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Protein

G-protein coupled receptor 61

Gene

Gpr61

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight (PubMed:21971119).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 61
Gene namesi
Name:Gpr61
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441719 Gpr61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 75CytoplasmicSequence analysis8
Transmembranei76 – 98Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini99 – 112ExtracellularSequence analysisAdd BLAST14
Transmembranei113 – 135Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini136 – 155CytoplasmicSequence analysisAdd BLAST20
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 206ExtracellularSequence analysisAdd BLAST28
Transmembranei207 – 229Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini230 – 287CytoplasmicSequence analysisAdd BLAST58
Transmembranei288 – 310Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini311 – 324ExtracellularSequence analysisAdd BLAST14
Transmembranei325 – 344Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini345 – 449CytoplasmicSequence analysisAdd BLAST105

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice exhibit obesity associated with hyperphagia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695791 – 449G-protein coupled receptor 61Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C010
PRIDEiQ8C010

PTM databases

PhosphoSitePlusiQ8C010

Expressioni

Tissue specificityi

Predominantly expressed in the brain and testes, with relatively lower expression observed in the eye, adrenal gland and pituitary gland.2 Publications

Gene expression databases

BgeeiENSMUSG00000046793
CleanExiMM_GPR61
GenevisibleiQ8C010 MM

Interactioni

Subunit structurei

Forms heterodimer with MTNR1B. Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055557

Structurei

3D structure databases

ProteinModelPortaliQ8C010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000110969
HOGENOMiHOG000133079
HOVERGENiHBG051815
InParanoidiQ8C010
KOiK08414
OMAiAMHHGPL
OrthoDBiEOG091G0719
TreeFamiTF332667

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPIPQSS GNSSTLGRAL QTPGPSTASG VPELGLRDVA SESVALFFML
60 70 80 90 100
LLDLTAVAGN AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS
110 120 130 140 150
SSALFDHALF GEVACRLYLF LSVCFVSLAI LSVSAINVER YYYVVHPMRY
160 170 180 190 200
EVRMTLGLVA SVLVGVWVKA LAMASVPVLG RVYWEEGAPS VNPGCSLQWS
210 220 230 240 250
HSAYCQLFVV VFAVLYFLLP LILIFVVYCS MFRVARVAAM QHGPLPTWME
260 270 280 290 300
TPRQRSESLS SRSTMVTSSG AHQTTPHRTF GGGKAAVVLL AVGGQFLLCW
310 320 330 340 350
LPYFSFHLYV ALSAQPISAG QVENVVTWIG YFCFTSNPFF YGCLNRQIRG
360 370 380 390 400
ELSKQFVCFF KAAPEEELRL PSREGSIEEN FLQFLQGTSE NWVSRPLPSP
410 420 430 440
KREPPPVVDF RIPGQIAEET SEFLEQQLTS DIIMSDSYLR PAPSPRLES
Length:449
Mass (Da):49,382
Last modified:July 27, 2011 - v2
Checksum:i5514589B4EAB6F0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218L → V in BAC27958 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032627 mRNA Translation: BAC27958.1
AK133702 mRNA Translation: BAE21789.1
AL671854 Genomic DNA Translation: CAM27257.1
CH466607 Genomic DNA Translation: EDL01951.1
BC116333 mRNA Translation: AAI16334.1
BC116334 mRNA Translation: AAI16335.1
CCDSiCCDS17752.1
RefSeqiNP_001292390.1, NM_001305461.1
XP_017175048.1, XM_017319559.1
UniGeneiMm.73666

Genome annotation databases

EnsembliENSMUST00000062028; ENSMUSP00000055557; ENSMUSG00000046793
ENSMUST00000116284; ENSMUSP00000111988; ENSMUSG00000046793
GeneIDi229714
KEGGimmu:229714
UCSCiuc008qye.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGPR61_MOUSE
AccessioniPrimary (citable) accession number: Q8C010
Secondary accession number(s): Q3UZR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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