Q8BZN2 (KCNV1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily V member 1

Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1

Gene names

Name:

Kcnv1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes By similarity.
Subunit structure	Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 By similarity.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.
Sequence similarities	Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular_component	voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Potassium voltage-gated channel subfamily V member 1		PRO_0000308353
Regions
	Topological domain	3 – 213	211	Cytoplasmic Potential
	Transmembrane	214 – 234	21	Helical; Name=Segment S1; Potential
	Topological domain	235 – 241	7	Extracellular Potential
	Transmembrane	242 – 262	21	Helical; Name=Segment S2; Potential
	Topological domain	263 – 279	17	Cytoplasmic Potential
	Transmembrane	280 – 300	21	Helical; Name=Segment S3; Potential
	Topological domain	301 – 312	12	Extracellular Potential
	Transmembrane	313 – 334	22	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	335 – 348	14	Cytoplasmic Potential
	Transmembrane	349 – 369	21	Helical; Name=Segment S5; Potential
	Transmembrane	410 – 430	21	Helical; Name=Segment S6; Potential
	Topological domain	431 – 503	73	Cytoplasmic Potential
	Motif	395 – 400	6	Selectivity filter By similarity
Experimental info
	Sequence conflict	52	1	R → A in BAC36198. Ref.1
	Sequence conflict	95	1	D → G in BAC36198. Ref.1
	Sequence conflict	272	1	H → R in BAC28581. Ref.1
	Sequence conflict	335 – 368	34	LRSLG…STIEY → IHISLVPFNFAFKIIFRYIG TEPPYILTHPPSIK in BAC30004. Ref.1
	Sequence conflict	413	1	F → Y in BAC36198. Ref.1
	Sequence conflict	462	1	A → V in BAC36198. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8BZN2 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 129B24D57EB69586	FASTA	503	56,669
	10 20 30 40 50 60 MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCFTVNVGG SRFVLSQQAL 70 80 90 100 110 120 SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV DNEYFFDRSS QAFRYVLHYY 130 140 150 160 170 180 RTGRLHVMEQ LCALSFLQEI QYWGIDELSI DSCCRDRYFR RKELSETLDF KKDTDDQESQ 190 200 210 220 230 240 HESEQDFSKG PCPTVRQKLW DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL 250 260 270 280 290 300 NLQLLEILEY VCISWFTGEF VLRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG 310 320 330 340 350 360 SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG LLLLFLSVGI 370 380 390 400 410 420 SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD IRPDTTTGKI VAFMCILSGI 430 440 450 460 470 480 LVLALPIAII NDRFSACYFT LKLKEAAVRQ REALKKLTKN IATDSYISVN LRDVYARSIM 490 500 EMLRLKGRER ASTRSSGGDD FWF

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain cortex, Diencephalon, Embryo and Hypothalamus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK012275 mRNA. Translation: BAB28134.1. AK034091 mRNA. Translation: BAC28581.1. AK038450 mRNA. Translation: BAC30004.1. AK076120 mRNA. Translation: BAC36198.1. AK139482 mRNA. Translation: BAE24032.1. BC128477 mRNA. Translation: AAI28478.1. BC128478 mRNA. Translation: AAI28479.1.
IPI	IPI00457660.
RefSeq	NP_080476.2. NM_026200.3.
UniGene	Mm.300079.
3D structure databases
HSSP	HSSP built from PDB template 2A79 based on UniProtKB P63142.
ProteinModelPortal	Q8BZN2.
SMR	Q8BZN2. Positions 46-438.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000022967.
Proteomic databases
PRIDE	Q8BZN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342.
GeneID	67498.
KEGG	mmu:67498.
UCSC	uc007vql.2. mouse.
Organism-specific databases
CTD	27012.
MGI	MGI:1914748. Kcnv1.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00680000099716.
HOGENOM	HOG000231016.
HOVERGEN	HBG052230.
InParanoid	Q8BZN2.
KO	K04934.
OMA	DRCHFLR.
OrthoDB	EOG4BRWKP.
Gene expression databases
Bgee	Q8BZN2.
CleanEx	MM_KCNV1.
Genevestigator	Q8BZN2.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003970. K_chnl_volt-dep_Kv8. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit. PTHR11537:SF38. PTHR11537:SF38. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01493. KV8CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	324746.
SOURCE	Search...

Entry information

Entry name

KCNV1_MOUSE

Accession

Primary (citable) accession number: Q8BZN2
Secondary accession number(s): Q8BK61, Q8BYS7, Q9CZR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program