UniProtKB - Q8BZ98 (DYN3_MOUSE)
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Protein
Dynamin-3
Gene
Dnm3
Organism
Mus musculus (Mouse)
Status
Functioni
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).By similarity
Catalytic activityi
GTP + H2O = GDP + phosphate.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 46 | GTPBy similarity | 9 | |
Nucleotide bindingi | 205 – 211 | GTPBy similarity | 7 | |
Nucleotide bindingi | 236 – 239 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: MGI
- microtubule binding Source: GO_Central
- nitric-oxide synthase binding Source: Ensembl
- type 1 metabotropic glutamate receptor binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: Ensembl
GO - Biological processi
- dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
- membrane fusion Source: GO_Central
- mitochondrial fission Source: GO_Central
- negative regulation of dendritic spine morphogenesis Source: Ensembl
- positive regulation of filopodium assembly Source: Ensembl
- positive regulation of synaptic vesicle recycling Source: Ensembl
- postsynaptic neurotransmitter receptor internalization Source: Ensembl
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: SynGO
Keywordsi
Molecular function | Hydrolase, Motor protein |
Biological process | Endocytosis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade. R-MMU-2132295. MHC class II antigen presentation. R-MMU-437239. Recycling pathway of L1. R-MMU-8856828. Clathrin-mediated endocytosis. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Dnm3 Synonyms:Kiaa0820 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341299. Dnm3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319951 | 1 – 863 | Dynamin-3Add BLAST | 863 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 80 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 125 | Nitrated tyrosine; alternateBy similarity | 1 | |
Modified residuei | 125 | Phosphotyrosine; alternateBy similarity | 1 | |
Modified residuei | 231 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 299 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 306 | PhosphoserineBy similarity | 1 | |
Modified residuei | 347 | PhosphoserineBy similarity | 1 | |
Modified residuei | 593 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 594 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 763 | PhosphoserineBy similarity | 1 | |
Modified residuei | 767 | PhosphoserineBy similarity | 1 | |
Modified residuei | 787 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 847 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, Nitration, PhosphoproteinProteomic databases
PaxDbi | Q8BZ98. |
PeptideAtlasi | Q8BZ98. |
PRIDEi | Q8BZ98. |
PTM databases
iPTMneti | Q8BZ98. |
PhosphoSitePlusi | Q8BZ98. |
SwissPalmi | Q8BZ98. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040265. |
CleanExi | MM_DNM3. |
ExpressionAtlasi | Q8BZ98. baseline and differential. |
Genevisiblei | Q8BZ98. MM. |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Amph | Q7TQF7 | 2 | EBI-6880033,EBI-775139 |
GO - Molecular functioni
- identical protein binding Source: MGI
- microtubule binding Source: GO_Central
- nitric-oxide synthase binding Source: Ensembl
- type 1 metabotropic glutamate receptor binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 222243. 1 interactor. |
IntActi | Q8BZ98. 9 interactors. |
MINTi | Q8BZ98. |
STRINGi | 10090.ENSMUSP00000064538. |
Structurei
3D structure databases
ProteinModelPortali | Q8BZ98. |
SMRi | Q8BZ98. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 294 | Dynamin-type GAdd BLAST | 267 | |
Domaini | 515 – 621 | PHPROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 653 – 744 | GEDPROSITE-ProRule annotationAdd BLAST | 92 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0446. Eukaryota. COG0699. LUCA. |
GeneTreei | ENSGT00760000119213. |
HOGENOMi | HOG000161069. |
HOVERGENi | HBG107833. |
InParanoidi | Q8BZ98. |
KOi | K01528. |
PhylomeDBi | Q8BZ98. |
TreeFami | TF300362. |
Family and domain databases
CDDi | cd08771. DLP_1. 1 hit. |
Gene3Di | 2.30.29.30. 1 hit. |
InterProi | View protein in InterPro IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR022812. Dynamin_SF. IPR030381. G_DYNAMIN_dom. IPR003130. GED. IPR020850. GED_dom. IPR027417. P-loop_NTPase. IPR011993. PH-like_dom_sf. IPR001849. PH_domain. |
PANTHERi | PTHR11566. PTHR11566. 1 hit. |
Pfami | View protein in Pfam PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit. |
PRINTSi | PR00195. DYNAMIN. |
SMARTi | View protein in SMART SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. SM00233. PH. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS00410. G_DYNAMIN_1. 1 hit. PS51718. G_DYNAMIN_2. 1 hit. PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BZ98-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE
110 120 130 140 150
IEAETDRVTG MNKGISSIPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP
160 170 180 190 200
DIEYQIRDMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA
260 270 280 290 300
AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL
310 320 330 340 350
QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VMQELINTVK KCTKRLANFP
460 470 480 490 500
RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ
510 520 530 540 550
QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV LTAESLSWYK
560 570 580 590 600
DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRFLE
610 620 630 640 650
LACDSQEDVD SWKASLLRAG VYPDKSVGSN KTENDENGQA ENFSMDPQLE
660 670 680 690 700
RQVETIRNLV DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY
710 720 730 740 750
SSEDQNTLME ESAEQAQRRD EMLRMYQALK EALAIIGDIN TATVSTPAPP
760 770 780 790 800
PVDDSWLQHS RRSPPPSPTT QRRLTISAPL PRPTSGRGPA PAIPSPGPHS
810 820 830 840 850
GAPPVPFRPG PLPPFPNSSD SFGAPPQVPS RPTRAPPSVP SRRPPPSPTR
860
PTIIRPLESS LLD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | G → A in BAE28068 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 532 – 549 | Missing in BAC65661 (PubMed:12693553).CuratedAdd BLAST | 18 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031548 | 628 – 631 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036199 mRNA. Translation: BAC29343.1. AK049724 mRNA. Translation: BAC33895.1. AK147678 mRNA. Translation: BAE28068.1. BC141143 mRNA. Translation: AAI41144.1. BC141144 mRNA. Translation: AAI41145.1. AK122379 Transcribed RNA. Translation: BAC65661.1. |
CCDSi | CCDS48417.1. [Q8BZ98-2] |
RefSeqi | NP_001033708.1. NM_001038619.1. [Q8BZ98-1] NP_766234.1. NM_172646.2. [Q8BZ98-2] |
UniGenei | Mm.441620. |
Genome annotation databases
Ensembli | ENSMUST00000070330; ENSMUSP00000064538; ENSMUSG00000040265. [Q8BZ98-2] |
GeneIDi | 103967. |
KEGGi | mmu:103967. |
UCSCi | uc007dga.2. mouse. [Q8BZ98-1] uc007dgb.2. mouse. [Q8BZ98-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | DYN3_MOUSE | |
Accessioni | Q8BZ98Primary (citable) accession number: Q8BZ98 Secondary accession number(s): B2RUH0 Q8BWW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | March 28, 2018 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |