Dnm3

Functionⁱ

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).By similarity

Catalytic activityⁱ

GTP + H₂O = GDP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	38 – 46	GTPBy similarity	9
Nucleotide bindingⁱ	205 – 211	GTPBy similarity	7
Nucleotide bindingⁱ	236 – 239	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: GO_Central
GTP binding Source: UniProtKB-KW
identical protein binding Source: MGI
microtubule binding Source: GO_Central
nitric-oxide synthase binding Source: Ensembl
type 1 metabotropic glutamate receptor binding Source: Ensembl
type 5 metabotropic glutamate receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
membrane fusion Source: GO_Central
mitochondrial fission Source: GO_Central
negative regulation of dendritic spine morphogenesis Source: Ensembl
positive regulation of filopodium assembly Source: Ensembl
positive regulation of synaptic vesicle recycling Source: Ensembl
postsynaptic neurotransmitter receptor internalization Source: Ensembl
synaptic vesicle budding from presynaptic endocytic zone membrane
Source: SynGO
Inferred from genetic interactionⁱ
- 21689597

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Motor protein
Biological process	Endocytosis
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade. R-MMU-2132295. MHC class II antigen presentation. R-MMU-437239. Recycling pathway of L1. R-MMU-8856828. Clathrin-mediated endocytosis.

Reactomeⁱ

R-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-437239. Recycling pathway of L1.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dynamin-3 (EC:3.6.5.5)
Gene namesⁱ	Name:Dnm3 Synonyms:Kiaa0820
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1341299. Dnm3.

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000319951	1 – 863	Dynamin-3Add BLAST		863

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	80	PhosphotyrosineBy similarity	1
Modified residueⁱ	125	Nitrated tyrosine; alternateBy similarity	1
Modified residueⁱ	125	Phosphotyrosine; alternateBy similarity	1
Modified residueⁱ	231	PhosphotyrosineBy similarity	1
Modified residueⁱ	299	N6-acetyllysineBy similarity	1
Modified residueⁱ	306	PhosphoserineBy similarity	1
Modified residueⁱ	347	PhosphoserineBy similarity	1
Modified residueⁱ	593	PhosphotyrosineBy similarity	1
Modified residueⁱ	594	N6-acetyllysineBy similarity	1
Modified residueⁱ	763	PhosphoserineBy similarity	1
Modified residueⁱ	767	PhosphoserineBy similarity	1
Modified residueⁱ	787	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	847	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Nitration, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8BZ98.
PeptideAtlas More...PeptideAtlasⁱ	Q8BZ98.
PRIDEⁱ	Q8BZ98.

PTM databases

iPTMnetⁱ	Q8BZ98.
PhosphoSitePlusⁱ	Q8BZ98.
SwissPalmⁱ	Q8BZ98.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000040265.
CleanExⁱ	MM_DNM3.
ExpressionAtlasⁱ	Q8BZ98. baseline and differential.
Genevisibleⁱ	Q8BZ98. MM.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Amph	Q7TQF7	2	EBI-6880033,EBI-775139

With

Entry

#Exp.

IntAct

Notes

Amph

Q7TQF7

2

EBI-6880033,EBI-775139

GO - Molecular functionⁱ

identical protein binding Source: MGI
microtubule binding Source: GO_Central
nitric-oxide synthase binding Source: Ensembl
type 1 metabotropic glutamate receptor binding Source: Ensembl
type 5 metabotropic glutamate receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	222243. 1 interactor.
IntActⁱ	Q8BZ98. 9 interactors.
Molecular INTeraction database More...MINTⁱ	Q8BZ98.
STRINGⁱ	10090.ENSMUSP00000064538.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BZ98.
SMRⁱ	Q8BZ98.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 294	Dynamin-type GAdd BLAST	267
Domainⁱ	515 – 621	PHPROSITE-ProRule annotationAdd BLAST	107
Domainⁱ	653 – 744	GEDPROSITE-ProRule annotationAdd BLAST	92

