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Protein

Transcription initiation factor TFIID subunit 5

Gene

Taf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 5
Alternative name(s):
Transcription initiation factor TFIID 100 kDa subunit
Short name:
TAF(II)100
Short name:
TAFII-100
Short name:
TAFII100
Gene namesi
Name:Taf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442144. Taf5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512581 – 801Transcription initiation factor TFIID subunit 5Add BLAST801

Proteomic databases

EPDiQ8C092.
MaxQBiQ8C092.
PaxDbiQ8C092.
PeptideAtlasiQ8C092.
PRIDEiQ8C092.

PTM databases

PhosphoSitePlusiQ8C092.

Interactioni

Subunit structurei

Homodimer. TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230488. 2 interactors.
STRINGi10090.ENSMUSP00000026027.

Structurei

3D structure databases

ProteinModelPortaliQ8C092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 125LisHPROSITE-ProRule annotationAdd BLAST33
Repeati469 – 508WD 1Add BLAST40
Repeati542 – 581WD 2Add BLAST40
Repeati584 – 625WD 3Add BLAST42
Repeati626 – 667WD 4Add BLAST42
Repeati668 – 707WD 5Add BLAST40
Repeati710 – 749WD 6Add BLAST40

Domaini

Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.By similarity

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0263. Eukaryota.
ENOG410XPM5. LUCA.
HOGENOMiHOG000212424.
HOVERGENiHBG050226.
InParanoidiQ8C092.
KOiK03130.
PhylomeDBiQ8C092.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALAEEQTE VAVKLEPEGP PTLLPPQAGD GAGEGSGGTP NNGPNGGGGG
60 70 80 90 100
NVAVAAAAGG DGGTPKPGVA VSAAAPAGAA PVPAAPAEAG APHDRQTLLA
110 120 130 140 150
VLQFLRQSNL REAEEALRRE ARLLEEAVAG SGAPGELDGA GAEAASALLS
160 170 180 190 200
RVTASVPGSA APEPPGTGAS VTSVFSGSAS GPAAPGKVAS VAVEDQPDVS
210 220 230 240 250
AVLSAYNQQG DPTMYEEYYS GLKHFIECSL DCHRAELSQL FYPLFVHMYL
260 270 280 290 300
ELVYNQHENE AKSFFEKFHG DQECYYQDDL RVLSSLTKKE HMKGNETMLD
310 320 330 340 350
FRTSKFVLRI YRDSYQLLKR HLQEKQNNQI WNIVQEHLYI DIFDGMPRSK
360 370 380 390 400
QQIDAMVGSL AGEAKREANK SKVFFGLLKE PEIEVPLDDE DEEGENEEGK
410 420 430 440 450
PKKKKPKKDS IGSKSKKQDP NAPPQNRIPL PELKDSDKLD KIMNMKETTK
460 470 480 490 500
RVRLGPDCLP SICFYTFLNA YQGLTAVDVT DDSSLIAGGF ADSTVRVWSV
510 520 530 540 550
TPKKLRSVKQ ASDLSLIDKE SDDVLERIMD EKTASELKIL YGHSGPVYGA
560 570 580 590 600
SFSPDRNYLL SSSEDGTVRL WSLQTFTCLV GYKGHNYPVW DTQFSPYGYY
610 620 630 640 650
FVSGGHDRVA RLWATDHYQP LRIFAGHLAD VNCTRYHPNS NYVATGSADR
660 670 680 690 700
TVRLWDVLNG NCVRIFTGHK GPIHSLTFSP NGRFLATGAT DGRVLLWDIG
710 720 730 740 750
HGLMVGELKG HTDTVCSLRF SRDGEILASG SMDNTVRLWD AVKAFEDLET
760 770 780 790 800
DDFTTATGHI NLPENSQELL LGTYMTKSTP VVHLHFTRRN LVLAAGAYSP

Q
Length:801
Mass (Da):87,045
Last modified:March 1, 2003 - v1
Checksum:i3E71FF4A99741CCB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Q → E in BAC27638 (PubMed:16141072).Curated1
Sequence conflicti33G → C in BAC27638 (PubMed:16141072).Curated1
Sequence conflicti37 – 38GG → VV in BAC27638 (PubMed:16141072).Curated2
Sequence conflicti56A → S in BAC27638 (PubMed:16141072).Curated1
Sequence conflicti70 – 80AVSAAAPAGAA → GASGGDPEEAV in BAC27638 (PubMed:16141072).CuratedAdd BLAST11
Sequence conflicti84 – 86AAP → DAL in BAC27638 (PubMed:16141072).Curated3
Sequence conflicti92 – 93PH → TN in BAC27638 (PubMed:16141072).Curated2
Sequence conflicti311Y → S in BAC27638 (PubMed:16141072).Curated1
Sequence conflicti636Y → F in BAC27638 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031985 mRNA. Translation: BAC27638.1.
AK088953 mRNA. Translation: BAC40670.1.
CCDSiCCDS29886.1.
RefSeqiNP_796316.2. NM_177342.3.
UniGeneiMm.301522.

Genome annotation databases

GeneIDi226182.
KEGGimmu:226182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031985 mRNA. Translation: BAC27638.1.
AK088953 mRNA. Translation: BAC40670.1.
CCDSiCCDS29886.1.
RefSeqiNP_796316.2. NM_177342.3.
UniGeneiMm.301522.

3D structure databases

ProteinModelPortaliQ8C092.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230488. 2 interactors.
STRINGi10090.ENSMUSP00000026027.

PTM databases

PhosphoSitePlusiQ8C092.

Proteomic databases

EPDiQ8C092.
MaxQBiQ8C092.
PaxDbiQ8C092.
PeptideAtlasiQ8C092.
PRIDEiQ8C092.

Protocols and materials databases

DNASUi226182.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi226182.
KEGGimmu:226182.

Organism-specific databases

CTDi6877.
MGIiMGI:2442144. Taf5.

Phylogenomic databases

eggNOGiKOG0263. Eukaryota.
ENOG410XPM5. LUCA.
HOGENOMiHOG000212424.
HOVERGENiHBG050226.
InParanoidiQ8C092.
KOiK03130.
PhylomeDBiQ8C092.

Miscellaneous databases

PROiQ8C092.
SOURCEiSearch...

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF5_MOUSE
AccessioniPrimary (citable) accession number: Q8C092
Secondary accession number(s): Q8BTR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.