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Q8BZH4

- POGZ_MOUSE

UniProt

Q8BZH4 - POGZ_MOUSE

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Protein

Pogo transposable element with ZNF domain

Gene
Pogz, Kiaa0461
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1; atypicalAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 2Add
BLAST
Zinc fingeri527 – 55024C2H2-type 3Add
BLAST
Zinc fingeri557 – 58024C2H2-type 4Add
BLAST
Zinc fingeri587 – 61024C2H2-type 5Add
BLAST
Zinc fingeri616 – 63823C2H2-type 6Add
BLAST
Zinc fingeri644 – 66724C2H2-type 7Add
BLAST
Zinc fingeri767 – 79024C2H2-type 8Add
BLAST
Zinc fingeri811 – 83626C2H2-type 9Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. kinetochore assembly Source: UniProtKB
  2. mitotic sister chromatid cohesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with ZNF domain
Gene namesi
Name:Pogz
Synonyms:Kiaa0461
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2442117. Pogz.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity. Cytoplasm By similarity
Note: Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3) By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14091409Pogo transposable element with ZNF domainPRO_0000047225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Phosphoserine By similarity
Modified residuei422 – 4221Phosphoserine By similarity
Modified residuei436 – 4361Phosphothreonine By similarity
Modified residuei442 – 4421Phosphoserine By similarity
Modified residuei1334 – 13341Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BZH4.
PRIDEiQ8BZH4.

PTM databases

PhosphoSiteiQ8BZH4.

Expressioni

Gene expression databases

ArrayExpressiQ8BZH4.
BgeeiQ8BZH4.
CleanExiMM_POGZ.
GenevestigatoriQ8BZH4.

Interactioni

Subunit structurei

Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1 By similarity.

Protein-protein interaction databases

BioGridi230865. 4 interactions.
IntActiQ8BZH4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BZH4.
SMRiQ8BZH4. Positions 371-402, 490-677, 767-797.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1011 – 108171HTH CENPB-typeAdd
BLAST
Domaini1113 – 1319207DDEAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni806 – 84641Required for interaction with CBX5 By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1336 – 136429 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi872 – 92756Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1; atypicalAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 2Add
BLAST
Zinc fingeri527 – 55024C2H2-type 3Add
BLAST
Zinc fingeri557 – 58024C2H2-type 4Add
BLAST
Zinc fingeri587 – 61024C2H2-type 5Add
BLAST
Zinc fingeri616 – 63823C2H2-type 6Add
BLAST
Zinc fingeri644 – 66724C2H2-type 7Add
BLAST
Zinc fingeri767 – 79024C2H2-type 8Add
BLAST
Zinc fingeri811 – 83626C2H2-type 9Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG269034.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000010309.
HOVERGENiHBG049435.
InParanoidiQ8BZH4.
OMAiTPTHPQP.
OrthoDBiEOG7QVM24.
PhylomeDBiQ8BZH4.
TreeFamiTF331707.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZH4-1 [UniParc]FASTAAdd to Basket

