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Protein

Glomulin

Gene

Glmn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. May stimulate the p70S6K pathway. May inhibit cell proliferation and increase IL2 production (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glomulin
Alternative name(s):
FK506-binding protein-associated protein
Short name:
FAP
FKBP-associated protein
Gene namesi
Name:Glmn
Synonyms:Fap48
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141180 Glmn

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000875142 – 596GlomulinAdd BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BZM1
MaxQBiQ8BZM1
PaxDbiQ8BZM1
PRIDEiQ8BZM1

PTM databases

PhosphoSitePlusiQ8BZM1

Expressioni

Gene expression databases

BgeeiENSMUSG00000029276
CleanExiMM_GLMN
ExpressionAtlasiQ8BZM1 baseline and differential
GenevisibleiQ8BZM1 MM

Interactioni

Subunit structurei

Monomer. Interacts with notphosphorylated MET and is released upon receptor phosphorylation. Interacts with FKBP59 and FKBP12. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228459, 2 interactors
STRINGi10090.ENSMUSP00000077168

Structurei

3D structure databases

ProteinModelPortaliQ8BZM1
SMRiQ8BZM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 209Sequence analysisAdd BLAST17
Coiled coili515 – 532Sequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Leu4
Compositional biasi272 – 277Poly-Glu6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4H Eukaryota
ENOG410YJ4Z LUCA
GeneTreeiENSGT00390000018446
HOGENOMiHOG000043079
HOVERGENiHBG044811
InParanoidiQ8BZM1
OMAiKNQIDMS
OrthoDBiEOG091G054M
PhylomeDBiQ8BZM1
TreeFamiTF105319

Family and domain databases

InterProiView protein in InterPro
IPR019516 Glomulin/ALF4
IPR013877 YAP-bd/ALF4/Glomulin
PANTHERiPTHR15430 PTHR15430, 1 hit
PfamiView protein in Pfam
PF08568 Kinetochor_Ybp2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BZM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEELQSII KRCQILEEHD FKEEDFGLFQ LAGQRCIEDG YINQLLEIIQ
60 70 80 90 100
DEKNKTIIKS MGWNLVGPVV RCLLRGREED KREECFLIFD LLVKLCNPKE
110 120 130 140 150
LLLGLLELIE EPSGKQISQI ILLLLQPLQT VIQKLPNNKA YSVGLALSTL
160 170 180 190 200
WSQLSLLPVP HSEEQIQADD YGLCQCCKAL IEFTKPFVEE VISDKENKEN
210 220 230 240 250
AKLKDELLKF CFKGLKCPLL TAQFLEQSED VGNDPFRCFA SEIIGFLSKI
260 270 280 290 300
GHPVPQIILN HGRKKRTWDY LEFEEEEDKQ LAESVASLTY LVFVQGIGID
310 320 330 340 350
QLPMVLSPSY LLQLNMEHIE VFLQRTEQSI YSKGLELLET SLLRLEDNSL
360 370 380 390 400
CYQYLEIKSF LAVPQGLVKV MTLCPIETLR KKGLSMLQLF IDKLDSQGKY
410 420 430 440 450
TLFRCLLNTS NHSGVEAFVI QNIKNQIDLS FKKTYNKWFA GAQLISLLDL
460 470 480 490 500
VLSLPEGAET DLLQNSDRIM ASLNLLRYLV IKDNEDDNQT GLWTELGKIE
510 520 530 540 550
NNFLKPLHIG LNMSKAHYEA EIKNSQQNNQ VASMCKGVCS VTVGGEEIPS
560 570 580 590
MPPEMQLKVL HSALFTFDLI ESVLARVEEL IEIKSKSTSE ENVGIK
Length:596
Mass (Da):67,756
Last modified:March 1, 2003 - v1
Checksum:i4C306B16F3C206DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270Y → S in AAH03446 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566083 mRNA Translation: CAD92739.1
AK034160 mRNA Translation: BAC28612.1
AK169045 mRNA Translation: BAE40833.1
BC003446 mRNA Translation: AAH03446.1
CCDSiCCDS19505.1
RefSeqiNP_001155210.1, NM_001161738.1
NP_001155211.1, NM_001161739.1
NP_573511.2, NM_133248.2
XP_006534863.1, XM_006534800.3
UniGeneiMm.41417

Genome annotation databases

EnsembliENSMUST00000078021; ENSMUSP00000077168; ENSMUSG00000029276
ENSMUST00000082121; ENSMUSP00000080766; ENSMUSG00000029276
GeneIDi170823
KEGGimmu:170823
UCSCiuc008ymm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGLMN_MOUSE
AccessioniPrimary (citable) accession number: Q8BZM1
Secondary accession number(s): Q3TFR5, Q99LB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health