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Protein

Pogo transposable element with ZNF domain

Gene

Pogz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 55024C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 58024C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 61024C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 63823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri644 – 66724C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri767 – 79024C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri811 – 83626C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. kinetochore assembly Source: UniProtKB
  3. mitotic sister chromatid cohesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with ZNF domain
Gene namesi
Name:Pogz
Synonyms:Kiaa0461
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2442117. Pogz.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Chromosome By similarity. Cytoplasm By similarity
Note: Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear chromatin Source: UniProtKB
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14091409Pogo transposable element with ZNF domainPRO_0000047225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331PhosphoserineBy similarity
Modified residuei422 – 4221PhosphoserineBy similarity
Modified residuei436 – 4361PhosphothreonineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei1334 – 13341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZH4.
PaxDbiQ8BZH4.
PRIDEiQ8BZH4.

PTM databases

PhosphoSiteiQ8BZH4.

Expressioni

Gene expression databases

BgeeiQ8BZH4.
CleanExiMM_POGZ.
ExpressionAtlasiQ8BZH4. baseline and differential.
GenevestigatoriQ8BZH4.

Interactioni

Subunit structurei

Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230865. 4 interactions.
IntActiQ8BZH4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BZH4.
SMRiQ8BZH4. Positions 371-402, 489-677, 767-797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1011 – 108171HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini1113 – 1319207DDEAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni806 – 84641Required for interaction with CBX5By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1336 – 136429Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi872 – 92756Pro-richAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 55024C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 58024C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 61024C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 63823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri644 – 66724C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri767 – 79024C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri811 – 83626C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG269034.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000010309.
HOVERGENiHBG049435.
InParanoidiQ8BZH4.
OMAiTPTHPQP.
OrthoDBiEOG7QVM24.
PhylomeDBiQ8BZH4.
TreeFamiTF331707.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT SVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSNSGAQNSD STKKTLVTLI ANNNAGNTLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AGQPPGQSNQ TSNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTVPSL GQSPGPVVVS NNSSAQRTSG
360 370 380 390 400
PESSVKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE
410 420 430 440 450
YQKKGKSLDA EPSVPSAAKP SSPEKTAPVT STPSSTPIPA LSPPTKVPEP
460 470 480 490 500
NENAGDAVQT KLIMLVDDFY YGRDGGKAAQ LTSFPKVATS FRCPHCTKRL
510 520 530 540 550
KNNIRFMNHM KHHVELDQQN GEVDGHTICQ HCYRQFSTPF QLQCHLENVH
560 570 580 590 600
SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ VCQYRSSLYS
610 620 630 640 650
EVDVHFRMIH EDTRHLLCPY CLKVFKNGNA FQQHYMRHQK RNVYHCNKCR
660 670 680 690 700
LQFLFAKDKI EHKLQHHKTF RKPKQLEGLK PGTKVTIRAS RGQPRTVPVS
710 720 730 740 750
SNDAPSGTLQ EAAALTSTDP LPVFLYPPVQ RNIQKRAVRK MSVMGRQTCL
760 770 780 790 800
ECSFEIPDFP NHFPTYVHCS LCRYSTCCSR AYANHMINNH VPRKSPKYLA
810 820 830 840 850
LFKNSVSGIK LACTSCTFAT SVGDAMAKHL VFNPSHRSSN ILPRGLSWMS
860 870 880 890 900
HLRPGQASER VFDWSMKNTY LPPPLVPNKA ATVKPVGVTP AEPQELAGPV
910 920 930 940 950
LQALPSPAST ATPPATPTHP QPSALPPSAT EGTECLNVSE QEEGSPVTQD
960 970 980 990 1000
PEPASGGGGG SGVGKKEQLS VKKLRVVLFA LCCNTEQAAE HFRNPQRRIR
1010 1020 1030 1040 1050
RWLRRFQASQ GENLEGKYLS FEAEEKLAEW VLIQREQQLP VNEETLFQKA
1060 1070 1080 1090 1100
TKIGRSLEGG FKISYEWAVR FMLRHHLTPH ARRAVAHTLP KHVAENAGLF
1110 1120 1130 1140 1150
IEFVQRQIHN QDLPLSMIVA IDEISLFLDT EVLSSDDRKE NALQTVGTGE
1160 1170 1180 1190 1200
PWCDVVLAIL ADGTVLPTLV FFRGQANRFA NVPDSILLEA KDSGYSDDEI
1210 1220 1230 1240 1250
MELWSTRVWK KHTACQHSKS MLVMDCHRTH LSEEVLALLS ASSTLPAVVP
1260 1270 1280 1290 1300
AGCSSKIQPL DVCIKRTVKN FLHKKWKEQA REMADAACDS DVLLQLVLVW
1310 1320 1330 1340 1350
LGEVLGVIGD SPELVQRSFL VASVLPGPDG NVNSPTRNAD MQEELIASLE
1360 1370 1380 1390 1400
EQLKLNGEQS EEHSASAPRP RSSPEETVEP ESLHQLFEGE SETESFYGFE

