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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:Kcnv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914748 Kcnv1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini3 – 213CytoplasmicSequence analysisAdd BLAST211
Transmembranei214 – 234Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini235 – 241ExtracellularSequence analysis7
Transmembranei242 – 262Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini263 – 279CytoplasmicSequence analysisAdd BLAST17
Transmembranei280 – 300Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini301 – 312ExtracellularSequence analysisAdd BLAST12
Transmembranei313 – 334Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST22
Topological domaini335 – 348CytoplasmicSequence analysisAdd BLAST14
Transmembranei349 – 369Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei410 – 430Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini431 – 503CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083531 – 503Potassium voltage-gated channel subfamily V member 1Add BLAST503

Proteomic databases

PaxDbiQ8BZN2
PeptideAtlasiQ8BZN2
PRIDEiQ8BZN2

PTM databases

PhosphoSitePlusiQ8BZN2

Expressioni

Gene expression databases

BgeeiENSMUSG00000022342
CleanExiMM_KCNV1
GenevisibleiQ8BZN2 MM

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022967

Structurei

3D structure databases

ProteinModelPortaliQ8BZN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi395 – 400Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiQ8BZN2
KOiK04934
OMAiMTIAQCY
OrthoDBiEOG091G0FP3
PhylomeDBiQ8BZN2
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003970 K_chnl_volt-dep_Kv8.1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF38 PTHR11537:SF38, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01493 KV8CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BZN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCFTVNVGG
60 70 80 90 100
SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV
110 120 130 140 150
DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI
160 170 180 190 200
DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSKG PCPTVRQKLW
210 220 230 240 250
DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY
260 270 280 290 300
VCISWFTGEF VLRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG
310 320 330 340 350
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG
360 370 380 390 400
LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD
410 420 430 440 450
IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ
460 470 480 490 500
REALKKLTKN IATDSYISVN LRDVYARSIM EMLRLKGRER ASTRSSGGDD

FWF
Length:503
Mass (Da):56,669
Last modified:October 23, 2007 - v2
Checksum:i129B24D57EB69586
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → A in BAC36198 (PubMed:16141072).Curated1
Sequence conflicti95D → G in BAC36198 (PubMed:16141072).Curated1
Sequence conflicti272H → R in BAC28581 (PubMed:16141072).Curated1
Sequence conflicti335 – 368LRSLG…STIEY → IHISLVPFNFAFKIIFRYIG TEPPYILTHPPSIK in BAC30004 (PubMed:16141072).CuratedAdd BLAST34
Sequence conflicti413F → Y in BAC36198 (PubMed:16141072).Curated1
Sequence conflicti462A → V in BAC36198 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012275 mRNA Translation: BAB28134.1
AK034091 mRNA Translation: BAC28581.1
AK038450 mRNA Translation: BAC30004.1
AK076120 mRNA Translation: BAC36198.1
AK139482 mRNA Translation: BAE24032.1
BC128477 mRNA Translation: AAI28478.1
BC128478 mRNA Translation: AAI28479.1
CCDSiCCDS27459.1
RefSeqiNP_080476.2, NM_026200.3
XP_006521360.1, XM_006521297.3
UniGeneiMm.300079

Genome annotation databases

EnsembliENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342
GeneIDi67498
KEGGimmu:67498
UCSCiuc007vql.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNV1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZN2
Secondary accession number(s): Q8BK61, Q8BYS7, Q9CZR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health