« Hide

MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT SVSVSQQPVS     50
APVPIAAHAS VAGHLSTSTT VSNSGAQNSD STKKTLVTLI ANNNAGNTLV 100
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI 150
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV 200
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK 250
STPSTSTTPT ATQPTSLGQL AGQPPGQSNQ TSNPKLAPSF PSPPAVSIAS 300
FVTVKRPGVT GENSNEVAKL VNTLNTVPSL GQSPGPVVVS NNSSAQRTSG 350
PESSVKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE 400
YQKKGKSLDA EPSVPSAAKP SSPEKTAPVT STPSSTPIPA LSPPTKVPEP 450
NENAGDAVQT KLIMLVDDFY YGRDGGKAAQ LTSFPKVATS FRCPHCTKRL 500
KNNIRFMNHM KHHVELDQQN GEVDGHTICQ HCYRQFSTPF QLQCHLENVH 550
SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ VCQYRSSLYS 600
EVDVHFRMIH EDTRHLLCPY CLKVFKNGNA FQQHYMRHQK RNVYHCNKCR 650
LQFLFAKDKI EHKLQHHKTF RKPKQLEGLK PGTKVTIRAS RGQPRTVPVS 700
SNDAPSGTLQ EAAALTSTDP LPVFLYPPVQ RNIQKRAVRK MSVMGRQTCL 750
ECSFEIPDFP NHFPTYVHCS LCRYSTCCSR AYANHMINNH VPRKSPKYLA 800
LFKNSVSGIK LACTSCTFAT SVGDAMAKHL VFNPSHRSSN ILPRGLSWMS 850
HLRPGQASER VFDWSMKNTY LPPPLVPNKA ATVKPVGVTP AEPQELAGPV 900
LQALPSPAST ATPPATPTHP QPSALPPSAT EGTECLNVSE QEEGSPVTQD 950
PEPASGGGGG SGVGKKEQLS VKKLRVVLFA LCCNTEQAAE HFRNPQRRIR 1000
RWLRRFQASQ GENLEGKYLS FEAEEKLAEW VLIQREQQLP VNEETLFQKA 1050
TKIGRSLEGG FKISYEWAVR FMLRHHLTPH ARRAVAHTLP KHVAENAGLF 1100
IEFVQRQIHN QDLPLSMIVA IDEISLFLDT EVLSSDDRKE NALQTVGTGE 1150
PWCDVVLAIL ADGTVLPTLV FFRGQANRFA NVPDSILLEA KDSGYSDDEI 1200
MELWSTRVWK KHTACQHSKS MLVMDCHRTH LSEEVLALLS ASSTLPAVVP 1250
AGCSSKIQPL DVCIKRTVKN FLHKKWKEQA REMADAACDS DVLLQLVLVW 1300
LGEVLGVIGD SPELVQRSFL VASVLPGPDG NVNSPTRNAD MQEELIASLE 1350
EQLKLNGEQS EEHSASAPRP RSSPEETVEP ESLHQLFEGE SETESFYGFE 1400
EADLDLMEI 1409
Length:1,409
Mass (Da):154,910
Last modified:April 26, 2004 - v2
Checksum:iED08A5E2C1E719A5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti513 – 5153HVE → TRP in AAH32176. 1 Publication
Sequence conflicti1342 – 13421Q → E in BAC29003. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030880 mRNA. Translation: BAC27169.1.
AK035255 mRNA. Translation: BAC29003.1.
BC032176 mRNA. Translation: AAH32176.1.
BC096492 mRNA. Translation: AAH96492.1.
AK122288 mRNA. Translation: BAC65570.1.
CCDSiCCDS17596.1.
RefSeqiNP_766271.2. NM_172683.3.
UniGeneiMm.274787.

Genome annotation databases

EnsembliENSMUST00000107270; ENSMUSP00000102891; ENSMUSG00000038902.
GeneIDi229584.
KEGGimmu:229584.
UCSCiuc008qhc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030880 mRNA. Translation: BAC27169.1 .
AK035255 mRNA. Translation: BAC29003.1 .
BC032176 mRNA. Translation: AAH32176.1 .
BC096492 mRNA. Translation: AAH96492.1 .
AK122288 mRNA. Translation: BAC65570.1 .
CCDSi CCDS17596.1.
RefSeqi NP_766271.2. NM_172683.3.
UniGenei Mm.274787.

3D structure databases

ProteinModelPortali Q8BZH4.
SMRi Q8BZH4. Positions 371-402, 490-677, 767-797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230865. 4 interactions.
IntActi Q8BZH4. 1 interaction.

PTM databases

PhosphoSitei Q8BZH4.

Proteomic databases

PaxDbi Q8BZH4.
PRIDEi Q8BZH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107270 ; ENSMUSP00000102891 ; ENSMUSG00000038902 .
GeneIDi 229584.
KEGGi mmu:229584.
UCSCi uc008qhc.2. mouse.

Organism-specific databases

CTDi 23126.
MGIi MGI:2442117. Pogz.
Rougei Search...

Phylogenomic databases

eggNOGi NOG269034.
GeneTreei ENSGT00530000063300.
HOGENOMi HOG000010309.
HOVERGENi HBG049435.
InParanoidi Q8BZH4.
OMAi TPTHPQP.
OrthoDBi EOG7QVM24.
PhylomeDBi Q8BZH4.
TreeFami TF331707.

Miscellaneous databases

ChiTaRSi POGZ. mouse.
NextBioi 379525.
PROi Q8BZH4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BZH4.
Bgeei Q8BZH4.
CleanExi MM_POGZ.
Genevestigatori Q8BZH4.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus and Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Mammary tumor and Mesenchymal stem cell.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 557-1409.
    Tissue: Brain.

Entry informationi

Entry nameiPOGZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BZH4
Secondary accession number(s): Q4VA94
, Q80TZ8, Q8C0K1, Q8K294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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