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Protein

Neuromedin-U receptor 2

Gene

Nmur2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Gene namesi
Name:Nmur2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2441765. Nmur2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini63 – 7412CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini96 – 11520ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13823Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 21234ExtracellularSequence analysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini234 – 25724CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 29315ExtracellularSequence analysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini315 – 39581CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3351217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Neuromedin-U receptor 2PRO_0000069911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi111 ↔ 196PROSITE-ProRule annotation
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BZ39.
PRIDEiQ8BZ39.

PTM databases

PhosphoSiteiQ8BZ39.

Expressioni

Tissue specificityi

Expressed primarily in brain tissues, more specifically in medulla and spinal cord. Widespread distribution in peripheral tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000037393.
CleanExiMM_NMUR2.
GenevisibleiQ8BZ39. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044718.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ39.
SMRiQ8BZ39. Positions 33-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ8BZ39.
KOiK05053.
OMAiHYFPNGS.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ8BZ39.
TreeFamiTF318522.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLENASWI HDSLMKYLNS TEEYLAYLCG PKRSDLSLPV SVVYALIFVV
60 70 80 90 100
GVIGNLLVCL VIARHQTLKT PTNYYLFSLA VSDLLVLLLG MPLEVYELWH
110 120 130 140 150
NYPFLFGPVG CYFKTALFET VCFASILSVT TVSIERYVAI VHPFRAKLES
160 170 180 190 200
TRRRALRILS LVWSFSVVFS LPNTSIHGIK FQQFPNGSSV PGSATCTVTK
210 220 230 240 250
PIWVYNFIIQ ATSFLFYILP MTLISVLYYL MGLRLKRDES LEADKVTVNI
260 270 280 290 300
HRPSRKSVTK MLFVLVLVFA ICWTPFHVDR LFFSFVDEWT ESLAAVFNLI
310 320 330 340 350
HVVSGVFFYL SSAVNPIIYN LLSRRFRAAF RNVVSPSCKW CHPQHRPQGP
360 370 380 390
PAQKVIFLTE CHLVELTEDA GPQFPCQSSI HNTQLTTVPC VEEVP
Length:395
Mass (Da):44,827
Last modified:March 1, 2003 - v1
Checksum:i0EA292C1947142FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021I → M in AAL26695 (PubMed:12217421).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057384 mRNA. Translation: AAL26695.1.
AK036756 mRNA. Translation: BAC29564.1.
AL671969 Genomic DNA. Translation: CAI25254.1.
CCDSiCCDS24716.1.
RefSeqiNP_694719.2. NM_153079.4.
UniGeneiMm.213205.

Genome annotation databases

EnsembliENSMUST00000037682; ENSMUSP00000044718; ENSMUSG00000037393.
GeneIDi216749.
KEGGimmu:216749.
UCSCiuc007izq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057384 mRNA. Translation: AAL26695.1.
AK036756 mRNA. Translation: BAC29564.1.
AL671969 Genomic DNA. Translation: CAI25254.1.
CCDSiCCDS24716.1.
RefSeqiNP_694719.2. NM_153079.4.
UniGeneiMm.213205.

3D structure databases

ProteinModelPortaliQ8BZ39.
SMRiQ8BZ39. Positions 33-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044718.

Chemistry

ChEMBLiCHEMBL3351217.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BZ39.

Proteomic databases

PaxDbiQ8BZ39.
PRIDEiQ8BZ39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037682; ENSMUSP00000044718; ENSMUSG00000037393.
GeneIDi216749.
KEGGimmu:216749.
UCSCiuc007izq.1. mouse.

Organism-specific databases

CTDi56923.
MGIiMGI:2441765. Nmur2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ8BZ39.
KOiK05053.
OMAiHYFPNGS.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ8BZ39.
TreeFamiTF318522.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ8BZ39.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037393.
CleanExiMM_NMUR2.
GenevisibleiQ8BZ39. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMUR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ39
Secondary accession number(s): Q91Z76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.