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Protein

Probable G-protein coupled receptor 61

Gene

Gpr61

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 61
Gene namesi
Name:Gpr61
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441719. Gpr61.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini68 – 758CytoplasmicSequence analysis
Transmembranei76 – 9823Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 11214ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13523Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini136 – 15520CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17823Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 20628ExtracellularSequence analysisAdd
BLAST
Transmembranei207 – 22923Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 28758CytoplasmicSequence analysisAdd
BLAST
Transmembranei288 – 31023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini311 – 32414ExtracellularSequence analysisAdd
BLAST
Transmembranei325 – 34420Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini345 – 449105CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Probable G-protein coupled receptor 61PRO_0000069579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C010.
PRIDEiQ8C010.

PTM databases

PhosphoSiteiQ8C010.

Expressioni

Gene expression databases

BgeeiQ8C010.
CleanExiMM_GPR61.
GenevisibleiQ8C010. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055557.

Structurei

3D structure databases

ProteinModelPortaliQ8C010.
SMRiQ8C010. Positions 43-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000133079.
HOVERGENiHBG051815.
InParanoidiQ8C010.
KOiK08414.
OMAiAMHHGPL.
OrthoDBiEOG722J8X.
TreeFamiTF332667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPIPQSS GNSSTLGRAL QTPGPSTASG VPELGLRDVA SESVALFFML
60 70 80 90 100
LLDLTAVAGN AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS
110 120 130 140 150
SSALFDHALF GEVACRLYLF LSVCFVSLAI LSVSAINVER YYYVVHPMRY
160 170 180 190 200
EVRMTLGLVA SVLVGVWVKA LAMASVPVLG RVYWEEGAPS VNPGCSLQWS
210 220 230 240 250
HSAYCQLFVV VFAVLYFLLP LILIFVVYCS MFRVARVAAM QHGPLPTWME
260 270 280 290 300
TPRQRSESLS SRSTMVTSSG AHQTTPHRTF GGGKAAVVLL AVGGQFLLCW
310 320 330 340 350
LPYFSFHLYV ALSAQPISAG QVENVVTWIG YFCFTSNPFF YGCLNRQIRG
360 370 380 390 400
ELSKQFVCFF KAAPEEELRL PSREGSIEEN FLQFLQGTSE NWVSRPLPSP
410 420 430 440
KREPPPVVDF RIPGQIAEET SEFLEQQLTS DIIMSDSYLR PAPSPRLES
Length:449
Mass (Da):49,382
Last modified:July 27, 2011 - v2
Checksum:i5514589B4EAB6F0B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181L → V in BAC27958 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032627 mRNA. Translation: BAC27958.1.
AK133702 mRNA. Translation: BAE21789.1.
AL671854 Genomic DNA. Translation: CAM27257.1.
CH466607 Genomic DNA. Translation: EDL01951.1.
BC116333 mRNA. Translation: AAI16334.1.
BC116334 mRNA. Translation: AAI16335.1.
CCDSiCCDS17752.1.
RefSeqiNP_001292390.1. NM_001305461.1.
UniGeneiMm.73666.

Genome annotation databases

EnsembliENSMUST00000062028; ENSMUSP00000055557; ENSMUSG00000046793.
ENSMUST00000116284; ENSMUSP00000111988; ENSMUSG00000046793.
GeneIDi229714.
KEGGimmu:229714.
UCSCiuc008qye.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032627 mRNA. Translation: BAC27958.1.
AK133702 mRNA. Translation: BAE21789.1.
AL671854 Genomic DNA. Translation: CAM27257.1.
CH466607 Genomic DNA. Translation: EDL01951.1.
BC116333 mRNA. Translation: AAI16334.1.
BC116334 mRNA. Translation: AAI16335.1.
CCDSiCCDS17752.1.
RefSeqiNP_001292390.1. NM_001305461.1.
UniGeneiMm.73666.

3D structure databases

ProteinModelPortaliQ8C010.
SMRiQ8C010. Positions 43-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055557.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8C010.

Proteomic databases

PaxDbiQ8C010.
PRIDEiQ8C010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062028; ENSMUSP00000055557; ENSMUSG00000046793.
ENSMUST00000116284; ENSMUSP00000111988; ENSMUSG00000046793.
GeneIDi229714.
KEGGimmu:229714.
UCSCiuc008qye.2. mouse.

Organism-specific databases

CTDi83873.
MGIiMGI:2441719. Gpr61.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOGENOMiHOG000133079.
HOVERGENiHBG051815.
InParanoidiQ8C010.
KOiK08414.
OMAiAMHHGPL.
OrthoDBiEOG722J8X.
TreeFamiTF332667.

Miscellaneous databases

NextBioi379635.
PROiQ8C010.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C010.
CleanExiMM_GPR61.
GenevisibleiQ8C010. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Olfactory bulb.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPR61_MOUSE
AccessioniPrimary (citable) accession number: Q8C010
Secondary accession number(s): Q3UZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: November 11, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.