Sequence similaritiesⁱ

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0446. Eukaryota. COG0699. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119213.
HOGENOMⁱ	HOG000161069.
HOVERGENⁱ	HBG107833.
InParanoidⁱ	Q8BZ98.
KEGG Orthology (KO) More...KOⁱ	K01528.
PhylomeDBⁱ	Q8BZ98.
TreeFamⁱ	TF300362.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08771. DLP_1. 1 hit.
Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR022812. Dynamin_SF. IPR030381. G_DYNAMIN_dom. IPR003130. GED. IPR020850. GED_dom. IPR027417. P-loop_NTPase. IPR011993. PH-like_dom_sf. IPR001849. PH_domain.
PANTHERⁱ	PTHR11566. PTHR11566. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit.
PRINTSⁱ	PR00195. DYNAMIN.
SMARTⁱ	View protein in SMART SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. SM00233. PH. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00410. G_DYNAMIN_1. 1 hit. PS51718. G_DYNAMIN_2. 1 hit. PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8BZ98-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE 
       110        120        130        140        150
IEAETDRVTG MNKGISSIPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIRDMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA 
       260        270        280        290        300
AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 
       310        320        330        340        350
QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT 
       410        420        430        440        450
GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VMQELINTVK KCTKRLANFP 
       460        470        480        490        500
RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV LTAESLSWYK 
       560        570        580        590        600
DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRFLE 
       610        620        630        640        650
LACDSQEDVD SWKASLLRAG VYPDKSVGSN KTENDENGQA ENFSMDPQLE 
       660        670        680        690        700
RQVETIRNLV DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY 
       710        720        730        740        750
SSEDQNTLME ESAEQAQRRD EMLRMYQALK EALAIIGDIN TATVSTPAPP 
       760        770        780        790        800
PVDDSWLQHS RRSPPPSPTT QRRLTISAPL PRPTSGRGPA PAIPSPGPHS 
       810        820        830        840        850
GAPPVPFRPG PLPPFPNSSD SFGAPPQVPS RPTRAPPSVP SRRPPPSPTR 
       860 
PTIIRPLESS LLD

Length:863

Mass (Da):97,190

Last modified:March 1, 2003 - v1

Checksum:ⁱ8BDBB091CB10D264

GO

Isoform 2 (identifier: Q8BZ98-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
628-631: Missing.

« Hide

        10         20         30         40         50
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE 
       110        120        130        140        150
IEAETDRVTG MNKGISSIPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIRDMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA 
       260        270        280        290        300
AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 
       310        320        330        340        350
QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT 
       410        420        430        440        450
GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VMQELINTVK KCTKRLANFP 
       460        470        480        490        500
RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV LTAESLSWYK 
       560        570        580        590        600
DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRFLE 
       610        620        630        640        650
LACDSQEDVD SWKASLLRAG VYPDKSVTEN DENGQAENFS MDPQLERQVE 
       660        670        680        690        700
TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED 
       710        720        730        740        750
QNTLMEESAE QAQRRDEMLR MYQALKEALA IIGDINTATV STPAPPPVDD 
       760        770        780        790        800
SWLQHSRRSP PPSPTTQRRL TISAPLPRPT SGRGPAPAIP SPGPHSGAPP 
       810        820        830        840        850
VPFRPGPLPP FPNSSDSFGA PPQVPSRPTR APPSVPSRRP PPSPTRPTII 

RPLESSLLD

Note: No experimental confirmation available.

Show »

Length:859

Mass (Da):96,804

Checksum:ⁱ591E1B65A81A26D0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	139	G → A in BAE28068 (PubMed:16141072).Curated		1
Sequence conflictⁱ	532 – 549	Missing in BAC65661 (PubMed:12693553).CuratedAdd BLAST		18

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031548	628 – 631	Missing in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK036199 mRNA. Translation: BAC29343.1. AK049724 mRNA. Translation: BAC33895.1. AK147678 mRNA. Translation: BAE28068.1. BC141143 mRNA. Translation: AAI41144.1. BC141144 mRNA. Translation: AAI41145.1. AK122379 Transcribed RNA. Translation: BAC65661.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48417.1. [Q8BZ98-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001033708.1. NM_001038619.1. [Q8BZ98-1] NP_766234.1. NM_172646.2. [Q8BZ98-2]
UniGeneⁱ	Mm.441620.

Genome annotation databases

Ensemblⁱ	ENSMUST00000070330; ENSMUSP00000064538; ENSMUSG00000040265. [Q8BZ98-2]
GeneIDⁱ	103967.
KEGGⁱ	mmu:103967.
UCSC genome browser More...UCSCⁱ	uc007dga.2. mouse. [Q8BZ98-1] uc007dgb.2. mouse. [Q8BZ98-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8BZ98	Q08877 F7FMU7 UPI0004D0579B Q08877-5 A0A1A6FYU1 UPI000B3E2C0A UPI000905041F F7HY76 UPI000C2FECF6 UPI000904A972 +518	Rattus norvegicus (Rat) Monodelphis domestica (Gray short-tailed opossum) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Neotoma lepida (Desert woodrat) Numida meleagris (Helmeted guineafowl) (Phasianus meleagris) Panthera pardus (Leopard) (Felis pardus) Callithrix jacchus (White-tufted-ear marmoset) Felis catus (Cat) (Felis silvestris catus) Loxodonta africana (African elephant) Mus musculus (Mouse) And more	869	UniRef90_Q08877	Cluster: Dynamin-3	529

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8BZ98	P50570 K7CG09 A0A2I2Y8E6 A0A2J8S0U1 UPI00077D964E UPI00077DC816 UPI00077DBD37 UPI000945BC93 UPI000A2B5CF9 UPI000A2B89BF +1469	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Peromyscus maniculatus bairdii (Prairie deer mouse) Rhinolophus sinicus (Chinese rufous horseshoe bat) Sus scrofa (Pig) Monodelphis domestica (Gray short-tailed opossum) Mus musculus (Mouse) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) And more	870	UniRef50_P50570	Cluster: Dynamin-2	1,480

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK036199 mRNA. Translation: BAC29343.1. AK049724 mRNA. Translation: BAC33895.1. AK147678 mRNA. Translation: BAE28068.1. BC141143 mRNA. Translation: AAI41144.1. BC141144 mRNA. Translation: AAI41145.1. AK122379 Transcribed RNA. Translation: BAC65661.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48417.1. [Q8BZ98-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001033708.1. NM_001038619.1. [Q8BZ98-1] NP_766234.1. NM_172646.2. [Q8BZ98-2]
UniGeneⁱ	Mm.441620.

3D structure databases

ProteinModelPortalⁱ	Q8BZ98.
SMRⁱ	Q8BZ98.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	222243. 1 interactor.
IntActⁱ	Q8BZ98. 9 interactors.
Molecular INTeraction database More...MINTⁱ	Q8BZ98.
STRINGⁱ	10090.ENSMUSP00000064538.

PTM databases

iPTMnetⁱ	Q8BZ98.
PhosphoSitePlusⁱ	Q8BZ98.
SwissPalmⁱ	Q8BZ98.

Proteomic databases

PaxDbⁱ	Q8BZ98.
PeptideAtlas More...PeptideAtlasⁱ	Q8BZ98.
PRIDEⁱ	Q8BZ98.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000070330; ENSMUSP00000064538; ENSMUSG00000040265. [Q8BZ98-2]
GeneIDⁱ	103967.
KEGGⁱ	mmu:103967.
UCSC genome browser More...UCSCⁱ	uc007dga.2. mouse. [Q8BZ98-1] uc007dgb.2. mouse. [Q8BZ98-2]

Organism-specific databases

CTDⁱ	26052.
MGIⁱ	MGI:1341299. Dnm3.
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0446. Eukaryota. COG0699. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119213.
HOGENOMⁱ	HOG000161069.
HOVERGENⁱ	HBG107833.
InParanoidⁱ	Q8BZ98.
KEGG Orthology (KO) More...KOⁱ	K01528.
PhylomeDBⁱ	Q8BZ98.
TreeFamⁱ	TF300362.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade. R-MMU-2132295. MHC class II antigen presentation. R-MMU-437239. Recycling pathway of L1. R-MMU-8856828. Clathrin-mediated endocytosis.

Reactomeⁱ

R-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-437239. Recycling pathway of L1.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSⁱ	Dnm3. mouse.
Protein Ontology More...PROⁱ	PR:Q8BZ98.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040265.
CleanExⁱ	MM_DNM3.
ExpressionAtlasⁱ	Q8BZ98. baseline and differential.
Genevisibleⁱ	Q8BZ98. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08771. DLP_1. 1 hit.
Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR022812. Dynamin_SF. IPR030381. G_DYNAMIN_dom. IPR003130. GED. IPR020850. GED_dom. IPR027417. P-loop_NTPase. IPR011993. PH-like_dom_sf. IPR001849. PH_domain.
PANTHERⁱ	PTHR11566. PTHR11566. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit.
PRINTSⁱ	PR00195. DYNAMIN.
SMARTⁱ	View protein in SMART SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. SM00233. PH. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00410. G_DYNAMIN_1. 1 hit. PS51718. G_DYNAMIN_2. 1 hit. PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DYN3_MOUSE
Accessionⁱ	Q8BZ98Primary (citable) accession number: Q8BZ98 Secondary accession number(s): B2RUH0 , Q3UGY9, Q80TR2, Q8BWW6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	March 1, 2003
	Last modified:	March 28, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BZ98 (DYN3_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Dynamin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Extracellular region or secreted

Golgi apparatus

Mitochondrion

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