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Protein

Cysteine-rich secretory protein LCCL domain-containing 2

Gene

Crispld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes matrix assembly.1 Publication

GO - Molecular functioni

  • glycosaminoglycan binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • face morphogenesis Source: MGI
  • lung development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein LCCL domain-containing 2
Alternative name(s):
Coffeecrisp
Gene namesi
Name:Crispld2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1926142. Crispld2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • transport vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 495473Cysteine-rich secretory protein LCCL domain-containing 2PRO_0000363885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi288 ↔ 306PROSITE-ProRule annotation
Disulfide bondi310 ↔ 330PROSITE-ProRule annotation
Disulfide bondi389 ↔ 411PROSITE-ProRule annotation
Disulfide bondi415 ↔ 438PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BZQ2.
PaxDbiQ8BZQ2.
PRIDEiQ8BZQ2.

PTM databases

PhosphoSiteiQ8BZQ2.

Expressioni

Tissue specificityi

Present in kidney renal tubules (at protein level).1 Publication

Developmental stagei

Expressed in the developing oropharynx and nasopharynx at 13.5 dpc, in the mandible at 14.5 dpc and in the cartilage primordia of the nasal bones, palate and tooth germs at 17.5 dpc. Detected in the embryonic liver at 13.5, 14.5 and 17.5 dpc.1 Publication

Gene expression databases

BgeeiQ8BZQ2.
GenevisibleiQ8BZQ2. MM.

Interactioni

Subunit structurei

Binds to heparin, dermatan sulfate and chondroitin sulfate.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104600.

Structurei

3D structure databases

ProteinModelPortaliQ8BZQ2.
SMRiQ8BZQ2. Positions 57-234, 306-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 200141SCPAdd
BLAST
Domaini282 – 37796LCCL 1PROSITE-ProRule annotationAdd
BLAST
Domaini383 – 486104LCCL 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 LCCL domains.PROSITE-ProRule annotation
Contains 1 SCP domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000294224.
HOVERGENiHBG062505.
InParanoidiQ8BZQ2.
OMAiKDKCKGS.
OrthoDBiEOG7F7WB4.
TreeFamiTF316148.

Family and domain databases

Gene3Di2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEiPS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BZQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCLLNNMVL MGLALLVCGV QAFFLPNTTS LEKLLSKYQH AEPHSRVRRA
60 70 80 90 100
IPMSDRQEIL MLHNKLRGQV YPPASNMEHM TWDEELERSA AAWAHRCLWE
110 120 130 140 150
HGPAGLLRSI GQNLAVHWGR YRSPGFHVQS WYDEVKDYTY PYPHECTPRC
160 170 180 190 200
RERCSGPMCT HYTQMVWATT NKIGCAVHTC RNMNVWGDTW ENAVYLVCNY
210 220 230 240 250
SPKGNWIGEA PYKHGRPCSE CPSSYGGGCL NNLCHRAEKP HKHKPEVDMM
260 270 280 290 300
NEVESPPAPE ETHVWVQPRV IKTKKTPVIN FMTQVVHCDT KMKDSCKGST
310 320 330 340 350
CNRYQCPAGC LSNKAKVFGS LFYESSSSIC RAAIHYGVID DRGGLVDVTR
360 370 380 390 400
NGMVPFFVKS QKNGMESLSK YKPSSSFTVS KVTETAVDCH ATVAQLCPFE
410 420 430 440 450
KPATHCPRIQ CPARCGEEPS YWAPVYGTNI YADTSSICKA AVHAGVIVDE
460 470 480 490
VGGYADVMPV DKKKSYVGSL RNGVQSESLN TPQNGNAFRI FAVRQ
Length:495
Mass (Da):55,432
Last modified:March 1, 2003 - v1
Checksum:i7F6D25DDC489610C
GO
Isoform 2 (identifier: Q8BZQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-237: Missing.

Show »
Length:494
Mass (Da):55,361
Checksum:i9B11C19FA833D600
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551D → G in BAE32505 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 2371Missing in isoform 2. 2 PublicationsVSP_036331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019034 mRNA. Translation: BAB31519.2.
AK033858 mRNA. Translation: BAC28498.1.
AK154308 mRNA. Translation: BAE32505.1.
CH466525 Genomic DNA. Translation: EDL11621.1.
CH466525 Genomic DNA. Translation: EDL11622.1.
BC090642 mRNA. Translation: AAH90642.1.
CCDSiCCDS22714.1. [Q8BZQ2-2]
CCDS80939.1. [Q8BZQ2-1]
RefSeqiNP_001297564.1. NM_001310635.1. [Q8BZQ2-1]
NP_084485.1. NM_030209.4. [Q8BZQ2-2]
XP_006531571.1. XM_006531508.1. [Q8BZQ2-1]
XP_006531572.1. XM_006531509.1. [Q8BZQ2-2]
UniGeneiMm.264680.

Genome annotation databases

EnsembliENSMUST00000034282; ENSMUSP00000034282; ENSMUSG00000031825. [Q8BZQ2-1]
ENSMUST00000108972; ENSMUSP00000104600; ENSMUSG00000031825. [Q8BZQ2-2]
ENSMUST00000132583; ENSMUSP00000122962; ENSMUSG00000031825. [Q8BZQ2-2]
GeneIDi78892.
KEGGimmu:78892.
UCSCiuc009nqq.2. mouse. [Q8BZQ2-2]
uc012glv.1. mouse. [Q8BZQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019034 mRNA. Translation: BAB31519.2.
AK033858 mRNA. Translation: BAC28498.1.
AK154308 mRNA. Translation: BAE32505.1.
CH466525 Genomic DNA. Translation: EDL11621.1.
CH466525 Genomic DNA. Translation: EDL11622.1.
BC090642 mRNA. Translation: AAH90642.1.
CCDSiCCDS22714.1. [Q8BZQ2-2]
CCDS80939.1. [Q8BZQ2-1]
RefSeqiNP_001297564.1. NM_001310635.1. [Q8BZQ2-1]
NP_084485.1. NM_030209.4. [Q8BZQ2-2]
XP_006531571.1. XM_006531508.1. [Q8BZQ2-1]
XP_006531572.1. XM_006531509.1. [Q8BZQ2-2]
UniGeneiMm.264680.

3D structure databases

ProteinModelPortaliQ8BZQ2.
SMRiQ8BZQ2. Positions 57-234, 306-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104600.

PTM databases

PhosphoSiteiQ8BZQ2.

Proteomic databases

MaxQBiQ8BZQ2.
PaxDbiQ8BZQ2.
PRIDEiQ8BZQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034282; ENSMUSP00000034282; ENSMUSG00000031825. [Q8BZQ2-1]
ENSMUST00000108972; ENSMUSP00000104600; ENSMUSG00000031825. [Q8BZQ2-2]
ENSMUST00000132583; ENSMUSP00000122962; ENSMUSG00000031825. [Q8BZQ2-2]
GeneIDi78892.
KEGGimmu:78892.
UCSCiuc009nqq.2. mouse. [Q8BZQ2-2]
uc012glv.1. mouse. [Q8BZQ2-1]

Organism-specific databases

CTDi83716.
MGIiMGI:1926142. Crispld2.

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000294224.
HOVERGENiHBG062505.
InParanoidiQ8BZQ2.
OMAiKDKCKGS.
OrthoDBiEOG7F7WB4.
TreeFamiTF316148.

Miscellaneous databases

NextBioi349686.
PROiQ8BZQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZQ2.
GenevisibleiQ8BZQ2. MM.

Family and domain databases

Gene3Di2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEiPS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Diencephalon and Pancreas.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Eye.
  4. Cited for: DEVELOPMENTAL STAGE.
  5. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCRLD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BZQ2
Secondary accession number(s): Q3U4C7, Q9D2R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.