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Q8C078

- KKCC2_MOUSE

UniProt

Q8C078 - KKCC2_MOUSE

Protein

Calcium/calmodulin-dependent protein kinase kinase 2

Gene

Camkk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D By similarity. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals By similarity. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching By similarity. May be involved in hippocampal activation of CREB1.By similarity1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by Ca2+/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei194 – 1941ATPPROSITE-ProRule annotation
    Active sitei312 – 3121Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi171 – 1799ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: UniProtKB
    3. calmodulin-dependent protein kinase activity Source: UniProtKB-EC
    4. protein binding Source: IntAct

    GO - Biological processi

    1. protein autophosphorylation Source: UniProtKB
    2. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 2 (EC:2.7.11.17)
    Short name:
    CaM-KK 2
    Short name:
    CaM-kinase kinase 2
    Short name:
    CaMKK 2
    Alternative name(s):
    Calcium/calmodulin-dependent protein kinase kinase beta
    Short name:
    CaM-KK beta
    Short name:
    CaM-kinase kinase beta
    Short name:
    CaMKK beta
    Gene namesi
    Name:Camkk2
    Synonyms:Kiaa0787
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2444812. Camkk2.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell projection By similarity
    Note: Predominantly nuclear in unstimulated cells. Found in the cytoplasm and neurites after forskolin induction.By similarity

    GO - Cellular componenti

    1. cell projection Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are unable to form spatial long-term memory.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 588587Calcium/calmodulin-dependent protein kinase kinase 2PRO_0000086145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei129 – 1291Phosphoserine1 Publication
    Modified residuei133 – 1331Phosphoserine1 Publication
    Modified residuei495 – 4951PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8C078.
    PaxDbiQ8C078.
    PRIDEiQ8C078.

    PTM databases

    PhosphoSiteiQ8C078.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested. A differential expression pattern compared to CAMKK1 is observed in the brain.1 Publication

    Gene expression databases

    GenevestigatoriQ8C078.

    Interactioni

    Subunit structurei

    Interacts with calmodulin.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPM1FP495933EBI-937199,EBI-719945From a different organism.

    Protein-protein interaction databases

    IntActiQ8C078. 3 interactions.
    MINTiMINT-4099835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C078.
    SMRiQ8C078. Positions 160-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 446282Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni204 – 22623RP domainAdd
    BLAST
    Regioni472 – 4776Autoinhibitory domainBy similarity
    Regioni475 – 50026Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi549 – 5524Poly-Gly

    Domaini

    The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
    The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00530000063214.
    HOGENOMiHOG000007846.
    HOVERGENiHBG052262.
    InParanoidiQ8C078.
    KOiK07359.
    OMAiMNGRCIC.
    OrthoDBiEOG7F5114.
    PhylomeDBiQ8C078.
    TreeFamiTF313013.

    Family and domain databases

    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C078-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSCVSSQPT SDRVAPQDEL GSGGGSREGQ KPCEALRGLS SLSIHLGMES    50
    FIVVTECEPG RGVDLNLARD QPPEADGQEL PLEASDPESR SPLSGRKMSL 100
    QEPSQGGPAS SSNSLDMNGR CICPSLSYSP ASSPQSSPRM PRRPTVESHH 150
    VSITGLQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 200
    LIRQAGFPRR PPPRGARPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 250
    LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 300
    EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 350
    PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 400
    KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG 450
    AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF 500
    EGSRREERSL SAPGNLLTKK PTREWEPLSE PKEARQRRQP PGPRAGPCGG 550
    GGSALVKGGP CVESWGAPAP GSPPRMPPLQ PEEVMEPE 588
    Length:588
    Mass (Da):64,618
    Last modified:December 7, 2004 - v2
    Checksum:iAED7433ADB3477A5
    GO
    Isoform 2 (identifier: Q8C078-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         520-588: KPTREWEPLS...LQPEEVMEPE → QGSEDSPRGPEPAPVGEEEVLL

    Note: Contains a phosphoserine at position 522.By similarity

    Show »
    Length:541
    Mass (Da):59,617
    Checksum:iFEB2385A4D793FF2
    GO
    Isoform 3 (identifier: Q8C078-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         498-498: N → T
         499-507: Missing.
         508-588: RSLSAPGNLL...LQPEEVMEPE → RSKVAAGRNV...DGAGVAAWTT

    Show »
    Length:579
    Mass (Da):63,477
    Checksum:iA79C6F3E1CE6DDCA
    GO
    Isoform 4 (identifier: Q8C078-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         485-503: ILVKTMIRKRSFGNPFEGS → VRRAGPLTKNKNRESPRQG
         504-588: Missing.

    Show »
    Length:503
    Mass (Da):55,517
    Checksum:i0ADB843145944187
    GO
    Isoform 5 (identifier: Q8C078-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         533-588: EARQRRQPPG...LQPEEVMEPE → VNACLPACAI...YPGSSGPLDG

    Note: No experimental confirmation available.

