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Protein

Zinc transporter ZIP13

Gene

Slc39a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a zinc-influx transporter.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • zinc ion transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  • cellular zinc ion homeostasis Source: BHF-UCL
  • connective tissue development Source: BHF-UCL
  • zinc II ion transmembrane transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.5.4.9. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP13
Alternative name(s):
Solute carrier family 39 member 13
Zrt- and Irt-like protein 13
Short name:
ZIP-13
Gene namesi
Name:Slc39a13
Synonyms:Zip13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915677. Slc39a13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6LumenalSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 68CytoplasmicSequence analysisAdd BLAST41
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 108LumenalSequence analysisAdd BLAST19
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 150CytoplasmicSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 232LumenalSequence analysisAdd BLAST61
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 275CytoplasmicSequence analysisAdd BLAST22
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 306LumenalSequence analysis10
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 339CytoplasmicSequence analysisAdd BLAST12
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361LumenalSequence analysis1

GO - Cellular componenti

  • Golgi apparatus Source: BHF-UCL
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: MGI
  • perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123101 – 361Zinc transporter ZIP13Add BLAST361

Proteomic databases

PaxDbiQ8BZH0.
PRIDEiQ8BZH0.

PTM databases

PhosphoSitePlusiQ8BZH0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002105.
ExpressionAtlasiQ8BZH0. baseline and differential.
GenevisibleiQ8BZH0. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073263.

Structurei

3D structure databases

ProteinModelPortaliQ8BZH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi254 – 259XEXPHE-motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 45Poly-Ala4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2694. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ8BZH0.
KOiK14719.
OMAiEEDDPWH.
OrthoDBiEOG091G0GD1.
PhylomeDBiQ8BZH0.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BZH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGCPCPGCG MAGQRLLFLT VLALELLERA GGSQPALRSL GAAAACRLDN
60 70 80 90 100
KESESWGALL SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTLLQSE
110 120 130 140 150
AGAWRLRQLL SFALGGLLGN VFLHLLPEAW AYTCNITPGG EGQSLQRQQQ
160 170 180 190 200
LGLWVIAGFL TFLALEKMFL NSKEDPSQAP SKDPTAAALN GGHCLAQPAA
210 220 230 240 250
EPGLRAVVRN LKVSGYLNLL ANTIDNFTHG LAVAASFLVS KKIGLLTTMA
260 270 280 290 300
ILLHEIPHEV GDFAILLRAG FDRWTAAKLQ FSTALGGLLG ACFAICTQSP
310 320 330 340 350
KGVEETVVWI LPFTSGGFLY IALVNVLPDL LEEDDPWHSL QQVLLLCSGV
360
LVMVLLSLFV E
Length:361
Mass (Da):38,502
Last modified:March 1, 2003 - v1
Checksum:i41CE56EE98FE9EDA
GO
Isoform 2 (identifier: Q8BZH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: P → PATGLAWPVSAPPA

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):39,722
Checksum:i45BE4E15F2949BE2
GO
Isoform 3 (identifier: Q8BZH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     179-212: Missing.

Show »
Length:160
Mass (Da):17,376
Checksum:i4FD8F416E9D6C1EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169F → L in AAH20106 (PubMed:15489334).Curated1
Sequence conflicti173K → Q in AAH20106 (PubMed:15489334).Curated1
Sequence conflicti360V → A in AAH20106 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298201 – 167Missing in isoform 3. 2 PublicationsAdd BLAST167
Alternative sequenceiVSP_029821138P → PATGLAWPVSAPPA in isoform 2. 1 Publication1
Alternative sequenceiVSP_029822179 – 212Missing in isoform 3. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003191 mRNA. Translation: BAB22631.1.
AK035296 mRNA. Translation: BAC29020.1.
AK156951 mRNA. Translation: BAE33911.1.
AL691439 Genomic DNA. Translation: CAM19026.1.
AL691439 Genomic DNA. Translation: CAM19027.1.
AL691439 Genomic DNA. Translation: CAX15266.1.
BC100463 mRNA. Translation: AAI00464.1.
BC020106 mRNA. Translation: AAH20106.1.
BC125525 mRNA. Translation: AAI25526.1.
CCDSiCCDS16424.1. [Q8BZH0-1]
CCDS71095.1. [Q8BZH0-2]
RefSeqiNP_001277694.1. NM_001290765.1. [Q8BZH0-2]
NP_080997.1. NM_026721.3. [Q8BZH0-1]
XP_006500162.1. XM_006500099.3. [Q8BZH0-2]
XP_017174725.1. XM_017319236.1. [Q8BZH0-1]
XP_017174727.1. XM_017319238.1. [Q8BZH0-3]
UniGeneiMm.192375.

