Q8C078 (KKCC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium/calmodulin-dependent protein kinase kinase 2
Short name=CaM-KK 2
Short name=CaM-kinase kinase 2
Short name=CaMKK 2
EC=2.7.11.17

Alternative name(s):
Calcium/calmodulin-dependent protein kinase kinase beta
Short name=CaM-KK beta
Short name=CaM-kinase kinase beta
Short name=CaMKK beta

Gene names

Name:	Camkk2
Synonyms:	Kiaa0787

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D By similarity. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals By similarity. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching By similarity. May be involved in hippocampal activation of CREB1. Ref.5
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Activated by Ca2+/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.
Subunit structure	Interacts with calmodulin By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Cell projection By similarity. Note: Predominantly nuclear in unstimulated cells By similarity. Found in the cytoplasm and neurites after forskolin induction By similarity.
Tissue specificity	Expressed in all tissues tested. A differential expression pattern compared to CAMKK1 is observed in the brain. Ref.1
Domain	The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates By similarity.
Post-translational modification	Autophosphorylated and phosphorylated by PKA By similarity. Each isoform may show a different pattern of phosphorylation By similarity.
Disruption phenotype	Mice are unable to form spatial long-term memory. Ref.5
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell projection Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8C078-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8C078-2)

The sequence of this isoform differs from the canonical sequence as follows:
     520-588: KPTREWEPLS...LQPEEVMEPE → QGSEDSPRGPEPAPVGEEEVLL

Note: Contains a phosphoserine at position 522 (By similarity).

Isoform 3 (identifier: Q8C078-3)

The sequence of this isoform differs from the canonical sequence as follows:
     498-498: N → T
     499-507: Missing.
     508-588: RSLSAPGNLL...LQPEEVMEPE → RSKVAAGRNV...DGAGVAAWTT

Isoform 4 (identifier: Q8C078-4)

The sequence of this isoform differs from the canonical sequence as follows:
     485-503: ILVKTMIRKRSFGNPFEGS → VRRAGPLTKNKNRESPRQG
     504-588: Missing.

Isoform 5 (identifier: Q8C078-5)

