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Q8C050

- KS6A5_MOUSE

UniProt

Q8C050 - KS6A5_MOUSE

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Protein

Ribosomal protein S6 kinase alpha-5

Gene
Rps6ka5, Msk1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.9 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Magnesium By similarity.1 Publication

Enzyme regulationi

Activated by phosphorylation at Ser-359, Thr-645 and Thr-764 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-211, Ser-375 and Ser-380 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-814, Ser-816 and Ser-822 in its own C-terminal region.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801ATP By similarityBy similarity
Active sitei176 – 1761Proton acceptor By similarityBy similarity
Binding sitei454 – 4541ATP By similarityBy similarity
Active sitei608 – 6081Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 629ATP By similarityBy similarity
Nucleotide bindingi431 – 44010ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: InterPro
  3. protein binding Source: IntAct
  4. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. histone H2A-S1 phosphorylation Source: UniProtKB
  2. histone H3-S10 phosphorylation Source: UniProtKB
  3. histone H3-S28 phosphorylation Source: UniProtKB
  4. inflammatory response Source: UniProtKB-KW
  5. interleukin-1-mediated signaling pathway Source: Ensembl
  6. intracellular signal transduction Source: UniProtKB
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of histone acetylation Source: Ensembl
  9. positive regulation of histone phosphorylation Source: Ensembl
  10. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. protein phosphorylation Source: UniProtKB
  13. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Inflammatory response, Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_215063. ERK/MAPK targets.
REACT_224314. CREB phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase alpha-5 (EC:2.7.11.1)
Short name:
S6K-alpha-5
Alternative name(s):
90 kDa ribosomal protein S6 kinase 5
Nuclear mitogen- and stress-activated protein kinase 1
RSK-like protein kinase
Short name:
RLSK
Gene namesi
Name:Rps6ka5
Synonyms:Msk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1920336. Rps6ka5.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Ribosomal protein S6 kinase alpha-5PRO_0000086208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111Phosphoserine; by autocatalysis By similarityBy similarity
Modified residuei359 – 3591Phosphoserine; by MAPK1, MAPK3 and MAPK14 By similarityBy similarity
Modified residuei375 – 3751Phosphoserine; by autocatalysis By similarityBy similarity
Modified residuei380 – 3801Phosphoserine; by autocatalysis By similarity
Modified residuei645 – 6451Phosphothreonine; by MAPK1, MAPK3 and MAPK14 By similarity
Modified residuei711 – 7111Phosphoserine By similarity
Modified residuei721 – 7211Phosphoserine By similarity
Modified residuei759 – 7591Phosphoserine By similarity
Modified residuei764 – 7641Phosphothreonine; by MAPK1, MAPK3 and MAPK14 By similarity
Modified residuei814 – 8141Phosphoserine; by autocatalysis By similarityBy similarity
Modified residuei816 – 8161Phosphoserine; by autocatalysis By similarity
Modified residuei822 – 8221Phosphoserine; by autocatalysis By similarity

Post-translational modificationi

Ser-375 and Thr-645 phosphorylation is required for kinase activity. Ser-375 and Ser-211 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-359, Thr-645 and Thr-764 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-814, Ser-816 and Ser-822 by the N-terminal kinase domain By similarity.
Ubiquitinated By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8C050.
PaxDbiQ8C050.
PRIDEiQ8C050.

PTM databases

PhosphoSiteiQ8C050.

Expressioni

Gene expression databases

BgeeiQ8C050.
CleanExiMM_RPS6KA5.
GenevestigatoriQ8C050.

Interactioni

Subunit structurei

Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
RaraP114162EBI-8391218,EBI-346736

Protein-protein interaction databases

BioGridi215759. 6 interactions.
IntActiQ8C050. 2 interactions.
MINTiMINT-4116279.
STRINGi10090.ENSMUSP00000042987.

