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Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

Farsa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei329L-phenylalanineBy similarity1
Binding sitei435L-phenylalanineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20By similarity)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:Farsa
Synonyms:Farsla
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913840 Farsa

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002804472 – 508Phenylalanine--tRNA ligase alpha subunitAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei301PhosphoserineCombined sources1
Modified residuei311N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8C0C7
MaxQBiQ8C0C7
PaxDbiQ8C0C7
PeptideAtlasiQ8C0C7
PRIDEiQ8C0C7

PTM databases

iPTMnetiQ8C0C7
PhosphoSitePlusiQ8C0C7

Expressioni

Gene expression databases

BgeeiENSMUSG00000003808
CleanExiMM_FARSA
ExpressionAtlasiQ8C0C7 baseline and differential
GenevisibleiQ8C0C7 MM

Interactioni

Subunit structurei

Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.By similarity

Protein-protein interaction databases

BioGridi211576, 4 interactors
IntActiQ8C0C7, 7 interactors
MINTiQ8C0C7
STRINGi10090.ENSMUSP00000003906

Structurei

3D structure databases

ProteinModelPortaliQ8C0C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni372 – 374L-phenylalanine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2784 Eukaryota
COG0016 LUCA
GeneTreeiENSGT00390000006387
HOGENOMiHOG000230294
HOVERGENiHBG068046
InParanoidiQ8C0C7
KOiK01889
OMAiRFKPAFN
OrthoDBiEOG091G04JI
PhylomeDBiQ8C0C7
TreeFamiTF300647

Family and domain databases

InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004529 Phe-tRNA-synth_IIc_asu
IPR002319 Phenylalanyl-tRNA_Synthase
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01409 tRNA-synt_2d, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
TIGRFAMsiTIGR00468 pheS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C0C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNPVLELL LRRLEVADGG LDSAELATQL GVEHQAVVGA VKSLQALGEV
60 70 80 90 100
IEAELRSTKC WELTTEGEEI AREGSHEARV FRSIPLEGLV QSELMHLPSG
110 120 130 140 150
KVGFSKAMSN KWIRVDKSAA DGPRVFRVVD SIEDEVQKRL QLVQAGQAEK
160 170 180 190 200
LAEKERNELR KRKLLTEVIL KTYWVSKGKA FSTSVSKQEA ELSPEMISSG
210 220 230 240 250
SWRDRPFKPY NFSARGVLPD SGHLHPLLKV RSQFRQIFLE MGFTEMPTDN
260 270 280 290 300
FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM GYVQRVKRTH
310 320 330 340 350
SQGGYGSQGY KYTWKLEEAR KNLLRTHTTA ASARALYQLA QKKPFTPAKY
360 370 380 390 400
FSIDRVFRNE TLDATHLAEF HQIEGVIADH GLTLGHLMGV LREFFTKLGI
410 420 430 440 450
TQLRFKPAYN PYTEPSMEVF SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE
460 470 480 490 500
NVSVIAWGLS LERPTMIKYG INNIRELVGH KVNLQMVYDS PVCRLDIEPR

SSKTQEAA
Length:508
Mass (Da):57,599
Last modified:March 1, 2003 - v1
Checksum:i9C125BC4D4A26DAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291G → D in AAH06862 (PubMed:15489334).Curated1
Sequence conflicti291G → D in AAH13533 (PubMed:15489334).Curated1
Sequence conflicti343Missing in AAH13533 (PubMed:15489334).Curated1
Sequence conflicti455I → T in AAH06862 (PubMed:15489334).Curated1
Sequence conflicti455I → V in BAE32726 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031697 mRNA Translation: BAC27519.1
AK154629 mRNA Translation: BAE32726.1
BC006862 mRNA Translation: AAH06862.1
BC013533 mRNA Translation: AAH13533.1
CCDSiCCDS22480.2
RefSeqiNP_079924.2, NM_025648.3
UniGeneiMm.292517

Genome annotation databases

EnsembliENSMUST00000003906; ENSMUSP00000003906; ENSMUSG00000003808
GeneIDi66590
KEGGimmu:66590
UCSCiuc009mnt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSYFA_MOUSE
AccessioniPrimary (citable) accession number: Q8C0C7
Secondary accession number(s): Q3U3Q9, Q91WR4, Q922S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health