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Q8BZ98

- DYN3_MOUSE

UniProt

Q8BZ98 - DYN3_MOUSE

Protein

Dynamin-3

Gene

Dnm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis By similarity.By similarity

    Catalytic activityi

    GTP + H2O = GDP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458GTPBy similarity
    Nucleotide bindingi136 – 1405GTPBy similarity
    Nucleotide bindingi205 – 2084GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Motor protein

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_202778. Retrograde neurotrophin signalling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynamin-3 (EC:3.6.5.5)
    Gene namesi
    Name:Dnm3
    Synonyms:Kiaa0820
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1341299. Dnm3.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: Microtubule-associated.By similarity

    GO - Cellular componenti

    1. microtubule Source: UniProtKB-KW
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Dynamin-3PRO_0000319951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei763 – 7631PhosphoserineBy similarity
    Modified residuei767 – 7671PhosphoserineBy similarity
    Modified residuei847 – 8471PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BZ98.
    PaxDbiQ8BZ98.
    PRIDEiQ8BZ98.

    PTM databases

    PhosphoSiteiQ8BZ98.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BZ98.
    BgeeiQ8BZ98.
    CleanExiMM_DNM3.
    GenevestigatoriQ8BZ98.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8BZ98. 5 interactions.
    MINTiMINT-1856052.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZ98.
    SMRiQ8BZ98. Positions 6-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 294267Dynamin-type GAdd
    BLAST
    Domaini515 – 621107PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini653 – 74492GEDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GED domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0699.
    GeneTreeiENSGT00740000115253.
    HOGENOMiHOG000161069.
    HOVERGENiHBG107833.
    InParanoidiB2RUH0.
    KOiK01528.
    PhylomeDBiQ8BZ98.
    TreeFamiTF300362.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR027743. Dnm3.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF54. PTHR11566:SF54. 1 hit.
    PfamiPF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00195. DYNAMIN.
    SMARTiSM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BZ98-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN    50
    FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE 100
    IEAETDRVTG MNKGISSIPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 150
    DIEYQIRDMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT 200
    IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA 250
    AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 300
    QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ 350
    VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT 400
    GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VMQELINTVK KCTKRLANFP 450
    RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ 500
    QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV LTAESLSWYK 550
    DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRFLE 600
    LACDSQEDVD SWKASLLRAG VYPDKSVGSN KTENDENGQA ENFSMDPQLE 650
    RQVETIRNLV DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY 700
    SSEDQNTLME ESAEQAQRRD EMLRMYQALK EALAIIGDIN TATVSTPAPP 750
    PVDDSWLQHS RRSPPPSPTT QRRLTISAPL PRPTSGRGPA PAIPSPGPHS 800
    GAPPVPFRPG PLPPFPNSSD SFGAPPQVPS RPTRAPPSVP SRRPPPSPTR 850
    PTIIRPLESS LLD 863
    Length:863
    Mass (Da):97,190
    Last modified:March 1, 2003 - v1
    Checksum:i8BDBB091CB10D264
    GO
    Isoform 2 (identifier: Q8BZ98-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         628-631: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:859
    Mass (Da):96,804
    Checksum:i591E1B65A81A26D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391G → A in BAE28068. (PubMed:16141072)Curated
    Sequence conflicti532 – 54918Missing in BAC65661. (PubMed:12693553)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei628 – 6314Missing in isoform 2. 1 PublicationVSP_031548

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036199 mRNA. Translation: BAC29343.1.
    AK049724 mRNA. Translation: BAC33895.1.
    AK147678 mRNA. Translation: BAE28068.1.
    BC141143 mRNA. Translation: AAI41144.1.
    BC141144 mRNA. Translation: AAI41145.1.
    AK122379 Transcribed RNA. Translation: BAC65661.1.
    CCDSiCCDS48417.1. [Q8BZ98-2]
    RefSeqiNP_001033708.1. NM_001038619.1. [Q8BZ98-1]
    NP_766234.1. NM_172646.2. [Q8BZ98-2]
    UniGeneiMm.441620.

    Genome annotation databases

    EnsembliENSMUST00000070330; ENSMUSP00000064538; ENSMUSG00000040265. [Q8BZ98-2]
    GeneIDi103967.
    KEGGimmu:103967.
    UCSCiuc007dga.2. mouse. [Q8BZ98-1]
    uc007dgb.2. mouse. [Q8BZ98-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036199 mRNA. Translation: BAC29343.1 .
    AK049724 mRNA. Translation: BAC33895.1 .
    AK147678 mRNA. Translation: BAE28068.1 .
    BC141143 mRNA. Translation: AAI41144.1 .
    BC141144 mRNA. Translation: AAI41145.1 .
    AK122379 Transcribed RNA. Translation: BAC65661.1 .
    CCDSi CCDS48417.1. [Q8BZ98-2 ]
    RefSeqi NP_001033708.1. NM_001038619.1. [Q8BZ98-1 ]
    NP_766234.1. NM_172646.2. [Q8BZ98-2 ]
    UniGenei Mm.441620.

    3D structure databases

    ProteinModelPortali Q8BZ98.
    SMRi Q8BZ98. Positions 6-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BZ98. 5 interactions.
    MINTi MINT-1856052.

    PTM databases

    PhosphoSitei Q8BZ98.

    Proteomic databases

    MaxQBi Q8BZ98.
    PaxDbi Q8BZ98.
    PRIDEi Q8BZ98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070330 ; ENSMUSP00000064538 ; ENSMUSG00000040265 . [Q8BZ98-2 ]
    GeneIDi 103967.
    KEGGi mmu:103967.
    UCSCi uc007dga.2. mouse. [Q8BZ98-1 ]
    uc007dgb.2. mouse. [Q8BZ98-2 ]

    Organism-specific databases

    CTDi 26052.
    MGIi MGI:1341299. Dnm3.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0699.
    GeneTreei ENSGT00740000115253.
    HOGENOMi HOG000161069.
    HOVERGENi HBG107833.
    InParanoidi B2RUH0.
    KOi K01528.
    PhylomeDBi Q8BZ98.
    TreeFami TF300362.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_202778. Retrograde neurotrophin signalling.

    Miscellaneous databases

    ChiTaRSi DNM3. mouse.
    NextBioi 356261.
    PROi Q8BZ98.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BZ98.
    Bgeei Q8BZ98.
    CleanExi MM_DNM3.
    Genevestigatori Q8BZ98.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR027743. Dnm3.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF54. PTHR11566:SF54. 1 hit.
    Pfami PF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00195. DYNAMIN.
    SMARTi SM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Brain, Cerebellum and Spinal cord.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-863 (ISOFORM 1).
      Tissue: Brain.
    4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiDYN3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZ98
    Secondary accession number(s): B2RUH0
    , Q3UGY9, Q80TR2, Q8BWW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3