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Protein

G-protein coupled receptor 26

Gene

Gpr26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 26
Gene namesi
Name:Gpr26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2441758. Gpr26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010ExtracellularSequence analysis
Transmembranei11 – 3121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini32 – 4716CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini69 – 8113ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini145 – 16824ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini190 – 24556CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 27610ExtracellularSequence analysis
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 33740CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337G-protein coupled receptor 26PRO_0000069546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8BZA7.
PaxDbiQ8BZA7.
PRIDEiQ8BZA7.

PTM databases

PhosphoSiteiQ8BZA7.

Expressioni

Tissue specificityi

Exclusively expressed in the brain. Prominent expression is detected throughout the entire neocortex at all rostrocaudal and dorsoventral levels. Strong expression is detected in olfactory and auditory sensory areas.1 Publication

Developmental stagei

At E14.5, expression is limited to the developing nervous system with strong expression in the developing cortex, midbrain, cerebellum and medulla. Weaker expression is also detected in the trigeminal ganglion.1 Publication

Gene expression databases

BgeeiQ8BZA7.
CleanExiMM_GPR26.
ExpressionAtlasiQ8BZA7. baseline and differential.
GenevisibleiQ8BZA7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041664.

Structurei

3D structure databases

ProteinModelPortaliQ8BZA7.
SMRiQ8BZA7. Positions 11-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOGENOMiHOG000059564.
HOVERGENiHBG051804.
InParanoidiQ8BZA7.
KOiK08411.
OMAiTQFVIFT.
OrthoDBiEOG7HMS1F.
PhylomeDBiQ8BZA7.
TreeFamiTF332434.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWDAGLAG LLVGTIGVSL LSNGLVLLCL LHSADIRRQA PALFTLNLTC
60 70 80 90 100
GNLLCTVVNM PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL
110 120 130 140 150
SIDRWVAVVF PLSYRAKMRL RDAAFMVAYT WLHALTFPAT ALALSWLGFH
160 170 180 190 200
QLYASCTLCS RRPDERLRFA VFTSAFHALS FLLSFIVLCF TYLKVLKVAR
210 220 230 240 250
FHCKRIDVIT MQTLVLLVDI HPSVRERCLE EQKRRRQRAT KKISTFIGTF
260 270 280 290 300
LVCFAPYVIT RLVELFSTAP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ
310 320 330
YRRSCKELLN RIFNRRSLHS VGLTGDSHSQ NILPVSE
Length:337
Mass (Da):37,747
Last modified:March 1, 2003 - v1
Checksum:iCD7CF15744E722DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561C → R in AAO85097 (PubMed:12679517).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036100 mRNA. Translation: BAC29305.1.
AK042755 mRNA. Translation: BAC31354.1.
AY255585 mRNA. Translation: AAO85097.1.
CCDSiCCDS21920.1.
RefSeqiNP_775586.1. NM_173410.3.
UniGeneiMm.208740.

Genome annotation databases

EnsembliENSMUST00000045840; ENSMUSP00000041664; ENSMUSG00000040125.
GeneIDi233919.
KEGGimmu:233919.
UCSCiuc009kbs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036100 mRNA. Translation: BAC29305.1.
AK042755 mRNA. Translation: BAC31354.1.
AY255585 mRNA. Translation: AAO85097.1.
CCDSiCCDS21920.1.
RefSeqiNP_775586.1. NM_173410.3.
UniGeneiMm.208740.

3D structure databases

ProteinModelPortaliQ8BZA7.
SMRiQ8BZA7. Positions 11-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041664.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BZA7.

Proteomic databases

MaxQBiQ8BZA7.
PaxDbiQ8BZA7.
PRIDEiQ8BZA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045840; ENSMUSP00000041664; ENSMUSG00000040125.
GeneIDi233919.
KEGGimmu:233919.
UCSCiuc009kbs.1. mouse.

Organism-specific databases

CTDi2849.
MGIiMGI:2441758. Gpr26.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOGENOMiHOG000059564.
HOVERGENiHBG051804.
InParanoidiQ8BZA7.
KOiK08411.
OMAiTQFVIFT.
OrthoDBiEOG7HMS1F.
PhylomeDBiQ8BZA7.
TreeFamiTF332434.

Miscellaneous databases

NextBioi381967.
PROiQ8BZA7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZA7.
CleanExiMM_GPR26.
ExpressionAtlasiQ8BZA7. baseline and differential.
GenevisibleiQ8BZA7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 117-291.
  3. "Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78."
    Jones P.G., Nawoschik S.P., Sreekumar K., Uveges A.J., Tseng E., Zhang L., Johnson J., He L., Paulsen J.E., Bates B., Pausch M.H.
    Biochim. Biophys. Acta 1770:890-901(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR26_MOUSE
AccessioniPrimary (citable) accession number: Q8BZA7
Secondary accession number(s): Q80T55, Q8BXZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: February 17, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.