Q8BZP8 (NPSR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide S receptor

Alternative name(s):
G-protein coupled receptor 154
G-protein coupled receptor PGR14

Gene names

Name:	Npsr1
Synonyms:	Gpr154, Pgr14

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Induction	Increased expression in lung after ovalbumin induction in a mouse model of ovalbumin-induced lung inflammation. Ref.3
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Sequence caution	The sequence BAC30949.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Neuropeptide S receptor		PRO_0000069641
Regions
	Topological domain	1 – 52	52	Extracellular Potential
	Transmembrane	53 – 73	21	Helical; Name=1; Potential
	Topological domain	74 – 82	9	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Name=2; Potential
	Topological domain	104 – 123	20	Extracellular Potential
	Transmembrane	124 – 144	21	Helical; Name=3; Potential
	Topological domain	145 – 164	20	Cytoplasmic Potential
	Transmembrane	165 – 185	21	Helical; Name=4; Potential
	Topological domain	186 – 212	27	Extracellular Potential
	Transmembrane	213 – 233	21	Helical; Name=5; Potential
	Topological domain	234 – 275	42	Cytoplasmic Potential
	Transmembrane	276 – 296	21	Helical; Name=6; Potential
	Topological domain	297 – 312	16	Extracellular Potential
	Transmembrane	313 – 333	21	Helical; Name=7; Potential
	Topological domain	334 – 371	38	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Disulfide bond	121 ↔ 197		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8BZP8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: FBAF7B45BEE5F844	FASTA	371	42,439
	10 20 30 40 50 60 MPANLTEGSF HANQTVPMLD SSPVACTEIV TFTEALVAEE WGSFYSSFKT EQLITLWVLF 70 80 90 100 110 120 VVTIVGNSVV LFSTCRRKRK SRMTFFVTQL AITDSFTGLI NILTDIIWRF TGDFMAPDLV 130 140 150 160 170 180 CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQAKVLIGIA WSLSFLFSIP 190 200 210 220 230 240 TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLAIISVIY GLVIRTIWMK 250 260 270 280 290 300 SKTHETVISN CSDGKLCCSY NRGLISKAKI KAIKYSIVII LAFICCWSPY FLFDILDNFN 310 320 330 340 350 360 VLPDTKERFY ASVIIQNLPA LNSAINPLIY CIFSSSICSP CKMQRSQDSR MTYRERSERH 370 EMQILSKPEF I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Diencephalon and Thymus.
[2]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed: 12679517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-222.
[3]	"Characterization of a common susceptibility locus for asthma-related traits." Laitinen T., Polvi A., Rydman P., Vendelin J., Pulkkinen V., Salmikangas P., Maekelae S., Rehn M., Pirskanen A., Rautanen A., Zucchelli M., Gullsten H., Leino M., Alenius H., Petaeys T., Haahtela T., Laitinen A., Laprise C. , Hudson T.J., Laitinen L.A., Kere J. Science 304:300-304(2004) [PubMed: 15073379] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK033957 mRNA. Translation: BAC28526.1. AK041451 mRNA. Translation: BAC30949.1. Different initiation. AY255574 mRNA. Translation: AAO85086.1.
IPI	IPI00227643.
RefSeq	NP_783609.1. NM_175678.3.
UniGene	Mm.130824.
3D structure databases
ProteinModelPortal	Q8BZP8.
SMR	Q8BZP8. Positions 48-348.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BZP8.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8BZP8.
Proteomic databases
PRIDE	Q8BZP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000059650; ENSMUSP00000056432; ENSMUSG00000043659.
GeneID	319239.
KEGG	mmu:319239.
Organism-specific databases
CTD	387129.
MGI	MGI:2441738. Npsr1.
Phylogenomic databases
GeneTree	ENSGT00550000074198.
HOGENOM	HBG127167.
HOVERGEN	HBG106615.
InParanoid	Q8BZP8.
OMA	GEKQARV.
OrthoDB	EOG4W6NWJ.
PhylomeDB	Q8BZP8.
Gene expression databases
ArrayExpress	Q8BZP8.
Bgee	Q8BZP8.
CleanEx	MM_NPSR1.
Genevestigator	Q8BZP8.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001817. Vasoprsn_rcpt. [Graphical view]
KO	K08376.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	394446.
SOURCE	Search...

Entry information

Entry name

NPSR1_MOUSE

Accession

Primary (citable) accession number: Q8BZP8
Secondary accession number(s): Q80T64, Q8BYA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program