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Protein

Rho guanine nucleotide exchange factor 10

Gene

Arhgef10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in developmental myelination of peripheral nerves.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10
Gene namesi
Name:Arhgef10
Synonyms:Kiaa0294
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2444453. Arhgef10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13451345Rho guanine nucleotide exchange factor 10PRO_0000080927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571PhosphoserineCombined sources
Modified residuei355 – 3551PhosphoserineBy similarity
Modified residuei1262 – 12621PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C033.
MaxQBiQ8C033.
PaxDbiQ8C033.
PRIDEiQ8C033.

PTM databases

iPTMnetiQ8C033.
PhosphoSiteiQ8C033.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Found in the neuroepithelium of the meninges at E8.5, and in the roof plate of the rhombencephalon at E9.5. In E12.5 embryos, it is ubiquitously expressed, with a pronounced expression in the neuroepithelium of brain vesicles, the neural tube, the ganglia and the neural layer of the retina.1 Publication

Gene expression databases

BgeeiQ8C033.
CleanExiMM_ARHGEF10.
ExpressionAtlasiQ8C033. baseline and differential.
GenevisibleiQ8C033. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8C033. 1 interaction.
MINTiMINT-4088277.
STRINGi10090.ENSMUSP00000081225.

Structurei

3D structure databases

ProteinModelPortaliQ8C033.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini397 – 584188DHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili307 – 33529Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
ENOG410ZJK1. LUCA.
GeneTreeiENSGT00670000097546.
HOGENOMiHOG000232060.
HOVERGENiHBG050570.
InParanoidiQ8C033.
KOiK16727.
OMAiGSWNSEP.
OrthoDBiEOG7V765J.
PhylomeDBiQ8C033.
TreeFamiTF331430.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 2 hits.
InterProiIPR030632. ARHGEF10.
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12877:SF14. PTHR12877:SF14. 1 hit.
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q8C033-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQGEASPPV PAEHEAKCDT SNNEEEGELF DFDSGDEVPE ADRQVPSADD
60 70 80 90 100
RTRGAEAGGA DENTCPAGNG TGAEPAPEAE PAKLVVPTKV NPYSVIDITP
110 120 130 140 150
LQEDQPSSPD ANTEEEGVGL RVPSGYSVPV PCGYAVPSNL PLLLPAYSSP
160 170 180 190 200
VIIRAESVEE EEAAETVGDG QCNSLSSEDL PHSSEQGSQE GSALARWAAD
210 220 230 240 250
PANTAWMENP EEAIYDDVPR ENSDSEPDEM IYDDVENGEE GGNSSPEYGW
260 270 280 290 300
SSSEFESYEE PSDSEGKNGI PRSFLRSSHK KQLSHDLTRF KAHCEEKMRG
310 320 330 340 350
LVASTVGAME IQQAKQRQER KMQKLMKAAK EGTKDGLEKT KAAVKRGGSF
360 370 380 390 400
IRTRSLVSQD HRCYFEEEQN LFIDVDCKHP EAVLTPMPEG LSQQQVVRRY
410 420 430 440 450
ILGSIVESEK NYVDALRRIL EQYEKPLSEM EPRLLSDRKL RMVFYRVKEI
460 470 480 490 500
LQCHSMFQIA LASRVSEWDV VETIGDVFVA SFSKSMVLDA YSEYVNNFST
510 520 530 540 550
AVAVLKKTCA TKPAFLEFLK LSQDSSPDRV TLHSLMMRPI QRFPQFILLL
560 570 580 590 600
QDMLKNTAKG HPDRLPLQMA LTELETLAEK LNERKRDADQ RCEIKQIAKA
610 620 630 640 650
INERYLNKLL SSGNRYLVRS DDVIETVYND RGEIVKTKQR RIFMLNDVLM
660 670 680 690 700
CATASSRNSH ESHAVMSQRY LLKWSVPLGH VDVIQYNGGS GAGEHCRHHA
710 720 730 740 750
AHSPESLAVV ANAKPHKVYM GPGQLYQDLQ NLLHDLNVVG QISQLIGNLR
760 770 780 790 800
GSYQNLNQSV AHDWTSGLQR LILRKEDAIR AADRCRIQLQ LPGKQDKSGR
810 820 830 840 850
PTFFTAVFNT LTPAIKESWV SSLQMAKLAL EEENHMGWFC VDDDGNLAKK
860 870 880 890 900
ETHPLLVGHM PVMVAKQPEF KIECAAYNPE PYLSNESQPA SPSTARGFLW
910 920 930 940 950
IGSCSNQMGQ VAIVSFQGSN PKVIECFNVE SRILCMVYIP AEESKPQETT
960 970 980 990 1000
ETKDPEATAS RAPHVPTICL GTEEGSISIY KSSQGCKKVR LQHFYAPDKS
1010 1020 1030 1040 1050
TVMSLACSPQ GLYAGLVNGS VASYTKAPDG SWNSEPQQVI KLGVLPVRSL
1060 1070 1080 1090 1100
LLVEGALWAA SGGQVFMASV ETHTIENQLE AHQDEGMVIS HMAVAGVGIW
1110 1120 1130 1140 1150
IAFTSGSTLR LFHTETLKHL QDVNIDAPVH SMLPGHQRLS VTSLLVCHGL
1160 1170 1180 1190 1200
LMVGTSLGVV VALPVPRLQG IPKVTGRGMV SYHAHNGPVK FIVSATAFQN
1210 1220 1230 1240 1250
KDRARDSPRS GSELQDEDPK DLLCSEEGPS CPGQPDTYTS VWLGDSLGLP
1260 1270 1280 1290 1300
TQKNDLSSSS GSLNLSHGSS SLEHRSVDSS LCDLLRDPSA SPRSRPQGSR
1310 1320 1330 1340
RARASSALVV CGGQGHRRVH RKARQPSQED LVSSVMVWQI PLLGM
Length:1,345
Mass (Da):147,946
Last modified:June 27, 2006 - v2
Checksum:i8583299B5A4C5835
GO
Isoform 2 (identifier: Q8C033-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-321: Missing.

