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Protein

TRAF3-interacting JNK-activating modulator

Gene

Traf3ip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

Protein family/group databases

MEROPSiS01.372.

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF3-interacting JNK-activating modulator
Alternative name(s):
TRAF3-interacting protein 3
Gene namesi
Name:Traf3ip3
Synonyms:T3jam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2441706. Traf3ip3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 485485CytoplasmicSequence analysisAdd
BLAST
Transmembranei486 – 50621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini507 – 5137ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513TRAF3-interacting JNK-activating modulatorPRO_0000072404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki268 – 268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8C0G2.
MaxQBiQ8C0G2.
PaxDbiQ8C0G2.
PRIDEiQ8C0G2.

PTM databases

PhosphoSiteiQ8C0G2.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen and thymus. Not detected in heart, kidney and liver.1 Publication

Gene expression databases

CleanExiMM_TRAF3IP3.

Interactioni

Subunit structurei

Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.

Protein-protein interaction databases

BioGridi229607. 1 interaction.
STRINGi10090.ENSMUSP00000040977.

Structurei

3D structure databases

ProteinModelPortaliQ8C0G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili266 – 488223Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 375Poly-Arg
Compositional biasi300 – 431132Gln/Glu-richAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHX6. Eukaryota.
ENOG410ZX9A. LUCA.
HOGENOMiHOG000070108.
HOVERGENiHBG054704.
InParanoidiQ8C0G2.
PhylomeDBiQ8C0G2.

Sequencei

Sequence statusi: Complete.

Q8C0G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSDSRSSP GLARWAESYE AKCERRQETR ENRRRRRNET TCRQPGKVLR
60 70 80 90 100
TQHKERLQGA RQLQFLKRRN LEEEKKGQAR EQGPSSKTDG GTGQVSILKE
110 120 130 140 150
SLPGANKASF PGQQETGISS EVFPALHHSS SGIQRDLGGH HASHGRAFPP
160 170 180 190 200
QDSDIKKPHR QHRGTQTKAE EALPTIKNDA SQQTNCGVAV LDKDIIQLSE
210 220 230 240 250
YLKEALHREL ILKKKMVILQ DLLPALIRAS DSSWKGQLNE DKLKGKLRSL
260 270 280 290 300
ENQLYTCLQK HSPWGMKKVL LEMEDQRSSY EQKAKASLQK VLEEKMCAEQ
310 320 330 340 350
QLQRAQLSLA LAEQKCQEWK SQYEALKEDW RTLGDQHREL ESQLHVLQSK
360 370 380 390 400
LQGADSRDSQ MSQALQLLEN EHQELQTKLE SLQGDGEQQS SETQDLQDQL
410 420 430 440 450
KKSEEEKQAL VSKVQQLQSL LQNQSLQLQE QEKLLKKDQG LPVWNPKLSL
460 470 480 490 500
DEVKPEGTRK EKEEELRDQL QKETFQLQVK ENELQCGQWL PVLMVVIATA
510
LAVFLANKGN LVI
Length:513
Mass (Da):58,564
Last modified:June 7, 2004 - v2
Checksum:i6FF754048DB64353
GO

Sequence cautioni

The sequence AAQ84304.1 differs from that shown.Sequencing errors.Curated
The sequence AAQ84304.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851N → K in BAC27388 (PubMed:16141072).Curated
Sequence conflicti185 – 1851N → K in BAC31127 (PubMed:16141072).Curated
Sequence conflicti355 – 3551D → G in BAC27388 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY383616 mRNA. Translation: AAQ84304.1. Sequence problems.
AK031400 mRNA. Translation: BAC27388.1.
AK041994 mRNA. Translation: BAC31127.2.
BC036561 mRNA. No translation available.
CCDSiCCDS15634.1.
RefSeqiNP_694777.3. NM_153137.4.
UniGeneiMm.261259.

Genome annotation databases

GeneIDi215243.
KEGGimmu:215243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY383616 mRNA. Translation: AAQ84304.1. Sequence problems.
AK031400 mRNA. Translation: BAC27388.1.
AK041994 mRNA. Translation: BAC31127.2.
BC036561 mRNA. No translation available.
CCDSiCCDS15634.1.
RefSeqiNP_694777.3. NM_153137.4.
UniGeneiMm.261259.

3D structure databases

ProteinModelPortaliQ8C0G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229607. 1 interaction.
STRINGi10090.ENSMUSP00000040977.

Protein family/group databases

MEROPSiS01.372.

PTM databases

PhosphoSiteiQ8C0G2.

Proteomic databases

EPDiQ8C0G2.
MaxQBiQ8C0G2.
PaxDbiQ8C0G2.
PRIDEiQ8C0G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi215243.
KEGGimmu:215243.

Organism-specific databases

CTDi80342.
MGIiMGI:2441706. Traf3ip3.

Phylogenomic databases

eggNOGiENOG410IHX6. Eukaryota.
ENOG410ZX9A. LUCA.
HOGENOMiHOG000070108.
HOVERGENiHBG054704.
InParanoidiQ8C0G2.
PhylomeDBiQ8C0G2.

Miscellaneous databases

ChiTaRSiTraf3ip3. mouse.
PROiQ8C0G2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRAF3IP3.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK."
    Dadgostar H., Doyle S.E., Shahangian A., Garcia D.E., Cheng G.
    FEBS Lett. 553:403-407(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH TRAF3.
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiT3JAM_MOUSE
AccessioniPrimary (citable) accession number: Q8C0G2
Secondary accession number(s): Q8BY50, Q8K1Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 6, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.