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Q8BZQ7 (ANC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anaphase-promoting complex subunit 2
Short name=APC2
Alternative name(s):
Cyclosome subunit 2
Gene names
Name:Anapc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length837 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Ref.5

Pathway

Protein modification; protein ubiquitination.

Subunit structure

The APC/C is composed of at least 12 subunits By similarity. Interacts with NEUROD2. Ref.5

Sequence similarities

Belongs to the cullin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 837837Anaphase-promoting complex subunit 2
PRO_0000119812

Amino acid modifications

Modified residue2331Phosphoserine By similarity
Modified residue3291Phosphoserine By similarity
Modified residue4851Phosphoserine By similarity
Modified residue5491Phosphoserine By similarity
Modified residue8251Phosphotyrosine Ref.4

Experimental info

Sequence conflict6801V → L in BAC28472. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BZQ7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 02E62B928C0E20B3

FASTA83795,307
        10         20         30         40         50         60 
MEAEGVAVAA AAAAAAAAAT IIASDDCDSR PGQELLVAWN TVSTGLVPPA ALGLASSRTS 

        70         80         90        100        110        120 
GAVPPKEEEL RAAVEVLRGH GLHSVLEEWF VEVLQNDLQG NIATEFWNAI ALRENSVDEP 

       130        140        150        160        170        180 
QCLGLLLDAF GLLESRLDPY LHSLELLEKW TRLGLLMGAG AQGLREKVHT MLRGVLFFST 

       190        200        210        220        230        240 
PRTFQEMVQR LYGRFLRVYM QSKRKGEGGT DPELEGELDS RYARRRYYRL LQSPLCAGCG 

       250        260        270        280        290        300 
SDKQQCWCRQ ALEQFNQLSQ VLHRLSLLER VCAEAVTTTL HQVTRERMED RCRGEYERSF 

       310        320        330        340        350        360 
LREFHKWIER VVGWLGKVFL QDNPTRPTSP EAGNTLRRWR CHVQRFFYRI YATLRIEELF 

       370        380        390        400        410        420 
SIIRDFPDSR PAIEDLKYCL ERTDQRQQLL VSLKVALETR LLHPGVNTCD IITLYISAIK 

       430        440        450        460        470        480 
ALRVLDPSMV ILEVACEPIR RYLRTREDTV RQIVAGLTGD SDGTGDLAVE LSKTDPACLE 

       490        500        510        520        530        540 
TGQDSEDDSG EPEDWVPDPV DADPVKSSSK RRSSDIISLL VSIYGSKDLF INEYRSLLAD 

       550        560        570        580        590        600 
RLLHQFSFSP EREIRNVELL KLRFGEAPMH FCEVMLKDMA DSRRINANIR EEDEKRPVEE 

       610        620        630        640        650        660 
QPPFGVYAVI LSSEFWPPFK DEKLEVPEDI RAALDVYCKK YEKLKAMRTL SWKHTLGLVT 

       670        680        690        700        710        720 
MDVELADRTL SVAVTPVQAV VLLYFQNQAS WTLEELSKVV KMPVALLRRR MSVWLQQGVL 

       730        740        750        760        770        780 
REEPPGTFSV IEEERPQDRD NMVLIDSDDE SDSGMASQAD QKEEELLLFW AYIQAMLTNL 

       790        800        810        820        830 
ESLSLERIYS MLRMFVMTGP ALAEIDLQEL QGYLQKKVRD QQLIYSAGVY RLPKNSN

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Epididymis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-825, MASS SPECTROMETRY.
Tissue: Mast cell.
[5]"A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation."
Yang Y., Kim A.H., Yamada T., Wu B., Bilimoria P.M., Ikeuchi Y., de la Iglesia N., Shen J., Bonni A.
Science 326:575-578(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NEUROD2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK033784 mRNA. Translation: BAC28472.1.
AK170676 mRNA. Translation: BAE41951.1.
AL732309 Genomic DNA. Translation: CAM14680.1.
BC027351 mRNA. Translation: AAH27351.1.
BC137583 mRNA. Translation: AAI37584.1.
IPIIPI00227654.
RefSeqNP_780509.2. NM_175300.4.
UniGeneMm.291624.

3D structure databases

ProteinModelPortalQ8BZQ7.
SMRQ8BZQ7. Positions 495-711.
ModBaseSearch...

PTM databases

PhosphoSiteQ8BZQ7.

Proteomic databases

PaxDbQ8BZQ7.
PRIDEQ8BZQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028341; ENSMUSP00000028341; ENSMUSG00000026965.
GeneID99152.
KEGGmmu:99152.

Organism-specific databases

CTD29882.
MGIMGI:2139135. Anapc2.

Phylogenomic databases

eggNOGCOG5647.
GeneTreeENSGT00390000016127.
HOVERGENHBG045327.
InParanoidQ3TCK5.
KOK03349.
OMAMLRGVLF.
OrthoDBEOG4T1HM4.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8BZQ7.
BgeeQ8BZQ7.
CleanExMM_ANAPC2.
GenevestigatorQ8BZQ7.
GermOnlineENSMUSG00000026965. Mus musculus.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR014786. APC_su2_C.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF08672. APC2. 1 hit.
PF00888. Cullin. 1 hit.
[Graphical view]
SMARTSM01013. APC2. 1 hit.
SM00182. CULLIN. 1 hit.
[Graphical view]
SUPFAMSSF75632. Cullin_homology. 1 hit.
PROSITEPS50069. CULLIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio353811.
SOURCESearch...

Entry information

Entry nameANC2_MOUSE
AccessionPrimary (citable) accession number: Q8BZQ7
Secondary accession number(s): Q3TCK5, Q8R2Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents