.

    GO - Cellular componenti

    1. autophagic vacuole Source: MGI
    2. autophagic vacuole membrane Source: MGI
    3. axoneme Source: UniProtKB
    4. pre-autophagosomal structure membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi299 – 2991D → E: Prevents cleavage by activated CASP3. 1 Publication
    Mutagenesisi300 – 3001T → A: No effect on the stability of the protein. Enhances cleavage and degradation mediated by activated CASP3. Results in reduced autophagy and defective clearance of intestinal pathogens. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 607607Autophagy-related protein 16-1PRO_0000050849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691PhosphoserineBy similarity
    Modified residuei287 – 2871PhosphoserineBy similarity

    Post-translational modificationi

    Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8C0J2.
    PaxDbiQ8C0J2.
    PRIDEiQ8C0J2.

    2D gel databases

    REPRODUCTION-2DPAGEQ8C0J2.

    PTM databases

    PhosphoSiteiQ8C0J2.

    Expressioni

    Tissue specificityi

    Widely expressed. In the liver, isoform 2 is highly expressed and isoform 1 is weakly expressed. Isoform 3 is expressed in the brain.1 Publication

    Gene expression databases

    ArrayExpressiQ8C0J2.
    BgeeiQ8C0J2.
    CleanExiMM_ATG16L1.
    GenevestigatoriQ8C0J2.

    Interactioni

    Subunit structurei

    Interacts with TMEM59, TLR2 and NOD2 By similarity. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Interacts with RAB33B.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Rb1cc1Q9ESK93EBI-769195,EBI-647302

    Protein-protein interaction databases

    BioGridi218476. 5 interactions.
    DIPiDIP-31966N.
    IntActiQ8C0J2. 4 interactions.
    MINTiMINT-136268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C0J2.
    SMRiQ8C0J2. Positions 267-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati320 – 35940WD 1Add
    BLAST
    Repeati364 – 40340WD 2Add
    BLAST
    Repeati406 – 44540WD 3Add
    BLAST
    Repeati447 – 48438WD 4Add
    BLAST
    Repeati486 – 52540WD 5Add
    BLAST
    Repeati532 – 57342WD 6Add
    BLAST
    Repeati575 – 60733WD 7Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili79 – 230152Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi296 – 2994Caspase cleavage

    Sequence similaritiesi

    Belongs to the WD repeat ATG16 family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00740000115355.
    HOVERGENiHBG050534.
    KOiK17890.
    OMAiLETECQE.
    OrthoDBiEOG70CR6M.
    PhylomeDBiQ8C0J2.
    TreeFamiTF315541.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR013923. Autophagy-rel_prot_16.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF08614. ATG16. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C0J2-1) [UniParc]FASTAAdd to Basket

    Also known as: Apg16Lbeta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSGLRAADF PRWKRHIAEE LRRRDRLQRQ AFEEIILQYT KLLEKSDLHS    50
    VLTQKLQAEK HDMPNRHEIS PGHDGAWNDS QLQEMAQLRI KHQEELTELH 100
    KKRGELAQLV IDLNNQMQQK DKEIQMNEAK ISEYLQTISD LETNCLDLRT 150
    KLQDLEVANQ TLKDEYDALQ ITFTALEEKL RKTTEENQEL VTRWMAEKAQ 200
    EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI EVIVDETSDH 250
    TEETSPVRAV SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS IPVPQDIMDT 300
    HPASGKDVRV PTTASYVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE 350
    AFGDKCEFKG SLSGSNAGIT SIEFDSAGAY LLAASNDFAS RIWTVDDYRL 400
    RHTLTGHSGK VLSAKFLLDN ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS 450
    SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES VVREMELLGK ITALDLNPER 500
    TELLSCSRDD LLKVIDLRTN AVKQTFSAPG FKCGSDWTRV VFSPDGSYVA 550
    AGSAEGSLYV WSVLTGKVEK VLSKQHSSSI NAVAWAPSGL HVVSVDKGSR 600
    AVLWAQP 607
    Length:607
    Mass (Da):68,172
    Last modified:March 1, 2003 - v1
    Checksum:i63920320883A69DF
    GO
    Isoform 2 (identifier: Q8C0J2-2) [UniParc]FASTAAdd to Basket

    Also known as: Apg16Lalpha

    The sequence of this isoform differs from the canonical sequence as follows:
         266-284: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:588
    Mass (Da):66,203
    Checksum:iCE2AB829A7911274
    GO
    Isoform 3 (identifier: Q8C0J2-3) [UniParc]FASTAAdd to Basket

    Also known as: Apg16Lgamma

    The sequence of this isoform differs from the canonical sequence as follows:
         284-284: G → GLSESPLLGHHSSDAAR

    Show »
    Length:623
    Mass (Da):69,831
    Checksum:i823453BB5D7DE6FE
    GO
    Isoform 4 (identifier: Q8C0J2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         284-284: G → GLSESPLLGHHSSDAAR
         443-452: IKTVFAGSSC → EEMQSLCVFM
         453-607: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:468
    Mass (Da):53,024
    Checksum:iFFB7AC4AE34DF8F7
    GO
    Isoform 5 (identifier: Q8C0J2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         266-284: Missing.
         442-442: C → CEEMQSLCVLMVFGFLSG

    Note: No experimental confirmation available.