Genome annotation databases

EnsembliENSMUST00000073575; ENSMUSP00000073263; ENSMUSG00000002105. [Q8BZH0-1]
ENSMUST00000079976; ENSMUSP00000078892; ENSMUSG00000002105. [Q8BZH0-3]
ENSMUST00000111436; ENSMUSP00000107063; ENSMUSG00000002105. [Q8BZH0-2]
GeneIDi68427.
KEGGimmu:68427.
UCSCiuc008kug.2. mouse. [Q8BZH0-1]
uc008kuh.2. mouse. [Q8BZH0-2]
uc008kui.2. mouse. [Q8BZH0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003191 mRNA. Translation: BAB22631.1.
AK035296 mRNA. Translation: BAC29020.1.
AK156951 mRNA. Translation: BAE33911.1.
AL691439 Genomic DNA. Translation: CAM19026.1.
AL691439 Genomic DNA. Translation: CAM19027.1.
AL691439 Genomic DNA. Translation: CAX15266.1.
BC100463 mRNA. Translation: AAI00464.1.
BC020106 mRNA. Translation: AAH20106.1.
BC125525 mRNA. Translation: AAI25526.1.
CCDSiCCDS16424.1. [Q8BZH0-1]
CCDS71095.1. [Q8BZH0-2]
RefSeqiNP_001277694.1. NM_001290765.1. [Q8BZH0-2]
NP_080997.1. NM_026721.3. [Q8BZH0-1]
XP_006500162.1. XM_006500099.3. [Q8BZH0-2]
XP_017174725.1. XM_017319236.1. [Q8BZH0-1]
XP_017174727.1. XM_017319238.1. [Q8BZH0-3]
UniGeneiMm.192375.

3D structure databases

ProteinModelPortaliQ8BZH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073263.

Protein family/group databases

TCDBi2.A.5.4.9. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSitePlusiQ8BZH0.

Proteomic databases

PaxDbiQ8BZH0.
PRIDEiQ8BZH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073575; ENSMUSP00000073263; ENSMUSG00000002105. [Q8BZH0-1]
ENSMUST00000079976; ENSMUSP00000078892; ENSMUSG00000002105. [Q8BZH0-3]
ENSMUST00000111436; ENSMUSP00000107063; ENSMUSG00000002105. [Q8BZH0-2]
GeneIDi68427.
KEGGimmu:68427.
UCSCiuc008kug.2. mouse. [Q8BZH0-1]
uc008kuh.2. mouse. [Q8BZH0-2]
uc008kui.2. mouse. [Q8BZH0-3]

Organism-specific databases

CTDi91252.
MGIiMGI:1915677. Slc39a13.

Phylogenomic databases

eggNOGiKOG2694. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ8BZH0.
KOiK14719.
OMAiEEDDPWH.
OrthoDBiEOG091G0GD1.
PhylomeDBiQ8BZH0.
TreeFamiTF318470.

Miscellaneous databases

PROiQ8BZH0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002105.
ExpressionAtlasiQ8BZH0. baseline and differential.
GenevisibleiQ8BZH0. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39AD_MOUSE
AccessioniPrimary (citable) accession number: Q8BZH0
Secondary accession number(s): B7ZCF2
, Q497M5, Q8VDX1, Q9D1R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.