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Q8C0D9

- CEP68_MOUSE

UniProt

Q8C0D9 - CEP68_MOUSE

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Protein

Centrosomal protein of 68 kDa

Gene
Cep68
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. centrosome organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 68 kDa
Short name:
Cep68
Gene namesi
Name:Cep68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2667663. Cep68.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Centrosomal protein of 68 kDaPRO_0000089495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei459 – 4591Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C0D9.
PRIDEiQ8C0D9.

PTM databases

PhosphoSiteiQ8C0D9.

Expressioni

Gene expression databases

ArrayExpressiQ8C0D9.
BgeeiQ8C0D9.
CleanExiMM_CEP68.
GenevestigatoriQ8C0D9.

Structurei

3D structure databases

ProteinModelPortaliQ8C0D9.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG44343.
GeneTreeiENSGT00750000117779.
HOGENOMiHOG000070069.
HOVERGENiHBG050898.
InParanoidiQ8C0D9.
KOiK16764.
OMAiLSFQAEY.
OrthoDBiEOG7NW68J.
PhylomeDBiQ8C0D9.
TreeFamiTF333570.

Family and domain databases

InterProiIPR026696. AKAP6/CEP68.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR14514. PTHR14514. 1 hit.
SMARTiSM00150. SPEC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C0D9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALSEDEAEA EVSVNTKVPS CGRWNSGKLL PSGLEPDQPL HLGVEGGPLW    50
RAEADPGCIS GVFLSRVHTA SKEPVADRSK PPLRGPLPSA SVGTGEVLHS 100
MGSQMEEDRL PASQDLLPAL QVFGTITVCS GQEADSEDFQ ATLDPSQVLG 150
LSQQPHTSGL PLPPQWKSTV SPGAPQLSSR SISASSVGSS LQDHQEKAGP 200
QRASFANVSS PELTVPQAAH SVVGAGPPLQ GSAQPLTSGS DATGLGKRHL 250
SFQAEYWACA LPNSLPPSPN RHSALWDPNK EYEDLLDYTY PLRPGPQLPK 300
QPESHVLTEP VLQDSGVDLD SLSVSPASTL KSPTNVSHNC SSAEVPTLPF 350
SGARESCLKR WPLGIFQKQG GTSLSSWNQL ASTPRAPGTE DASWENREAA 400
LRGTAEDCLP IGEDLRMGSP QLKTKEKEPP FPRQKRGRQH VSCPACVTPG 450
WPSEEEVGSD EEYLALPTRL TQVSSLVSYS GARPSFVNLH TGAAEEHSSL 500
QVSDSDKPAS PTLDSSHRKH PSGTSFQGPV GQNPCFRHSI QPQDSRGKSS 550
LMSNQTLGVS SKPLKTQPAS KAMTDRRLFS ELVAGETLPR TTDEQEKASL 600
VQCVQTFCCR LEELICWLYN VTDVADLSAP PRTSLTGLKS SLQLYRQFKK 650
DVDEHQSLTE SVLEKGEILL QCLLDNTPVL KDVLERIAKQ SGELESRADH 700
LYDSILASLD MLAGCTLIPD NRPTAAEHPH EGL 733
Length:733
Mass (Da):78,749
Last modified:April 26, 2005 - v2
Checksum:i15D93FCECDDC92A9
GO
Isoform 2 (identifier: Q8C0D9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     647-733: QFKKDVDEHQ...TAAEHPHEGL → VICSPGLFIHGDGS

Note: No experimental confirmation available.

Show »
Length:660
Mass (Da):70,487
Checksum:i4076BCB810C66E65
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei647 – 73387QFKKD…PHEGL → VICSPGLFIHGDGS in isoform 2. VSP_013477Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281P → Q in BAC27484. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031622 mRNA. Translation: BAC27484.1.
AK140820 mRNA. Translation: BAE24488.1.
AL606522 Genomic DNA. Translation: CAI24452.1.
AL606522 Genomic DNA. Translation: CAI24453.1.
BC027174 mRNA. Translation: AAH27174.1.
CCDSiCCDS24456.1. [Q8C0D9-1]
RefSeqiNP_758464.2. NM_172260.3. [Q8C0D9-1]
UniGeneiMm.260314.

Genome annotation databases

EnsembliENSMUST00000050611; ENSMUSP00000054943; ENSMUSG00000044066. [Q8C0D9-1]
ENSMUST00000109596; ENSMUSP00000105225; ENSMUSG00000044066. [Q8C0D9-2]
GeneIDi216543.
KEGGimmu:216543.
UCSCiuc007icw.1. mouse. [Q8C0D9-1]
uc007icx.1. mouse. [Q8C0D9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031622 mRNA. Translation: BAC27484.1 .
AK140820 mRNA. Translation: BAE24488.1 .
AL606522 Genomic DNA. Translation: CAI24452.1 .
AL606522 Genomic DNA. Translation: CAI24453.1 .
BC027174 mRNA. Translation: AAH27174.1 .
CCDSi CCDS24456.1. [Q8C0D9-1 ]
RefSeqi NP_758464.2. NM_172260.3. [Q8C0D9-1 ]
UniGenei Mm.260314.

3D structure databases

ProteinModelPortali Q8C0D9.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8C0D9.

Proteomic databases

PaxDbi Q8C0D9.
PRIDEi Q8C0D9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050611 ; ENSMUSP00000054943 ; ENSMUSG00000044066 . [Q8C0D9-1 ]
ENSMUST00000109596 ; ENSMUSP00000105225 ; ENSMUSG00000044066 . [Q8C0D9-2 ]
GeneIDi 216543.
KEGGi mmu:216543.
UCSCi uc007icw.1. mouse. [Q8C0D9-1 ]
uc007icx.1. mouse. [Q8C0D9-2 ]

Organism-specific databases

CTDi 23177.
MGIi MGI:2667663. Cep68.

Phylogenomic databases

eggNOGi NOG44343.
GeneTreei ENSGT00750000117779.
HOGENOMi HOG000070069.
HOVERGENi HBG050898.
InParanoidi Q8C0D9.
KOi K16764.
OMAi LSFQAEY.
OrthoDBi EOG7NW68J.
PhylomeDBi Q8C0D9.
TreeFami TF333570.

Miscellaneous databases

NextBioi 375198.
PROi Q8C0D9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8C0D9.
Bgeei Q8C0D9.
CleanExi MM_CEP68.
Genevestigatori Q8C0D9.

Family and domain databases

InterProi IPR026696. AKAP6/CEP68.
IPR018159. Spectrin/alpha-actinin.
[Graphical view ]
PANTHERi PTHR14514. PTHR14514. 1 hit.
SMARTi SM00150. SPEC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: 129.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCEP68_MOUSE
AccessioniPrimary (citable) accession number: Q8C0D9
Secondary accession number(s): Q3US49, Q5SW85, Q8R2V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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