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Q8C0D9 (CEP68_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centrosomal protein of 68 kDa

Short name=Cep68
Gene names
Name:Cep68
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length733 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentrosome organization

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcentrosome

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C0D9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C0D9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     647-733: QFKKDVDEHQ...TAAEHPHEGL → VICSPGLFIHGDGS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 733733Centrosomal protein of 68 kDa
PRO_0000089495

Amino acid modifications

Modified residue4591Phosphoserine By similarity

Natural variations

Alternative sequence647 – 73387QFKKD…PHEGL → VICSPGLFIHGDGS in isoform 2.
VSP_013477

Experimental info

Sequence conflict2281P → Q in BAC27484. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 15D93FCECDDC92A9

FASTA73378,749
        10         20         30         40         50         60 
MALSEDEAEA EVSVNTKVPS CGRWNSGKLL PSGLEPDQPL HLGVEGGPLW RAEADPGCIS 

        70         80         90        100        110        120 
GVFLSRVHTA SKEPVADRSK PPLRGPLPSA SVGTGEVLHS MGSQMEEDRL PASQDLLPAL 

       130        140        150        160        170        180 
QVFGTITVCS GQEADSEDFQ ATLDPSQVLG LSQQPHTSGL PLPPQWKSTV SPGAPQLSSR 

       190        200        210        220        230        240 
SISASSVGSS LQDHQEKAGP QRASFANVSS PELTVPQAAH SVVGAGPPLQ GSAQPLTSGS 

       250        260        270        280        290        300 
DATGLGKRHL SFQAEYWACA LPNSLPPSPN RHSALWDPNK EYEDLLDYTY PLRPGPQLPK 

       310        320        330        340        350        360 
QPESHVLTEP VLQDSGVDLD SLSVSPASTL KSPTNVSHNC SSAEVPTLPF SGARESCLKR 

       370        380        390        400        410        420 
WPLGIFQKQG GTSLSSWNQL ASTPRAPGTE DASWENREAA LRGTAEDCLP IGEDLRMGSP 

       430        440        450        460        470        480 
QLKTKEKEPP FPRQKRGRQH VSCPACVTPG WPSEEEVGSD EEYLALPTRL TQVSSLVSYS 

       490        500        510        520        530        540 
GARPSFVNLH TGAAEEHSSL QVSDSDKPAS PTLDSSHRKH PSGTSFQGPV GQNPCFRHSI 

       550        560        570        580        590        600 
QPQDSRGKSS LMSNQTLGVS SKPLKTQPAS KAMTDRRLFS ELVAGETLPR TTDEQEKASL 

       610        620        630        640        650        660 
VQCVQTFCCR LEELICWLYN VTDVADLSAP PRTSLTGLKS SLQLYRQFKK DVDEHQSLTE 

       670        680        690        700        710        720 
SVLEKGEILL QCLLDNTPVL KDVLERIAKQ SGELESRADH LYDSILASLD MLAGCTLIPD 

       730 
NRPTAAEHPH EGL 

« Hide

Isoform 2 [UniParc].

Checksum: 4076BCB810C66E65
Show »

FASTA66070,487

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Head and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: 129.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK031622 mRNA. Translation: BAC27484.1.
AK140820 mRNA. Translation: BAE24488.1.
AL606522 Genomic DNA. Translation: CAI24452.1.
AL606522 Genomic DNA. Translation: CAI24453.1.
BC027174 mRNA. Translation: AAH27174.1.
CCDSCCDS24456.1. [Q8C0D9-1]
RefSeqNP_758464.2. NM_172260.3. [Q8C0D9-1]
UniGeneMm.260314.

3D structure databases

ProteinModelPortalQ8C0D9.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8C0D9.

Proteomic databases

PaxDbQ8C0D9.
PRIDEQ8C0D9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050611; ENSMUSP00000054943; ENSMUSG00000044066. [Q8C0D9-1]
ENSMUST00000109596; ENSMUSP00000105225; ENSMUSG00000044066. [Q8C0D9-2]
GeneID216543.
KEGGmmu:216543.
UCSCuc007icw.1. mouse. [Q8C0D9-1]
uc007icx.1. mouse. [Q8C0D9-2]

Organism-specific databases

CTD23177.
MGIMGI:2667663. Cep68.

Phylogenomic databases

eggNOGNOG44343.
GeneTreeENSGT00750000117779.
HOGENOMHOG000070069.
HOVERGENHBG050898.
InParanoidQ8C0D9.
KOK16764.
OMALSFQAEY.
OrthoDBEOG7NW68J.
PhylomeDBQ8C0D9.
TreeFamTF333570.

Gene expression databases

ArrayExpressQ8C0D9.
BgeeQ8C0D9.
CleanExMM_CEP68.
GenevestigatorQ8C0D9.

Family and domain databases

InterProIPR026696. AKAP6/CEP68.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERPTHR14514. PTHR14514. 1 hit.
SMARTSM00150. SPEC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio375198.
PROQ8C0D9.
SOURCESearch...

Entry information

Entry nameCEP68_MOUSE
AccessionPrimary (citable) accession number: Q8C0D9
Secondary accession number(s): Q3US49, Q5SW85, Q8R2V0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot