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Q8BZN2

- KCNV1_MOUSE

UniProt

Q8BZN2 - KCNV1_MOUSE

Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily V member 1
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv8.1
    Gene namesi
    Name:Kcnv1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1914748. Kcnv1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 By similarity.By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Potassium voltage-gated channel subfamily V member 1PRO_0000308353Add
    BLAST

    Proteomic databases

    PRIDEiQ8BZN2.

    Expressioni

    Gene expression databases

    BgeeiQ8BZN2.
    CleanExiMM_KCNV1.
    GenevestigatoriQ8BZN2.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022967.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZN2.
    SMRiQ8BZN2. Positions 46-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini3 – 213211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 2417ExtracellularSequence Analysis
    Topological domaini263 – 27917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini301 – 31212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 34814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 50373CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei214 – 23421Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei313 – 33422Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei349 – 36921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi395 – 4006Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00730000110784.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiQ8BZN2.
    KOiK04934.
    OMAiGMTIAQC.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ8BZN2.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003970. K_chnl_volt-dep_Kv8.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF38. PTHR11537:SF38. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01493. KV8CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BZN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCFTVNVGG    50
    SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV 100
    DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI 150
    DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSKG PCPTVRQKLW 200
    DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY 250
    VCISWFTGEF VLRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG 300
    SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG 350
    LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD 400
    IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ 450
    REALKKLTKN IATDSYISVN LRDVYARSIM EMLRLKGRER ASTRSSGGDD 500
    FWF 503
    Length:503
    Mass (Da):56,669
    Last modified:October 23, 2007 - v2
    Checksum:i129B24D57EB69586
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521R → A in BAC36198. (PubMed:16141072)Curated
    Sequence conflicti95 – 951D → G in BAC36198. (PubMed:16141072)Curated
    Sequence conflicti272 – 2721H → R in BAC28581. (PubMed:16141072)Curated
    Sequence conflicti335 – 36834LRSLG…STIEY → IHISLVPFNFAFKIIFRYIG TEPPYILTHPPSIK in BAC30004. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti413 – 4131F → Y in BAC36198. (PubMed:16141072)Curated
    Sequence conflicti462 – 4621A → V in BAC36198. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012275 mRNA. Translation: BAB28134.1.
    AK034091 mRNA. Translation: BAC28581.1.
    AK038450 mRNA. Translation: BAC30004.1.
    AK076120 mRNA. Translation: BAC36198.1.
    AK139482 mRNA. Translation: BAE24032.1.
    BC128477 mRNA. Translation: AAI28478.1.
    BC128478 mRNA. Translation: AAI28479.1.
    CCDSiCCDS27459.1.
    RefSeqiNP_080476.2. NM_026200.3.
    XP_006521360.1. XM_006521297.1.
    UniGeneiMm.300079.

    Genome annotation databases

    EnsembliENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342.
    GeneIDi67498.
    KEGGimmu:67498.
    UCSCiuc007vql.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012275 mRNA. Translation: BAB28134.1 .
    AK034091 mRNA. Translation: BAC28581.1 .
    AK038450 mRNA. Translation: BAC30004.1 .
    AK076120 mRNA. Translation: BAC36198.1 .
    AK139482 mRNA. Translation: BAE24032.1 .
    BC128477 mRNA. Translation: AAI28478.1 .
    BC128478 mRNA. Translation: AAI28479.1 .
    CCDSi CCDS27459.1.
    RefSeqi NP_080476.2. NM_026200.3.
    XP_006521360.1. XM_006521297.1.
    UniGenei Mm.300079.

    3D structure databases

    ProteinModelPortali Q8BZN2.
    SMRi Q8BZN2. Positions 46-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022967.

    Proteomic databases

    PRIDEi Q8BZN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022967 ; ENSMUSP00000022967 ; ENSMUSG00000022342 .
    GeneIDi 67498.
    KEGGi mmu:67498.
    UCSCi uc007vql.2. mouse.

    Organism-specific databases

    CTDi 27012.
    MGIi MGI:1914748. Kcnv1.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00730000110784.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi Q8BZN2.
    KOi K04934.
    OMAi GMTIAQC.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q8BZN2.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 324746.
    PROi Q8BZN2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BZN2.
    CleanExi MM_KCNV1.
    Genevestigatori Q8BZN2.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003970. K_chnl_volt-dep_Kv8.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF38. PTHR11537:SF38. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01493. KV8CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex, Diencephalon, Embryo and Hypothalamus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKCNV1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZN2
    Secondary accession number(s): Q8BK61, Q8BYS7, Q9CZR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3