Show »
Length:1,306
Mass (Da):143,451
Checksum:iD7C283159543F50E
GO

Sequence cautioni

The sequence AAH59212.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH66074.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC27875.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD90400.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841Missing in BAC35629 (PubMed:16141072).Curated
Sequence conflicti196 – 1961R → Q in BAC27875 (PubMed:16141072).Curated
Sequence conflicti207 – 2071M → I in BAD90400 (Ref. 2) Curated
Sequence conflicti348 – 3481G → R in BAD90400 (Ref. 2) Curated
Sequence conflicti528 – 5281D → Y in BAC27875 (PubMed:16141072).Curated
Sequence conflicti581 – 5811L → R in BAC35629 (PubMed:16141072).Curated
Sequence conflicti1332 – 13321V → F in AAH06842 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei283 – 32139Missing in isoform 2. 2 PublicationsVSP_010707Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032452 mRNA. Translation: BAC27875.1. Different initiation.
AK054038 mRNA. Translation: BAC35629.2.
AK220332 mRNA. Translation: BAD90400.1. Different initiation.
BC006842 mRNA. Translation: AAH06842.1.
BC047430 mRNA. Translation: AAH47430.1.
BC059212 mRNA. Translation: AAH59212.1. Different initiation.
BC066074 mRNA. Translation: AAH66074.1. Different initiation.
CCDSiCCDS40240.1. [Q8C033-1]
CCDS40241.1. [Q8C033-2]
RefSeqiNP_001032825.1. NM_001037736.2. [Q8C033-2]
NP_766339.2. NM_172751.3. [Q8C033-1]
UniGeneiMm.240298.

Genome annotation databases

EnsembliENSMUST00000084207; ENSMUSP00000081225; ENSMUSG00000071176. [Q8C033-1]
ENSMUST00000110800; ENSMUSP00000106424; ENSMUSG00000071176. [Q8C033-2]
GeneIDi234094.
KEGGimmu:234094.
UCSCiuc009kzg.2. mouse. [Q8C033-1]
uc009kzh.2. mouse. [Q8C033-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032452 mRNA. Translation: BAC27875.1. Different initiation.
AK054038 mRNA. Translation: BAC35629.2.
AK220332 mRNA. Translation: BAD90400.1. Different initiation.
BC006842 mRNA. Translation: AAH06842.1.
BC047430 mRNA. Translation: AAH47430.1.
BC059212 mRNA. Translation: AAH59212.1. Different initiation.
BC066074 mRNA. Translation: AAH66074.1. Different initiation.
CCDSiCCDS40240.1. [Q8C033-1]
CCDS40241.1. [Q8C033-2]
RefSeqiNP_001032825.1. NM_001037736.2. [Q8C033-2]
NP_766339.2. NM_172751.3. [Q8C033-1]
UniGeneiMm.240298.

3D structure databases

ProteinModelPortaliQ8C033.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C033. 1 interaction.
MINTiMINT-4088277.
STRINGi10090.ENSMUSP00000081225.

PTM databases

iPTMnetiQ8C033.
PhosphoSiteiQ8C033.

Proteomic databases

EPDiQ8C033.
MaxQBiQ8C033.
PaxDbiQ8C033.
PRIDEiQ8C033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084207; ENSMUSP00000081225; ENSMUSG00000071176. [Q8C033-1]
ENSMUST00000110800; ENSMUSP00000106424; ENSMUSG00000071176. [Q8C033-2]
GeneIDi234094.
KEGGimmu:234094.
UCSCiuc009kzg.2. mouse. [Q8C033-1]
uc009kzh.2. mouse. [Q8C033-2]

Organism-specific databases

CTDi9639.
MGIiMGI:2444453. Arhgef10.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
ENOG410ZJK1. LUCA.
GeneTreeiENSGT00670000097546.
HOGENOMiHOG000232060.
HOVERGENiHBG050570.
InParanoidiQ8C033.
KOiK16727.
OMAiGSWNSEP.
OrthoDBiEOG7V765J.
PhylomeDBiQ8C033.
TreeFamiTF331430.

Miscellaneous databases

ChiTaRSiArhgef10. mouse.
PROiQ8C033.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C033.
CleanExiMM_ARHGEF10.
ExpressionAtlasiQ8C033. baseline and differential.
GenevisibleiQ8C033. MM.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 2 hits.
InterProiIPR030632. ARHGEF10.
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12877:SF14. PTHR12877:SF14. 1 hit.
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Oviduct.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.
  4. "Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10."
    Verhoeven K., De Jonghe P., Van de Putte T., Nelis E., Zwijsen A., Verpoorten N., De Vriendt E., Jacobs A., Van Gerwen V., Francis A., Ceuterick C., Huylebroeck D., Timmerman V.
    Am. J. Hum. Genet. 73:926-932(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, ALTERNATIVE SPLICING.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157 AND SER-1262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiARHGA_MOUSE
AccessioniPrimary (citable) accession number: Q8C033
Secondary accession number(s): Q5DU38
, Q80VH8, Q8BW76, Q922S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.