Structurei

3D structure databases

ProteinModelPortaliQ8C050.
SMRiQ8C050. Positions 23-379, 414-793.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 317270Protein kinase 1Add
BLAST
Domaini318 – 38669AGC-kinase C-terminalAdd
BLAST
Domaini428 – 675248Protein kinase 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110260.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ8C050.
KOiK04445.
OMAiFQSHDKS.
OrthoDBiEOG76HQ0Z.
PhylomeDBiQ8C050.
TreeFamiTF313438.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 3 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q8C050-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGEGGGSGG AGTSGDSGDG GEQLLTVKHE LRTANLTGHA EKVGIENFEL    50
LKVLGTGAYG KVFLVRKISG HDAGKLYAMK VLKKATIVQK AKTTEHTRTE 100
RQVLEHIRQS PFLVTLHYAF QTETKLHLIL DYINGGELFT HLSQRERFTE 150
HEVQIYVGEI VLALEHLHKL GIIYRDIKLE NILLDSNGHV VLTDFGLSKE 200
FVADETERAY SFCGTIEYMA PDIVRGGDSG HDKAVDWWSL GVLMYELLTG 250
ASPFTVDGEK NSQAEISRRI LKSEPPYPQE MSTVAKDLLQ RLLMKDPKKR 300
LGCGPRDAEE IKEHLFFEKI KWDDLAAKKV PAPFKPVIRD ELDVSNFAEE 350
FTEMDPTYSP AALPQSSERL FQGYSFVAPS ILFKRNAAVI DPLQFHMGVD 400
RPGVTNVARS AMMKDSPFYQ HYDLDLKDKP LGEGSFSICR KCVHKKTNQA 450
FAVKIISKRM EANTQKEITA LKLCEGHPNI VKLHEVFHDQ VAASAQPPGQ 500
VVLCSLLLLA LLFNRSLTRK PVTWTWLVHS TSQLPPLPPP MPEIVLFILL 550
SDNGQLHTFL VMELLNGGEL FERIKRKKHF SETEASYIMR KLVSAVSHMH 600
DVGVVHRDLK PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL 650
HYAAPELLTH NGYDESCDLW SLGVILYTML SGQVPFQSHD RSLTCTSAVE 700
IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG LLTVDPNKRL KMSGLRYNEW 750
LQDGSQLSSN PLMTPDILGS SGAAVHTCVK ATFHAFNKYK REGFCLQNVD 800
KAPLAKRRKM KRTSTSTETR SSSSESSRSS SSQSHGKTTP TKTLQPSNPT 850
EGSNPDTLFQ FSD 863
Length:863
Mass (Da):96,583
Last modified:October 24, 2003 - v2
Checksum:i7A3C76D4036EA3EA
GO
Isoform 1 (identifier: Q8C050-2) [UniParc]FASTAAdd to Basket

Also known as: 5

The sequence of this isoform differs from the canonical sequence as follows:
     490-554: Missing.

Show »
Length:798
Mass (Da):89,515
Checksum:i57AB12399BEF7B0E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei490 – 55465Missing in isoform 1. VSP_050613Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 1514EGEGG…AGTSG → GGRAAAAAARAPAE in AAQ24165. 1 PublicationAdd
BLAST
Sequence conflicti117 – 1171H → N in BAC27809. 1 Publication
Sequence conflicti376 – 3761F → Y in BAC27809. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY341873 mRNA. Translation: AAQ24158.1.
AY341881 mRNA. Translation: AAQ24165.1.
AK032316 mRNA. Translation: BAC27809.1.
BC035298 mRNA. Translation: AAH35298.1.
CCDSiCCDS26107.1. [Q8C050-1]
RefSeqiNP_705815.1. NM_153587.2. [Q8C050-1]
XP_006516337.1. XM_006516274.1. [Q8C050-2]
UniGeneiMm.220417.
Mm.392855.

Genome annotation databases

EnsembliENSMUST00000043599; ENSMUSP00000042987; ENSMUSG00000021180. [Q8C050-1]
GeneIDi73086.
KEGGimmu:73086.
UCSCiuc007ost.1. mouse. [Q8C050-1]
uc007osu.1. mouse. [Q8C050-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY341873 mRNA. Translation: AAQ24158.1 .
AY341881 mRNA. Translation: AAQ24165.1 .
AK032316 mRNA. Translation: BAC27809.1 .
BC035298 mRNA. Translation: AAH35298.1 .
CCDSi CCDS26107.1. [Q8C050-1 ]
RefSeqi NP_705815.1. NM_153587.2. [Q8C050-1 ]
XP_006516337.1. XM_006516274.1. [Q8C050-2 ]
UniGenei Mm.220417.
Mm.392855.

