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Protein

Probable G-protein coupled receptor 61

Gene

Gpr61

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 61
Gene namesi
Name:Gpr61
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441719. Gpr61.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 75CytoplasmicSequence analysis8
Transmembranei76 – 98Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini99 – 112ExtracellularSequence analysisAdd BLAST14
Transmembranei113 – 135Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini136 – 155CytoplasmicSequence analysisAdd BLAST20
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 206ExtracellularSequence analysisAdd BLAST28
Transmembranei207 – 229Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini230 – 287CytoplasmicSequence analysisAdd BLAST58
Transmembranei288 – 310Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini311 – 324ExtracellularSequence analysisAdd BLAST14
Transmembranei325 – 344Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini345 – 449CytoplasmicSequence analysisAdd BLAST105

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695791 – 449Probable G-protein coupled receptor 61Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C010.
PRIDEiQ8C010.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046793.
CleanExiMM_GPR61.
GenevisibleiQ8C010. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055557.

Structurei

3D structure databases

ProteinModelPortaliQ8C010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000133079.
HOVERGENiHBG051815.
InParanoidiQ8C010.
KOiK08414.
OMAiAMHHGPL.
OrthoDBiEOG091G0719.
TreeFamiTF332667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPIPQSS GNSSTLGRAL QTPGPSTASG VPELGLRDVA SESVALFFML
60 70 80 90 100
LLDLTAVAGN AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS
110 120 130 140 150
SSALFDHALF GEVACRLYLF LSVCFVSLAI LSVSAINVER YYYVVHPMRY
160 170 180 190 200
EVRMTLGLVA SVLVGVWVKA LAMASVPVLG RVYWEEGAPS VNPGCSLQWS
210 220 230 240 250
HSAYCQLFVV VFAVLYFLLP LILIFVVYCS MFRVARVAAM QHGPLPTWME
260 270 280 290 300
TPRQRSESLS SRSTMVTSSG AHQTTPHRTF GGGKAAVVLL AVGGQFLLCW
310 320 330 340 350
LPYFSFHLYV ALSAQPISAG QVENVVTWIG YFCFTSNPFF YGCLNRQIRG
360 370 380 390 400
ELSKQFVCFF KAAPEEELRL PSREGSIEEN FLQFLQGTSE NWVSRPLPSP
410 420 430 440
KREPPPVVDF RIPGQIAEET SEFLEQQLTS DIIMSDSYLR PAPSPRLES
Length:449
Mass (Da):49,382
Last modified:July 27, 2011 - v2
Checksum:i5514589B4EAB6F0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218L → V in BAC27958 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032627 mRNA. Translation: BAC27958.1.
AK133702 mRNA. Translation: BAE21789.1.
AL671854 Genomic DNA. Translation: CAM27257.1.
CH466607 Genomic DNA. Translation: EDL01951.1.
BC116333 mRNA. Translation: AAI16334.1.
BC116334 mRNA. Translation: AAI16335.1.
CCDSiCCDS17752.1.
RefSeqiNP_001292390.1. NM_001305461.1.
XP_017175048.1. XM_017319559.1.
UniGeneiMm.73666.

Genome annotation databases

EnsembliENSMUST00000062028; ENSMUSP00000055557; ENSMUSG00000046793.
ENSMUST00000116284; ENSMUSP00000111988; ENSMUSG00000046793.
GeneIDi229714.
KEGGimmu:229714.
UCSCiuc008qye.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032627 mRNA. Translation: BAC27958.1.
AK133702 mRNA. Translation: BAE21789.1.
AL671854 Genomic DNA. Translation: CAM27257.1.
CH466607 Genomic DNA. Translation: EDL01951.1.
BC116333 mRNA. Translation: AAI16334.1.
BC116334 mRNA. Translation: AAI16335.1.
CCDSiCCDS17752.1.
RefSeqiNP_001292390.1. NM_001305461.1.
XP_017175048.1. XM_017319559.1.
UniGeneiMm.73666.

3D structure databases

ProteinModelPortaliQ8C010.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055557.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8C010.
PRIDEiQ8C010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062028; ENSMUSP00000055557; ENSMUSG00000046793.
ENSMUST00000116284; ENSMUSP00000111988; ENSMUSG00000046793.
GeneIDi229714.
KEGGimmu:229714.
UCSCiuc008qye.2. mouse.

Organism-specific databases

CTDi83873.
MGIiMGI:2441719. Gpr61.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000133079.
HOVERGENiHBG051815.
InParanoidiQ8C010.
KOiK08414.
OMAiAMHHGPL.
OrthoDBiEOG091G0719.
TreeFamiTF332667.

Miscellaneous databases

PROiQ8C010.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046793.
CleanExiMM_GPR61.
GenevisibleiQ8C010. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR61_MOUSE
AccessioniPrimary (citable) accession number: Q8C010
Secondary accession number(s): Q3UZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.