Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8BZ39 (NMUR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuromedin-U receptor 2
Short name=NMU-R2
Gene names
Name:Nmur2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides By similarity. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed primarily in brain tissues, more specifically in medulla and spinal cord. Widespread distribution in peripheral tissues. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Neuromedin-U receptor 2
PRO_0000069911

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 7412Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 11520Extracellular Potential
Transmembrane116 – 13823Helical; Name=3; Potential
Topological domain139 – 15719Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 21234Extracellular Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Topological domain234 – 25724Cytoplasmic Potential
Transmembrane258 – 27821Helical; Name=6; Potential
Topological domain279 – 29315Extracellular Potential
Transmembrane294 – 31421Helical; Name=7; Potential
Topological domain315 – 39581Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 196 By similarity

Experimental info

Sequence conflict2021I → M in AAL26695. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BZ39 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0EA292C1947142FD

FASTA39544,827
        10         20         30         40         50         60 
MGKLENASWI HDSLMKYLNS TEEYLAYLCG PKRSDLSLPV SVVYALIFVV GVIGNLLVCL 

        70         80         90        100        110        120 
VIARHQTLKT PTNYYLFSLA VSDLLVLLLG MPLEVYELWH NYPFLFGPVG CYFKTALFET 

       130        140        150        160        170        180 
VCFASILSVT TVSIERYVAI VHPFRAKLES TRRRALRILS LVWSFSVVFS LPNTSIHGIK 

       190        200        210        220        230        240 
FQQFPNGSSV PGSATCTVTK PIWVYNFIIQ ATSFLFYILP MTLISVLYYL MGLRLKRDES 

       250        260        270        280        290        300 
LEADKVTVNI HRPSRKSVTK MLFVLVLVFA ICWTPFHVDR LFFSFVDEWT ESLAAVFNLI 

       310        320        330        340        350        360 
HVVSGVFFYL SSAVNPIIYN LLSRRFRAAF RNVVSPSCKW CHPQHRPQGP PAQKVIFLTE 

       370        380        390 
CHLVELTEDA GPQFPCQSSI HNTQLTTVPC VEEVP

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of murine neuromedin U receptors."
Funes S., Hedrick J.A., Yang S., Shan L., Bayne M., Monsma F.J. Jr., Gustafson E.L.
Peptides 23:1607-1615(2002) [PubMed: 12217421] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Vagina.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY057384 mRNA. Translation: AAL26695.1.
AK036756 mRNA. Translation: BAC29564.1.
AL671969 Genomic DNA. Translation: CAI25254.1.
IPIIPI00313724.
RefSeqNP_694719.2. NM_153079.4.
UniGeneMm.213205.

3D structure databases

ProteinModelPortalQ8BZ39.
SMRQ8BZ39. Positions 35-337.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8BZ39.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ8BZ39.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037682; ENSMUSP00000044718; ENSMUSG00000037393.
GeneID216749.
KEGGmmu:216749.
UCSCuc007izq.1. mouse.

Organism-specific databases

CTD56923.
MGIMGI:2441765. Nmur2.

Phylogenomic databases

eggNOGroNOG09093.
GeneTreeENSGT00550000074225.
HOGENOMHBG447291.
HOVERGENHBG103506.
InParanoidQ8BZ39.
OMANFIIQVT.
OrthoDBEOG42822B.
PhylomeDBQ8BZ39.

Gene expression databases

ArrayExpressQ8BZ39.
BgeeQ8BZ39.
CleanExMM_NMUR2.
GenevestigatorQ8BZ39.
GermOnlineENSMUSG00000037393. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
KOK05053.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio375286.
SOURCESearch...

Entry information

Entry nameNMUR2_MOUSE
AccessionPrimary (citable) accession number: Q8BZ39
Secondary accession number(s): Q91Z76
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents