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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:Kcnv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914748. Kcnv1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini3 – 213CytoplasmicSequence analysisAdd BLAST211
Transmembranei214 – 234Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini235 – 241ExtracellularSequence analysis7
Transmembranei242 – 262Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini263 – 279CytoplasmicSequence analysisAdd BLAST17
Transmembranei280 – 300Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini301 – 312ExtracellularSequence analysisAdd BLAST12
Transmembranei313 – 334Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST22
Topological domaini335 – 348CytoplasmicSequence analysisAdd BLAST14
Transmembranei349 – 369Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei410 – 430Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini431 – 503CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083531 – 503Potassium voltage-gated channel subfamily V member 1Add BLAST503

Proteomic databases

PaxDbiQ8BZN2.
PeptideAtlasiQ8BZN2.
PRIDEiQ8BZN2.

PTM databases

PhosphoSitePlusiQ8BZN2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022342.
CleanExiMM_KCNV1.
GenevisibleiQ8BZN2. MM.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022967.

Structurei

3D structure databases

ProteinModelPortaliQ8BZN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi395 – 400Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ8BZN2.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ8BZN2.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PTHR11537:SF38. PTHR11537:SF38. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BZN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCFTVNVGG
60 70 80 90 100
SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV
110 120 130 140 150
DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI
160 170 180 190 200
DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSKG PCPTVRQKLW
210 220 230 240 250
DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY
260 270 280 290 300
VCISWFTGEF VLRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG
310 320 330 340 350
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG
360 370 380 390 400
LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD
410 420 430 440 450
IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ
460 470 480 490 500
REALKKLTKN IATDSYISVN LRDVYARSIM EMLRLKGRER ASTRSSGGDD

FWF
Length:503
Mass (Da):56,669
Last modified:October 23, 2007 - v2
Checksum:i129B24D57EB69586
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → A in BAC36198 (PubMed:16141072).Curated1
Sequence conflicti95D → G in BAC36198 (PubMed:16141072).Curated1
Sequence conflicti272H → R in BAC28581 (PubMed:16141072).Curated1
Sequence conflicti335 – 368LRSLG…STIEY → IHISLVPFNFAFKIIFRYIG TEPPYILTHPPSIK in BAC30004 (PubMed:16141072).CuratedAdd BLAST34
Sequence conflicti413F → Y in BAC36198 (PubMed:16141072).Curated1
Sequence conflicti462A → V in BAC36198 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012275 mRNA. Translation: BAB28134.1.
AK034091 mRNA. Translation: BAC28581.1.
AK038450 mRNA. Translation: BAC30004.1.
AK076120 mRNA. Translation: BAC36198.1.
AK139482 mRNA. Translation: BAE24032.1.
BC128477 mRNA. Translation: AAI28478.1.
BC128478 mRNA. Translation: AAI28479.1.
CCDSiCCDS27459.1.
RefSeqiNP_080476.2. NM_026200.3.
XP_006521360.1. XM_006521297.3.
UniGeneiMm.300079.

Genome annotation databases

EnsembliENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342.
GeneIDi67498.
KEGGimmu:67498.
UCSCiuc007vql.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012275 mRNA. Translation: BAB28134.1.
AK034091 mRNA. Translation: BAC28581.1.
AK038450 mRNA. Translation: BAC30004.1.
AK076120 mRNA. Translation: BAC36198.1.
AK139482 mRNA. Translation: BAE24032.1.
BC128477 mRNA. Translation: AAI28478.1.
BC128478 mRNA. Translation: AAI28479.1.
CCDSiCCDS27459.1.
RefSeqiNP_080476.2. NM_026200.3.
XP_006521360.1. XM_006521297.3.
UniGeneiMm.300079.

3D structure databases

ProteinModelPortaliQ8BZN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022967.

PTM databases

PhosphoSitePlusiQ8BZN2.

Proteomic databases

PaxDbiQ8BZN2.
PeptideAtlasiQ8BZN2.
PRIDEiQ8BZN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342.
GeneIDi67498.
KEGGimmu:67498.
UCSCiuc007vql.2. mouse.

Organism-specific databases

CTDi27012.
MGIiMGI:1914748. Kcnv1.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ8BZN2.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ8BZN2.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ8BZN2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022342.
CleanExiMM_KCNV1.
GenevisibleiQ8BZN2. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PTHR11537:SF38. PTHR11537:SF38. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNV1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZN2
Secondary accession number(s): Q8BK61, Q8BYS7, Q9CZR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.