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Protein

Actin filament-associated protein 1-like 1

Gene

Afap1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in podosome and invadosome formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Actin filament-associated protein 1-like 1
Short name:
AFAP1-like protein 1
Gene namesi
Name:Afap1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147199 Afap1l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002952401 – 768Actin filament-associated protein 1-like 1Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei153PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei557PhosphotyrosineCombined sources1
Modified residuei747PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BZI0
PRIDEiQ8BZI0

PTM databases

iPTMnetiQ8BZI0
PhosphoSitePlusiQ8BZI0

Expressioni

Gene expression databases

BgeeiENSMUSG00000033032
CleanExiMM_AFAP1L1
ExpressionAtlasiQ8BZI0 baseline and differential
GenevisibleiQ8BZI0 MM

Interactioni

Subunit structurei

Interacts with CTTN.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113286

Structurei

3D structure databases

ProteinModelPortaliQ8BZI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 316PH 1PROSITE-ProRule annotationAdd BLAST97
Domaini418 – 512PH 2PROSITE-ProRule annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili611 – 701Sequence analysisAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 199Poly-Glu6

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEU6 Eukaryota
ENOG4111CMN LUCA
GeneTreeiENSGT00390000003998
HOGENOMiHOG000033832
HOVERGENiHBG106875
InParanoidiQ8BZI0
OMAiISSHNGC
OrthoDBiEOG091G03NB
PhylomeDBiQ8BZI0
TreeFamiTF332622

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR030113 AFAP
IPR030112 AFAP1L1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR14338 PTHR14338, 1 hit
PTHR14338:SF1 PTHR14338:SF1, 1 hit
PfamiView protein in Pfam
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BZI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRSRVLEQL IPELTGLLSL LDHEYLSDST LEKKMAVASL LQSLQPLPAK
60 70 80 90 100
EVSFLYVNTA DLHSGPSFVE SLFEEFDCDL GDLRDMSDDG EPSKGASPEP
110 120 130 140 150
TKSPSLRSAA ADVPPPLPNK PPPEDYYEEA LPLGPGKSPE YISSHNGCSP
160 170 180 190 200
AQSIVDGYYE DADNSYPTTR MNGELKNSYN DSDAMSSSYE SYDEEEEEEK
210 220 230 240 250
GRQPKHQWPS EEASMHLVRD CRICAFLLRK KRFGQWAKQL TVIKEEQLLC
260 270 280 290 300
YKSSKDRQPH LRLALDVCTV IYVPKDSRHK RHELRFSQGA TEVLVLALQS
310 320 330 340 350
REQAEEWLKV IREVSRPIVG AEGLEVPRSP VILCKADQDK RLSQEKQNSD
360 370 380 390 400
SDSLGMNDSG STLGRREACE HGKGKKNSLA ELKGSMSRAA GRKITRIISF
410 420 430 440 450
SKKKALSEDL QTFSSEDEVP CCGYLNVLVN QGWKERWCRL RCNTLYFHKD
460 470 480 490 500
RTDLHTHVNS IALRGCEVAP GFGPRHPFAF RILRNRQEVA ILEASCSEDM
510 520 530 540 550
GRWLGLLLVE MGSKVTPEAL HYDYVDVETL TSIVSAGRNS FLYAQSCQDQ
560 570 580 590 600
WPEPRIYDEV PYEKVQDEEP QRPTGAQVKR HASSCSEKSH RADPQVKVKR
610 620 630 640 650
HASSANQYKY GKNRAEEDAR RYLVEKERLE KEKETIRTEL TALRQEKKEL
660 670 680 690 700
KEAIRNNPGA KSKALEEAVA TLEAQCRAKE EQRIDLELKL VAVKERLQQS
710 720 730 740 750
LAGGPALGLS VSNKNKSQDT TNKPQSNAPE QSLPVNCVSE LRKRSPSIVT
760
SNQGRVLQKA KEWEMKKT
Length:768
Mass (Da):86,638
Last modified:March 1, 2003 - v1
Checksum:i5913993426EBCFB2
GO
Isoform 2 (identifier: Q8BZI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-458: KGKKNSLAEL...KDRTDLHTHV → RSYHELPLVH...RTAWLSLRAP
     459-768: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):51,943
Checksum:i071F580415B167E6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026860373 – 458KGKKN…LHTHV → RSYHELPLVHAGECQRWEGL CYRSTVTEQITGTRVRPLGL SYLVITGRLQGLLGRPEVGR SGTVASFPIPVSPLLWCQAK GRRTAWLSLRAP in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_026861459 – 768Missing in isoform 2. 1 PublicationAdd BLAST310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035227 mRNA Translation: BAC28988.1
AK053714 mRNA Translation: BAC35486.1
CCDSiCCDS50303.1 [Q8BZI0-1]
RefSeqiNP_849259.2, NM_178928.4 [Q8BZI0-1]
UniGeneiMm.26632

Genome annotation databases

EnsembliENSMUST00000120472; ENSMUSP00000113286; ENSMUSG00000033032 [Q8BZI0-1]
GeneIDi106877
KEGGimmu:106877
UCSCiuc008fcq.1 mouse [Q8BZI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAF1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZI0
Secondary accession number(s): Q8BKB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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