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Q8BZH4

- POGZ_MOUSE

UniProt

Q8BZH4 - POGZ_MOUSE

Protein

Pogo transposable element with ZNF domain

Gene

Pogz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39423C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri491 – 51323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri527 – 55024C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri557 – 58024C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri587 – 61024C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 63823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri644 – 66724C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri767 – 79024C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri811 – 83626C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. kinetochore assembly Source: UniProtKB
    2. mitotic sister chromatid cohesion Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pogo transposable element with ZNF domain
    Gene namesi
    Name:Pogz
    Synonyms:Kiaa0461
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2442117. Pogz.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome By similarity. Cytoplasm By similarity
    Note: Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nuclear chromatin Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14091409Pogo transposable element with ZNF domainPRO_0000047225Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331PhosphoserineBy similarity
    Modified residuei422 – 4221PhosphoserineBy similarity
    Modified residuei436 – 4361PhosphothreonineBy similarity
    Modified residuei442 – 4421PhosphoserineBy similarity
    Modified residuei1334 – 13341PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8BZH4.
    PRIDEiQ8BZH4.

    PTM databases

    PhosphoSiteiQ8BZH4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BZH4.
    BgeeiQ8BZH4.
    CleanExiMM_POGZ.
    GenevestigatoriQ8BZH4.

    Interactioni

    Subunit structurei

    Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi230865. 4 interactions.
    IntActiQ8BZH4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZH4.
    SMRiQ8BZH4. Positions 371-402, 490-677, 767-797.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1011 – 108171HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini1113 – 1319207DDEAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni806 – 84641Required for interaction with CBX5By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1336 – 136429Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi872 – 92756Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39423C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri491 – 51323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri527 – 55024C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri557 – 58024C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri587 – 61024C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 63823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri644 – 66724C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri767 – 79024C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri811 – 83626C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG269034.
    GeneTreeiENSGT00530000063300.
    HOGENOMiHOG000010309.
    HOVERGENiHBG049435.
    InParanoidiQ8BZH4.
    OMAiTPTHPQP.
    OrthoDBiEOG7QVM24.
    PhylomeDBiQ8BZH4.
    TreeFamiTF331707.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BZH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT SVSVSQQPVS     50
    APVPIAAHAS VAGHLSTSTT VSNSGAQNSD STKKTLVTLI ANNNAGNTLV 100
    QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI 150
    TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV 200
    GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK 250
    STPSTSTTPT ATQPTSLGQL AGQPPGQSNQ TSNPKLAPSF PSPPAVSIAS 300
    FVTVKRPGVT GENSNEVAKL VNTLNTVPSL GQSPGPVVVS NNSSAQRTSG 350
    PESSVKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE 400
    YQKKGKSLDA EPSVPSAAKP SSPEKTAPVT STPSSTPIPA LSPPTKVPEP 450
    NENAGDAVQT KLIMLVDDFY YGRDGGKAAQ LTSFPKVATS FRCPHCTKRL 500
    KNNIRFMNHM KHHVELDQQN GEVDGHTICQ HCYRQFSTPF QLQCHLENVH 550
    SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ VCQYRSSLYS 600
    EVDVHFRMIH EDTRHLLCPY CLKVFKNGNA FQQHYMRHQK RNVYHCNKCR 650
    LQFLFAKDKI EHKLQHHKTF RKPKQLEGLK PGTKVTIRAS RGQPRTVPVS 700
    SNDAPSGTLQ EAAALTSTDP LPVFLYPPVQ RNIQKRAVRK MSVMGRQTCL 750
    ECSFEIPDFP NHFPTYVHCS LCRYSTCCSR AYANHMINNH VPRKSPKYLA 800
    LFKNSVSGIK LACTSCTFAT SVGDAMAKHL VFNPSHRSSN ILPRGLSWMS 850
    HLRPGQASER VFDWSMKNTY LPPPLVPNKA ATVKPVGVTP AEPQELAGPV 900
    LQALPSPAST ATPPATPTHP QPSALPPSAT EGTECLNVSE QEEGSPVTQD 950
    PEPASGGGGG SGVGKKEQLS VKKLRVVLFA LCCNTEQAAE HFRNPQRRIR 1000
    RWLRRFQASQ GENLEGKYLS FEAEEKLAEW VLIQREQQLP VNEETLFQKA 1050
    TKIGRSLEGG FKISYEWAVR FMLRHHLTPH ARRAVAHTLP KHVAENAGLF 1100
    IEFVQRQIHN QDLPLSMIVA IDEISLFLDT EVLSSDDRKE NALQTVGTGE 1150
    PWCDVVLAIL ADGTVLPTLV FFRGQANRFA NVPDSILLEA KDSGYSDDEI 1200
    MELWSTRVWK KHTACQHSKS MLVMDCHRTH LSEEVLALLS ASSTLPAVVP 1250
    AGCSSKIQPL DVCIKRTVKN FLHKKWKEQA REMADAACDS DVLLQLVLVW 1300
    LGEVLGVIGD SPELVQRSFL VASVLPGPDG NVNSPTRNAD MQEELIASLE 1350
    EQLKLNGEQS EEHSASAPRP RSSPEETVEP ESLHQLFEGE SETESFYGFE 1400
    EADLDLMEI 1409
    Length:1,409
    Mass (Da):154,910
    Last modified:April 26, 2004 - v2
    Checksum:iED08A5E2C1E719A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti513 – 5153HVE → TRP in AAH32176. (PubMed:15489334)Curated
    Sequence conflicti1342 – 13421Q → E in BAC29003. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030880 mRNA. Translation: BAC27169.1.
    AK035255 mRNA. Translation: BAC29003.1.
    BC032176 mRNA. Translation: AAH32176.1.
    BC096492 mRNA. Translation: AAH96492.1.
    AK122288 mRNA. Translation: BAC65570.1.
    CCDSiCCDS17596.1.
    RefSeqiNP_766271.2. NM_172683.3.
    UniGeneiMm.274787.

