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Protein

Phosphopantothenoylcysteine decarboxylase

Gene

Ppcdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine (By similarity).By similarity

Catalytic activityi

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (Pank4), Pantothenate kinase 3 (Pank3), Pantothenate kinase 1 (Pank1)
  2. Phosphopantothenate--cysteine ligase (Ppcs)
  3. Phosphopantothenoylcysteine decarboxylase (Ppcdc)
  4. Bifunctional coenzyme A synthase (Coasy)
  5. Bifunctional coenzyme A synthase (Coasy)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59FMNBy similarity1
Binding sitei140SubstrateBy similarity1
Active sitei173Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 107FMNBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCoenzyme A biosynthesis
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciMOUSE:MONOMER3DJ-561.
ReactomeiR-MMU-196783. Coenzyme A biosynthesis.
UniPathwayiUPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)
Short name:
PPC-DC
Alternative name(s):
CoaC
Gene namesi
Name:Ppcdc
Synonyms:Coac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914062. Ppcdc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001820311 – 204Phosphopantothenoylcysteine decarboxylaseAdd BLAST204

Proteomic databases

MaxQBiQ8BZB2.
PaxDbiQ8BZB2.
PeptideAtlasiQ8BZB2.
PRIDEiQ8BZB2.

PTM databases

iPTMnetiQ8BZB2.
PhosphoSitePlusiQ8BZB2.
SwissPalmiQ8BZB2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063849.
CleanExiMM_PPCDC.
ExpressionAtlasiQ8BZB2. baseline and differential.
GenevisibleiQ8BZB2. MM.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082856.

Structurei

3D structure databases

ProteinModelPortaliQ8BZB2.
SMRiQ8BZB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0672. Eukaryota.
COG0452. LUCA.
GeneTreeiENSGT00440000038107.
HOGENOMiHOG000187629.
HOVERGENiHBG054722.
InParanoidiQ8BZB2.
KOiK01598.
OMAiKHFYSPQ.
OrthoDBiEOG091G0SB2.
PhylomeDBiQ8BZB2.
TreeFamiTF315740.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR036551. Flavin_trans-like.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF52507. SSF52507. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BZB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPKAPCPAA VPSEERKFRV LVGVTGSVAA LKLPLLVSKL LDVPGLEVTV
60 70 80 90 100
VTTERAKHFY SPQDVPVTLY SDADEWEMWK RRSDPVLHID LRRWADLMLV
110 120 130 140 150
APLDANTLGK VASGICDNLL TCVIRAWDLN KPLLFCPAMN TAMWEHPLTA
160 170 180 190 200
QQVAQLKAFG YVEIPCVSKK LVCGDQGLGA MAEVETIVAK VQAVLSQHGS

IQQS
Length:204
Mass (Da):22,344
Last modified:March 1, 2003 - v1
Checksum:i8BA847F773F80ABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036042 mRNA. Translation: BAC29285.1.
BC052928 mRNA. Translation: AAH52928.1.
BC089351 mRNA. Translation: AAH89351.1.
CCDSiCCDS23221.1.
RefSeqiNP_789801.1. NM_176831.4.
XP_006511423.1. XM_006511360.3.
XP_006511424.1. XM_006511361.3.
XP_006511425.1. XM_006511362.3.
XP_006511426.1. XM_006511363.3.
XP_011241091.1. XM_011242789.2.
XP_017169007.1. XM_017313518.1.
UniGeneiMm.250508.

Genome annotation databases

EnsembliENSMUST00000085709; ENSMUSP00000082856; ENSMUSG00000063849.
GeneIDi66812.
KEGGimmu:66812.
UCSCiuc009put.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCOAC_MOUSE
AccessioniPrimary (citable) accession number: Q8BZB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families