EADLDLMEI
Length:1,409
Mass (Da):154,910
Last modified:April 26, 2004 - v2
Checksum:iED08A5E2C1E719A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti513 – 5153HVE → TRP in AAH32176. (PubMed:15489334)Curated
Sequence conflicti1342 – 13421Q → E in BAC29003. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030880 mRNA. Translation: BAC27169.1.
AK035255 mRNA. Translation: BAC29003.1.
BC032176 mRNA. Translation: AAH32176.1.
BC096492 mRNA. Translation: AAH96492.1.
AK122288 mRNA. Translation: BAC65570.1.
CCDSiCCDS17596.1.
RefSeqiNP_766271.2. NM_172683.3.
UniGeneiMm.274787.

Genome annotation databases

EnsembliENSMUST00000107270; ENSMUSP00000102891; ENSMUSG00000038902.
GeneIDi229584.
KEGGimmu:229584.
UCSCiuc008qhc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030880 mRNA. Translation: BAC27169.1.
AK035255 mRNA. Translation: BAC29003.1.
BC032176 mRNA. Translation: AAH32176.1.
BC096492 mRNA. Translation: AAH96492.1.
AK122288 mRNA. Translation: BAC65570.1.
CCDSiCCDS17596.1.
RefSeqiNP_766271.2. NM_172683.3.
UniGeneiMm.274787.

3D structure databases

ProteinModelPortaliQ8BZH4.
SMRiQ8BZH4. Positions 371-402, 489-677, 767-797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230865. 4 interactions.
IntActiQ8BZH4. 1 interaction.

PTM databases

PhosphoSiteiQ8BZH4.

Proteomic databases

MaxQBiQ8BZH4.
PaxDbiQ8BZH4.
PRIDEiQ8BZH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107270; ENSMUSP00000102891; ENSMUSG00000038902.
GeneIDi229584.
KEGGimmu:229584.
UCSCiuc008qhc.2. mouse.

Organism-specific databases

CTDi23126.
MGIiMGI:2442117. Pogz.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG269034.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000010309.
HOVERGENiHBG049435.
InParanoidiQ8BZH4.
OMAiTPTHPQP.
OrthoDBiEOG7QVM24.
PhylomeDBiQ8BZH4.
TreeFamiTF331707.

Miscellaneous databases

ChiTaRSiPogz. mouse.
NextBioi379525.
PROiQ8BZH4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZH4.
CleanExiMM_POGZ.
ExpressionAtlasiQ8BZH4. baseline and differential.
GenevestigatoriQ8BZH4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus and Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Mammary tumor and Mesenchymal stem cell.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 557-1409.
    Tissue: Brain.

Entry informationi

Entry nameiPOGZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BZH4
Secondary accession number(s): Q4VA94
, Q80TZ8, Q8C0K1, Q8K294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 4, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.