    Genome annotation databases

    EnsembliENSMUST00000107270; ENSMUSP00000102891; ENSMUSG00000038902.
    GeneIDi229584.
    KEGGimmu:229584.
    UCSCiuc008qhc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030880 mRNA. Translation: BAC27169.1 .
    AK035255 mRNA. Translation: BAC29003.1 .
    BC032176 mRNA. Translation: AAH32176.1 .
    BC096492 mRNA. Translation: AAH96492.1 .
    AK122288 mRNA. Translation: BAC65570.1 .
    CCDSi CCDS17596.1.
    RefSeqi NP_766271.2. NM_172683.3.
    UniGenei Mm.274787.

    3D structure databases

    ProteinModelPortali Q8BZH4.
    SMRi Q8BZH4. Positions 371-402, 490-677, 767-797.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230865. 4 interactions.
    IntActi Q8BZH4. 1 interaction.

    PTM databases

    PhosphoSitei Q8BZH4.

    Proteomic databases

    PaxDbi Q8BZH4.
    PRIDEi Q8BZH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107270 ; ENSMUSP00000102891 ; ENSMUSG00000038902 .
    GeneIDi 229584.
    KEGGi mmu:229584.
    UCSCi uc008qhc.2. mouse.

    Organism-specific databases

    CTDi 23126.
    MGIi MGI:2442117. Pogz.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG269034.
    GeneTreei ENSGT00530000063300.
    HOGENOMi HOG000010309.
    HOVERGENi HBG049435.
    InParanoidi Q8BZH4.
    OMAi TPTHPQP.
    OrthoDBi EOG7QVM24.
    PhylomeDBi Q8BZH4.
    TreeFami TF331707.

    Miscellaneous databases

    ChiTaRSi POGZ. mouse.
    NextBioi 379525.
    PROi Q8BZH4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BZH4.
    Bgeei Q8BZH4.
    CleanExi MM_POGZ.
    Genevestigatori Q8BZH4.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus and Urinary bladder.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He.
      Tissue: Mammary tumor and Mesenchymal stem cell.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 557-1409.
      Tissue: Brain.

    Entry informationi

    Entry nameiPOGZ_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZH4
    Secondary accession number(s): Q4VA94
    , Q80TZ8, Q8C0K1, Q8K294
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3