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Protein

Enhancer of polycomb homolog 2

Gene

Epc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in transcription or DNA repair.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of polycomb homolog 2
Alternative name(s):
EPC-like
Gene namesi
Name:Epc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1278321. Epc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Enhancer of polycomb homolog 2PRO_0000239296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki324 – 324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8C0I4.
MaxQBiQ8C0I4.
PaxDbiQ8C0I4.
PRIDEiQ8C0I4.

PTM databases

iPTMnetiQ8C0I4.
PhosphoSiteiQ8C0I4.

Expressioni

Gene expression databases

BgeeiQ8C0I4.
CleanExiMM_EPC2.
ExpressionAtlasiQ8C0I4. baseline and differential.
GenevisibleiQ8C0I4. MM.

Interactioni

Protein-protein interaction databases

BioGridi230690. 2 interactions.
IntActiQ8C0I4. 3 interactions.
STRINGi10090.ENSMUSP00000089758.

Structurei

3D structure databases

ProteinModelPortaliQ8C0I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 4894Poly-Ser
Compositional biasi583 – 62038Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the enhancer of polycomb family.Curated

Phylogenomic databases

eggNOGiKOG2261. Eukaryota.
ENOG410XSSX. LUCA.
GeneTreeiENSGT00390000013262.
HOGENOMiHOG000231800.
HOVERGENiHBG051489.
InParanoidiQ8C0I4.
KOiK11322.
OMAiETTVAME.
OrthoDBiEOG7P5T10.
PhylomeDBiQ8C0I4.
TreeFamiTF106438.

Family and domain databases

InterProiIPR024943. Enhancer_polycomb.
IPR019542. Enhancer_polycomb-like_N.
IPR009607. Enhancer_polycomb_C.
[Graphical view]
PANTHERiPTHR14898. PTHR14898. 1 hit.
PfamiPF06752. E_Pc_C. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C0I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSFRARA LDAAKPLPIY RGKDMPDLND CVSINRAVPQ MPTGMEKEEE
60 70 80 90 100
SEHHLQRAIS AQQVFREKKE SMVIPVPEAE SNVNYYNRLY KGEFKQPKQF
110 120 130 140 150
IHIQPFNLDN EQPDYDMDSE DETLLNRLNR KMEIKPLQFE IMIDRLEKAS
160 170 180 190 200
SNQLVTLQEA KLLLNEDDYL IKAVYDYWVR KRKNCRGPSL IPQIKQEKRD
210 220 230 240 250
GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE FSRAITILEM
260 270 280 290 300
IKRREKTKRE LLHLTLEVVE KRYHLGDYGG EILNEVKVNR SEKELYASPA
310 320 330 340 350
TLHNGNHHKV QECKTKHPHH LSLKEEASDV VRQKKKYPKK PKAEAGIAPQ
360 370 380 390 400
QPTPETLPVI NKSDIKQYDF QSSDEDEFPQ VLSPASEAEE ENDPDGSCAF
410 420 430 440 450
RRRAGCQYYA PRLDQANNHM CENSELADLD KLRYKHCLTT LTVPRRCIGF
460 470 480 490 500
ARRRIGRGGR VIMDRISTEH DPVLKQIDPE MLNGFSSSSQ TIDFSSNFSR
510 520 530 540 550
TNASSKPCEN RLSLSEILSN IRSCRLQCFQ PRLLNVQDID SEECTSRKPG
560 570 580 590 600
QTVSSKRVSA ASVALLNTSK NGISVTGGIT EEQFQTHQQQ LVQMQRQQLA
610 620 630 640 650
QLHQKQQSQH SSQQTHPKAQ GSSTSDCMSK TLDSASAHFA ASAVVSAPVP
660 670 680 690 700
SRSEGSKEQN TGHNNMNGVV QPSGPSKTLY STNMALSSSP GISAVQLVRT
710 720 730 740 750
VGHTTTNHLI PALCTSSPQT LPMNNSCLTN AVHLNNVSVV SPVNVHINTR
760 770 780 790 800
TSAPSPTALK LATVAASMDR VPKVTPSSAI SSIARENHEP ERLGLNGLAE

TTVAMEVT
Length:808
Mass (Da):90,960
Last modified:June 13, 2006 - v2
Checksum:iF1DAAC73786B349B
GO

Sequence cautioni

The sequence BAC33197.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51S → A in BAC33197 (PubMed:16141072).Curated
Sequence conflicti260 – 2601E → K in BAE24558 (PubMed:16141072).Curated
Sequence conflicti382 – 3821L → P in AAH48785 (PubMed:15489334).Curated
Sequence conflicti451 – 4511A → V in BAC27218 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031025 mRNA. Translation: BAC27218.1.
AK047947 mRNA. Translation: BAC33197.1. Different initiation.
AK141073 mRNA. Translation: BAE24558.1.
AL845163 Genomic DNA. Translation: CAM19640.1.
BC048785 mRNA. Translation: AAH48785.1.
CCDSiCCDS16023.1.
RefSeqiNP_766251.3. NM_172663.4.
UniGeneiMm.29167.

Genome annotation databases

EnsembliENSMUST00000092123; ENSMUSP00000089758; ENSMUSG00000069495.
GeneIDi227867.
KEGGimmu:227867.
UCSCiuc008jpw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031025 mRNA. Translation: BAC27218.1.
AK047947 mRNA. Translation: BAC33197.1. Different initiation.
AK141073 mRNA. Translation: BAE24558.1.
AL845163 Genomic DNA. Translation: CAM19640.1.
BC048785 mRNA. Translation: AAH48785.1.
CCDSiCCDS16023.1.
RefSeqiNP_766251.3. NM_172663.4.
UniGeneiMm.29167.

3D structure databases

ProteinModelPortaliQ8C0I4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230690. 2 interactions.
IntActiQ8C0I4. 3 interactions.
STRINGi10090.ENSMUSP00000089758.

PTM databases

iPTMnetiQ8C0I4.
PhosphoSiteiQ8C0I4.

Proteomic databases

EPDiQ8C0I4.
MaxQBiQ8C0I4.
PaxDbiQ8C0I4.
PRIDEiQ8C0I4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092123; ENSMUSP00000089758; ENSMUSG00000069495.
GeneIDi227867.
KEGGimmu:227867.
UCSCiuc008jpw.2. mouse.

Organism-specific databases

CTDi26122.
MGIiMGI:1278321. Epc2.

Phylogenomic databases

eggNOGiKOG2261. Eukaryota.
ENOG410XSSX. LUCA.
GeneTreeiENSGT00390000013262.
HOGENOMiHOG000231800.
HOVERGENiHBG051489.
InParanoidiQ8C0I4.
KOiK11322.
OMAiETTVAME.
OrthoDBiEOG7P5T10.
PhylomeDBiQ8C0I4.
TreeFamiTF106438.

Miscellaneous databases

PROiQ8C0I4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C0I4.
CleanExiMM_EPC2.
ExpressionAtlasiQ8C0I4. baseline and differential.
GenevisibleiQ8C0I4. MM.

Family and domain databases

InterProiIPR024943. Enhancer_polycomb.
IPR019542. Enhancer_polycomb-like_N.
IPR009607. Enhancer_polycomb_C.
[Graphical view]
PANTHERiPTHR14898. PTHR14898. 1 hit.
PfamiPF06752. E_Pc_C. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-808.
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiEPC2_MOUSE
AccessioniPrimary (citable) accession number: Q8C0I4
Secondary accession number(s): A2AQU9
, Q3URX9, Q80Y70, Q8BXC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.