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Q8BZN2

- KCNV1_MOUSE

UniProt

Q8BZN2 - KCNV1_MOUSE

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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:Kcnv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1914748. Kcnv1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 (By similarity).By similarity

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Potassium voltage-gated channel subfamily V member 1PRO_0000308353Add
BLAST

Proteomic databases

PRIDEiQ8BZN2.

Expressioni

Gene expression databases

BgeeiQ8BZN2.
CleanExiMM_KCNV1.
GenevestigatoriQ8BZN2.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022967.

Structurei

3D structure databases

ProteinModelPortaliQ8BZN2.
SMRiQ8BZN2. Positions 46-438.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini3 – 213211CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini235 – 2417ExtracellularSequence Analysis
Topological domaini263 – 27917CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini301 – 31212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini335 – 34814CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini431 – 50373CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei214 – 23421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei313 – 33422Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei349 – 36921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi395 – 4006Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ8BZN2.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8BZN2.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BZN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCFTVNVGG
60 70 80 90 100
SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV
110 120 130 140 150
DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI
160 170 180 190 200
DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSKG PCPTVRQKLW
210 220 230 240 250
DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY
260 270 280 290 300
VCISWFTGEF VLRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG
310 320 330 340 350
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG
360 370 380 390 400
LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD
410 420 430 440 450
IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ
460 470 480 490 500
REALKKLTKN IATDSYISVN LRDVYARSIM EMLRLKGRER ASTRSSGGDD

FWF
Length:503
Mass (Da):56,669
Last modified:October 23, 2007 - v2
Checksum:i129B24D57EB69586
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521R → A in BAC36198. (PubMed:16141072)Curated
Sequence conflicti95 – 951D → G in BAC36198. (PubMed:16141072)Curated
Sequence conflicti272 – 2721H → R in BAC28581. (PubMed:16141072)Curated
Sequence conflicti335 – 36834LRSLG…STIEY → IHISLVPFNFAFKIIFRYIG TEPPYILTHPPSIK in BAC30004. (PubMed:16141072)CuratedAdd
BLAST
Sequence conflicti413 – 4131F → Y in BAC36198. (PubMed:16141072)Curated
Sequence conflicti462 – 4621A → V in BAC36198. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012275 mRNA. Translation: BAB28134.1.
AK034091 mRNA. Translation: BAC28581.1.
AK038450 mRNA. Translation: BAC30004.1.
AK076120 mRNA. Translation: BAC36198.1.
AK139482 mRNA. Translation: BAE24032.1.
BC128477 mRNA. Translation: AAI28478.1.
BC128478 mRNA. Translation: AAI28479.1.
CCDSiCCDS27459.1.
RefSeqiNP_080476.2. NM_026200.3.
XP_006521360.1. XM_006521297.1.
UniGeneiMm.300079.

Genome annotation databases

EnsembliENSMUST00000022967; ENSMUSP00000022967; ENSMUSG00000022342.
GeneIDi67498.
KEGGimmu:67498.
UCSCiuc007vql.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012275 mRNA. Translation: BAB28134.1 .
AK034091 mRNA. Translation: BAC28581.1 .
AK038450 mRNA. Translation: BAC30004.1 .
AK076120 mRNA. Translation: BAC36198.1 .
AK139482 mRNA. Translation: BAE24032.1 .
BC128477 mRNA. Translation: AAI28478.1 .
BC128478 mRNA. Translation: AAI28479.1 .
CCDSi CCDS27459.1.
RefSeqi NP_080476.2. NM_026200.3.
XP_006521360.1. XM_006521297.1.
UniGenei Mm.300079.

3D structure databases

ProteinModelPortali Q8BZN2.
SMRi Q8BZN2. Positions 46-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022967.

Proteomic databases

PRIDEi Q8BZN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022967 ; ENSMUSP00000022967 ; ENSMUSG00000022342 .
GeneIDi 67498.
KEGGi mmu:67498.
UCSCi uc007vql.2. mouse.

Organism-specific databases

CTDi 27012.
MGIi MGI:1914748. Kcnv1.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q8BZN2.
KOi K04934.
OMAi GMTIAQC.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q8BZN2.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 324746.
PROi Q8BZN2.
SOURCEi Search...

Gene expression databases

Bgeei Q8BZN2.
CleanExi MM_KCNV1.
Genevestigatori Q8BZN2.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Diencephalon, Embryo and Hypothalamus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCNV1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZN2
Secondary accession number(s): Q8BK61, Q8BYS7, Q9CZR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3