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Protein

LIM domain only protein 3

Gene

Lmo3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain only protein 3
Short name:
LMO-3
Alternative name(s):
Neuronal-specific transcription factor DAT1
Gene namesi
Name:Lmo3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102810. Lmo3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145LIM domain only protein 3PRO_0000075818Add
BLAST

Proteomic databases

PaxDbiQ8BZL8.
PRIDEiQ8BZL8.

PTM databases

PhosphoSiteiQ8BZL8.

Expressioni

Gene expression databases

BgeeiQ8BZL8.
CleanExiMM_LMO3.
ExpressionAtlasiQ8BZL8. baseline and differential.
GenevisibleiQ8BZL8. MM.

Interactioni

Protein-protein interaction databases

BioGridi224886. 5 interactions.
STRINGi10090.ENSMUSP00000124862.

Structurei

3D structure databases

ProteinModelPortaliQ8BZL8.
SMRiQ8BZL8. Positions 13-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 7363LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini75 – 13763LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00720000108603.
HOVERGENiHBG054231.
InParanoidiQ8BZL8.
OrthoDBiEOG75J0PF.
PhylomeDBiQ8BZL8.
TreeFamiTF351071.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVQPDTKP KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV
60 70 80 90 100
GSTLYTKANL ILCRRDYLRL FGVTGNCAAC SKLIPAFEMV MRAKDNVYHL
110 120 130 140
DCFACQLCNQ RFCVGDKFFL KNNMILCQTD YEEGLMKEGY APQVR
Length:145
Mass (Da):16,594
Last modified:March 1, 2003 - v1
Checksum:i05284546BA5EC226
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034177 mRNA. Translation: BAC28617.1.
BC057086 mRNA. Translation: AAH57086.1.
CCDSiCCDS20669.1.
RefSeqiNP_997105.1. NM_207222.2.
XP_006505403.1. XM_006505340.1.
XP_006505404.1. XM_006505341.2.
XP_006505405.1. XM_006505342.1.
XP_006505407.1. XM_006505344.2.
XP_011239432.1. XM_011241130.1.
XP_011239433.1. XM_011241131.1.
XP_011239434.1. XM_011241132.1.
XP_011239435.1. XM_011241133.1.
UniGeneiMm.490545.

Genome annotation databases

EnsembliENSMUST00000161450; ENSMUSP00000124862; ENSMUSG00000030226.
ENSMUST00000162772; ENSMUSP00000125335; ENSMUSG00000030226.
ENSMUST00000163024; ENSMUSP00000125589; ENSMUSG00000030226.
ENSMUST00000203435; ENSMUSP00000145048; ENSMUSG00000030226.
GeneIDi109593.
KEGGimmu:109593.
UCSCiuc009enl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034177 mRNA. Translation: BAC28617.1.
BC057086 mRNA. Translation: AAH57086.1.
CCDSiCCDS20669.1.
RefSeqiNP_997105.1. NM_207222.2.
XP_006505403.1. XM_006505340.1.
XP_006505404.1. XM_006505341.2.
XP_006505405.1. XM_006505342.1.
XP_006505407.1. XM_006505344.2.
XP_011239432.1. XM_011241130.1.
XP_011239433.1. XM_011241131.1.
XP_011239434.1. XM_011241132.1.
XP_011239435.1. XM_011241133.1.
UniGeneiMm.490545.

3D structure databases

ProteinModelPortaliQ8BZL8.
SMRiQ8BZL8. Positions 13-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224886. 5 interactions.
STRINGi10090.ENSMUSP00000124862.

PTM databases

PhosphoSiteiQ8BZL8.

Proteomic databases

PaxDbiQ8BZL8.
PRIDEiQ8BZL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161450; ENSMUSP00000124862; ENSMUSG00000030226.
ENSMUST00000162772; ENSMUSP00000125335; ENSMUSG00000030226.
ENSMUST00000163024; ENSMUSP00000125589; ENSMUSG00000030226.
ENSMUST00000203435; ENSMUSP00000145048; ENSMUSG00000030226.
GeneIDi109593.
KEGGimmu:109593.
UCSCiuc009enl.1. mouse.

Organism-specific databases

CTDi55885.
MGIiMGI:102810. Lmo3.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00720000108603.
HOVERGENiHBG054231.
InParanoidiQ8BZL8.
OrthoDBiEOG75J0PF.
PhylomeDBiQ8BZL8.
TreeFamiTF351071.

Miscellaneous databases

PROiQ8BZL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZL8.
CleanExiMM_LMO3.
ExpressionAtlasiQ8BZL8. baseline and differential.
GenevisibleiQ8BZL8. MM.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiLMO3_MOUSE
AccessioniPrimary (citable) accession number: Q8BZL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.