The sequence of this isoform differs from the canonical sequence as follows:
     533-588: EARQRRQPPG...LQPEEVMEPE → VNACLPACAI...YPGSSGPLDG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	Calcium/calmodulin-dependent protein kinase kinase 2		PRO_0000086145
Regions
	Domain	165 – 446	282	Protein kinase
	Nucleotide binding	171 – 179	9	ATP By similarity
	Region	204 – 226	23	RP domain
	Region	472 – 477	6	Autoinhibitory domain By similarity
	Region	475 – 500	26	Calmodulin-binding By similarity
	Compositional bias	549 – 552	4	Poly-Gly
Sites
	Active site	312	1	Proton acceptor By similarity
	Binding site	194	1	ATP By similarity
Amino acid modifications
	Modified residue	129	1	Phosphoserine Ref.7
	Modified residue	133	1	Phosphoserine Ref.7
	Modified residue	495	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	485 – 503	19	ILVKT…PFEGS → VRRAGPLTKNKNRESPRQG in isoform 4.		VSP_012150
	Alternative sequence	498	1	N → T in isoform 3.		VSP_012151
	Alternative sequence	499 – 507	9	Missing in isoform 3.		VSP_012152
	Alternative sequence	504 – 588	85	Missing in isoform 4.		VSP_012153
	Alternative sequence	508 – 588	81	RSLSA…VMEPE → RSKVAAGRNVPCQRLETCSR SKAAKTAPGAQSRPLWGRRK CSCERWSLRGKLGGSGPWLP TTHASTAARGGDGAGVAAWT T in isoform 3.		VSP_012154
	Alternative sequence	520 – 588	69	KPTRE…VMEPE → QGSEDSPRGPEPAPVGEEEV LL in isoform 2.		VSP_012155
	Alternative sequence	533 – 588	56	EARQR…VMEPE → VNACLPACAIASPPLGPGGG QLQSKHVGISSRQDVPSAGA AVPGSLRASGFPARGIQGLG SHGVSCMRAGLRCMALHPEC LRTYPGSSGPLDG in isoform 5.		VSP_012156
Experimental info
	Sequence conflict	176	1	Y → F in BAC32023. Ref.2
	Sequence conflict	290	1	R → H in BAC27681. Ref.2
	Sequence conflict	396 – 398	3	MCL → IWR Ref.1
	Sequence conflict	401	1	K → R Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 2. Checksum: AED7433ADB3477A5	FASTA	588	64,618
	10 20 30 40 50 60 MSSCVSSQPT SDRVAPQDEL GSGGGSREGQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 70 80 90 100 110 120 RGVDLNLARD QPPEADGQEL PLEASDPESR SPLSGRKMSL QEPSQGGPAS SSNSLDMNGR 130 140 150 160 170 180 CICPSLSYSP ASSPQSSPRM PRRPTVESHH VSITGLQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGARPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTREWEPLSE PKEARQRRQP 550 560 570 580 PGPRAGPCGG GGSALVKGGP CVESWGAPAP GSPPRMPPLQ PEEVMEPE
	Isoform 2 [UniParc]. Checksum: FEB2385A4D793FF2	FASTA	541	59,617
	10 20 30 40 50 60 MSSCVSSQPT SDRVAPQDEL GSGGGSREGQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 70 80 90 100 110 120 RGVDLNLARD QPPEADGQEL PLEASDPESR SPLSGRKMSL QEPSQGGPAS SSNSLDMNGR 130 140 150 160 170 180 CICPSLSYSP ASSPQSSPRM PRRPTVESHH VSITGLQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGARPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKQ GSEDSPRGPE PAPVGEEEVL L
	Isoform 3 [UniParc]. Checksum: A79C6F3E1CE6DDCA	FASTA	579	63,477
	10 20 30 40 50 60 MSSCVSSQPT SDRVAPQDEL GSGGGSREGQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 70 80 90 100 110 120 RGVDLNLARD QPPEADGQEL PLEASDPESR SPLSGRKMSL QEPSQGGPAS SSNSLDMNGR 130 140 150 160 170 180 CICPSLSYSP ASSPQSSPRM PRRPTVESHH VSITGLQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGARPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGTRS KVAAGRNVPC QRLETCSRSK AAKTAPGAQS RPLWGRRKCS 550 560 570 CERWSLRGKL GGSGPWLPTT HASTAARGGD GAGVAAWTT
	Isoform 4 [UniParc]. Checksum: 0ADB843145944187	FASTA	503	55,517
	10 20 30 40 50 60 MSSCVSSQPT SDRVAPQDEL GSGGGSREGQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 70 80 90 100 110 120 RGVDLNLARD QPPEADGQEL PLEASDPESR SPLSGRKMSL QEPSQGGPAS SSNSLDMNGR 130 140 150 160 170 180 CICPSLSYSP ASSPQSSPRM PRRPTVESHH VSITGLQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGARPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 LATVVRRAGP LTKNKNRESP RQG
	Isoform 5 [UniParc]. Checksum: 83E6E29CA297E2B5	FASTA	625	68,051
	10 20 30 40 50 60 MSSCVSSQPT SDRVAPQDEL GSGGGSREGQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 70 80 90 100 110 120 RGVDLNLARD QPPEADGQEL PLEASDPESR SPLSGRKMSL QEPSQGGPAS SSNSLDMNGR 130 140 150 160 170 180 CICPSLSYSP ASSPQSSPRM PRRPTVESHH VSITGLQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGARPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTREWEPLSE PKVNACLPAC 550 560 570 580 590 600 AIASPPLGPG GGQLQSKHVG ISSRQDVPSA GAAVPGSLRA SGFPARGIQG LGSHGVSCMR 610 620 AGLRCMALHP ECLRTYPGSS GPLDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain." Vinet J., Carra S., Blom J.M.C., Harvey M., Brunello N., Barden N., Tascedda F. Brain Res. Mol. Brain Res. 111:216-221(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). Strain: C57BL/6J. Tissue: Medulla oblongata, Retina and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Mammary tumor.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-588 (ISOFORM 5). Tissue: Brain.
[5]	"Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory." Peters M., Mizuno K., Ris L., Angelo M., Godaux E., Giese K.P. J. Neurosci. 23:9752-9760(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[6]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, MASS SPECTROMETRY. Tissue: Brain cortex.
[7]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129 AND SER-133, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF453383 mRNA. Translation: AAN75696.1. AK031399 mRNA. Translation: BAC27387.1. AK032070 mRNA. Translation: BAC27681.1. AK044660 mRNA. Translation: BAC32023.1. BC023103 mRNA. Translation: AAH23103.1. AK122370 mRNA. Translation: BAC65652.1.
IPI	IPI00404152. IPI00404236. IPI00457626. IPI00480226. IPI00480493.
RefSeq	NP_001186605.1. NM_001199676.1. NP_663333.1. NM_145358.2.
UniGene	Mm.289237. Mm.474852.
3D structure databases
ProteinModelPortal	Q8C078.
SMR	Q8C078. Positions 160-507.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8C078. 1 interaction.
PTM databases
PhosphoSite	Q8C078.
Proteomic databases
PaxDb	Q8C078.
PRIDE	Q8C078.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000111668; ENSMUSP00000107297; ENSMUSG00000029471.
GeneID	207565.
KEGG	mmu:207565.
UCSC	uc008zlz.2. mouse. uc008zma.2. mouse. uc008zmb.1. mouse. uc008zmc.2. mouse.
Organism-specific databases
CTD	10645.
MGI	MGI:2444812. Camkk2.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00530000063214.
HOGENOM	HOG000007846.
HOVERGEN	HBG052262.
InParanoid	Q8C078.
KO	K07359.
OrthoDB	EOG4C5CJQ.
Gene expression databases
Genevestigator	Q8C078.
GermOnline	ENSMUSG00000029471. Mus musculus.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
PANTHER	PTHR24347. PTHR24347. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	371961.
SOURCE	Search...

Entry information

Entry name

KKCC2_MOUSE

Accession

Primary (citable) accession number: Q8C078
Secondary accession number(s): Q80TS0 , Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program