    Show »
    Length:605
    Mass (Da):68,075
    Checksum:iB0BB8DE0748401B6
    GO

    Sequence cautioni

    The sequence BAD21370.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831Q → H in BAC55090. (PubMed:12665549)Curated
    Sequence conflicti83 – 831Q → H in BAC55091. (PubMed:12665549)Curated
    Sequence conflicti83 – 831Q → H in BAC55092. (PubMed:12665549)Curated
    Sequence conflicti83 – 831Q → H in BAB23866. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei266 – 28419Missing in isoform 2 and isoform 5. 2 PublicationsVSP_013391Add
    BLAST
    Alternative sequencei284 – 2841G → GLSESPLLGHHSSDAAR in isoform 3 and isoform 4. 3 PublicationsVSP_013392
    Alternative sequencei442 – 4421C → CEEMQSLCVLMVFGFLSG in isoform 5. 1 PublicationVSP_013393
    Alternative sequencei443 – 45210IKTVFAGSSC → EEMQSLCVFM in isoform 4. 1 PublicationVSP_013394
    Alternative sequencei453 – 607155Missing in isoform 4. 1 PublicationVSP_013395Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB087879 mRNA. Translation: BAC55090.1.
    AB087880 mRNA. Translation: BAC55091.1.
    AB087881 mRNA. Translation: BAC55092.1.
    AK005181 mRNA. Translation: BAB23866.1.
    AK030983 mRNA. Translation: BAC27201.1.
    AK131120 Transcribed RNA. Translation: BAD21370.1. Different initiation.
    BC049122 mRNA. Translation: AAH49122.1.
    CCDSiCCDS15136.1. [Q8C0J2-1]
    CCDS56637.1. [Q8C0J2-3]
    CCDS56638.1. [Q8C0J2-2]
    RefSeqiNP_001192320.1. NM_001205391.1. [Q8C0J2-3]
    NP_084122.2. NM_029846.4. [Q8C0J2-1]
    UniGeneiMm.272972.
    Mm.456099.

    Genome annotation databases

    EnsembliENSMUST00000027512; ENSMUSP00000027512; ENSMUSG00000026289. [Q8C0J2-1]
    ENSMUST00000113186; ENSMUSP00000108811; ENSMUSG00000026289. [Q8C0J2-2]
    ENSMUST00000113190; ENSMUSP00000108815; ENSMUSG00000026289. [Q8C0J2-3]
    GeneIDi77040.
    KEGGimmu:77040.
    UCSCiuc007bxl.2. mouse. [Q8C0J2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB087879 mRNA. Translation: BAC55090.1 .
    AB087880 mRNA. Translation: BAC55091.1 .
    AB087881 mRNA. Translation: BAC55092.1 .
    AK005181 mRNA. Translation: BAB23866.1 .
    AK030983 mRNA. Translation: BAC27201.1 .
    AK131120 Transcribed RNA. Translation: BAD21370.1 . Different initiation.
    BC049122 mRNA. Translation: AAH49122.1 .
    CCDSi CCDS15136.1. [Q8C0J2-1 ]
    CCDS56637.1. [Q8C0J2-3 ]
    CCDS56638.1. [Q8C0J2-2 ]
    RefSeqi NP_001192320.1. NM_001205391.1. [Q8C0J2-3 ]
    NP_084122.2. NM_029846.4. [Q8C0J2-1 ]
    UniGenei Mm.272972.
    Mm.456099.

    3D structure databases

    ProteinModelPortali Q8C0J2.
    SMRi Q8C0J2. Positions 267-604.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218476. 5 interactions.
    DIPi DIP-31966N.
    IntActi Q8C0J2. 4 interactions.
    MINTi MINT-136268.

    PTM databases

    PhosphoSitei Q8C0J2.

    2D gel databases

    REPRODUCTION-2DPAGE Q8C0J2.

    Proteomic databases

    MaxQBi Q8C0J2.
    PaxDbi Q8C0J2.
    PRIDEi Q8C0J2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027512 ; ENSMUSP00000027512 ; ENSMUSG00000026289 . [Q8C0J2-1 ]
    ENSMUST00000113186 ; ENSMUSP00000108811 ; ENSMUSG00000026289 . [Q8C0J2-2 ]
    ENSMUST00000113190 ; ENSMUSP00000108815 ; ENSMUSG00000026289 . [Q8C0J2-3 ]
    GeneIDi 77040.
    KEGGi mmu:77040.
    UCSCi uc007bxl.2. mouse. [Q8C0J2-1 ]

    Organism-specific databases

    CTDi 55054.
    MGIi MGI:1924290. Atg16l1.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00740000115355.
    HOVERGENi HBG050534.
    KOi K17890.
    OMAi LETECQE.
    OrthoDBi EOG70CR6M.
    PhylomeDBi Q8C0J2.
    TreeFami TF315541.

    Miscellaneous databases

    NextBioi 346354.
    PROi Q8C0J2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C0J2.
    Bgeei Q8C0J2.
    CleanExi MM_ATG16L1.
    Genevestigatori Q8C0J2.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR013923. Autophagy-rel_prot_16.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF08614. ATG16. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate."
      Mizushima N., Kuma A., Kobayashi Y., Yamamoto A., Matsubae M., Takao T., Natsume T., Ohsumi Y., Yoshimori T.
      J. Cell Sci. 116:1679-1688(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ATG5.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Thymus.
    3. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
      DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Fetal brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation."
      Itoh T., Fujita N., Kanno E., Yamamoto A., Yoshimori T., Fukuda M.
      Mol. Biol. Cell 19:2916-2925(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB33B.
    6. Cited for: SUBCELLULAR LOCATION.
    7. Cited for: FUNCTION IN AUTOPHAGY, CLEAVAGE BY CASP3, MUTAGENESIS OF ASP-299 AND THR-300.

    Entry informationi

    Entry nameiA16L1_MOUSE
    AccessioniPrimary (citable) accession number: Q8C0J2
    Secondary accession number(s): Q6KAT7
    , Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3