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Protein

Sorting nexin-16

Gene

Snx16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei144 – 1441Phosphatidylinositol 3-phosphateBy similarity
Binding sitei146 – 1461Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei184 – 1841Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-16
Gene namesi
Name:Snx16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1921968. Snx16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Sorting nexin-16PRO_0000236204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei222 – 2221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C080.
PaxDbiQ8C080.
PRIDEiQ8C080.

PTM databases

iPTMnetiQ8C080.
PhosphoSiteiQ8C080.

Expressioni

Gene expression databases

BgeeiQ8C080.
CleanExiMM_SNX16.
ExpressionAtlasiQ8C080. baseline and differential.
GenevisibleiQ8C080. MM.

Interactioni

Subunit structurei

Homooligomer. Interacts with EGFR (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029047.

Structurei

3D structure databases

ProteinModelPortaliQ8C080.
SMRiQ8C080. Positions 107-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 218114PXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili223 – 27856Sequence analysisAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IMHW. Eukaryota.
ENOG410Z8KU. LUCA.
GeneTreeiENSGT00390000005651.
HOGENOMiHOG000013075.
HOVERGENiHBG057106.
InParanoidiQ8C080.
KOiK17928.
OMAiMGNFKQT.
TreeFamiTF324116.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPYVPVPM PIGNSASSFT NNRNQRSSSF GSVSTSSTSS KGQLEDSAVG
60 70 80 90 100
SLKQTNVQDQ MDSASSMCGS PLIRTKFTGT DSSIEYSARP REAEEQHPEA
110 120 130 140 150
VNWEDRPSTP TILGYEVMEE RAKFTVYKIL VKKSPEESWV VFRRYTDFSR
160 170 180 190 200
LNDKLKEMFP GFRLALPPKR WFKDNYNAEF LEDRQLGLQA FLQNLVAHKD
210 220 230 240 250
IANCLAVREF LCLDDPPGPF DSLEESRAFC ETLEETNYHL QRELLEKQKE
260 270 280 290 300
VESLKKLLGE KQLHIDALET RIRTLSLEPG ASLYVSRAEG GQILRVEPSV
310 320 330 340
LQVNRDVLDE ESRADHKPHF NSREAGSVIA GIEVAQLAYN AEDD
Length:344
Mass (Da):38,817
Last modified:July 27, 2011 - v2
Checksum:iF8AD14C543A8EBC6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811L → V in BAC27673 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015872 mRNA. Translation: BAB30011.1.
AK032055 mRNA. Translation: BAC27673.1.
CH466577 Genomic DNA. Translation: EDL05159.1.
BC019424 mRNA. Translation: AAH19424.1.
CCDSiCCDS17244.1.
RefSeqiNP_083344.3. NM_029068.4.
UniGeneiMm.440548.

Genome annotation databases

EnsembliENSMUST00000029047; ENSMUSP00000029047; ENSMUSG00000027534.
GeneIDi74718.
KEGGimmu:74718.
UCSCiuc008opw.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015872 mRNA. Translation: BAB30011.1.
AK032055 mRNA. Translation: BAC27673.1.
CH466577 Genomic DNA. Translation: EDL05159.1.
BC019424 mRNA. Translation: AAH19424.1.
CCDSiCCDS17244.1.
RefSeqiNP_083344.3. NM_029068.4.
UniGeneiMm.440548.

3D structure databases

ProteinModelPortaliQ8C080.
SMRiQ8C080. Positions 107-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029047.

PTM databases

iPTMnetiQ8C080.
PhosphoSiteiQ8C080.

Proteomic databases

MaxQBiQ8C080.
PaxDbiQ8C080.
PRIDEiQ8C080.

Protocols and materials databases

DNASUi74718.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029047; ENSMUSP00000029047; ENSMUSG00000027534.
GeneIDi74718.
KEGGimmu:74718.
UCSCiuc008opw.3. mouse.

Organism-specific databases

CTDi64089.
MGIiMGI:1921968. Snx16.

Phylogenomic databases

eggNOGiENOG410IMHW. Eukaryota.
ENOG410Z8KU. LUCA.
GeneTreeiENSGT00390000005651.
HOGENOMiHOG000013075.
HOVERGENiHBG057106.
InParanoidiQ8C080.
KOiK17928.
OMAiMGNFKQT.
TreeFamiTF324116.

Miscellaneous databases

PROiQ8C080.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C080.
CleanExiMM_SNX16.
ExpressionAtlasiQ8C080. baseline and differential.
GenevisibleiQ8C080. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Testis.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung and Testis.

Entry informationi

Entry nameiSNX16_MOUSE
AccessioniPrimary (citable) accession number: Q8C080
Secondary accession number(s): Q9D525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.