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Q8C0C7

- SYFA_MOUSE

UniProt

Q8C0C7 - SYFA_MOUSE

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Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

Farsa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phenylalanine-tRNA ligase activity Source: UniProtKB-EC
  3. poly(A) RNA binding Source: Ensembl
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:Farsa
Synonyms:Farsla
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1913840. Farsa.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 508507Phenylalanine--tRNA ligase alpha subunitPRO_0000280447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei193 – 1931PhosphoserineBy similarity
Modified residuei311 – 3111N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8C0C7.
PaxDbiQ8C0C7.
PRIDEiQ8C0C7.

PTM databases

PhosphoSiteiQ8C0C7.

Expressioni

Gene expression databases

BgeeiQ8C0C7.
CleanExiMM_FARSA.
ExpressionAtlasiQ8C0C7. baseline.
GenevestigatoriQ8C0C7.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

BioGridi211576. 4 interactions.
IntActiQ8C0C7. 4 interactions.
MINTiMINT-4113807.

Structurei

3D structure databases

ProteinModelPortaliQ8C0C7.
SMRiQ8C0C7. Positions 1-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0016.
GeneTreeiENSGT00390000006387.
HOGENOMiHOG000230294.
HOVERGENiHBG068046.
InParanoidiQ8C0C7.
KOiK01889.
OMAiGYKYDWK.
OrthoDBiEOG789CB8.
PhylomeDBiQ8C0C7.
TreeFamiTF300647.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00468. pheS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C0C7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADNPVLELL LRRLEVADGG LDSAELATQL GVEHQAVVGA VKSLQALGEV
60 70 80 90 100
IEAELRSTKC WELTTEGEEI AREGSHEARV FRSIPLEGLV QSELMHLPSG
110 120 130 140 150
KVGFSKAMSN KWIRVDKSAA DGPRVFRVVD SIEDEVQKRL QLVQAGQAEK
160 170 180 190 200
LAEKERNELR KRKLLTEVIL KTYWVSKGKA FSTSVSKQEA ELSPEMISSG
210 220 230 240 250
SWRDRPFKPY NFSARGVLPD SGHLHPLLKV RSQFRQIFLE MGFTEMPTDN
260 270 280 290 300
FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM GYVQRVKRTH
310 320 330 340 350
SQGGYGSQGY KYTWKLEEAR KNLLRTHTTA ASARALYQLA QKKPFTPAKY
360 370 380 390 400
FSIDRVFRNE TLDATHLAEF HQIEGVIADH GLTLGHLMGV LREFFTKLGI
410 420 430 440 450
TQLRFKPAYN PYTEPSMEVF SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE
460 470 480 490 500
NVSVIAWGLS LERPTMIKYG INNIRELVGH KVNLQMVYDS PVCRLDIEPR

SSKTQEAA
Length:508
Mass (Da):57,599
Last modified:March 1, 2003 - v1
Checksum:i9C125BC4D4A26DAA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911G → D in AAH06862. (PubMed:15489334)Curated
Sequence conflicti291 – 2911G → D in AAH13533. (PubMed:15489334)Curated
Sequence conflicti343 – 3431Missing in AAH13533. (PubMed:15489334)Curated
Sequence conflicti455 – 4551I → T in AAH06862. (PubMed:15489334)Curated
Sequence conflicti455 – 4551I → V in BAE32726. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031697 mRNA. Translation: BAC27519.1.
AK154629 mRNA. Translation: BAE32726.1.
BC006862 mRNA. Translation: AAH06862.1.
BC013533 mRNA. Translation: AAH13533.1.
CCDSiCCDS22480.2.
RefSeqiNP_079924.2. NM_025648.3.
UniGeneiMm.292517.

Genome annotation databases

EnsembliENSMUST00000003906; ENSMUSP00000003906; ENSMUSG00000003808.
GeneIDi66590.
KEGGimmu:66590.
UCSCiuc009mnt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031697 mRNA. Translation: BAC27519.1 .
AK154629 mRNA. Translation: BAE32726.1 .
BC006862 mRNA. Translation: AAH06862.1 .
BC013533 mRNA. Translation: AAH13533.1 .
CCDSi CCDS22480.2.
RefSeqi NP_079924.2. NM_025648.3.
UniGenei Mm.292517.

3D structure databases

ProteinModelPortali Q8C0C7.
SMRi Q8C0C7. Positions 1-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211576. 4 interactions.
IntActi Q8C0C7. 4 interactions.
MINTi MINT-4113807.

PTM databases

PhosphoSitei Q8C0C7.

Proteomic databases

MaxQBi Q8C0C7.
PaxDbi Q8C0C7.
PRIDEi Q8C0C7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003906 ; ENSMUSP00000003906 ; ENSMUSG00000003808 .
GeneIDi 66590.
KEGGi mmu:66590.
UCSCi uc009mnt.2. mouse.

Organism-specific databases

CTDi 2193.
MGIi MGI:1913840. Farsa.

Phylogenomic databases

eggNOGi COG0016.
GeneTreei ENSGT00390000006387.
HOGENOMi HOG000230294.
HOVERGENi HBG068046.
InParanoidi Q8C0C7.
KOi K01889.
OMAi GYKYDWK.
OrthoDBi EOG789CB8.
PhylomeDBi Q8C0C7.
TreeFami TF300647.

Miscellaneous databases

ChiTaRSi Farsa. mouse.
NextBioi 322092.
PROi Q8C0C7.
SOURCEi Search...

Gene expression databases

Bgeei Q8C0C7.
CleanExi MM_FARSA.
ExpressionAtlasi Q8C0C7. baseline.
Genevestigatori Q8C0C7.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01409. tRNA-synt_2d. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00468. pheS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Mammary tumor.

Entry informationi

Entry nameiSYFA_MOUSE
AccessioniPrimary (citable) accession number: Q8C0C7
Secondary accession number(s): Q3U3Q9, Q91WR4, Q922S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3