    Show »
    Length:625
    Mass (Da):68,051
    Checksum:i83E6E29CA297E2B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761Y → F in BAC32023. (PubMed:16141072)Curated
    Sequence conflicti290 – 2901R → H in BAC27681. (PubMed:16141072)Curated
    Sequence conflicti396 – 3983MCL → IWR(PubMed:12654522)Curated
    Sequence conflicti401 – 4011K → R(PubMed:12654522)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei485 – 50319ILVKT…PFEGS → VRRAGPLTKNKNRESPRQG in isoform 4. 1 PublicationVSP_012150Add
    BLAST
    Alternative sequencei498 – 4981N → T in isoform 3. 1 PublicationVSP_012151
    Alternative sequencei499 – 5079Missing in isoform 3. 1 PublicationVSP_012152
    Alternative sequencei504 – 58885Missing in isoform 4. 1 PublicationVSP_012153Add
    BLAST
    Alternative sequencei508 – 58881RSLSA…VMEPE → RSKVAAGRNVPCQRLETCSR SKAAKTAPGAQSRPLWGRRK CSCERWSLRGKLGGSGPWLP TTHASTAARGGDGAGVAAWT T in isoform 3. 1 PublicationVSP_012154Add
    BLAST
    Alternative sequencei520 – 58869KPTRE…VMEPE → QGSEDSPRGPEPAPVGEEEV LL in isoform 2. 1 PublicationVSP_012155Add
    BLAST
    Alternative sequencei533 – 58856EARQR…VMEPE → VNACLPACAIASPPLGPGGG QLQSKHVGISSRQDVPSAGA AVPGSLRASGFPARGIQGLG SHGVSCMRAGLRCMALHPEC LRTYPGSSGPLDG in isoform 5. 1 PublicationVSP_012156Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453383 mRNA. Translation: AAN75696.1.
    AK031399 mRNA. Translation: BAC27387.1.
    AK032070 mRNA. Translation: BAC27681.1.
    AK044660 mRNA. Translation: BAC32023.1.
    BC023103 mRNA. Translation: AAH23103.1.
    AK122370 mRNA. Translation: BAC65652.1.
    CCDSiCCDS19655.1. [Q8C078-2]
    RefSeqiNP_001186605.1. NM_001199676.1. [Q8C078-1]
    NP_663333.1. NM_145358.2. [Q8C078-2]
    XP_006530293.1. XM_006530230.1. [Q8C078-5]
    XP_006530294.1. XM_006530231.1. [Q8C078-5]
    UniGeneiMm.289237.

    Genome annotation databases

    EnsembliENSMUST00000111668; ENSMUSP00000107297; ENSMUSG00000029471. [Q8C078-2]
    GeneIDi207565.
    KEGGimmu:207565.
    UCSCiuc008zlz.3. mouse. [Q8C078-1]
    uc008zma.3. mouse. [Q8C078-2]
    uc008zmb.1. mouse. [Q8C078-5]
    uc008zmc.2. mouse. [Q8C078-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453383 mRNA. Translation: AAN75696.1 .
    AK031399 mRNA. Translation: BAC27387.1 .
    AK032070 mRNA. Translation: BAC27681.1 .
    AK044660 mRNA. Translation: BAC32023.1 .
    BC023103 mRNA. Translation: AAH23103.1 .
    AK122370 mRNA. Translation: BAC65652.1 .
    CCDSi CCDS19655.1. [Q8C078-2 ]
    RefSeqi NP_001186605.1. NM_001199676.1. [Q8C078-1 ]
    NP_663333.1. NM_145358.2. [Q8C078-2 ]
    XP_006530293.1. XM_006530230.1. [Q8C078-5 ]
    XP_006530294.1. XM_006530231.1. [Q8C078-5 ]
    UniGenei Mm.289237.

    3D structure databases

    ProteinModelPortali Q8C078.
    SMRi Q8C078. Positions 160-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8C078. 3 interactions.
    MINTi MINT-4099835.

    PTM databases

    PhosphoSitei Q8C078.

    Proteomic databases

    MaxQBi Q8C078.
    PaxDbi Q8C078.
    PRIDEi Q8C078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111668 ; ENSMUSP00000107297 ; ENSMUSG00000029471 . [Q8C078-2 ]
    GeneIDi 207565.
    KEGGi mmu:207565.
    UCSCi uc008zlz.3. mouse. [Q8C078-1 ]
    uc008zma.3. mouse. [Q8C078-2 ]
    uc008zmb.1. mouse. [Q8C078-5 ]
    uc008zmc.2. mouse. [Q8C078-4 ]

    Organism-specific databases

    CTDi 10645.
    MGIi MGI:2444812. Camkk2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00530000063214.
    HOGENOMi HOG000007846.
    HOVERGENi HBG052262.
    InParanoidi Q8C078.
    KOi K07359.
    OMAi MNGRCIC.
    OrthoDBi EOG7F5114.
    PhylomeDBi Q8C078.
    TreeFami TF313013.

    Miscellaneous databases

    NextBioi 371961.
    PROi Q8C078.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8C078.

    Family and domain databases

    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain."
      Vinet J., Carra S., Blom J.M.C., Harvey M., Brunello N., Barden N., Tascedda F.
      Brain Res. Mol. Brain Res. 111:216-221(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Strain: C57BL/6J.
      Tissue: Medulla oblongata, Retina and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-588 (ISOFORM 5).
      Tissue: Brain.
    5. "Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory."
      Peters M., Mizuno K., Ris L., Angelo M., Godaux E., Giese K.P.
      J. Neurosci. 23:9752-9760(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129 AND SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiKKCC2_MOUSE
    AccessioniPrimary (citable) accession number: Q8C078
    Secondary accession number(s): Q80TS0
    , Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3