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Protein

Phosphoglucomutase-like protein 5

Gene

Pgm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity (By similarity).By similarity

Cofactori

Mg2+CuratedNote: Binds 1 Mg2+ ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstrateBy similarity1
Active sitei122Phosphoserine intermediateBy similarity1
Metal bindingi122Magnesium; via phosphate groupBy similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi293MagnesiumBy similarity1
Metal bindingi295MagnesiumBy similarity1
Metal bindingi297MagnesiumBy similarity1
Binding sitei394SubstrateBy similarity1
Binding sitei520SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Cell adhesion, Glucose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglucomutase-like protein 5
Gene namesi
Name:Pgm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1925668. Pgm5.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • cell-substrate junction Source: MGI
  • costamere Source: MGI
  • cytoplasmic side of plasma membrane Source: MGI
  • dystrophin-associated glycoprotein complex Source: MGI
  • focal adhesion Source: MGI
  • intercalated disc Source: MGI
  • sarcolemma Source: MGI
  • spot adherens junction Source: MGI
  • stress fiber Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002940641 – 567Phosphoglucomutase-like protein 5Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphothreonineCombined sources1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZF8.
PaxDbiQ8BZF8.
PeptideAtlasiQ8BZF8.
PRIDEiQ8BZF8.

PTM databases

iPTMnetiQ8BZF8.
PhosphoSitePlusiQ8BZF8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041731.
CleanExiMM_PGM5.
GenevisibleiQ8BZF8. MM.

Interactioni

Subunit structurei

Interacts with cytoskeletal proteins dystrophin and utrophin.By similarity

Protein-protein interaction databases

BioGridi230463. 2 interactors.
STRINGi10090.ENSMUSP00000036025.

Structurei

3D structure databases

ProteinModelPortaliQ8BZF8.
SMRiQ8BZF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 123Substrate bindingBy similarity2
Regioni297 – 298Substrate bindingBy similarity2
Regioni381 – 383Substrate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi510 – 513Poly-Ser4

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG0625. Eukaryota.
COG0033. LUCA.
GeneTreeiENSGT00390000011831.
HOGENOMiHOG000009550.
HOVERGENiHBG001599.
InParanoidiQ8BZF8.
KOiK15636.
OMAiPTAPYED.
OrthoDBiEOG091G0HZ0.
PhylomeDBiQ8BZF8.
TreeFamiTF300350.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSPIPVLT VPTAPYEDQR PTGGGGLRRP TGLFEGQRNY LPNFIQSVLS
60 70 80 90 100
SIDLRDRQGC TMVVGSDGRY FSRTATEIVV QMAAANGIGR LIIGQNGILS
110 120 130 140 150
TPAVSCIIRK IKAAGGIILT ASHCPGGPGG EFGVKFNVAN GGPAPDVVSD
160 170 180 190 200
KIYQISKTIE EYAICPDLRI DLSRLGRQEF DLENKFKPFR VEIVDPVDIY
210 220 230 240 250
LNLLRNIFDF NAIKSLLTGP SQLKIRVDAM HGVMGPYVRK VLCDELGAPA
260 270 280 290 300
NSAINCVPLE DFGGQHPDPN LTYATTLLEA MKGGEYGFGA AFDADGDRYM
310 320 330 340 350
ILGQNGFFVS PSDSLAIIAA NLSCIPYFRQ MGVRGFGRSM PTSTALDRVA
360 370 380 390 400
KSMKVPVYET PAGWRFFSNL MDSGRCSLCG EESFGTGSDH LREKDGLWAV
410 420 430 440 450
LVWLSIIAAR KQSVEEIVRD HWAKYGRHYY CRFDYEGLEP KATYYIMRDL
460 470 480 490 500
EALVTDKSFI GQQFAVGSHI YSIAKTDSFE YVDPVDGTVT KKQGLRIIFS
510 520 530 540 550
DASRLIFRLS SSSGVRATIR LYAESYERDP SGHDQEPQAV LSPLIAIALK
560
ISQIHERTGR RGPTVIT
Length:567
Mass (Da):62,220
Last modified:July 10, 2007 - v2
Checksum:i46CD383095054BEB
GO

Sequence cautioni

The sequence BAC29083 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035507 mRNA. Translation: BAC29083.1. Different initiation.
CCDSiCCDS29714.1.
RefSeqiNP_778178.3. NM_175013.2.
UniGeneiMm.105222.
Mm.391170.

Genome annotation databases

EnsembliENSMUST00000047666; ENSMUSP00000036025; ENSMUSG00000041731.
GeneIDi226041.
KEGGimmu:226041.
UCSCiuc008has.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035507 mRNA. Translation: BAC29083.1. Different initiation.
CCDSiCCDS29714.1.
RefSeqiNP_778178.3. NM_175013.2.
UniGeneiMm.105222.
Mm.391170.

3D structure databases

ProteinModelPortaliQ8BZF8.
SMRiQ8BZF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230463. 2 interactors.
STRINGi10090.ENSMUSP00000036025.

PTM databases

iPTMnetiQ8BZF8.
PhosphoSitePlusiQ8BZF8.

Proteomic databases

MaxQBiQ8BZF8.
PaxDbiQ8BZF8.
PeptideAtlasiQ8BZF8.
PRIDEiQ8BZF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047666; ENSMUSP00000036025; ENSMUSG00000041731.
GeneIDi226041.
KEGGimmu:226041.
UCSCiuc008has.1. mouse.

Organism-specific databases

CTDi5239.
MGIiMGI:1925668. Pgm5.

Phylogenomic databases

eggNOGiKOG0625. Eukaryota.
COG0033. LUCA.
GeneTreeiENSGT00390000011831.
HOGENOMiHOG000009550.
HOVERGENiHBG001599.
InParanoidiQ8BZF8.
KOiK15636.
OMAiPTAPYED.
OrthoDBiEOG091G0HZ0.
PhylomeDBiQ8BZF8.
TreeFamiTF300350.

Miscellaneous databases

ChiTaRSiPgm5. mouse.
PROiQ8BZF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041731.
CleanExiMM_PGM5.
GenevisibleiQ8BZF8. MM.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGM5_MOUSE
AccessioniPrimary (citable) accession number: Q8BZF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.