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Q8BZN2

- KCNV1_MOUSE

UniProt

Q8BZN2 - KCNV1_MOUSE

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Protein
Potassium voltage-gated channel subfamily V member 1
Gene
Kcnv1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes By similarity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:Kcnv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1914748. Kcnv1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini3 – 213211Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini235 – 2417Extracellular Reviewed prediction
Transmembranei242 – 26221Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini263 – 27917Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei280 – 30021Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini301 – 31212Extracellular Reviewed prediction
Add
BLAST
Transmembranei313 – 33422Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini335 – 34814Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei349 – 36921Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Transmembranei410 – 43021Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini431 – 50373Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Potassium voltage-gated channel subfamily V member 1
PRO_0000308353Add
BLAST

Proteomic databases

PRIDEiQ8BZN2.

Expressioni

Gene expression databases

BgeeiQ8BZN2.
CleanExiMM_KCNV1.
GenevestigatoriQ8BZN2.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022967.

Structurei

3D structure databases

ProteinModelPortaliQ8BZN2.
SMRiQ8BZN2. Positions 46-438.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi395 – 4006Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00730000110784.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ8BZN2.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8BZN2.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BZN2-1 [UniParc]FASTAAdd to Basket

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MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCFTVNVGG    50
SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV 100
DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI 150
DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSKG PCPTVRQKLW 200
DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY 250
VCISWFTGEF VLRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG 300
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG 350
LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD 400
IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ 450
REALKKLTKN IATDSYISVN LRDVYARSIM EMLRLKGRER ASTRSSGGDD 500
FWF 503
Length:503
Mass (Da):56,669
Last modified:October 23, 2007 - v2
Checksum:i129B24D57EB69586
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521R → A in BAC36198. 1 Publication
Sequence conflicti95 – 951D → G in BAC36198. 1 Publication
Sequence conflicti272 – 2721H → R in BAC28581. 1 Publication
Sequence conflicti335 – 36834LRSLG…STIEY → IHISLVPFNFAFKIIFRYIG TEPPYILTHPPSIK in BAC30004. 1 Publication
Add
BLAST
Sequence conflicti413 – 4131F → Y in BAC36198. 1 Publication
Sequence conflicti462 – 4621A → V in BAC36198. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012275 mRNA. Translation: BAB28134.1.
AK034091 mRNA. Translation: BAC28581.1.
AK038450 mRNA. Translation: BAC30004.1.
AK076120 mRNA. Translation: BAC36198.1.
AK139482 mRNA. Translation: BAE24032.1.
BC128477 mRNA. Translation: AAI28478.1.
BC128478 mRNA. Translation: AAI28479.1.
CCDSiCCDS27459.1.
RefSeqiNP_080476.2. NM_026200.3.
XP_006521360.1. XM_006521297.1.
UniGeneiMm.300079.

Genome annotation databases

EnsembliENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342.
GeneIDi67498.
KEGGimmu:67498.
UCSCiuc007vql.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012275 mRNA. Translation: BAB28134.1 .
AK034091 mRNA. Translation: BAC28581.1 .
AK038450 mRNA. Translation: BAC30004.1 .
AK076120 mRNA. Translation: BAC36198.1 .
AK139482 mRNA. Translation: BAE24032.1 .
BC128477 mRNA. Translation: AAI28478.1 .
BC128478 mRNA. Translation: AAI28479.1 .
CCDSi CCDS27459.1.
RefSeqi NP_080476.2. NM_026200.3.
XP_006521360.1. XM_006521297.1.
UniGenei Mm.300079.

3D structure databases

ProteinModelPortali Q8BZN2.
SMRi Q8BZN2. Positions 46-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022967.

Proteomic databases

PRIDEi Q8BZN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022967 ; ENSMUSP00000022967 ; ENSMUSG00000022342 .
GeneIDi 67498.
KEGGi mmu:67498.
UCSCi uc007vql.2. mouse.

Organism-specific databases

CTDi 27012.
MGIi MGI:1914748. Kcnv1.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00730000110784.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q8BZN2.
KOi K04934.
OMAi GMTIAQC.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q8BZN2.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 324746.
PROi Q8BZN2.
SOURCEi Search...

Gene expression databases

Bgeei Q8BZN2.
CleanExi MM_KCNV1.
Genevestigatori Q8BZN2.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Diencephalon, Embryo and Hypothalamus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCNV1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZN2
Secondary accession number(s): Q8BK61, Q8BYS7, Q9CZR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi