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Protein

Probable G-protein coupled receptor 22

Gene

Gpr22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 22
Gene namesi
Name:Gpr22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920260. Gpr22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 8519CytoplasmicSequence analysisAdd
BLAST
Transmembranei86 – 10621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini107 – 1159ExtracellularSequence analysis
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15620CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 31485CytoplasmicSequence analysisAdd
BLAST
Transmembranei315 – 33521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini336 – 34813ExtracellularSequence analysisAdd
BLAST
Transmembranei349 – 36921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini370 – 43263CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Probable G-protein coupled receptor 22PRO_0000303235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BZL4.
PRIDEiQ8BZL4.

PTM databases

PhosphoSiteiQ8BZL4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044067.
CleanExiMM_GPR22.
ExpressionAtlasiQ8BZL4. baseline and differential.
GenevisibleiQ8BZL4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056125.

Structurei

3D structure databases

ProteinModelPortaliQ8BZL4.
SMRiQ8BZL4. Positions 60-238, 287-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000111017.
HOVERGENiHBG051802.
InParanoidiQ8BZL4.
KOiK04319.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCFSPVLEIN MQSESNVTVR DDIDDIDTNM YQPLSYPLSF QVSLTGFLML
60 70 80 90 100
EIVLGLGSNL TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI
110 120 130 140 150
VILLLSLESN TALICCFHEA CVSFASVSTA INVFAITLDR YDISVKPANR
160 170 180 190 200
ILTMGRAVML MTSIWIFSFF SFLIPFIEVN FFSLQSGNTW ANKTLLCVST
210 220 230 240 250
SEYYTELGMY YHLLVQIPIF FFTVIVMLIT YTKILQALNI RIGTRFSTGQ
260 270 280 290 300
KKKARKKKTI SLATHETTDM SQSSGGRNVV FGVRTSVSVI IALRRAVKRH
310 320 330 340 350
RERRERQKRV FKMSLLIIST FLLCWTPISV LNTTILCLGP SDLLVKLRLC
360 370 380 390 400
FLVMAYGTTI FHPLLYAFTR QKFQKVLKSK MKKRVVSIVE ADPMPNNAVI
410 420 430
HNSWIDPKRN KKVTYEDSEI REKCLVPQVV TD
Length:432
Mass (Da):49,019
Last modified:March 1, 2003 - v1
Checksum:i5321177CBDF00BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034194 mRNA. Translation: BAC28626.1.
BC089509 mRNA. Translation: AAH89509.1.
AY255527 mRNA. Translation: AAO85039.1.
RefSeqiNP_780400.2. NM_175191.4.
UniGeneiMm.441517.

Genome annotation databases

EnsembliENSMUST00000176710; ENSMUSP00000134839; ENSMUSG00000044067.
GeneIDi73010.
KEGGimmu:73010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034194 mRNA. Translation: BAC28626.1.
BC089509 mRNA. Translation: AAH89509.1.
AY255527 mRNA. Translation: AAO85039.1.
RefSeqiNP_780400.2. NM_175191.4.
UniGeneiMm.441517.

3D structure databases

ProteinModelPortaliQ8BZL4.
SMRiQ8BZL4. Positions 60-238, 287-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056125.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BZL4.

Proteomic databases

PaxDbiQ8BZL4.
PRIDEiQ8BZL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000176710; ENSMUSP00000134839; ENSMUSG00000044067.
GeneIDi73010.
KEGGimmu:73010.

Organism-specific databases

CTDi2845.
MGIiMGI:1920260. Gpr22.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000111017.
HOVERGENiHBG051802.
InParanoidiQ8BZL4.
KOiK04319.

Miscellaneous databases

PROiQ8BZL4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044067.
CleanExiMM_GPR22.
ExpressionAtlasiQ8BZL4. baseline and differential.
GenevisibleiQ8BZL4. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR22_MOUSE
AccessioniPrimary (citable) accession number: Q8BZL4
Secondary accession number(s): Q80UE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.