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Protein

Actin filament-associated protein 1-like 1

Gene

Afap1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in podosome and invadosome formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Actin filament-associated protein 1-like 1
Short name:
AFAP1-like protein 1
Gene namesi
Name:Afap1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147199. Afap1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002952401 – 768Actin filament-associated protein 1-like 1Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei153PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei557PhosphotyrosineCombined sources1
Modified residuei747PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BZI0.
PRIDEiQ8BZI0.

PTM databases

iPTMnetiQ8BZI0.
PhosphoSitePlusiQ8BZI0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033032.
CleanExiMM_AFAP1L1.
ExpressionAtlasiQ8BZI0. baseline and differential.
GenevisibleiQ8BZI0. MM.

Interactioni

Subunit structurei

Interacts with CTTN.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113286.

Structurei

3D structure databases

ProteinModelPortaliQ8BZI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 316PH 1PROSITE-ProRule annotationAdd BLAST97
Domaini418 – 512PH 2PROSITE-ProRule annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili611 – 701Sequence analysisAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 199Poly-Glu6

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEU6. Eukaryota.
ENOG4111CMN. LUCA.
GeneTreeiENSGT00390000003998.
HOGENOMiHOG000033832.
HOVERGENiHBG106875.
InParanoidiQ8BZI0.
OMAiGRRETCD.
OrthoDBiEOG091G03NB.
PhylomeDBiQ8BZI0.
TreeFamiTF332622.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR030113. AFAP.
IPR030112. AFAP1L1.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14338. PTHR14338. 1 hit.
PTHR14338:SF1. PTHR14338:SF1. 1 hit.
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BZI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRSRVLEQL IPELTGLLSL LDHEYLSDST LEKKMAVASL LQSLQPLPAK
60 70 80 90 100
EVSFLYVNTA DLHSGPSFVE SLFEEFDCDL GDLRDMSDDG EPSKGASPEP
110 120 130 140 150
TKSPSLRSAA ADVPPPLPNK PPPEDYYEEA LPLGPGKSPE YISSHNGCSP
160 170 180 190 200
AQSIVDGYYE DADNSYPTTR MNGELKNSYN DSDAMSSSYE SYDEEEEEEK
210 220 230 240 250
GRQPKHQWPS EEASMHLVRD CRICAFLLRK KRFGQWAKQL TVIKEEQLLC
260 270 280 290 300
YKSSKDRQPH LRLALDVCTV IYVPKDSRHK RHELRFSQGA TEVLVLALQS
310 320 330 340 350
REQAEEWLKV IREVSRPIVG AEGLEVPRSP VILCKADQDK RLSQEKQNSD
360 370 380 390 400
SDSLGMNDSG STLGRREACE HGKGKKNSLA ELKGSMSRAA GRKITRIISF
410 420 430 440 450
SKKKALSEDL QTFSSEDEVP CCGYLNVLVN QGWKERWCRL RCNTLYFHKD
460 470 480 490 500
RTDLHTHVNS IALRGCEVAP GFGPRHPFAF RILRNRQEVA ILEASCSEDM
510 520 530 540 550
GRWLGLLLVE MGSKVTPEAL HYDYVDVETL TSIVSAGRNS FLYAQSCQDQ
560 570 580 590 600
WPEPRIYDEV PYEKVQDEEP QRPTGAQVKR HASSCSEKSH RADPQVKVKR
610 620 630 640 650
HASSANQYKY GKNRAEEDAR RYLVEKERLE KEKETIRTEL TALRQEKKEL
660 670 680 690 700
KEAIRNNPGA KSKALEEAVA TLEAQCRAKE EQRIDLELKL VAVKERLQQS
710 720 730 740 750
LAGGPALGLS VSNKNKSQDT TNKPQSNAPE QSLPVNCVSE LRKRSPSIVT
760
SNQGRVLQKA KEWEMKKT
Length:768
Mass (Da):86,638
Last modified:March 1, 2003 - v1
Checksum:i5913993426EBCFB2
GO
Isoform 2 (identifier: Q8BZI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-458: KGKKNSLAEL...KDRTDLHTHV → RSYHELPLVH...RTAWLSLRAP
     459-768: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):51,943
Checksum:i071F580415B167E6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026860373 – 458KGKKN…LHTHV → RSYHELPLVHAGECQRWEGL CYRSTVTEQITGTRVRPLGL SYLVITGRLQGLLGRPEVGR SGTVASFPIPVSPLLWCQAK GRRTAWLSLRAP in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_026861459 – 768Missing in isoform 2. 1 PublicationAdd BLAST310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035227 mRNA. Translation: BAC28988.1.
AK053714 mRNA. Translation: BAC35486.1.
CCDSiCCDS50303.1. [Q8BZI0-1]
RefSeqiNP_849259.2. NM_178928.4. [Q8BZI0-1]
UniGeneiMm.26632.

Genome annotation databases

EnsembliENSMUST00000120472; ENSMUSP00000113286; ENSMUSG00000033032. [Q8BZI0-1]
GeneIDi106877.
KEGGimmu:106877.
UCSCiuc008fcq.1. mouse. [Q8BZI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035227 mRNA. Translation: BAC28988.1.
AK053714 mRNA. Translation: BAC35486.1.
CCDSiCCDS50303.1. [Q8BZI0-1]
RefSeqiNP_849259.2. NM_178928.4. [Q8BZI0-1]
UniGeneiMm.26632.

3D structure databases

ProteinModelPortaliQ8BZI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113286.

PTM databases

iPTMnetiQ8BZI0.
PhosphoSitePlusiQ8BZI0.

Proteomic databases

PaxDbiQ8BZI0.
PRIDEiQ8BZI0.

Protocols and materials databases

DNASUi106877.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120472; ENSMUSP00000113286; ENSMUSG00000033032. [Q8BZI0-1]
GeneIDi106877.
KEGGimmu:106877.
UCSCiuc008fcq.1. mouse. [Q8BZI0-1]

Organism-specific databases

CTDi134265.
MGIiMGI:2147199. Afap1l1.

Phylogenomic databases

eggNOGiENOG410IEU6. Eukaryota.
ENOG4111CMN. LUCA.
GeneTreeiENSGT00390000003998.
HOGENOMiHOG000033832.
HOVERGENiHBG106875.
InParanoidiQ8BZI0.
OMAiGRRETCD.
OrthoDBiEOG091G03NB.
PhylomeDBiQ8BZI0.
TreeFamiTF332622.

Miscellaneous databases

PROiQ8BZI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033032.
CleanExiMM_AFAP1L1.
ExpressionAtlasiQ8BZI0. baseline and differential.
GenevisibleiQ8BZI0. MM.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR030113. AFAP.
IPR030112. AFAP1L1.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14338. PTHR14338. 1 hit.
PTHR14338:SF1. PTHR14338:SF1. 1 hit.
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAF1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZI0
Secondary accession number(s): Q8BKB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.