3D structure databases

ProteinModelPortali Q8C050.
SMRi Q8C050. Positions 23-379, 414-793.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215759. 6 interactions.
IntActi Q8C050. 2 interactions.
MINTi MINT-4116279.
STRINGi 10090.ENSMUSP00000042987.

PTM databases

PhosphoSitei Q8C050.

Proteomic databases

MaxQBi Q8C050.
PaxDbi Q8C050.
PRIDEi Q8C050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043599 ; ENSMUSP00000042987 ; ENSMUSG00000021180 . [Q8C050-1 ]
GeneIDi 73086.
KEGGi mmu:73086.
UCSCi uc007ost.1. mouse. [Q8C050-1 ]
uc007osu.1. mouse. [Q8C050-2 ]

Organism-specific databases

CTDi 9252.
MGIi MGI:1920336. Rps6ka5.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110260.
HOGENOMi HOG000233033.
HOVERGENi HBG108317.
InParanoidi Q8C050.
KOi K04445.
OMAi FQSHDKS.
OrthoDBi EOG76HQ0Z.
PhylomeDBi Q8C050.
TreeFami TF313438.

Enzyme and pathway databases

Reactomei REACT_215063. ERK/MAPK targets.
REACT_224314. CREB phosphorylation.

Miscellaneous databases

NextBioi 337443.
PROi Q8C050.
SOURCEi Search...

Gene expression databases

Bgeei Q8C050.
CleanExi MM_RPS6KA5.
Genevestigatori Q8C050.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 3 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTi SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 3 hits.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse ribosomal protein S6 kinase, 90kDa, polypeptide 5 (RPS6KA5)."
    Zhou G., Wang J., Xu W.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  4. "Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1."
    Zhong S., Jansen C., She Q.-B., Goto H., Inagaki M., Bode A.M., Ma W.-Y., Dong Z.
    J. Biol. Chem. 276:33213-33219(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF HISTONE H3.
  5. "MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells."
    Zhang Y., Liu G., Dong Z.
    J. Biol. Chem. 276:42534-42542(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF STAT3.
  6. "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts."
    Wiggin G.R., Soloaga A., Foster J.M., Murray-Tait V., Cohen P., Arthur J.S.
    Mol. Cell. Biol. 22:2871-2881(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF CREB1 AND ATF1.
  7. "Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)."
    Vermeulen L., De Wilde G., Van Damme P., Vanden Berghe W., Haegeman G.
    EMBO J. 22:1313-1324(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neurones."
    Hughes J.P., Staton P.C., Wilkinson M.G., Strijbos P.J., Skaper S.D., Arthur J.S., Reith A.D.
    J. Neurochem. 86:25-32(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL DEATH.
  9. "MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2."
    Dyson M.H., Thomson S., Inagaki M., Goto H., Arthur S.J., Nightingale K., Iborra F.J., Mahadevan L.C.
    J. Cell Sci. 118:2247-2259(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF HISTONE H3.
  10. "ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts."
    Kefaloyianni E., Gaitanaki C., Beis I.
    Cell. Signal. 18:2238-2251(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF RELA/NFKB3.
  11. "The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation."
    Duncan E.A., Anest V., Cogswell P., Baldwin A.S.
    J. Biol. Chem. 281:12521-12525(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF HISTONE H3.
  12. "The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling."
    Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J., Park J.M., Wingate A., Monk C.E., Toth R., Santos S.G., Iversen L., Arthur J.S.
    Nat. Immunol. 9:1028-1036(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF CREB1; ATF1 AND HISTONE H3.

Entry informationi

Entry nameiKS6A5_MOUSE
AccessioniPrimary (citable) accession number: Q8C050
Secondary accession number(s): Q8CI92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Enzyme activity requires the presence of both kinase domains By similarity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi