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Protein

Neuropeptide S receptor

Gene

Npsr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca2+ stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S receptor
Alternative name(s):
G-protein coupled receptor 154
G-protein coupled receptor PGR14
Gene namesi
Name:Npsr1
Synonyms:Gpr154, Pgr14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2441738. Npsr1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini74 – 829CytoplasmicSequence analysis
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 12320ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini145 – 16420CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini186 – 21227ExtracellularSequence analysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini234 – 27542CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini297 – 31216ExtracellularSequence analysisAdd
BLAST
Transmembranei313 – 33321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini334 – 37138CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5497.
GuidetoPHARMACOLOGYi302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Neuropeptide S receptorPRO_0000069641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BZP8.
PRIDEiQ8BZP8.

PTM databases

PhosphoSiteiQ8BZP8.

Expressioni

Inductioni

Increased expression in lung after ovalbumin induction in a mouse model of ovalbumin-induced lung inflammation.1 Publication

Gene expression databases

BgeeiENSMUSG00000043659.
CleanExiMM_NPSR1.
ExpressionAtlasiQ8BZP8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056432.

Chemistry

BindingDBiQ8BZP8.

Structurei

3D structure databases

ProteinModelPortaliQ8BZP8.
SMRiQ8BZP8. Positions 53-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
KOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000220789.
HOVERGENiHBG106615.
InParanoidiQ8BZP8.
KOiK08376.
OMAiTIWMKSK.
OrthoDBiEOG091G0A5H.
PhylomeDBiQ8BZP8.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24244:SF2. PTHR24244:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANLTEGSF HANQTVPMLD SSPVACTEIV TFTEALVAEE WGSFYSSFKT
60 70 80 90 100
EQLITLWVLF VVTIVGNSVV LFSTCRRKRK SRMTFFVTQL AITDSFTGLI
110 120 130 140 150
NILTDIIWRF TGDFMAPDLV CRVVRYLQVV LLYASTYVLV SLSIDRYHAI
160 170 180 190 200
VYPMKFLQGE KQAKVLIGIA WSLSFLFSIP TLIIFGKRTL SNGEVQCWAL
210 220 230 240 250
WPDDSYWTPY MTIVAFLVYF IPLAIISVIY GLVIRTIWMK SKTHETVISN
260 270 280 290 300
CSDGKLCCSY NRGLISKAKI KAIKYSIVII LAFICCWSPY FLFDILDNFN
310 320 330 340 350
VLPDTKERFY ASVIIQNLPA LNSAINPLIY CIFSSSICSP CKMQRSQDSR
360 370
MTYRERSERH EMQILSKPEF I
Length:371
Mass (Da):42,439
Last modified:March 1, 2003 - v1
Checksum:iFBAF7B45BEE5F844
GO

Sequence cautioni

The sequence BAC30949 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033957 mRNA. Translation: BAC28526.1.
AK041451 mRNA. Translation: BAC30949.1. Different initiation.
AY255574 mRNA. Translation: AAO85086.1.
CCDSiCCDS22930.1.
RefSeqiNP_783609.1. NM_175678.3.
XP_006510465.1. XM_006510402.2.
UniGeneiMm.130824.

Genome annotation databases

EnsembliENSMUST00000059650; ENSMUSP00000056432; ENSMUSG00000043659.
GeneIDi319239.
KEGGimmu:319239.
UCSCiuc009oox.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033957 mRNA. Translation: BAC28526.1.
AK041451 mRNA. Translation: BAC30949.1. Different initiation.
AY255574 mRNA. Translation: AAO85086.1.
CCDSiCCDS22930.1.
RefSeqiNP_783609.1. NM_175678.3.
XP_006510465.1. XM_006510402.2.
UniGeneiMm.130824.

3D structure databases

ProteinModelPortaliQ8BZP8.
SMRiQ8BZP8. Positions 53-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056432.

Chemistry

BindingDBiQ8BZP8.
ChEMBLiCHEMBL5497.
GuidetoPHARMACOLOGYi302.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BZP8.

Proteomic databases

PaxDbiQ8BZP8.
PRIDEiQ8BZP8.

Protocols and materials databases

DNASUi319239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059650; ENSMUSP00000056432; ENSMUSG00000043659.
GeneIDi319239.
KEGGimmu:319239.
UCSCiuc009oox.1. mouse.

Organism-specific databases

CTDi387129.
MGIiMGI:2441738. Npsr1.

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
KOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000220789.
HOVERGENiHBG106615.
InParanoidiQ8BZP8.
KOiK08376.
OMAiTIWMKSK.
OrthoDBiEOG091G0A5H.
PhylomeDBiQ8BZP8.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ8BZP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043659.
CleanExiMM_NPSR1.
ExpressionAtlasiQ8BZP8. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24244:SF2. PTHR24244:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPSR1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZP8
Secondary accession number(s): Q80T64, Q8BYA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.