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Q8C0D9

- CEP68_MOUSE

UniProt

Q8C0D9 - CEP68_MOUSE

Protein

Centrosomal protein of 68 kDa

Gene

Cep68

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. centrosome organization Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein of 68 kDa
    Short name:
    Cep68
    Gene namesi
    Name:Cep68
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2667663. Cep68.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 733733Centrosomal protein of 68 kDaPRO_0000089495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei459 – 4591PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8C0D9.
    PRIDEiQ8C0D9.

    PTM databases

    PhosphoSiteiQ8C0D9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8C0D9.
    BgeeiQ8C0D9.
    CleanExiMM_CEP68.
    GenevestigatoriQ8C0D9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C0D9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG44343.
    GeneTreeiENSGT00750000117779.
    HOGENOMiHOG000070069.
    HOVERGENiHBG050898.
    InParanoidiQ8C0D9.
    KOiK16764.
    OMAiLSFQAEY.
    OrthoDBiEOG7NW68J.
    PhylomeDBiQ8C0D9.
    TreeFamiTF333570.

    Family and domain databases

    InterProiIPR026696. AKAP6/CEP68.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view]
    PANTHERiPTHR14514. PTHR14514. 1 hit.
    SMARTiSM00150. SPEC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C0D9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALSEDEAEA EVSVNTKVPS CGRWNSGKLL PSGLEPDQPL HLGVEGGPLW    50
    RAEADPGCIS GVFLSRVHTA SKEPVADRSK PPLRGPLPSA SVGTGEVLHS 100
    MGSQMEEDRL PASQDLLPAL QVFGTITVCS GQEADSEDFQ ATLDPSQVLG 150
    LSQQPHTSGL PLPPQWKSTV SPGAPQLSSR SISASSVGSS LQDHQEKAGP 200
    QRASFANVSS PELTVPQAAH SVVGAGPPLQ GSAQPLTSGS DATGLGKRHL 250
    SFQAEYWACA LPNSLPPSPN RHSALWDPNK EYEDLLDYTY PLRPGPQLPK 300
    QPESHVLTEP VLQDSGVDLD SLSVSPASTL KSPTNVSHNC SSAEVPTLPF 350
    SGARESCLKR WPLGIFQKQG GTSLSSWNQL ASTPRAPGTE DASWENREAA 400
    LRGTAEDCLP IGEDLRMGSP QLKTKEKEPP FPRQKRGRQH VSCPACVTPG 450
    WPSEEEVGSD EEYLALPTRL TQVSSLVSYS GARPSFVNLH TGAAEEHSSL 500
    QVSDSDKPAS PTLDSSHRKH PSGTSFQGPV GQNPCFRHSI QPQDSRGKSS 550
    LMSNQTLGVS SKPLKTQPAS KAMTDRRLFS ELVAGETLPR TTDEQEKASL 600
    VQCVQTFCCR LEELICWLYN VTDVADLSAP PRTSLTGLKS SLQLYRQFKK 650
    DVDEHQSLTE SVLEKGEILL QCLLDNTPVL KDVLERIAKQ SGELESRADH 700
    LYDSILASLD MLAGCTLIPD NRPTAAEHPH EGL 733
    Length:733
    Mass (Da):78,749
    Last modified:April 26, 2005 - v2
    Checksum:i15D93FCECDDC92A9
    GO
    Isoform 2 (identifier: Q8C0D9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         647-733: QFKKDVDEHQ...TAAEHPHEGL → VICSPGLFIHGDGS

    Note: No experimental confirmation available.

    Show »
    Length:660
    Mass (Da):70,487
    Checksum:i4076BCB810C66E65
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2281P → Q in BAC27484. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei647 – 73387QFKKD…PHEGL → VICSPGLFIHGDGS in isoform 2. 1 PublicationVSP_013477Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031622 mRNA. Translation: BAC27484.1.
    AK140820 mRNA. Translation: BAE24488.1.
    AL606522 Genomic DNA. Translation: CAI24452.1.
    AL606522 Genomic DNA. Translation: CAI24453.1.
    BC027174 mRNA. Translation: AAH27174.1.
    CCDSiCCDS24456.1. [Q8C0D9-1]
    RefSeqiNP_758464.2. NM_172260.3. [Q8C0D9-1]
    UniGeneiMm.260314.

    Genome annotation databases

    EnsembliENSMUST00000050611; ENSMUSP00000054943; ENSMUSG00000044066. [Q8C0D9-1]
    ENSMUST00000109596; ENSMUSP00000105225; ENSMUSG00000044066. [Q8C0D9-2]
    GeneIDi216543.
    KEGGimmu:216543.
    UCSCiuc007icw.1. mouse. [Q8C0D9-1]
    uc007icx.1. mouse. [Q8C0D9-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031622 mRNA. Translation: BAC27484.1 .
    AK140820 mRNA. Translation: BAE24488.1 .
    AL606522 Genomic DNA. Translation: CAI24452.1 .
    AL606522 Genomic DNA. Translation: CAI24453.1 .
    BC027174 mRNA. Translation: AAH27174.1 .
    CCDSi CCDS24456.1. [Q8C0D9-1 ]
    RefSeqi NP_758464.2. NM_172260.3. [Q8C0D9-1 ]
    UniGenei Mm.260314.

    3D structure databases

    ProteinModelPortali Q8C0D9.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8C0D9.

    Proteomic databases

    PaxDbi Q8C0D9.
    PRIDEi Q8C0D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050611 ; ENSMUSP00000054943 ; ENSMUSG00000044066 . [Q8C0D9-1 ]
    ENSMUST00000109596 ; ENSMUSP00000105225 ; ENSMUSG00000044066 . [Q8C0D9-2 ]
    GeneIDi 216543.
    KEGGi mmu:216543.
    UCSCi uc007icw.1. mouse. [Q8C0D9-1 ]
    uc007icx.1. mouse. [Q8C0D9-2 ]

    Organism-specific databases

    CTDi 23177.
    MGIi MGI:2667663. Cep68.

    Phylogenomic databases

    eggNOGi NOG44343.
    GeneTreei ENSGT00750000117779.
    HOGENOMi HOG000070069.
    HOVERGENi HBG050898.
    InParanoidi Q8C0D9.
    KOi K16764.
    OMAi LSFQAEY.
    OrthoDBi EOG7NW68J.
    PhylomeDBi Q8C0D9.
    TreeFami TF333570.

    Miscellaneous databases

    NextBioi 375198.
    PROi Q8C0D9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C0D9.
    Bgeei Q8C0D9.
    CleanExi MM_CEP68.
    Genevestigatori Q8C0D9.

    Family and domain databases

    InterProi IPR026696. AKAP6/CEP68.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view ]
    PANTHERi PTHR14514. PTHR14514. 1 hit.
    SMARTi SM00150. SPEC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Head and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: 129.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCEP68_MOUSE
    AccessioniPrimary (citable) accession number: Q8C0D9
    Secondary accession number(s): Q3US49, Q5SW85, Q8R2V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3