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Protein

Cysteine-rich secretory protein LCCL domain-containing 2

Gene

Crispld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes matrix assembly.1 Publication

GO - Molecular functioni

  • glycosaminoglycan binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • face morphogenesis Source: MGI
  • lung development Source: Ensembl

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein LCCL domain-containing 2
Alternative name(s):
Coffeecrisp
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1926142 Crispld2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000036388523 – 495Cysteine-rich secretory protein LCCL domain-containing 2Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi288 ↔ 306PROSITE-ProRule annotation
Disulfide bondi310 ↔ 330PROSITE-ProRule annotation
Disulfide bondi389 ↔ 411PROSITE-ProRule annotation
Disulfide bondi415 ↔ 438PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BZQ2
PeptideAtlasiQ8BZQ2
PRIDEiQ8BZQ2

PTM databases

iPTMnetiQ8BZQ2
PhosphoSitePlusiQ8BZQ2

Expressioni

Tissue specificityi

Present in kidney renal tubules (at protein level).1 Publication

Developmental stagei

Expressed in the developing oropharynx and nasopharynx at 13.5 dpc, in the mandible at 14.5 dpc and in the cartilage primordia of the nasal bones, palate and tooth germs at 17.5 dpc. Detected in the embryonic liver at 13.5, 14.5 and 17.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000031825
GenevisibleiQ8BZQ2 MM

Interactioni

Subunit structurei

Binds to heparin, dermatan sulfate and chondroitin sulfate.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104600

Structurei

3D structure databases

ProteinModelPortaliQ8BZQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 200SCPAdd BLAST141
Domaini282 – 377LCCL 1PROSITE-ProRule annotationAdd BLAST96
Domaini383 – 486LCCL 2PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000294224
HOVERGENiHBG062505
InParanoidiQ8BZQ2
OMAiYRSPGFH
OrthoDBiEOG091G048D
TreeFamiTF316148

Family and domain databases

Gene3Di2.170.130.20, 2 hits
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR004043 LCCL
IPR036609 LCCL_sf
PANTHERiPTHR10334 PTHR10334, 2 hits
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF03815 LCCL, 2 hits
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00603 LCCL, 2 hits
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
SSF69848 SSF69848, 2 hits
PROSITEiView protein in PROSITE
PS01010 CRISP_2, 1 hit
PS50820 LCCL, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BZQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCLLNNMVL MGLALLVCGV QAFFLPNTTS LEKLLSKYQH AEPHSRVRRA
60 70 80 90 100
IPMSDRQEIL MLHNKLRGQV YPPASNMEHM TWDEELERSA AAWAHRCLWE
110 120 130 140 150
HGPAGLLRSI GQNLAVHWGR YRSPGFHVQS WYDEVKDYTY PYPHECTPRC
160 170 180 190 200
RERCSGPMCT HYTQMVWATT NKIGCAVHTC RNMNVWGDTW ENAVYLVCNY
210 220 230 240 250
SPKGNWIGEA PYKHGRPCSE CPSSYGGGCL NNLCHRAEKP HKHKPEVDMM
260 270 280 290 300
NEVESPPAPE ETHVWVQPRV IKTKKTPVIN FMTQVVHCDT KMKDSCKGST
310 320 330 340 350
CNRYQCPAGC LSNKAKVFGS LFYESSSSIC RAAIHYGVID DRGGLVDVTR
360 370 380 390 400
NGMVPFFVKS QKNGMESLSK YKPSSSFTVS KVTETAVDCH ATVAQLCPFE
410 420 430 440 450
KPATHCPRIQ CPARCGEEPS YWAPVYGTNI YADTSSICKA AVHAGVIVDE
460 470 480 490
VGGYADVMPV DKKKSYVGSL RNGVQSESLN TPQNGNAFRI FAVRQ
Length:495
Mass (Da):55,432
Last modified:March 1, 2003 - v1
Checksum:i7F6D25DDC489610C
GO
Isoform 2 (identifier: Q8BZQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-237: Missing.

Show »
Length:494
Mass (Da):55,361
Checksum:i9B11C19FA833D600
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55D → G in BAE32505 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036331237Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019034 mRNA Translation: BAB31519.2
AK033858 mRNA Translation: BAC28498.1
AK154308 mRNA Translation: BAE32505.1
CH466525 Genomic DNA Translation: EDL11621.1
CH466525 Genomic DNA Translation: EDL11622.1
BC090642 mRNA Translation: AAH90642.1
CCDSiCCDS22714.1 [Q8BZQ2-2]
CCDS80939.1 [Q8BZQ2-1]
RefSeqiNP_001297564.1, NM_001310635.1 [Q8BZQ2-1]
NP_084485.1, NM_030209.4 [Q8BZQ2-2]
XP_006531571.1, XM_006531508.1 [Q8BZQ2-1]
XP_006531572.1, XM_006531509.1 [Q8BZQ2-2]
UniGeneiMm.264680

Genome annotation databases

EnsembliENSMUST00000034282; ENSMUSP00000034282; ENSMUSG00000031825 [Q8BZQ2-1]
ENSMUST00000108972; ENSMUSP00000104600; ENSMUSG00000031825 [Q8BZQ2-2]
ENSMUST00000132583; ENSMUSP00000122962; ENSMUSG00000031825 [Q8BZQ2-2]
GeneIDi78892
KEGGimmu:78892
UCSCiuc009nqq.2 mouse [Q8BZQ2-2]
uc012glv.1 mouse [Q8BZQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRLD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BZQ2
Secondary accession number(s): Q3U4C7, Q9D2R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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