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Q8BZQ7

- ANC2_MOUSE

UniProt

Q8BZQ7 - ANC2_MOUSE

Protein

Anaphase-promoting complex subunit 2

Gene

Anapc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.1 Publication

    Pathwayi

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. positive regulation of axon extension Source: Ensembl
    3. positive regulation of dendrite morphogenesis Source: Ensembl
    4. positive regulation of synapse maturation Source: UniProtKB
    5. positive regulation of synaptic plasticity Source: UniProtKB
    6. protein K11-linked ubiquitination Source: UniProtKB
    7. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis, Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_205250. Phosphorylation of the APC/C.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_207679. Separation of Sister Chromatids.
    REACT_210462. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_215601. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_222875. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaphase-promoting complex subunit 2
    Short name:
    APC2
    Alternative name(s):
    Cyclosome subunit 2
    Gene namesi
    Name:Anapc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2139135. Anapc2.

    Subcellular locationi

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 837837Anaphase-promoting complex subunit 2PRO_0000119812Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei233 – 2331PhosphoserineBy similarity
    Modified residuei329 – 3291PhosphoserineBy similarity
    Modified residuei485 – 4851PhosphoserineBy similarity
    Modified residuei549 – 5491PhosphoserineBy similarity
    Modified residuei825 – 8251Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BZQ7.
    PaxDbiQ8BZQ7.
    PRIDEiQ8BZQ7.

    PTM databases

    PhosphoSiteiQ8BZQ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BZQ7.
    BgeeiQ8BZQ7.
    CleanExiMM_ANAPC2.
    GenevestigatoriQ8BZQ7.

    Interactioni

    Subunit structurei

    The APC/C is composed of at least 12 subunits By similarity. Interacts with NEUROD2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi221196. 13 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZQ7.
    SMRiQ8BZQ7. Positions 495-711.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cullin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5647.
    GeneTreeiENSGT00390000016127.
    HOVERGENiHBG045327.
    InParanoidiQ3TCK5.
    KOiK03349.
    OMAiELLVAWN.
    OrthoDBiEOG76MK7Q.
    TreeFamiTF105442.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR014786. APC_su2_C.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF08672. APC2. 1 hit.
    PF00888. Cullin. 1 hit.
    [Graphical view]
    SMARTiSM01013. APC2. 1 hit.
    SM00182. CULLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF75632. SSF75632. 1 hit.
    PROSITEiPS50069. CULLIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BZQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAEGVAVAA AAAAAAAAAT IIASDDCDSR PGQELLVAWN TVSTGLVPPA    50
    ALGLASSRTS GAVPPKEEEL RAAVEVLRGH GLHSVLEEWF VEVLQNDLQG 100
    NIATEFWNAI ALRENSVDEP QCLGLLLDAF GLLESRLDPY LHSLELLEKW 150
    TRLGLLMGAG AQGLREKVHT MLRGVLFFST PRTFQEMVQR LYGRFLRVYM 200
    QSKRKGEGGT DPELEGELDS RYARRRYYRL LQSPLCAGCG SDKQQCWCRQ 250
    ALEQFNQLSQ VLHRLSLLER VCAEAVTTTL HQVTRERMED RCRGEYERSF 300
    LREFHKWIER VVGWLGKVFL QDNPTRPTSP EAGNTLRRWR CHVQRFFYRI 350
    YATLRIEELF SIIRDFPDSR PAIEDLKYCL ERTDQRQQLL VSLKVALETR 400
    LLHPGVNTCD IITLYISAIK ALRVLDPSMV ILEVACEPIR RYLRTREDTV 450
    RQIVAGLTGD SDGTGDLAVE LSKTDPACLE TGQDSEDDSG EPEDWVPDPV 500
    DADPVKSSSK RRSSDIISLL VSIYGSKDLF INEYRSLLAD RLLHQFSFSP 550
    EREIRNVELL KLRFGEAPMH FCEVMLKDMA DSRRINANIR EEDEKRPVEE 600
    QPPFGVYAVI LSSEFWPPFK DEKLEVPEDI RAALDVYCKK YEKLKAMRTL 650
    SWKHTLGLVT MDVELADRTL SVAVTPVQAV VLLYFQNQAS WTLEELSKVV 700
    KMPVALLRRR MSVWLQQGVL REEPPGTFSV IEEERPQDRD NMVLIDSDDE 750
    SDSGMASQAD QKEEELLLFW AYIQAMLTNL ESLSLERIYS MLRMFVMTGP 800
    ALAEIDLQEL QGYLQKKVRD QQLIYSAGVY RLPKNSN 837
    Length:837
    Mass (Da):95,307
    Last modified:July 27, 2011 - v2
    Checksum:i02E62B928C0E20B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti680 – 6801V → L in BAC28472. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK033784 mRNA. Translation: BAC28472.1.
    AK170676 mRNA. Translation: BAE41951.1.
    AL732309 Genomic DNA. Translation: CAM14680.1.
    BC027351 mRNA. Translation: AAH27351.1.
    BC137583 mRNA. Translation: AAI37584.1.
    CCDSiCCDS15761.1.
    RefSeqiNP_780509.2. NM_175300.4.
    UniGeneiMm.291624.

    Genome annotation databases

    EnsembliENSMUST00000028341; ENSMUSP00000028341; ENSMUSG00000026965.
    GeneIDi99152.
    KEGGimmu:99152.
    UCSCiuc008ird.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK033784 mRNA. Translation: BAC28472.1 .
    AK170676 mRNA. Translation: BAE41951.1 .
    AL732309 Genomic DNA. Translation: CAM14680.1 .
    BC027351 mRNA. Translation: AAH27351.1 .
    BC137583 mRNA. Translation: AAI37584.1 .
    CCDSi CCDS15761.1.
    RefSeqi NP_780509.2. NM_175300.4.
    UniGenei Mm.291624.

    3D structure databases

    ProteinModelPortali Q8BZQ7.
    SMRi Q8BZQ7. Positions 495-711.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 221196. 13 interactions.

    PTM databases

    PhosphoSitei Q8BZQ7.

    Proteomic databases

    MaxQBi Q8BZQ7.
    PaxDbi Q8BZQ7.
    PRIDEi Q8BZQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028341 ; ENSMUSP00000028341 ; ENSMUSG00000026965 .
    GeneIDi 99152.
    KEGGi mmu:99152.
    UCSCi uc008ird.2. mouse.

    Organism-specific databases

    CTDi 29882.
    MGIi MGI:2139135. Anapc2.

    Phylogenomic databases

    eggNOGi COG5647.
    GeneTreei ENSGT00390000016127.
    HOVERGENi HBG045327.
    InParanoidi Q3TCK5.
    KOi K03349.
    OMAi ELLVAWN.
    OrthoDBi EOG76MK7Q.
    TreeFami TF105442.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_205250. Phosphorylation of the APC/C.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_207679. Separation of Sister Chromatids.
    REACT_210462. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_215601. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_222875. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.

    Miscellaneous databases

    NextBioi 353811.
    PROi Q8BZQ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BZQ7.
    Bgeei Q8BZQ7.
    CleanExi MM_ANAPC2.
    Genevestigatori Q8BZQ7.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR014786. APC_su2_C.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF08672. APC2. 1 hit.
    PF00888. Cullin. 1 hit.
    [Graphical view ]
    SMARTi SM01013. APC2. 1 hit.
    SM00182. CULLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75632. SSF75632. 1 hit.
    PROSITEi PS50069. CULLIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Epididymis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    5. "A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation."
      Yang Y., Kim A.H., Yamada T., Wu B., Bilimoria P.M., Ikeuchi Y., de la Iglesia N., Shen J., Bonni A.
      Science 326:575-578(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NEUROD2.

    Entry informationi

    Entry nameiANC2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZQ7
    Secondary accession number(s): Q3TCK5, Q8R2Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3